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Items: 25


Polymicrobial Sepsis Chronic Immunoparalysis Is Defined by Diminished Ag-Specific T Cell-Dependent B Cell Responses.

Sjaastad FV, Condotta SA, Kotov JA, Pape KA, Dail C, Danahy DB, Kucaba TA, Tygrett LT, Murphy KA, Cabrera-Perez J, Waldschmidt TJ, Badovinac VP, Griffith TS.

Front Immunol. 2018 Oct 31;9:2532. doi: 10.3389/fimmu.2018.02532. eCollection 2018.


Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM+ and Transient IgG+ Memory B Cells.

Pape KA, Maul RW, Dileepan T, Paustian AS, Gearhart PJ, Jenkins MK.

Immunity. 2018 Jun 19;48(6):1135-1143.e4. doi: 10.1016/j.immuni.2018.04.019. Epub 2018 Jun 5.


Do Memory B Cells Form Secondary Germinal Centers? It Depends.

Pape KA, Jenkins MK.

Cold Spring Harb Perspect Biol. 2018 Jan 2;10(1). pii: a029116. doi: 10.1101/cshperspect.a029116. Review.


Humoral immunity. Apoptosis and antigen affinity limit effector cell differentiation of a single naïve B cell.

Taylor JJ, Pape KA, Steach HR, Jenkins MK.

Science. 2015 Feb 13;347(6223):784-7. doi: 10.1126/science.aaa1342. Epub 2015 Jan 29.


Pillars article: visualization of Peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1994. 1: 327-339.

Kearney ER, Pape KA, Loh DY, Jenkins MK.

J Immunol. 2013 Dec 1;191(11):5327-39. No abstract available.


Heterogeneity in the differentiation and function of memory B cells.

Taylor JJ, Jenkins MK, Pape KA.

Trends Immunol. 2012 Dec;33(12):590-7. doi: 10.1016/ Epub 2012 Aug 21. Review.


A germinal center-independent pathway generates unswitched memory B cells early in the primary response.

Taylor JJ, Pape KA, Jenkins MK.

J Exp Med. 2012 Mar 12;209(3):597-606. doi: 10.1084/jem.20111696. Epub 2012 Feb 27.


Different B cell populations mediate early and late memory during an endogenous immune response.

Pape KA, Taylor JJ, Maul RW, Gearhart PJ, Jenkins MK.

Science. 2011 Mar 4;331(6021):1203-7. doi: 10.1126/science.1201730. Epub 2011 Feb 10.


Genome remodelling in a basal-like breast cancer metastasis and xenograft.

Ding L, Ellis MJ, Li S, Larson DE, Chen K, Wallis JW, Harris CC, McLellan MD, Fulton RS, Fulton LL, Abbott RM, Hoog J, Dooling DJ, Koboldt DC, Schmidt H, Kalicki J, Zhang Q, Chen L, Lin L, Wendl MC, McMichael JF, Magrini VJ, Cook L, McGrath SD, Vickery TL, Appelbaum E, Deschryver K, Davies S, Guintoli T, Lin L, Crowder R, Tao Y, Snider JE, Smith SM, Dukes AF, Sanderson GE, Pohl CS, Delehaunty KD, Fronick CC, Pape KA, Reed JS, Robinson JS, Hodges JS, Schierding W, Dees ND, Shen D, Locke DP, Wiechert ME, Eldred JM, Peck JB, Oberkfell BJ, Lolofie JT, Du F, Hawkins AE, O'Laughlin MD, Bernard KE, Cunningham M, Elliott G, Mason MD, Thompson DM Jr, Ivanovich JL, Goodfellow PJ, Perou CM, Weinstock GM, Aft R, Watson M, Ley TJ, Wilson RK, Mardis ER.

Nature. 2010 Apr 15;464(7291):999-1005. doi: 10.1038/nature08989.


A protease-dependent mechanism for initiating T-dependent B cell responses to large particulate antigens.

Catron DM, Pape KA, Fife BT, van Rooijen N, Jenkins MK.

J Immunol. 2010 Apr 1;184(7):3609-17. doi: 10.4049/jimmunol.1000077. Epub 2010 Mar 5.


The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles.

Pape KA, Catron DM, Itano AA, Jenkins MK.

Immunity. 2007 Apr;26(4):491-502. Epub 2007 Mar 22.


In vivo assessment of the relative contributions of deletion, anergy, and editing to B cell self-tolerance.

Hippen KL, Schram BR, Tze LE, Pape KA, Jenkins MK, Behrens TW.

J Immunol. 2005 Jul 15;175(2):909-16.


Visualizing the first 50 hr of the primary immune response to a soluble antigen.

Catron DM, Itano AA, Pape KA, Mueller DL, Jenkins MK.

Immunity. 2004 Sep;21(3):341-7. Review.


Visualization of the genesis and fate of isotype-switched B cells during a primary immune response.

Pape KA, Kouskoff V, Nemazee D, Tang HL, Cyster JG, Tze LE, Hippen KL, Behrens TW, Jenkins MK.

J Exp Med. 2003 Jun 16;197(12):1677-87. Epub 2003 Jun 9.


In vivo activation of antigen-specific CD4 T cells.

Jenkins MK, Khoruts A, Ingulli E, Mueller DL, McSorley SJ, Reinhardt RL, Itano A, Pape KA.

Annu Rev Immunol. 2001;19:23-45. Review.


Antigen-specific CD4+ T cells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defect.

Pape KA, Khoruts A, Ingulli E, Mondino A, Merica R, Jenkins MK.

Novartis Found Symp. 1998;215:103-13; discussion 113-9, 186-90. Review.


Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing.

Fang W, Weintraub BC, Dunlap B, Garside P, Pape KA, Jenkins MK, Goodnow CC, Mueller DL, Behrens TW.

Immunity. 1998 Jul;9(1):35-45.


Direct evidence that functionally impaired CD4+ T cells persist in vivo following induction of peripheral tolerance.

Pape KA, Merica R, Mondino A, Khoruts A, Jenkins MK.

J Immunol. 1998 May 15;160(10):4719-29.


A role for inflammatory cytokines in the productive activation of antigen-specific CD4+ T-cells.

Pape KA, Jenkins MK.

Agents Actions Suppl. 1998;49:23-31. Review.


Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.

Pape KA, Khoruts A, Mondino A, Jenkins MK.

J Immunol. 1997 Jul 15;159(2):591-8.


Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cell for the study of T-cell activation in vivo.

Pape KA, Kearney ER, Khoruts A, Mondino A, Merica R, Chen ZM, Ingulli E, White J, Johnson JG, Jenkins MK.

Immunol Rev. 1997 Apr;156:67-78. Review.


Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

Kearney ER, Pape KA, Loh DY, Jenkins MK.

Immunity. 1994 Jul;1(4):327-39.


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