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MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition.

Lu X, Chu CS, Fang T, Rayon-Estrada V, Fang F, Patke A, Qian Y, Clarke SH, Melnick AM, Zhang Y, Papavasiliou FN, Roeder RG.

Cell Rep. 2019 Jul 9;28(2):472-485.e5. doi: 10.1016/j.celrep.2019.06.029.


Mechanistic Similarities between Antigenic Variation and Antibody Diversification during Trypanosoma brucei Infection.

Aresta-Branco F, Erben E, Papavasiliou FN, Stebbins CE.

Trends Parasitol. 2019 Apr;35(4):302-315. doi: 10.1016/ Epub 2019 Feb 28. Review.


RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease.

Lerner T, Papavasiliou FN, Pecori R.

Genes (Basel). 2018 Dec 27;10(1). pii: E13. doi: 10.3390/genes10010013. Review.


African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat.

Pinger J, Nešić D, Ali L, Aresta-Branco F, Lilic M, Chowdhury S, Kim HS, Verdi J, Raper J, Ferguson MAJ, Papavasiliou FN, Stebbins CE.

Nat Microbiol. 2018 Aug;3(8):932-938. doi: 10.1038/s41564-018-0187-6. Epub 2018 Jul 9.


A New Chapter in Genetic Medicine: RNA Editing and its Role in Disease Pathogenesis.

Gagnidze K, Rayon-Estrada V, Harroch S, Bulloch K, Papavasiliou FN.

Trends Mol Med. 2018 Mar;24(3):294-303. doi: 10.1016/j.molmed.2018.01.002. Epub 2018 Feb 23. Review.


Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology.

Cole DC, Chung Y, Gagnidze K, Hajdarovic KH, Rayon-Estrada V, Harjanto D, Bigio B, Gal-Toth J, Milner TA, McEwen BS, Papavasiliou FN, Bulloch K.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13272-13277. doi: 10.1073/pnas.1710493114. Epub 2017 Nov 22.


Epitranscriptomic profiling across cell types reveals associations between APOBEC1-mediated RNA editing, gene expression outcomes, and cellular function.

Rayon-Estrada V, Harjanto D, Hamilton CE, Berchiche YA, Gantman EC, Sakmar TP, Bulloch K, Gagnidze K, Harroch S, McEwen BS, Papavasiliou FN.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13296-13301. doi: 10.1073/pnas.1714227114. Epub 2017 Nov 22.


Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation.

Pinger J, Chowdhury S, Papavasiliou FN.

Nat Commun. 2017 Oct 10;8(1):828. doi: 10.1038/s41467-017-00959-w.


Detection of Trypanosoma brucei Variant Surface Glycoprotein Switching by Magnetic Activated Cell Sorting and Flow Cytometry.

Schulz D, Mugnier MR, Boothroyd CE, Papavasiliou FN.

J Vis Exp. 2016 Oct 19;(116). doi: 10.3791/54715.


RNA Editing Dynamically Rewrites the Cancer Code.

Rayon-Estrada V, Papavasiliou FN, Harjanto D.

Trends Cancer. 2015 Dec;1(4):211-212. Epub 2015 Nov 26.


Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei.

Mugnier MR, Stebbins CE, Papavasiliou FN.

PLoS Pathog. 2016 Sep 1;12(9):e1005784. doi: 10.1371/journal.ppat.1005784. eCollection 2016 Sep. Review. No abstract available.


RNA editing generates cellular subsets with diverse sequence within populations.

Harjanto D, Papamarkou T, Oates CJ, Rayon-Estrada V, Papavasiliou FN, Papavasiliou A.

Nat Commun. 2016 Jul 15;7:12145. doi: 10.1038/ncomms12145.


The VEXing problem of monoallelic expression in the African trypanosome.

Schulz D, Papavasiliou FN.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7017-9. doi: 10.1073/pnas.1608546113. Epub 2016 Jun 17. No abstract available.


A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive.

Hovel-Miner G, Mugnier MR, Goldwater B, Cross GA, Papavasiliou FN.

PLoS Genet. 2016 May 5;12(5):e1005994. doi: 10.1371/journal.pgen.1005994. eCollection 2016 May.


Vesicles as Vehicles for Virulence.

Mugnier MR, Papavasiliou FN, Schulz D.

Trends Parasitol. 2016 Jun;32(6):435-436. doi: 10.1016/ Epub 2016 Mar 20.


Pseudouridylation meets next-generation sequencing.

Zaringhalam M, Papavasiliou FN.

Methods. 2016 Sep 1;107:63-72. doi: 10.1016/j.ymeth.2016.03.001. Epub 2016 Mar 8. Review.


Epigenetic Modulators of Monocytic Function: Implication for Steady State and Disease in the CNS.

Papavasiliou FN, Chung YC, Gagnidze K, Hajdarovic KH, Cole DC, Bulloch K.

Front Immunol. 2016 Jan 15;6:661. doi: 10.3389/fimmu.2015.00661. eCollection 2015. Review.


Base J and H3.V Regulate Transcriptional Termination in Trypanosoma brucei.

Schulz D, Zaringhalam M, Papavasiliou FN, Kim HS.

PLoS Genet. 2016 Jan 21;12(1):e1005762. doi: 10.1371/journal.pgen.1005762. eCollection 2016 Jan.


Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome.

Schulz D, Mugnier MR, Paulsen EM, Kim HS, Chung CW, Tough DF, Rioja I, Prinjha RK, Papavasiliou FN, Debler EW.

PLoS Biol. 2015 Dec 8;13(12):e1002316. doi: 10.1371/journal.pbio.1002316. eCollection 2015 Dec.


A Host-Pathogen Interaction Reduced to First Principles: Antigenic Variation in T. brucei.

Hovel-Miner G, Mugnier M, Papavasiliou FN, Pinger J, Schulz D.

Results Probl Cell Differ. 2015;57:23-46. doi: 10.1007/978-3-319-20819-0_2. Review.


DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.

Dominguez PM, Teater M, Chambwe N, Kormaksson M, Redmond D, Ishii J, Vuong B, Chaudhuri J, Melnick A, Vasanthakumar A, Godley LA, Papavasiliou FN, Elemento O, Shaknovich R.

Cell Rep. 2015 Sep 29;12(12):2086-98. doi: 10.1016/j.celrep.2015.08.036. Epub 2015 Sep 10.


The in vivo dynamics of antigenic variation in Trypanosoma brucei.

Mugnier MR, Cross GA, Papavasiliou FN.

Science. 2015 Mar 27;347(6229):1470-3. doi: 10.1126/science.aaa4502.


You break it, you fix it: functions for AID downstream of deamination.

Delker RK, Papavasiliou FN.

Nat Immunol. 2013 Nov;14(11):1112-4. doi: 10.1038/ni.2738. No abstract available.


A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells.

Fritz EL, Rosenberg BR, Lay K, Mihailović A, Tuschl T, Papavasiliou FN.

Nat Immunol. 2013 Jul;14(7):749-55. doi: 10.1038/ni.2616. Epub 2013 May 26.


Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase.

Delker RK, Zhou Y, Strikoudis A, Stebbins CE, Papavasiliou FN.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1029-34. doi: 10.1073/pnas.1214538110. Epub 2012 Dec 31.


Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei.

Hovel-Miner GA, Boothroyd CE, Mugnier M, Dreesen O, Cross GA, Papavasiliou FN.

PLoS Pathog. 2012;8(8):e1002900. doi: 10.1371/journal.ppat.1002900. Epub 2012 Aug 30.


The C-terminal end of the Trypanosoma brucei editing deaminase plays a critical role in tRNA binding.

Ragone FL, Spears JL, Wohlgamuth-Benedum JM, Kreel N, Papavasiliou FN, Alfonzo JD.

RNA. 2011 Jul;17(7):1296-306. doi: 10.1261/rna.2748211. Epub 2011 May 20.


A single zinc ion is sufficient for an active Trypanosoma brucei tRNA editing deaminase.

Spears JL, Rubio MA, Gaston KW, Wywial E, Strikoudis A, Bujnicki JM, Papavasiliou FN, Alfonzo JD.

J Biol Chem. 2011 Jun 10;286(23):20366-74. doi: 10.1074/jbc.M111.243568. Epub 2011 Apr 20.


Identifying mRNA editing deaminase targets by RNA-Seq.

Rosenberg BR, Dewell S, Papavasiliou FN.

Methods Mol Biol. 2011;718:103-19. doi: 10.1007/978-1-61779-018-8_6.


MicroRNA control of lymphocyte differentiation and function.

Belver L, Papavasiliou FN, Ramiro AR.

Curr Opin Immunol. 2011 Jun;23(3):368-73. doi: 10.1016/j.coi.2011.02.001. Epub 2011 Feb 24. Review.


Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3' UTRs.

Rosenberg BR, Hamilton CE, Mwangi MM, Dewell S, Papavasiliou FN.

Nat Struct Mol Biol. 2011 Feb;18(2):230-6. doi: 10.1038/nsmb.1975. Epub 2011 Jan 23. Erratum in: Nat Struct Mol Biol. 2012 Mar;19(3):364.


A role for autophagic protein beclin 1 early in lymphocyte development.

Arsov I, Adebayo A, Kucerova-Levisohn M, Haye J, MacNeil M, Papavasiliou FN, Yue Z, Ortiz BD.

J Immunol. 2011 Feb 15;186(4):2201-9. doi: 10.4049/jimmunol.1002223. Epub 2011 Jan 14.


Cytidine deaminases: AIDing DNA demethylation?

Fritz EL, Papavasiliou FN.

Genes Dev. 2010 Oct 1;24(19):2107-14. doi: 10.1101/gad.1963010. Review.


Using T. brucei as a biological epitope-display platform to elicit specific antibody responses.

Stavropoulos P, Papavasiliou FN.

J Immunol Methods. 2010 Oct 31;362(1-2):190-4. doi: 10.1016/j.jim.2010.08.009. Epub 2010 Aug 26.


Diverse functions for DNA and RNA editing in the immune system.

Hamilton CE, Papavasiliou FN, Rosenberg BR.

RNA Biol. 2010 Mar-Apr;7(2):220-8. Epub 2010 Mar 29. Review.


MicroRNAs of the immune system: roles in inflammation and cancer.

Davidson-Moncada J, Papavasiliou FN, Tam W.

Ann N Y Acad Sci. 2010 Jan;1183:183-94. doi: 10.1111/j.1749-6632.2009.05121.x. Review.


Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region.

Dunnick WA, Collins JT, Shi J, Westfield G, Fontaine C, Hakimpour P, Papavasiliou FN.

J Exp Med. 2009 Nov 23;206(12):2613-23. doi: 10.1084/jem.20091280. Epub 2009 Nov 2.


A coming-of-age story: activation-induced cytidine deaminase turns 10.

Delker RK, Fugmann SD, Papavasiliou FN.

Nat Immunol. 2009 Nov;10(11):1147-53. doi: 10.1038/ni.1799. Epub 2009 Oct 20. Review.


A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei.

Boothroyd CE, Dreesen O, Leonova T, Ly KI, Figueiredo LM, Cross GA, Papavasiliou FN.

Nature. 2009 May 14;459(7244):278-81. doi: 10.1038/nature07982. Epub 2009 Apr 15.


Long noncoding RNAs: implications for antigen receptor diversification.

Teng G, Papavasiliou FN.

Adv Immunol. 2009;104:25-50. doi: 10.1016/S0065-2776(08)04002-9. Epub 2009 Dec 1. Review.


Shhh! Silencing by microRNA-155.

Teng G, Papavasiliou FN.

Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):631-7. doi: 10.1098/rstb.2008.0209. Review.


MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase.

Teng G, Hakimpour P, Landgraf P, Rice A, Tuschl T, Casellas R, Papavasiliou FN.

Immunity. 2008 May;28(5):621-9. doi: 10.1016/j.immuni.2008.03.015. Epub 2008 May 1.


C to U editing at position 32 of the anticodon loop precedes tRNA 5' leader removal in trypanosomatids.

Gaston KW, Rubio MA, Spears JL, Pastar I, Papavasiliou FN, Alfonzo JD.

Nucleic Acids Res. 2007;35(20):6740-9. Epub 2007 Oct 4.


A mammalian microRNA expression atlas based on small RNA library sequencing.

Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T.

Cell. 2007 Jun 29;129(7):1401-14.


Immunoglobulin somatic hypermutation.

Teng G, Papavasiliou FN.

Annu Rev Genet. 2007;41:107-20. Review.


Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection.

Rosenberg BR, Papavasiliou FN.

Adv Immunol. 2007;94:215-44. Review.


An adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U deamination of DNA.

Rubio MA, Pastar I, Gaston KW, Ragone FL, Janzen CJ, Cross GA, Papavasiliou FN, Alfonzo JD.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7821-6. Epub 2007 May 1.


Regulation of AID expression in the immune response.

Crouch EE, Li Z, Takizawa M, Fichtner-Feigl S, Gourzi P, Montaño C, Feigenbaum L, Wilson P, Janz S, Papavasiliou FN, Casellas R.

J Exp Med. 2007 May 14;204(5):1145-56. Epub 2007 Apr 23.


Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.

Gourzi P, Leonova T, Papavasiliou FN.

J Exp Med. 2007 Feb 19;204(2):259-65. Epub 2007 Jan 22.


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