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A heparan sulfate-based matrix therapy reduces brain damage and enhances functional recovery following stroke.

Khelif Y, Toutain J, Quittet MS, Chantepie S, Laffray X, Valable S, Divoux D, Sineriz F, Pascolo-Rebouillat E, Papy-Garcia D, Barritault D, Touzani O, Bernaudin M.

Theranostics. 2018 Nov 12;8(21):5814-5827. doi: 10.7150/thno.28252. eCollection 2018.


Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau.

Huynh MB, Ouidja MO, Chantepie S, Carpentier G, Maïza A, Zhang G, Vilares J, Raisman-Vozari R, Papy-Garcia D.

PLoS One. 2019 Jan 4;14(1):e0209573. doi: 10.1371/journal.pone.0209573. eCollection 2019.


SLC10A7 mutations cause a skeletal dysplasia with amelogenesis imperfecta mediated by GAG biosynthesis defects.

Dubail J, Huber C, Chantepie S, Sonntag S, Tüysüz B, Mihci E, Gordon CT, Steichen-Gersdorf E, Amiel J, Nur B, Stolte-Dijkstra I, van Eerde AM, van Gassen KL, Breugem CC, Stegmann A, Lekszas C, Maroofian R, Karimiani EG, Bruneel A, Seta N, Munnich A, Papy-Garcia D, De La Dure-Molla M, Cormier-Daire V.

Nat Commun. 2018 Aug 6;9(1):3087. doi: 10.1038/s41467-018-05191-8.


New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors.

Byrne DP, Li Y, Ramakrishnan K, Barsukov IL, Yates EA, Eyers CE, Papy-Garcia D, Chantepie S, Pagadala V, Liu J, Wells C, Drewry DH, Zuercher WJ, Berry NG, Fernig DG, Eyers PA.

Biochem J. 2018 Aug 14;475(15):2417-2433. doi: 10.1042/BCJ20180265.


The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration.

Maïza A, Chantepie S, Vera C, Fifre A, Huynh MB, Stettler O, Ouidja MO, Papy-Garcia D.

FEBS Lett. 2018 Dec;592(23):3806-3818. doi: 10.1002/1873-3468.13082. Epub 2018 Jun 14. Review.


Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2) displays an unexpected subcellular localization in the plasma membrane.

Delos M, Foulquier F, Hellec C, Vicogne D, Fifre A, Carpentier M, Papy-Garcia D, Allain F, Denys A.

Biochim Biophys Acta Gen Subj. 2018 Jul;1862(7):1644-1655. doi: 10.1016/j.bbagen.2018.04.013. Epub 2018 Apr 13.


[Heparan sulphates, amyloidosis and neurodegeneration].

Vera C, Alvarez-Orozco JA, Maiza A, Chantepie S, Chehin RN, Ouidja MO, Papy-Garcia D.

Rev Neurol. 2017 Nov 16;65(10):457-468. Review. Spanish.


Heparan sulfate proteoglycans as key regulators of the mesenchymal niche of hematopoietic stem cells.

Papy-Garcia D, Albanese P.

Glycoconj J. 2017 Jun;34(3):377-391. doi: 10.1007/s10719-017-9773-8. Epub 2017 Jun 2. Review.


Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species.

González-Lizárraga F, Socías SB, Ávila CL, Torres-Bugeau CM, Barbosa LR, Binolfi A, Sepúlveda-Díaz JE, Del-Bel E, Fernandez CO, Papy-Garcia D, Itri R, Raisman-Vozari R, Chehín RN.

Sci Rep. 2017 Feb 3;7:41755. doi: 10.1038/srep41755.


RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients.

Barritault D, Gilbert-Sirieix M, Rice KL, Siñeriz F, Papy-Garcia D, Baudouin C, Desgranges P, Zakine G, Saffar JL, van Neck J.

Glycoconj J. 2017 Jun;34(3):325-338. doi: 10.1007/s10719-016-9744-5. Epub 2016 Dec 7. Review.


Poly(ethylene glycol acrylate)-functionalized hydrogels for heparan sulfate oligosaccharide recognition.

Mothéré M, Singabraya D, Driguez PA, Siñeriz F, Papy-Garcia D.

J Mol Recognit. 2017 Mar;30(3). doi: 10.1002/jmr.2584. Epub 2016 Oct 28.


Heparan sulfates and the decrease of N-glycans promote early adipogenic differentiation rather than myogenesis of murine myogenic progenitor cells.

Grassot V, Bouchatal A, Da Silva A, Chantepie S, Papy-Garcia D, Maftah A, Gallet PF, Petit JM.

Differentiation. 2017 Jan - Feb;93:15-26. doi: 10.1016/j.diff.2016.08.003. Epub 2016 Sep 28.


A fine structural modification of glycosaminoglycans is correlated with the progression of muscle regeneration after ischaemia: towards a matrix-based therapy?

Chevalier F, Arnaud D, Henault E, Guillevic O, Siñeriz F, Ponsen AC, Papy-Garcia D, Barritault D, Letourneur D, Uzan G, Meddahi-Pellé A, Hlawaty H, Albanese P.

Eur Cell Mater. 2015 Sep 4;30:51-68.


Modulation of inflammation and angiogenesis and changes in ECM GAG-activity via dual delivery of nucleic acids.

Browne S, Monaghan MG, Brauchle E, Berrio DC, Chantepie S, Papy-Garcia D, Schenke-Layland K, Pandit A.

Biomaterials. 2015 Nov;69:133-47. doi: 10.1016/j.biomaterials.2015.08.012. Epub 2015 Aug 6.


HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.

Sepulveda-Diaz JE, Alavi Naini SM, Huynh MB, Ouidja MO, Yanicostas C, Chantepie S, Villares J, Lamari F, Jospin E, van Kuppevelt TH, Mensah-Nyagan AG, Raisman-Vozari R, Soussi-Yanicostas N, Papy-Garcia D.

Brain. 2015 May;138(Pt 5):1339-54. doi: 10.1093/brain/awv056. Epub 2015 Apr 4.


New methods based on capillary electrophoresis for in vitro evaluation of protein tau phosphorylation by glycogen synthase kinase 3-β.

Nehmé H, Chantepie S, Defert J, Morin P, Papy-Garcia D, Nehmé R.

Anal Bioanal Chem. 2015 Apr;407(10):2821-8. doi: 10.1007/s00216-015-8495-7. Epub 2015 Feb 25.


New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease.

Lehri-Boufala S, Ouidja MO, Barbier-Chassefière V, Hénault E, Raisman-Vozari R, Garrigue-Antar L, Papy-Garcia D, Morin C.

PLoS One. 2015 Jan 24;10(1):e0116641. doi: 10.1371/journal.pone.0116641. eCollection 2015.


Glycosaminoglycan modifications in Duchenne muscular dystrophy: specific remodeling of chondroitin sulfate/dermatan sulfate.

Negroni E, Henault E, Chevalier F, Gilbert-Sirieix M, Van Kuppevelt TH, Papy-Garcia D, Uzan G, Albanese P.

J Neuropathol Exp Neurol. 2014 Aug;73(8):789-97. doi: 10.1097/NEN.0000000000000098.


Structural characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase protofibrils preventing α-synuclein oligomeric species toxicity.

Ávila CL, Torres-Bugeau CM, Barbosa LR, Sales EM, Ouidja MO, Socías SB, Celej MS, Raisman-Vozari R, Papy-Garcia D, Itri R, Chehín RN.

J Biol Chem. 2014 May 16;289(20):13838-50. doi: 10.1074/jbc.M113.544288. Epub 2014 Mar 26.


Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs.

Rouvinski A, Karniely S, Kounin M, Moussa S, Goldberg MD, Warburg G, Lyakhovetsky R, Papy-Garcia D, Kutzsche J, Korth C, Carlson GA, Godsave SF, Peters PJ, Luhr K, Kristensson K, Taraboulos A.

J Cell Biol. 2014 Feb 3;204(3):423-41. doi: 10.1083/jcb.201308028.


Greater glycosaminoglycan content in human patellar tendon biopsies is associated with more pain and a lower VISA score.

Attia M, Scott A, Carpentier G, Lian O, Van Kuppevelt T, Gossard C, Papy-Garcia D, Tassoni MC, Martelly I.

Br J Sports Med. 2014 Mar;48(6):469-75. doi: 10.1136/bjsports-2013-092633. Epub 2013 Oct 6.


Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds.

Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):E3138-47. doi: 10.1073/pnas.1301440110. Epub 2013 Jul 29.


Glycosaminoglycan mimetic associated to human mesenchymal stem cell-based scaffolds inhibit ectopic bone formation, but induce angiogenesis in vivo.

Frescaline G, Bouderlique T, Mansoor L, Carpentier G, Baroukh B, Sineriz F, Trouillas M, Saffar JL, Courty J, Lataillade JJ, Papy-Garcia D, Albanese P.

Tissue Eng Part A. 2013 Jul;19(13-14):1641-53. doi: 10.1089/ten.TEA.2012.0377.


Self-evolving oxidative stress with identifiable pre- and postmitochondrial phases in PC12 cells.

Zhang G, Morin C, Zhu X, Bao Huynh M, Ouidir Ouidja M, Sepulveda-Diaz JE, Raisman-Vozari R, Li P, Papy-Garcia D.

J Neurosci Res. 2013 Feb;91(2):273-84. doi: 10.1002/jnr.23146. Epub 2012 Nov 14.


Molecular imprinting technology for specific recognition of heparan sulfate like disaccharides.

Singabraya D, Bultel L, Siñeriz F, Mothéré M, Lesur D, Kovensky J, Papy-Garcia D.

Talanta. 2012 Sep 15;99:833-9. doi: 10.1016/j.talanta.2012.07.037. Epub 2012 Jul 23.


Heparin affin regulatory peptide modulates the endogenous anticoagulant activity of heparin and heparan sulphate mimetics.

Mejdoubi-Charef N, Courty J, Sineriz F, Papy-Garcia D, Charef S.

Basic Clin Pharmacol Toxicol. 2012 Nov;111(5):296-302. doi: 10.1111/j.1742-7843.2012.00906.x. Epub 2012 Jul 6.


Age-related changes in rat myocardium involve altered capacities of glycosaminoglycans to potentiate growth factor functions and heparan sulfate-altered sulfation.

Huynh MB, Morin C, Carpentier G, Garcia-Filipe S, Talhas-Perret S, Barbier-Chassefière V, van Kuppevelt TH, Martelly I, Albanese P, Papy-Garcia D.

J Biol Chem. 2012 Mar 30;287(14):11363-73. doi: 10.1074/jbc.M111.335901. Epub 2012 Feb 1.


Glycosaminoglycans mimetics potentiate the clonogenicity, proliferation, migration and differentiation properties of rat mesenchymal stem cells.

Frescaline G, Bouderlique T, Huynh MB, Papy-Garcia D, Courty J, Albanese P.

Stem Cell Res. 2012 Mar;8(2):180-92. doi: 10.1016/j.scr.2011.09.005. Epub 2011 Oct 8.


Characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase early amyloid-like oligomers and their implication in α-synuclein aggregation.

Torres-Bugeau CM, Ávila CL, Raisman-Vozari R, Papy-Garcia D, Itri R, Barbosa LR, Cortez LM, Sim VL, Chehín RN.

J Biol Chem. 2012 Jan 20;287(4):2398-409. doi: 10.1074/jbc.M111.303503. Epub 2011 Dec 1.


Glycosaminoglycans from aged human hippocampus have altered capacities to regulate trophic factors activities but not Aβ42 peptide toxicity.

Huynh MB, Villares J, Díaz JE, Christiaans S, Carpentier G, Ouidja MO, Sissoeff L, Raisman-Vozari R, Papy-Garcia D.

Neurobiol Aging. 2012 May;33(5):1005.e11-22. doi: 10.1016/j.neurobiolaging.2011.09.030. Epub 2011 Oct 27.


Variation in Chst8 gene expression level affects PrPC to PrPSc conversion efficiency in prion-infected Mov cells.

Martin R, Chantepie S, Chapuis J, Le-Duc A, Maftah A, Papy-Garcia D, Laude H, Petit JM, Gallet PF.

Biochem Biophys Res Commun. 2011 Oct 28;414(3):587-91. doi: 10.1016/j.bbrc.2011.09.126. Epub 2011 Oct 1.


Glycosaminoglycans, protein aggregation and neurodegeneration.

Papy-Garcia D, Christophe M, Huynh MB, Fernando S, Ludmilla S, Sepulveda-Diaz JE, Raisman-Vozari R.

Curr Protein Pept Sci. 2011 May;12(3):258-68. Review.


Matrix therapy with RGTA OTR4120 improves healing time and quality in hairless rats with deep second-degree burns.

Zakine G, Barbier V, Garcia-Filipe S, Luboinski J, Papy-Garcia D, Chachques JC, Carpentier A, Barritault D.

Plast Reconstr Surg. 2011 Feb;127(2):541-50. doi: 10.1097/PRS.0b013e318200a910.


Interactions of bexarotene (LGD1069, Targretin) with the coagulation system.

Hespel A, Mejdoubi-Charef N, Yous S, Courty J, Papy-Garcia D, Charef S.

Cancer Chemother Pharmacol. 2011 Oct;68(4):847-54. doi: 10.1007/s00280-010-1553-0. Epub 2011 Jan 13.


Synthesis and biological activities of a library of glycosaminoglycans mimetic oligosaccharides.

Ikeda Y, Charef S, Ouidja MO, Barbier-Chassefière V, Sineriz F, Duchesnay A, Narasimprakash H, Martelly I, Kern P, Barritault D, Petit E, Papy-Garcia D.

Biomaterials. 2011 Jan;32(3):769-76. doi: 10.1016/j.biomaterials.2010.09.043. Epub 2010 Oct 13.


Absorption and tissue distribution of a novel carboxymethyldextran after oral administration.

Charef S, Papy-Garcia D, Courty J.

Biomed Pharmacother. 2010 Nov;64(9):627-32. doi: 10.1016/j.biopha.2010.03.002.


Toxicological evaluation of RGTA OTR4120, a heparan sulfate mimetic.

Charef S, Tulliez M, Esmilaire L, Courty J, Papy-Garcia D.

Food Chem Toxicol. 2010 Jul;48(7):1965-8. doi: 10.1016/j.fct.2010.04.045. Epub 2010 May 7.


Glycosaminoglycan mimetics trigger IP3-dependent intracellular calcium release in myoblasts.

Martelly I, Singabraya D, Vandebrouck A, Papy-Garcia D, Cognard C, Raymond G, Guillet-Deniau I, Courty J, Constantin B.

Matrix Biol. 2010 May;29(4):317-29. doi: 10.1016/j.matbio.2010.02.002. Epub 2010 Mar 1.


Glycosaminoglycan mimetics inhibit SDF-1/CXCL12-mediated migration and invasion of human hepatoma cells.

Friand V, Haddad O, Papy-Garcia D, Hlawaty H, Vassy R, Hamma-Kourbali Y, Perret GY, Courty J, Baleux F, Oudar O, Gattegno L, Sutton A, Charnaux N.

Glycobiology. 2009 Dec;19(12):1511-24. doi: 10.1093/glycob/cwp130. Epub 2009 Aug 28.


Glycosaminoglycan mimetics-induced mobilization of hematopoietic progenitors and stem cells into mouse peripheral blood: structure/function insights.

Albanese P, Caruelle D, Frescaline G, Delbé J, Petit-Cocault L, Huet E, Charnaux N, Uzan G, Papy-Garcia D, Courty J.

Exp Hematol. 2009 Sep;37(9):1072-83. doi: 10.1016/j.exphem.2009.06.005. Epub 2009 Jun 17.


Insights on a new path of pre-mitochondrial apoptosis regulation by a glycosaminoglycan mimetic.

Yue XL, Lehri S, Li P, Barbier-Chassefière V, Petit E, Huang QF, Albanese P, Barritault D, Caruelle JP, Papy-Garcia D, Morin C.

Cell Death Differ. 2009 May;16(5):770-81. doi: 10.1038/cdd.2009.9. Epub 2009 Feb 20.


Matrix therapy in regenerative medicine, a new approach to chronic wound healing.

Barbier-Chassefière V, Garcia-Filipe S, Yue XL, Kerros ME, Petit E, Kern P, Saffar JL, Papy-Garcia D, Caruelle JP, Barritault D.

J Biomed Mater Res A. 2009 Sep 1;90(3):641-7. doi: 10.1002/jbm.a.32124.


Synthesis of a trisulfated heparan sulfate disaccharide analog and its use as a template for preliminary molecular imprinting studies.

Ikeda Y, Siñeriz F, Bultel L, Grand E, Kovensky J, Papy-Garcia D.

Carbohydr Res. 2008 Mar 17;343(4):587-95. doi: 10.1016/j.carres.2007.12.020. Epub 2007 Dec 28.


Glycosaminoglycans and their synthetic mimetics inhibit RANTES-induced migration and invasion of human hepatoma cells.

Sutton A, Friand V, Papy-Garcia D, Dagouassat M, Martin L, Vassy R, Haddad O, Sainte-Catherine O, Kraemer M, Saffar L, Perret GY, Courty J, Gattegno L, Charnaux N.

Mol Cancer Ther. 2007 Nov;6(11):2948-58.


Structure-activity studies of heparan mimetic polyanions for anti-prion therapies.

Ouidja MO, Petit E, Kerros ME, Ikeda Y, Morin C, Carpentier G, Barritault D, Brugère-Picoux J, Deslys JP, Adjou K, Papy-Garcia D.

Biochem Biophys Res Commun. 2007 Nov 9;363(1):95-100. Epub 2007 Aug 29.


Comparison of CR36, a new heparan mimetic, and pentosan polysulfate in the treatment of prion diseases.

Larramendy-Gozalo C, Barret A, Daudigeos E, Mathieu E, Antonangeli L, Riffet C, Petit E, Papy-Garcia D, Barritault D, Brown P, Deslys JP.

J Gen Virol. 2007 Mar;88(Pt 3):1062-7.


Efficient syntheses of a series of trehalose dimycolate (TDM)/trehalose dicorynomycolate (TDCM) analogues and their interleukin-6 level enhancement activity in mice sera.

Nishizawa M, Yamamoto H, Imagawa H, Barbier-Chassefière V, Petit E, Azuma I, Papy-Garcia D.

J Org Chem. 2007 Mar 2;72(5):1627-33. Epub 2007 Feb 8.


Chondroitin sulfate lyases: applications in analysis and glycobiology.

Petit E, Delattre C, Papy-Garcia D, Michaud P.

Adv Pharmacol. 2006;53:167-86. Review. No abstract available.


The 37-kDa/67-kDa laminin receptor acts as a receptor for infectious prions and is inhibited by polysulfated glycanes.

Gauczynski S, Nikles D, El-Gogo S, Papy-Garcia D, Rey C, Alban S, Barritault D, Lasmezas CI, Weiss S.

J Infect Dis. 2006 Sep 1;194(5):702-9. Epub 2006 Aug 1.


Novel glycosaminoglycan mimetic (RGTA, RGD120) contributes to enhance skeletal muscle satellite cell fusion by increasing intracellular Ca2+ and calpain activity.

Zimowska M, Constantin B, Papy-Garcia D, Raymond G, Cognard C, Caruelle JP, Moraczewski J, Martelly I.

J Cell Physiol. 2005 Nov;205(2):237-45.


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