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Clinical, biochemical, mitochondrial, and metabolomic aspects of methylmalonate semialdehyde dehydrogenase deficiency: Report of a fifth case.

Dobrowolski SF, Alodaib A, Karunanidhi A, Basu S, Holecko M, Lichter-Konecki U, Pappan KL, Vockley J.

Mol Genet Metab. 2020 Jan 11. pii: S1096-7192(19)31371-X. doi: 10.1016/j.ymgme.2020.01.005. [Epub ahead of print]


Corrigendum: 2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.

Kennedy AD, Pappan KL, Donti T, Delgado MR, Shinawi M, Pearson TS, Lalani SR, Craigen WJ, Sutton VR, Evans AM, Sun Q, Emrick LT, Elsea SH.

Front Neurosci. 2020 Jan 29;13:1344. doi: 10.3389/fnins.2019.01344. eCollection 2019.


Metabolomic analysis of Shiga toxin 2a-induced injury in conditionally immortalized glomerular endothelial cells.

Patry C, Plotnicki K, Betzen C, Ortiz AP, Pappan KL, Satchell SC, Mathieson PW, Bielaszewska M, Karch H, Tönshoff B, Rafat N.

Metabolomics. 2019 Oct 1;15(10):131. doi: 10.1007/s11306-019-1594-2.


2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.

Kennedy AD, Pappan KL, Donti T, Delgado MR, Shinawi M, Pearson TS, Lalani SR, Craigen WE, Sutton VR, Evans AM, Sun Q, Emrick LT, Elsea SH.

Front Neurosci. 2019 May 8;13:394. doi: 10.3389/fnins.2019.00394. eCollection 2019. Erratum in: Front Neurosci. 2020 Jan 29;13:1344.


Untargeted metabolomics identifies unique though benign biochemical changes in patients with pathogenic variants in UROC1.

Glinton KE, Levy HL, Kennedy AD, Pappan KL, Elsea SH.

Mol Genet Metab Rep. 2018 Dec 29;18:14-18. doi: 10.1016/j.ymgmr.2018.12.005. eCollection 2019 Mar.


Metabolomics in the clinic: A review of the shared and unique features of untargeted metabolomics for clinical research and clinical testing.

Kennedy AD, Wittmann BM, Evans AM, Miller LAD, Toal DR, Lonergan S, Elsea SH, Pappan KL.

J Mass Spectrom. 2018 Nov;53(11):1143-1154. doi: 10.1002/jms.4292. Review.


Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet.

Seferovic MD, Beamish CA, Mosser RE, Townsend SE, Pappan K, Poitout V, Aagaard KM, Gannon M.

Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1251-E1263. doi: 10.1152/ajpendo.00001.2018. Epub 2018 Aug 14.


Clinical Metabolomics to Segregate Aromatic Amino Acid Decarboxylase Deficiency From Drug-Induced Metabolite Elevations.

Pappan KL, Kennedy AD, Magoulas PL, Hanchard NA, Sun Q, Elsea SH.

Pediatr Neurol. 2017 Oct;75:66-72. doi: 10.1016/j.pediatrneurol.2017.06.014. Epub 2017 Jun 29.


Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets.

Garcia-Contreras M, Tamayo-Garcia A, Pappan KL, Michelotti GA, Stabler CL, Ricordi C, Buchwald P.

J Proteome Res. 2017 Jun 2;16(6):2294-2306. doi: 10.1021/acs.jproteome.7b00160. Epub 2017 May 9.


Elucidation of the complex metabolic profile of cerebrospinal fluid using an untargeted biochemical profiling assay.

Kennedy AD, Pappan KL, Donti TR, Evans AM, Wulff JE, Miller LAD, Reid Sutton V, Sun Q, Miller MJ, Elsea SH.

Mol Genet Metab. 2017 Jun;121(2):83-90. doi: 10.1016/j.ymgme.2017.04.005. Epub 2017 Apr 9.


IL-6 Linkage to Exercise-Induced Shifts in Lipid-Related Metabolites: A Metabolomics-Based Analysis.

Nieman DC, Sha W, Pappan KL.

J Proteome Res. 2017 Feb 3;16(2):970-977. doi: 10.1021/acs.jproteome.6b00892. Epub 2017 Jan 9.


Circulating levels of endocannabinoids and oxylipins altered by dietary lipids in older women are likely associated with previously identified gene targets.

Watkins BA, Kim J, Kenny A, Pedersen TL, Pappan KL, Newman JW.

Biochim Biophys Acta. 2016 Nov;1861(11):1693-1704. doi: 10.1016/j.bbalip.2016.07.007. Epub 2016 Jul 22.


Lipid profile of human synovial fluid following intra-articular ankle fracture.

Leimer EM, Pappan KL, Nettles DL, Bell RD, Easley ME, Olson SA, Setton LA, Adams SB.

J Orthop Res. 2017 Mar;35(3):657-666. doi: 10.1002/jor.23217. Epub 2016 Mar 14.


Conserved Metabolic Changes in Nondiabetic and Type 2 Diabetic Bariatric Surgery Patients: Global Metabolomic Pilot Study.

Sarosiek K, Pappan KL, Gandhi AV, Saxena S, Kang CY, McMahon H, Chipitsyna GI, Tichansky DS, Arafat HA.

J Diabetes Res. 2016;2016:3467403. doi: 10.1155/2016/3467403. Epub 2016 Jan 10.


Metabolite Profiles of the Serum of Patients with Non-Small Cell Carcinoma.

Mazzone PJ, Wang XF, Beukemann M, Zhang Q, Seeley M, Mohney R, Holt T, Pappan KL.

J Thorac Oncol. 2016 Jan;11(1):72-8. doi: 10.1016/j.jtho.2015.09.002.


Shiga Toxin 2a-Induced Endothelial Injury in Hemolytic Uremic Syndrome: A Metabolomic Analysis.

Betzen C, Plotnicki K, Fathalizadeh F, Pappan K, Fleming T, Bielaszewska M, Karch H, Tönshoff B, Rafat N.

J Infect Dis. 2016 Mar 15;213(6):1031-40. doi: 10.1093/infdis/jiv540. Epub 2015 Nov 17.


Metabolomics-Based Analysis of Banana and Pear Ingestion on Exercise Performance and Recovery.

Nieman DC, Gillitt ND, Sha W, Meaney MP, John C, Pappan KL, Kinchen JM.

J Proteome Res. 2015 Dec 4;14(12):5367-77. doi: 10.1021/acs.jproteome.5b00909. Epub 2015 Nov 23.


High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice.

Mosser RE, Maulis MF, Moullé VS, Dunn JC, Carboneau BA, Arasi K, Pappan K, Poitout V, Gannon M.

Am J Physiol Endocrinol Metab. 2015 Apr 1;308(7):E573-82. doi: 10.1152/ajpendo.00460.2014. Epub 2015 Jan 27.


Influence of pistachios on performance and exercise-induced inflammation, oxidative stress, immune dysfunction, and metabolite shifts in cyclists: a randomized, crossover trial.

Nieman DC, Scherr J, Luo B, Meaney MP, Dréau D, Sha W, Dew DA, Henson DA, Pappan KL.

PLoS One. 2014 Nov 19;9(11):e113725. doi: 10.1371/journal.pone.0113725. eCollection 2014.


Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention.

Miller JA, Pappan K, Thompson PA, Want EJ, Siskos AP, Keun HC, Wulff J, Hu C, Lang JE, Chow HH.

Cancer Prev Res (Phila). 2015 Jan;8(1):86-93. doi: 10.1158/1940-6207.CAPR-14-0100. Epub 2014 Nov 11.


Examination of physiological function and biochemical disorders in a rat model of prolonged asphyxia-induced cardiac arrest followed by cardio pulmonary bypass resuscitation.

Kim J, Yin T, Yin M, Zhang W, Shinozaki K, Selak MA, Pappan KL, Lampe JW, Becker LB.

PLoS One. 2014 Nov 10;9(11):e112012. doi: 10.1371/journal.pone.0112012. eCollection 2014.


The structure of rice weevil pectin methylesterase.

Teller DC, Behnke CA, Pappan K, Shen Z, Reese JC, Reeck GR, Stenkamp RE.

Acta Crystallogr F Struct Biol Commun. 2014 Nov;70(Pt 11):1480-4. doi: 10.1107/S2053230X14020433. Epub 2014 Oct 25.


Global biochemical profiling identifies β-hydroxypyruvate as a potential mediator of type 2 diabetes in mice and humans.

Zhang S, Wang S, Puhl MD, Jiang X, Hyrc KL, Laciny E, Wallendorf MJ, Pappan KL, Coyle JT, Wice BM.

Diabetes. 2015 Apr;64(4):1383-94. doi: 10.2337/db14-1188. Epub 2014 Nov 3.


Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling.

Nieman DC, Shanely RA, Luo B, Meaney MP, Dew DA, Pappan KL.

Am J Physiol Regul Integr Comp Physiol. 2014 Jul 1;307(1):R68-74. doi: 10.1152/ajpregu.00092.2014. Epub 2014 Apr 23.


Impaired metabolic reactivity to oxidative stress in early psychosis patients.

Fournier M, Ferrari C, Baumann PS, Polari A, Monin A, Bellier-Teichmann T, Wulff J, Pappan KL, Cuenod M, Conus P, Do KQ.

Schizophr Bull. 2014 Sep;40(5):973-83. doi: 10.1093/schbul/sbu053. Epub 2014 Mar 31.


Comparing serum responses to acute feedings of an extensively hydrolyzed whey protein concentrate versus a native whey protein concentrate in rats: a metabolomics approach.

Roberts MD, Cruthirds CL, Lockwood CM, Pappan K, Childs TE, Company JM, Brown JD, Toedebusch RG, Booth FW.

Appl Physiol Nutr Metab. 2014 Feb;39(2):158-67. doi: 10.1139/apnm-2013-0148. Epub 2013 Jul 30.


Serum metabolic signatures induced by a three-day intensified exercise period persist after 14 h of recovery in runners.

Nieman DC, Shanely RA, Gillitt ND, Pappan KL, Lila MA.

J Proteome Res. 2013 Oct 4;12(10):4577-84. doi: 10.1021/pr400717j. Epub 2013 Sep 13.


Influence of a polyphenol-enriched protein powder on exercise-induced inflammation and oxidative stress in athletes: a randomized trial using a metabolomics approach.

Nieman DC, Gillitt ND, Knab AM, Shanely RA, Pappan KL, Jin F, Lila MA.

PLoS One. 2013 Aug 15;8(8):e72215. doi: 10.1371/journal.pone.0072215. eCollection 2013.


Assaying different types of plant phospholipase D activities in vitro.

Pappan KL, Wang X.

Methods Mol Biol. 2013;1009:205-17. doi: 10.1007/978-1-62703-401-2_19.


Plasma metabolomic profiles in different stages of CKD.

Shah VO, Townsend RR, Feldman HI, Pappan KL, Kensicki E, Vander Jagt DL.

Clin J Am Soc Nephrol. 2013 Mar;8(3):363-70. doi: 10.2215/CJN.05540512. Epub 2012 Dec 6.


High-temperature enzymatic breakdown of cellulose.

Wang H, Squina F, Segato F, Mort A, Lee D, Pappan K, Prade R.

Appl Environ Microbiol. 2011 Aug;77(15):5199-206. doi: 10.1128/AEM.00199-11. Epub 2011 Jun 17.


Predicted effector molecules in the salivary secretome of the pea aphid (Acyrthosiphon pisum): a dual transcriptomic/proteomic approach.

Carolan JC, Caragea D, Reardon KT, Mutti NS, Dittmer N, Pappan K, Cui F, Castaneto M, Poulain J, Dossat C, Tagu D, Reese JC, Reeck GR, Wilkinson TL, Edwards OR.

J Proteome Res. 2011 Apr 1;10(4):1505-18. doi: 10.1021/pr100881q. Epub 2011 Mar 1.


Therapeutic Strategies to Increase Human β-Cell Growth and Proliferation by Regulating mTOR and GSK-3/β-Catenin Pathways.

Rohatgi N, Remedi MS, Kwon G, Pappan KL, Marshall CA, McDaniel ML.

Open Endocrinol J. 2010;4. doi: 10.2174/1874216501004010040.


Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets.

Liu H, Remedi MS, Pappan KL, Kwon G, Rohatgi N, Marshall CA, McDaniel ML.

Diabetes. 2009 Mar;58(3):663-72. doi: 10.2337/db07-1208. Epub 2008 Dec 10.


Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation.

Chakravarthy MV, Zhu Y, Yin L, Coleman T, Pappan KL, Marshall CA, McDaniel ML, Semenkovich CF.

J Lipid Res. 2009 Apr;50(4):630-40. doi: 10.1194/jlr.M800379-JLR200. Epub 2008 Nov 22.


A protein from the salivary glands of the pea aphid, Acyrthosiphon pisum, is essential in feeding on a host plant.

Mutti NS, Louis J, Pappan LK, Pappan K, Begum K, Chen MS, Park Y, Dittmer N, Marshall J, Reese JC, Reeck GR.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9965-9. doi: 10.1073/pnas.0708958105. Epub 2008 Jul 10.


Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age.

Chakravarthy MV, Zhu Y, Wice MB, Coleman T, Pappan KL, Marshall CA, McDaniel ML, Semenkovich CF.

Diabetes. 2008 Oct;57(10):2698-707. doi: 10.2337/db08-0404. Epub 2008 Jun 30.


Glucose-stimulated DNA synthesis through mammalian target of rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent islets.

Kwon G, Marshall CA, Liu H, Pappan KL, Remedi MS, McDaniel ML.

J Biol Chem. 2006 Feb 10;281(6):3261-7. Epub 2005 Dec 12.


Pectinmethylesterase from the rice weevil, Sitophilus oryzae: cDNA isolation and sequencing, genetic origin, and expression of the recombinant enzyme.

Shen Z, Pappan K, Mutti NS, He QJ, Denton M, Zhang Y, Kanost MR, Reese JC, Reeck GR.

J Insect Sci. 2005;5:21. Epub 2005 Aug 8.


Polygalacturonase from Sitophilus oryzae: possible horizontal transfer of a pectinase gene from fungi to weevils.

Shen Z, Denton M, Mutti N, Pappan K, Kanost MR, Reese JC, Reeck GR.

J Insect Sci. 2003;3:24. Epub 2003 Aug 12.


Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose metabolism and normal insulin secretion.

Pappan KL, Pan Z, Kwon G, Marshall CA, Coleman T, Goldberg IJ, McDaniel ML, Semenkovich CF.

J Biol Chem. 2005 Mar 11;280(10):9023-9. Epub 2005 Jan 6.


Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets.

Kwon G, Marshall CA, Pappan KL, Remedi MS, McDaniel ML.

Diabetes. 2004 Dec;53 Suppl 3:S225-32. Review.


Evidence for and characterization of Ca2+ binding to the catalytic region of Arabidopsis thaliana phospholipase Dbeta.

Pappan K, Zheng L, Krishnamoorthi R, Wang X.

J Biol Chem. 2004 Nov 12;279(46):47833-9. Epub 2004 Sep 8.


cAMP Dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells.

Kwon G, Pappan KL, Marshall CA, Schaffer JE, McDaniel ML.

J Biol Chem. 2004 Mar 5;279(10):8938-45. Epub 2003 Dec 19.


Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells.

McDaniel ML, Marshall CA, Pappan KL, Kwon G.

Diabetes. 2002 Oct;51(10):2877-85. Review.


Plant phospholipase Dalpha is an acidic phospholipase active at near-physiological Ca(2+) concentrations.

Pappan K, Wang X.

Arch Biochem Biophys. 1999 Aug 15;368(2):347-53.


Molecular and biochemical properties and physiological roles of plant phospholipase D.

Pappan K, Wang X.

Biochim Biophys Acta. 1999 Jul 30;1439(2):151-66. Review.


Substrate selectivities and lipid modulation of plant phospholipase D alpha, -beta, and -gamma.

Pappan K, Austin-Brown S, Chapman KD, Wang X.

Arch Biochem Biophys. 1998 May 1;353(1):131-40.


Molecular cloning and functional analysis of polyphosphoinositide-dependent phospholipase D, PLDbeta, from Arabidopsis.

Pappan K, Qin W, Dyer JH, Zheng L, Wang X.

J Biol Chem. 1997 Mar 14;272(11):7055-61.

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