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HDAd5/35++ Adenovirus Vector Expressing Anti-CRISPR Peptides Decreases CRISPR/Cas9 Toxicity in Human Hematopoietic Stem Cells.

Li C, Psatha N, Gil S, Wang H, Papayannopoulou T, Lieber A.

Mol Ther Methods Clin Dev. 2018 May 1;9:390-401. doi: 10.1016/j.omtm.2018.04.008. eCollection 2018 Jun 15.


Integrating HDAd5/35++ Vectors as a New Platform for HSC Gene Therapy of Hemoglobinopathies.

Li C, Psatha N, Wang H, Singh M, Samal HB, Zhang W, Ehrhardt A, Izsvák Z, Papayannopoulou T, Lieber A.

Mol Ther Methods Clin Dev. 2018 Feb 15;9:142-152. doi: 10.1016/j.omtm.2018.02.004. eCollection 2018 Jun 15.


A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice.

Wang H, Richter M, Psatha N, Li C, Kim J, Liu J, Ehrhardt A, Nilsson SK, Cao B, Palmer D, Ng P, Izsvák Z, Haworth KG, Kiem HP, Papayannopoulou T, Lieber A.

Mol Ther Methods Clin Dev. 2017 Nov 10;8:52-64. doi: 10.1016/j.omtm.2017.11.004. eCollection 2018 Mar 16.


In Vivo Hematopoietic Stem Cell Transduction.

Richter M, Stone D, Miao C, Humbert O, Kiem HP, Papayannopoulou T, Lieber A.

Hematol Oncol Clin North Am. 2017 Oct;31(5):771-785. doi: 10.1016/j.hoc.2017.06.001. Review.


Brief Report: A Differential Transcriptomic Profile of Ex Vivo Expanded Adult Human Hematopoietic Stem Cells Empowers Them for Engraftment Better than Their Surface Phenotype.

Psatha N, Georgolopoulos G, Phelps S, Papayannopoulou T.

Stem Cells Transl Med. 2017 Oct;6(10):1852-1858. doi: 10.1002/sctm.17-0048. Epub 2017 Aug 11.


β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability.

Izawa Y, Gu YH, Osada T, Kanazawa M, Hawkins BT, Koziol JA, Papayannopoulou T, Spatz M, Del Zoppo GJ.

J Cereb Blood Flow Metab. 2018 Apr;38(4):641-658. doi: 10.1177/0271678X17722108. Epub 2017 Aug 8.


A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity.

Chung KJ, Chatzigeorgiou A, Economopoulou M, Garcia-Martin R, Alexaki VI, Mitroulis I, Nati M, Gebler J, Ziemssen T, Goelz SE, Phieler J, Lim JH, Karalis KP, Papayannopoulou T, Blüher M, Hajishengallis G, Chavakis T.

Nat Immunol. 2017 Jun;18(6):654-664. doi: 10.1038/ni.3728. Epub 2017 Apr 17.


In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.

Richter M, Saydaminova K, Yumul R, Krishnan R, Liu J, Nagy EE, Singh M, Izsvák Z, Cattaneo R, Uckert W, Palmer D, Ng P, Haworth KG, Kiem HP, Ehrhardt A, Papayannopoulou T, Lieber A.

Blood. 2016 Nov 3;128(18):2206-2217. Epub 2016 Aug 23.


The macrophage contribution to stress erythropoiesis: when less is enough.

Ulyanova T, Phelps SR, Papayannopoulou T.

Blood. 2016 Sep 29;128(13):1756-65. doi: 10.1182/blood-2016-05-714527. Epub 2016 Aug 19.


Ataxia-Pancytopenia Syndrome Is Caused by Missense Mutations in SAMD9L.

Chen DH, Below JE, Shimamura A, Keel SB, Matsushita M, Wolff J, Sul Y, Bonkowski E, Castella M, Taniguchi T, Nickerson D, Papayannopoulou T, Bird TD, Raskind WH.

Am J Hum Genet. 2016 Jun 2;98(6):1146-1158. doi: 10.1016/j.ajhg.2016.04.009.


Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist.

Cao B, Zhang Z, Grassinger J, Williams B, Heazlewood CK, Churches QI, James SA, Li S, Papayannopoulou T, Nilsson SK.

Nat Commun. 2016 Mar 15;7:11007. doi: 10.1038/ncomms11007.


Evolving insights into the synergy between erythropoietin and thrombopoietin and the bipotent erythroid/megakaryocytic progenitor cell.

Papayannopoulou T, Kaushansky K.

Exp Hematol. 2016 Aug;44(8):664-8. doi: 10.1016/j.exphem.2015.11.010. Epub 2016 Jan 8. Review.


Interdependence between Interleukin-1 and Tumor Necrosis Factor Regulates TNF-Dependent Control of Mycobacterium tuberculosis Infection.

Di Paolo NC, Shafiani S, Day T, Papayannopoulou T, Russell DW, Iwakura Y, Sherman D, Urdahl K, Shayakhmetov DM.

Immunity. 2015 Dec 15;43(6):1125-36. doi: 10.1016/j.immuni.2015.11.016. Erratum in: Immunity. 2016 Feb 16;44(2):438. Papayannoupoulou, Thalia [corrected to Papayannopoulou, Thalia].


Functional footprinting of regulatory DNA.

Vierstra J, Reik A, Chang KH, Stehling-Sun S, Zhou Y, Hinkley SJ, Paschon DE, Zhang L, Psatha N, Bendana YR, O'Neil CM, Song AH, Mich AK, Liu PQ, Lee G, Bauer DE, Holmes MC, Orkin SH, Papayannopoulou T, Stamatoyannopoulos G, Rebar EJ, Gregory PD, Urnov FD, Stamatoyannopoulos JA.

Nat Methods. 2015 Oct;12(10):927-30. doi: 10.1038/nmeth.3554. Epub 2015 Aug 31.


An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference.

Blobel GA, Bodine D, Brand M, Crispino J, de Bruijn MF, Nathan D, Papayannopoulou T, Porcher C, Strouboulis J, Zon L, Higgs DR, Stamatoyannopoulos G, Engel JD.

Exp Hematol. 2015 Oct;43(10):821-37. doi: 10.1016/j.exphem.2015.06.008. Epub 2015 Jul 2. Review.


2p15-p16.1 microdeletions encompassing and proximal to BCL11A are associated with elevated HbF in addition to neurologic impairment.

Funnell AP, Prontera P, Ottaviani V, Piccione M, Giambona A, Maggio A, Ciaffoni F, Stehling-Sun S, Marra M, Masiello F, Varricchio L, Stamatoyannopoulos JA, Migliaccio AR, Papayannopoulou T.

Blood. 2015 Jul 2;126(1):89-93. doi: 10.1182/blood-2015-04-638528. Epub 2015 May 27.


Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution.

Vierstra J, Rynes E, Sandstrom R, Zhang M, Canfield T, Hansen RS, Stehling-Sun S, Sabo PJ, Byron R, Humbert R, Thurman RE, Johnson AK, Vong S, Lee K, Bates D, Neri F, Diegel M, Giste E, Haugen E, Dunn D, Wilken MS, Josefowicz S, Samstein R, Chang KH, Eichler EE, De Bruijn M, Reh TA, Skoultchi A, Rudensky A, Orkin SH, Papayannopoulou T, Treuting PM, Selleri L, Kaul R, Groudine M, Bender MA, Stamatoyannopoulos JA.

Science. 2014 Nov 21;346(6212):1007-12. doi: 10.1126/science.1246426.


A comparative encyclopedia of DNA elements in the mouse genome.

Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, Sandstrom R, Ma Z, Davis C, Pope BD, Shen Y, Pervouchine DD, Djebali S, Thurman RE, Kaul R, Rynes E, Kirilusha A, Marinov GK, Williams BA, Trout D, Amrhein H, Fisher-Aylor K, Antoshechkin I, DeSalvo G, See LH, Fastuca M, Drenkow J, Zaleski C, Dobin A, Prieto P, Lagarde J, Bussotti G, Tanzer A, Denas O, Li K, Bender MA, Zhang M, Byron R, Groudine MT, McCleary D, Pham L, Ye Z, Kuan S, Edsall L, Wu YC, Rasmussen MD, Bansal MS, Kellis M, Keller CA, Morrissey CS, Mishra T, Jain D, Dogan N, Harris RS, Cayting P, Kawli T, Boyle AP, Euskirchen G, Kundaje A, Lin S, Lin Y, Jansen C, Malladi VS, Cline MS, Erickson DT, Kirkup VM, Learned K, Sloan CA, Rosenbloom KR, Lacerda de Sousa B, Beal K, Pignatelli M, Flicek P, Lian J, Kahveci T, Lee D, Kent WJ, Ramalho Santos M, Herrero J, Notredame C, Johnson A, Vong S, Lee K, Bates D, Neri F, Diegel M, Canfield T, Sabo PJ, Wilken MS, Reh TA, Giste E, Shafer A, Kutyavin T, Haugen E, Dunn D, Reynolds AP, Neph S, Humbert R, Hansen RS, De Bruijn M, Selleri L, Rudensky A, Josefowicz S, Samstein R, Eichler EE, Orkin SH, Levasseur D, Papayannopoulou T, Chang KH, Skoultchi A, Gosh S, Disteche C, Treuting P, Wang Y, Weiss MJ, Blobel GA, Cao X, Zhong S, Wang T, Good PJ, Lowdon RF, Adams LB, Zhou XQ, Pazin MJ, Feingold EA, Wold B, Taylor J, Mortazavi A, Weissman SM, Stamatoyannopoulos JA, Snyder MP, Guigo R, Gingeras TR, Gilbert DM, Hardison RC, Beer MA, Ren B; Mouse ENCODE Consortium.

Nature. 2014 Nov 20;515(7527):355-64. doi: 10.1038/nature13992.


Superior long-term repopulating capacity of G-CSF+plerixafor-mobilized blood: implications for stem cell gene therapy by studies in the Hbb(th-3) mouse model.

Psatha N, Sgouramali E, Gkountis A, Siametis A, Baliakas P, Constantinou V, Athanasiou E, Arsenakis M, Anagnostopoulos A, Papayannopoulou T, Stamatoyannopoulos G, Yannaki E.

Hum Gene Ther Methods. 2014 Dec;25(6):317-27. doi: 10.1089/hgtb.2014.005.


Functional consequences of perturbed CXCL12 signal processing: analyses of immature hematopoiesis in GRK6-deficient mice.

Chudziak D, Spohn G, Karpova D, Dauber K, Wiercinska E, Miettinen JA, Papayannopoulou T, Bönig H.

Stem Cells Dev. 2015 Mar 15;24(6):737-46. doi: 10.1089/scd.2014.0284. Epub 2014 Nov 19.


Deletion of Dicer in late erythroid cells results in impaired stress erythropoiesis in mice.

Byon JC, Padilla SM, Papayannopoulou T.

Exp Hematol. 2014 Oct;42(10):852-6.e1. doi: 10.1016/j.exphem.2014.06.004. Epub 2014 Jun 24.


Modeling promising nonmyeloablative conditioning regimens in nonhuman primates.

Chandrasekaran D, Nakamoto B, Watts KL, Kiem HP, Papayannopoulou T.

Hum Gene Ther. 2014 Dec;25(12):1013-22. doi: 10.1089/hum.2014.031.


IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells.

Di Paolo NC, Baldwin LK, Irons EE, Papayannopoulou T, Tomlinson S, Shayakhmetov DM.

PLoS Pathog. 2014 Mar 20;10(3):e1004035. doi: 10.1371/journal.ppat.1004035. eCollection 2014 Mar.


Stage-specific functional roles of integrins in murine erythropoiesis.

Ulyanova T, Padilla SM, Papayannopoulou T.

Exp Hematol. 2014 May;42(5):404-409.e4. doi: 10.1016/j.exphem.2014.01.007. Epub 2014 Jan 23.


Hematopoietic stem cell mobilization for gene therapy: superior mobilization by the combination of granulocyte-colony stimulating factor plus plerixafor in patients with β-thalassemia major.

Yannaki E, Karponi G, Zervou F, Constantinou V, Bouinta A, Tachynopoulou V, Kotta K, Jonlin E, Papayannopoulou T, Anagnostopoulos A, Stamatoyannopoulos G.

Hum Gene Ther. 2013 Oct;24(10):852-60. doi: 10.1089/hum.2013.163.


Transcriptional environment and chromatin architecture interplay dictates globin expression patterns of heterospecific hybrids derived from undifferentiated human embryonic stem cells or from their erythroid progeny.

Chang KH, Huang A, Han H, Jiang Y, Fang X, Song CZ, Padilla S, Wang H, Qu H, Stamatoyannopoulos J, Li Q, Papayannopoulou T.

Exp Hematol. 2013 Nov;41(11):967-979.e6. doi: 10.1016/j.exphem.2013.08.005. Epub 2013 Aug 28.


β-Thalassemia due to intronic LINE-1 insertion in the β-globin gene (HBB): molecular mechanisms underlying reduced transcript levels of the β-globin(L1) allele.

Lanikova L, Kucerova J, Indrak K, Divoka M, Issa JP, Papayannopoulou T, Prchal JT, Divoky V.

Hum Mutat. 2013 Oct;34(10):1361-5. doi: 10.1002/humu.22383. Epub 2013 Aug 13.


Erythroid cells generated in the absence of specific β1-integrin heterodimers accumulate reactive oxygen species at homeostasis and are unable to mount effective antioxidant defenses.

Ulyanova T, Jiang Y, Padilla SM, Papayannopoulou T.

Haematologica. 2013 Nov;98(11):1769-77. doi: 10.3324/haematol.2013.087577. Epub 2013 Jun 28.


The transcription factor IRF3 triggers "defensive suicide" necrosis in response to viral and bacterial pathogens.

Di Paolo NC, Doronin K, Baldwin LK, Papayannopoulou T, Shayakhmetov DM.

Cell Rep. 2013 Jun 27;3(6):1840-6. doi: 10.1016/j.celrep.2013.05.025. Epub 2013 Jun 13.


Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy.

Hsieh YT, Gang EJ, Geng H, Park E, Huantes S, Chudziak D, Dauber K, Schaefer P, Scharman C, Shimada H, Shojaee S, Klemm L, Parameswaran R, Loh M, Kang ES, Koo HH, Hofmann WK, Andrade J, Crooks GM, Willman CL, Müschen M, Papayannopoulou T, Heisterkamp N, Bönig H, Kim YM.

Blood. 2013 Mar 7;121(10):1814-8. doi: 10.1182/blood-2012-01-406272. Epub 2013 Jan 14.


Trisomy correction in Down syndrome induced pluripotent stem cells.

Li LB, Chang KH, Wang PR, Hirata RK, Papayannopoulou T, Russell DW.

Cell Stem Cell. 2012 Nov 2;11(5):615-9. doi: 10.1016/j.stem.2012.08.004. Epub 2012 Oct 18.


Transcriptional regulation of miR-10a/b by TWIST-1 in myelodysplastic syndromes.

Li X, Xu F, Chang C, Byon J, Papayannopoulou T, Deeg HJ, Marcondes AM.

Haematologica. 2013 Mar;98(3):414-9. doi: 10.3324/haematol.2012.071753. Epub 2012 Sep 14.


Hematopoietic stem cell mobilization: updated conceptual renditions.

Bonig H, Papayannopoulou T.

Leukemia. 2013 Jan;27(1):24-31. doi: 10.1038/leu.2012.254. Epub 2012 Sep 6. Review.


The proportion of CD34(+)CD38(low or neg) myeloblasts, but not side population frequency, predicts initial response to induction therapy in patients with newly diagnosed acute myeloid leukemia.

Roshal M, Chien S, Othus M, Wood BL, Fang M, Appelbaum FR, Estey EH, Papayannopoulou T, Becker PS.

Leukemia. 2013 Mar;27(3):728-31. doi: 10.1038/leu.2012.217. Epub 2012 Jul 31. No abstract available.


Mobilization of hematopoietic stem/progenitor cells: general principles and molecular mechanisms.

Bonig H, Papayannopoulou T.

Methods Mol Biol. 2012;904:1-14. doi: 10.1007/978-1-61779-943-3_1. Review.


Is the post-transplantation treatment with AMD beneficial?

Jiang Y, Ulyanova T, Papayannopoulou T.

Blood Cells Mol Dis. 2012 Jun 15;49(1):29-31. doi: 10.1016/j.bcmd.2012.03.005. Epub 2012 Apr 5.


Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model.

Banerjee ER, Laflamme MA, Papayannopoulou T, Kahn M, Murry CE, Henderson WR Jr.

PLoS One. 2012;7(3):e33165. doi: 10.1371/journal.pone.0033165. Epub 2012 Mar 28.


Epigenetic modifications and chromosome conformations of the beta globin locus throughout development.

Chang KH, Fang X, Wang H, Huang A, Cao H, Yang Y, Bonig H, Stamatoyannopoulos JA, Papayannopoulou T.

Stem Cell Rev. 2013 Aug;9(4):397-407. doi: 10.1007/s12015-012-9355-x.


The potential of stem cells as an in vitro source of red blood cells for transfusion.

Migliaccio AR, Whitsett C, Papayannopoulou T, Sadelain M.

Cell Stem Cell. 2012 Feb 3;10(2):115-9. doi: 10.1016/j.stem.2012.01.001. Review.


Generation and characterization of erythroid cells from human embryonic stem cells and induced pluripotent stem cells: an overview.

Chang KH, Bonig H, Papayannopoulou T.

Stem Cells Int. 2011;2011:791604. doi: 10.4061/2011/791604. Epub 2011 Oct 26.


Hematopoietic stem cell mobilization for gene therapy of adult patients with severe β-thalassemia: results of clinical trials using G-CSF or plerixafor in splenectomized and nonsplenectomized subjects.

Yannaki E, Papayannopoulou T, Jonlin E, Zervou F, Karponi G, Xagorari A, Becker P, Psatha N, Batsis I, Kaloyannidis P, Tahynopoulou V, Constantinou V, Bouinta A, Kotta K, Athanassiadou A, Anagnostopoulos A, Fassas A, Stamatoyannopoulos G.

Mol Ther. 2012 Jan;20(1):230-8. doi: 10.1038/mt.2011.195. Epub 2011 Sep 27. Erratum in: Mol Ther. 2012 Feb;20(2):469.


MicroRNAs: Allies or foes in erythropoiesis?

Byon JC, Papayannopoulou T.

J Cell Physiol. 2012 Jan;227(1):7-13. doi: 10.1002/jcp.22729. Review.


Vagrant stem cells draft their gene companions.

Bonig H, Papayannopoulou T.

Cell Stem Cell. 2010 Nov 5;7(5):547-8. doi: 10.1016/j.stem.2010.10.006.


Combinatorial and distinct roles of α₅ and α₄ integrins in stress erythropoiesis in mice.

Ulyanova T, Jiang Y, Padilla S, Nakamoto B, Papayannopoulou T.

Blood. 2011 Jan 20;117(3):975-85. doi: 10.1182/blood-2010-05-283218. Epub 2010 Oct 18.


Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis.

Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA.

Cancer Res. 2010 Apr 15;70(8):3042-51. doi: 10.1158/0008-5472.CAN-09-3761. Epub 2010 Apr 13.


Globin phenotype of erythroid cells derived from human induced pluripotent stem cells.

Chang KH, Huang A, Hirata RK, Wang PR, Russell DW, Papayannopoulou T.

Blood. 2010 Mar 25;115(12):2553-4. doi: 10.1182/blood-2009-11-252650. No abstract available.


On the adaptation of endosteal stem cell niche function in response to stress.

Jiang Y, Bonig H, Ulyanova T, Chang K, Papayannopoulou T.

Blood. 2009 Oct 29;114(18):3773-82. doi: 10.1182/blood-2009-05-219840. Epub 2009 Sep 1.


Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.

Di Paolo NC, Miao EA, Iwakura Y, Murali-Krishna K, Aderem A, Flavell RA, Papayannopoulou T, Shayakhmetov DM.

Immunity. 2009 Jul 17;31(1):110-21. doi: 10.1016/j.immuni.2009.04.015. Epub 2009 Jul 2.


Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models.

Banerjee ER, Jiang Y, Henderson WR Jr, Latchman Y, Papayannopoulou T.

Exp Hematol. 2009 Jun;37(6):715-727.e3. doi: 10.1016/j.exphem.2009.03.010.


Concurrent blockade of alpha4-integrin and CXCR4 in hematopoietic stem/progenitor cell mobilization.

Bonig H, Watts KL, Chang KH, Kiem HP, Papayannopoulou T.

Stem Cells. 2009 Apr;27(4):836-7. doi: 10.1002/stem.9.

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