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Items: 1 to 50 of 97

1.

Nanoparticle-based fluoroionophore for analysis of potassium ion dynamics in 3D tissue models and in vivo.

Mueller BJ, Zhdanov AV, Borisov SM, Foley T, Okkelman IA, Tsytsarev V, Tang Q, Erzurumlu RS, Chen Y, Zhang H, Toncelli C, Klimant I, Papkovsky DB, Dmitriev RI.

Adv Funct Mater. 2018 Feb 28;28(9). pii: 1704598. doi: 10.1002/adfm.201704598. Epub 2018 Jan 5.

2.

Cellulose-based scaffolds for fluorescence lifetime imaging-assisted tissue engineering.

O'Donnell N, Okkelman IA, Timashev P, Gromovykh TI, Papkovsky DB, Dmitriev RI.

Acta Biomater. 2018 Oct 15;80:85-96. doi: 10.1016/j.actbio.2018.09.034. Epub 2018 Sep 25.

PMID:
30261339
3.

Protection of cerebral microcirculation, mitochondrial function, and electrocortical activity by small-volume resuscitation with terlipressin in a rat model of haemorrhagic shock.

Ida KK, Chisholm KI, Malbouisson LMS, Papkovsky DB, Dyson A, Singer M, Duchen MR, Smith KJ.

Br J Anaesth. 2018 Jun;120(6):1245-1254. doi: 10.1016/j.bja.2017.11.074. Epub 2017 Dec 5.

4.

Imaging of oxygen and hypoxia in cell and tissue samples.

Papkovsky DB, Dmitriev RI.

Cell Mol Life Sci. 2018 Aug;75(16):2963-2980. doi: 10.1007/s00018-018-2840-x. Epub 2018 May 14. Review.

PMID:
29761206
5.

AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation.

Yordanova MM, Loughran G, Zhdanov AV, Mariotti M, Kiniry SJ, O'Connor PBF, Andreev DE, Tzani I, Saffert P, Michel AM, Gladyshev VN, Papkovsky DB, Atkins JF, Baranov PV.

Nature. 2018 Jan 18;553(7688):356-360. doi: 10.1038/nature25174. Epub 2018 Jan 3.

PMID:
29310120
6.

Multi-Parametric Imaging of Hypoxia and Cell Cycle in Intestinal Organoid Culture.

Okkelman IA, Foley T, Papkovsky DB, Dmitriev RI.

Adv Exp Med Biol. 2017;1035:85-103. doi: 10.1007/978-3-319-67358-5_6.

PMID:
29080132
7.

Live cell imaging of mouse intestinal organoids reveals heterogeneity in their oxygenation.

Okkelman IA, Foley T, Papkovsky DB, Dmitriev RI.

Biomaterials. 2017 Nov;146:86-96. doi: 10.1016/j.biomaterials.2017.08.043. Epub 2017 Sep 3.

PMID:
28898760
8.

Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells.

Lyons A, Coleman M, Riis S, Favre C, O'Flanagan CH, Zhdanov AV, Papkovsky DB, Hursting SD, O'Connor R.

J Biol Chem. 2017 Oct 13;292(41):16983-16998. doi: 10.1074/jbc.M117.792838. Epub 2017 Aug 18.

9.

Single-cell time-lapse imaging of intracellular O2 in response to metabolic inhibition and mitochondrial cytochrome-c release.

Düssmann H, Perez-Alvarez S, Anilkumar U, Papkovsky DB, Prehn JH.

Cell Death Dis. 2017 Jun 1;8(6):e2853. doi: 10.1038/cddis.2017.247.

10.

Phosphorescent Oxygen and Mechanosensitive Nanostructured Materials Based on Hard Elastic Polypropylene Films.

Okkelman IA, Dolgova AA, Banerjee S, Kerry JP, Volynskii A, Arzhakova OV, Papkovsky DB.

ACS Appl Mater Interfaces. 2017 Apr 19;9(15):13587-13592. doi: 10.1021/acsami.7b00405. Epub 2017 Apr 10.

PMID:
28367617
11.

Steering surface topographies of electrospun fibers: understanding the mechanisms.

Yazgan G, Dmitriev RI, Tyagi V, Jenkins J, Rotaru GM, Rottmar M, Rossi RM, Toncelli C, Papkovsky DB, Maniura-Weber K, Fortunato G.

Sci Rep. 2017 Mar 13;7(1):158. doi: 10.1038/s41598-017-00181-0.

12.

Planar implantable sensor for in vivo measurement of cellular oxygen metabolism in brain tissue.

Tsytsarev V, Akkentli F, Pumbo E, Tang Q, Chen Y, Erzurumlu RS, Papkovsky DB.

J Neurosci Methods. 2017 Apr 1;281:1-6. doi: 10.1016/j.jneumeth.2017.02.005. Epub 2017 Feb 20.

13.

Low energy costs of F1Fo ATP synthase reversal in colon carcinoma cells deficient in mitochondrial complex IV.

Zhdanov AV, Andreev DE, Baranov PV, Papkovsky DB.

Free Radic Biol Med. 2017 May;106:184-195. doi: 10.1016/j.freeradbiomed.2017.02.025. Epub 2017 Feb 9.

PMID:
28189850
14.

Use of Fluorescence Lifetime Imaging Microscopy (FLIM) as a Timer of Cell Cycle S Phase.

Okkelman IA, Dmitriev RI, Foley T, Papkovsky DB.

PLoS One. 2016 Dec 14;11(12):e0167385. doi: 10.1371/journal.pone.0167385. eCollection 2016.

15.

Cellular ROS imaging with hydro-Cy3 dye is strongly influenced by mitochondrial membrane potential.

Zhdanov AV, Aviello G, Knaus UG, Papkovsky DB.

Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):198-204. doi: 10.1016/j.bbagen.2016.10.023. Epub 2016 Nov 4.

PMID:
27818165
16.

Phosphorescence based O2 sensors - Essential tools for monitoring cell and tissue oxygenation and its impact on metabolism.

Papkovsky DB, Zhdanov AV.

Free Radic Biol Med. 2016 Dec;101:202-210. doi: 10.1016/j.freeradbiomed.2016.09.018. Epub 2016 Oct 24. Review.

PMID:
27789291
17.

Hypothermia protects brain mitochondrial function from hypoxemia in a murine model of sepsis.

Chisholm KI, Ida KK, Davies AL, Tachtsidis I, Papkovsky DB, Dyson A, Singer M, Duchen MR, Smith KJ.

J Cereb Blood Flow Metab. 2016 Nov;36(11):1955-1964. Epub 2015 Nov 26.

18.

Sulforhodamine Nanothermometer for Multiparametric Fluorescence Lifetime Imaging Microscopy.

Jenkins J, Borisov SM, Papkovsky DB, Dmitriev RI.

Anal Chem. 2016 Nov 1;88(21):10566-10572. Epub 2016 Oct 10.

PMID:
27696826
19.

Quantitative analysis of mucosal oxygenation using ex vivo imaging of healthy and inflamed mammalian colon tissue.

Zhdanov AV, Okkelman IA, Golubeva AV, Doerr B, Hyland NP, Melgar S, Shanahan F, Cryan JF, Papkovsky DB.

Cell Mol Life Sci. 2017 Jan;74(1):141-151. doi: 10.1007/s00018-016-2323-x. Epub 2016 Aug 10.

PMID:
27510419
21.

The Ca2+/Mn2+-transporting SPCA2 pump is regulated by oxygen and cell density in colon cancer cells.

Jenkins J, Papkovsky DB, Dmitriev RI.

Biochem J. 2016 Aug 15;473(16):2507-18. doi: 10.1042/BCJ20160477. Epub 2016 Jun 17.

PMID:
27316461
22.

In Vivo Imaging of Flavoprotein Fluorescence During Hypoxia Reveals the Importance of Direct Arterial Oxygen Supply to Cerebral Cortex Tissue.

Chisholm KI, Ida KK, Davies AL, Papkovsky DB, Singer M, Dyson A, Tachtsidis I, Duchen MR, Smith KJ.

Adv Exp Med Biol. 2016;876:233-239. doi: 10.1007/978-1-4939-3023-4_29. Erratum in: Adv Exp Med Biol. 2016;876:E1-E2.

23.

Metallochelate Coupling of Phosphorescent Pt-Porphyrins to Peptides, Proteins, and Self-Assembling Protein Nanoparticles.

Dmitriev RI, O'Donnell N, Papkovsky DB.

Bioconjug Chem. 2016 Feb 17;27(2):439-45. doi: 10.1021/acs.bioconjchem.5b00535. Epub 2016 Jan 4.

PMID:
26704593
24.

Imaging of oxygen gradients in giant umbrella cells: an ex vivo PLIM study.

Zhdanov AV, Golubeva AV, Okkelman IA, Cryan JF, Papkovsky DB.

Am J Physiol Cell Physiol. 2015 Oct 1;309(7):C501-9. doi: 10.1152/ajpcell.00121.2015. Epub 2015 Aug 5.

25.

A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression.

Zhdanov AV, Okkelman IA, Collins FW, Melgar S, Papkovsky DB.

Biochim Biophys Acta. 2015 Oct;1847(10):1254-66. doi: 10.1016/j.bbabio.2015.06.016. Epub 2015 Jul 2.

26.

Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes.

Andreev DE, O'Connor PB, Zhdanov AV, Dmitriev RI, Shatsky IN, Papkovsky DB, Baranov PV.

Genome Biol. 2015 May 6;16:90. doi: 10.1186/s13059-015-0651-z.

27.

Intracellular probes for imaging oxygen concentration: how good are they?

Dmitriev RI, Papkovsky DB.

Methods Appl Fluoresc. 2015 Apr 21;3(3):034001. doi: 10.1088/2050-6120/3/3/034001.

PMID:
29148495
28.

Versatile Conjugated Polymer Nanoparticles for High-Resolution O2 Imaging in Cells and 3D Tissue Models.

Dmitriev RI, Borisov SM, Düssmann H, Sun S, Müller BJ, Prehn J, Baklaushev VP, Klimant I, Papkovsky DB.

ACS Nano. 2015 May 26;9(5):5275-88. doi: 10.1021/acsnano.5b00771. Epub 2015 Apr 15.

PMID:
25858428
29.

Oxygen-sensing scaffolds for 3-dimensional cell and tissue culture.

Jenkins J, Dmitriev RI, Morten K, McDermott KW, Papkovsky DB.

Acta Biomater. 2015 Apr;16:126-35. doi: 10.1016/j.actbio.2015.01.032. Epub 2015 Jan 31.

PMID:
25653216
30.

Cell energy budget platform for assessment of cell metabolism.

Papkovsky DB, Zhdanov AV.

Methods Mol Biol. 2015;1265:333-48. doi: 10.1007/978-1-4939-2288-8_23.

PMID:
25634285
31.

In vitro ischemia decreases histone H4K16 acetylation in neural cells.

Dmitriev RI, Papkovsky DB.

FEBS Lett. 2015 Jan 2;589(1):138-44. doi: 10.1016/j.febslet.2014.11.038. Epub 2014 Dec 3.

32.

Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling.

Zhdanov AV, Waters AH, Golubeva AV, Papkovsky DB.

Exp Cell Res. 2015 Jan 1;330(1):13-28. doi: 10.1016/j.yexcr.2014.10.005. Epub 2014 Oct 15.

PMID:
25447307
33.

Multi-parametric O₂ imaging in three-dimensional neural cell models with the phosphorescent probes.

Dmitriev RI, Papkovsky DB.

Methods Mol Biol. 2015;1254:55-71. doi: 10.1007/978-1-4939-2152-2_5.

PMID:
25431057
34.

Comparison of the three optical platforms for measurement of cellular respiration.

Kondrashina AV, Ogurtsov VI, Papkovsky DB.

Anal Biochem. 2015 Jan 1;468:1-3. doi: 10.1016/j.ab.2014.09.001. Epub 2014 Sep 16.

PMID:
25233002
35.

Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles.

Dmitriev RI, Borisov SM, Kondrashina AV, Pakan JM, Anilkumar U, Prehn JH, Zhdanov AV, McDermott KW, Klimant I, Papkovsky DB.

Cell Mol Life Sci. 2015 Jan;72(2):367-81. doi: 10.1007/s00018-014-1673-5. Epub 2014 Jul 9.

PMID:
25006059
36.

Kinetic analysis of local oxygenation and respiratory responses of mammalian cells using intracellular oxygen-sensitive probes and time-resolved fluorometry.

Zhdanov AV, Dmitriev RI, Hynes J, Papkovsky DB.

Methods Enzymol. 2014;542:183-207. doi: 10.1016/B978-0-12-416618-9.00010-8.

PMID:
24862267
37.

Oxygen-sensitive phosphorescent nanomaterials produced from high-density polyethylene films by local solvent-crazing.

Toncelli C, Arzhakova OV, Dolgova A, Volynskii AL, Bakeev NF, Kerry JP, Papkovsky DB.

Anal Chem. 2014 Feb 4;86(3):1917-23. doi: 10.1021/ac404072z. Epub 2014 Jan 22.

PMID:
24422456
39.

Imaging of neurosphere oxygenation with phosphorescent probes.

Dmitriev RI, Zhdanov AV, Nolan YM, Papkovsky DB.

Biomaterials. 2013 Dec;34(37):9307-17. doi: 10.1016/j.biomaterials.2013.08.065. Epub 2013 Sep 6.

PMID:
24016849
40.

Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling.

Zhdanov AV, Waters AH, Golubeva AV, Dmitriev RI, Papkovsky DB.

Biochim Biophys Acta. 2014 Jan;1837(1):51-62. doi: 10.1016/j.bbabio.2013.07.008. Epub 2013 Jul 23.

41.

Measurement of cell respiration and oxygenation in standard multichannel biochips using phosphorescent O2-sensitive probes.

Kondrashina AV, Papkovsky DB, Dmitriev RI.

Analyst. 2013 Sep 7;138(17):4915-21. doi: 10.1039/c3an00658a. Epub 2013 Jun 27.

PMID:
23803790
42.

Biological detection by optical oxygen sensing.

Papkovsky DB, Dmitriev RI.

Chem Soc Rev. 2013 Nov 21;42(22):8700-32. doi: 10.1039/c3cs60131e. Review.

PMID:
23775387
43.
45.

In vivo imaging of brain metabolism activity using a phosphorescent oxygen-sensitive probe.

Tsytsarev V, Arakawa H, Borisov S, Pumbo E, Erzurumlu RS, Papkovsky DB.

J Neurosci Methods. 2013 Jun 15;216(2):146-51. doi: 10.1016/j.jneumeth.2013.04.005. Epub 2013 Apr 25.

46.

Chronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells.

Zhdanov AV, Dmitriev RI, Golubeva AV, Gavrilova SA, Papkovsky DB.

Biochim Biophys Acta. 2013 Jun;1830(6):3553-69. doi: 10.1016/j.bbagen.2013.02.016. Epub 2013 Feb 24.

PMID:
23462283
47.

Genome-wide investigation of cellular targets and mode of action of the antifungal bacterial metabolite 2,4-diacetylphloroglucinol in Saccharomyces cerevisiae.

Troppens DM, Dmitriev RI, Papkovsky DB, O'Gara F, Morrissey JP.

FEMS Yeast Res. 2013 May;13(3):322-34. doi: 10.1111/1567-1364.12037. Epub 2013 Mar 5.

48.

Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling.

Zhdanov AV, Dmitriev RI, Papkovsky DB.

Biosci Rep. 2012 Dec;32(6):587-95. doi: 10.1042/BSR20120085.

49.

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization.

Papkovskaia TD, Chau KY, Inesta-Vaquera F, Papkovsky DB, Healy DG, Nishio K, Staddon J, Duchen MR, Hardy J, Schapira AH, Cooper JM.

Hum Mol Genet. 2012 Oct 1;21(19):4201-13. doi: 10.1093/hmg/dds244. Epub 2012 Jun 26.

50.

Complexes of Ir(III)-octaethylporphyrin with peptides as probes for sensing cellular O2.

Koren K, Dmitriev RI, Borisov SM, Papkovsky DB, Klimant I.

Chembiochem. 2012 May 29;13(8):1184-90. doi: 10.1002/cbic.201200083. Epub 2012 Apr 24.

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