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Items: 14


Loss of Smooth Muscle α-Actin Leads to NF-κB-Dependent Increased Sensitivity to Angiotensin II in Smooth Muscle Cells and Aortic Enlargement.

Chen J, Peters A, Papke CL, Villamizar C, Ringuette LJ, Cao J, Wang S, Ma S, Gong L, Byanova KL, Xiong J, Zhu MX, Madonna R, Kee P, Geng YJ, Brasier AR, Davis EC, Prakash S, Kwartler CS, Milewicz DM.

Circ Res. 2017 Jun 9;120(12):1903-1915. doi: 10.1161/CIRCRESAHA.117.310563. Epub 2017 May 1.


Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice.

Yamashiro Y, Papke CL, Kim J, Ringuette LJ, Zhang QJ, Liu ZP, Mirzaei H, Wagenseil JE, Davis EC, Yanagisawa H.

Sci Signal. 2015 Oct 20;8(399):ra105. doi: 10.1126/scisignal.aab3141.


Loss of fibulin-4 disrupts collagen synthesis and maturation: implications for pathology resulting from EFEMP2 mutations.

Papke CL, Tsunezumi J, Ringuette LJ, Nagaoka H, Terajima M, Yamashiro Y, Urquhart G, Yamauchi M, Davis EC, Yanagisawa H.

Hum Mol Genet. 2015 Oct 15;24(20):5867-79. doi: 10.1093/hmg/ddv308. Epub 2015 Jul 28.


MMP17/MT4-MMP and thoracic aortic aneurysms: OPNing new potential for effective treatment.

Papke CL, Yamashiro Y, Yanagisawa H.

Circ Res. 2015 Jul 3;117(2):109-12. doi: 10.1161/CIRCRESAHA.117.306851. No abstract available.


Fibulin-4 and fibulin-5 in elastogenesis and beyond: Insights from mouse and human studies.

Papke CL, Yanagisawa H.

Matrix Biol. 2014 Jul;37:142-9. doi: 10.1016/j.matbio.2014.02.004. Epub 2014 Mar 6. Review.


Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice.

Huang J, Yamashiro Y, Papke CL, Ikeda Y, Lin Y, Patel M, Inagami T, Le VP, Wagenseil JE, Yanagisawa H.

Sci Transl Med. 2013 May 1;5(183):183ra58, 1-11. doi: 10.1126/scitranslmed.3005025.


Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β.

Papke CL, Cao J, Kwartler CS, Villamizar C, Byanova KL, Lim SM, Sreenivasappa H, Fischer G, Pham J, Rees M, Wang M, Chaponnier C, Gabbiani G, Khakoo AY, Chandra J, Trache A, Zimmer W, Milewicz DM.

Hum Mol Genet. 2013 Aug 1;22(15):3123-37. doi: 10.1093/hmg/ddt167. Epub 2013 Apr 15.


Genetic variants promoting smooth muscle cell proliferation can result in diffuse and diverse vascular diseases: evidence for a hyperplastic vasculomyopathy.

Milewicz DM, Kwartler CS, Papke CL, Regalado ES, Cao J, Reid AJ.

Genet Med. 2010 Apr;12(4):196-203. doi: 10.1097/GIM.0b013e3181cdd687. Review.


Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.

Guo DC, Papke CL, Tran-Fadulu V, Regalado ES, Avidan N, Johnson RJ, Kim DH, Pannu H, Willing MC, Sparks E, Pyeritz RE, Singh MN, Dalman RL, Grotta JC, Marian AJ, Boerwinkle EA, Frazier LQ, LeMaire SA, Coselli JS, Estrera AL, Safi HJ, Veeraraghavan S, Muzny DM, Wheeler DA, Willerson JT, Yu RK, Shete SS, Scherer SE, Raman CS, Buja LM, Milewicz DM.

Am J Hum Genet. 2009 May;84(5):617-27. doi: 10.1016/j.ajhg.2009.04.007. Epub 2009 Apr 30.


Characterization of the inflammatory cells in ascending thoracic aortic aneurysms in patients with Marfan syndrome, familial thoracic aortic aneurysms, and sporadic aneurysms.

He R, Guo DC, Sun W, Papke CL, Duraisamy S, Estrera AL, Safi HJ, Ahn C, Buja LM, Arnett FC, Zhang J, Geng YJ, Milewicz DM.

J Thorac Cardiovasc Surg. 2008 Oct;136(4):922-9, 929.e1. doi: 10.1016/j.jtcvs.2007.12.063. Epub 2008 Jun 12.


Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction.

Milewicz DM, Guo DC, Tran-Fadulu V, Lafont AL, Papke CL, Inamoto S, Kwartler CS, Pannu H.

Annu Rev Genomics Hum Genet. 2008;9:283-302. doi: 10.1146/annurev.genom.8.080706.092303. Review.


Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.

Guo DC, Pannu H, Tran-Fadulu V, Papke CL, Yu RK, Avidan N, Bourgeois S, Estrera AL, Safi HJ, Sparks E, Amor D, Ades L, McConnell V, Willoughby CE, Abuelo D, Willing M, Lewis RA, Kim DH, Scherer S, Tung PP, Ahn C, Buja LM, Raman CS, Shete SS, Milewicz DM.

Nat Genet. 2007 Dec;39(12):1488-93. Epub 2007 Nov 11. Erratum in: Nat Genet. 2008 Feb;40(2):255.


MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II.

Pannu H, Tran-Fadulu V, Papke CL, Scherer S, Liu Y, Presley C, Guo D, Estrera AL, Safi HJ, Brasier AR, Vick GW, Marian AJ, Raman CS, Buja LM, Milewicz DM.

Hum Mol Genet. 2007 Oct 15;16(20):2453-62. Epub 2007 Jul 31. Erratum in: Hum Mol Genet. 2008 Jan 1;17(1):158.


Pathogenesis of thoracic and abdominal aortic aneurysms.

Guo DC, Papke CL, He R, Milewicz DM.

Ann N Y Acad Sci. 2006 Nov;1085:339-52. Review.


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