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Items: 25


HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors.

VandeKopple MJ, Wu J, Auer EN, Giaccia AJ, Denko NC, Papandreou I.

Mol Cancer Res. 2019 Oct;17(10):2089-2101. doi: 10.1158/1541-7786.MCR-18-1343. Epub 2019 Jul 15.


Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism.

Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen CS, Papandreou I, Denko NC.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10756-10761. doi: 10.1073/pnas.1808945115. Epub 2018 Sep 10. Erratum in: Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11561.


Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase.

Golias T, Kery M, Radenkovic S, Papandreou I.

Int J Cancer. 2019 Feb 15;144(4):674-686. doi: 10.1002/ijc.31812. Epub 2018 Oct 4. Review.


Stress-responsive HILPDA is necessary for thermoregulation during fasting.

VandeKopple MJ, Wu J, Baer LA, Bal NC, Maurya SK, Kalyanasundaram A, Periasamy M, Stanford KI, Giaccia AJ, Denko NC, Papandreou I.

J Endocrinol. 2017 Oct;235(1):27-38. doi: 10.1530/JOE-17-0289. Epub 2017 Jul 24.


Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours.

Golias T, Papandreou I, Sun R, Kumar B, Brown NV, Swanson BJ, Pai R, Jaitin D, Le QT, Teknos TN, Denko NC.

Sci Rep. 2016 Aug 8;6:31146. doi: 10.1038/srep31146.


Plant stilbenes induce endoplasmic reticulum stress and their anti-cancer activity can be enhanced by inhibitors of autophagy.

Papandreou I, Verras M, McNeil B, Koong AC, Denko NC.

Exp Cell Res. 2015 Nov 15;339(1):147-53. doi: 10.1016/j.yexcr.2015.10.014. Epub 2015 Oct 17.


5'-AMP-activated protein kinase (AMPK) supports the growth of aggressive experimental human breast cancer tumors.

Laderoute KR, Calaoagan JM, Chao WR, Dinh D, Denko N, Duellman S, Kalra J, Liu X, Papandreou I, Sambucetti L, Boros LG.

J Biol Chem. 2014 Aug 15;289(33):22850-64. doi: 10.1074/jbc.M114.576371. Epub 2014 Jul 3.


Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.

Sayers CM, Papandreou I, Guttmann DM, Maas NL, Diehl JA, Witze ES, Koong AC, Koumenis C.

Mol Pharmacol. 2013 Mar;83(3):594-604. doi: 10.1124/mol.112.081810. Epub 2012 Dec 10.


β-Catenin regulates hepatic mitochondrial function and energy balance in mice.

Lehwald N, Tao GZ, Jang KY, Papandreou I, Liu B, Liu B, Pysz MA, Willmann JK, Knoefel WT, Denko NC, Sylvester KG.

Gastroenterology. 2012 Sep;143(3):754-764. doi: 10.1053/j.gastro.2012.05.048. Epub 2012 Jun 7.


Identification of a protein mediating respiratory supercomplex stability.

Chen YC, Taylor EB, Dephoure N, Heo JM, Tonhato A, Papandreou I, Nath N, Denko NC, Gygi SP, Rutter J.

Cell Metab. 2012 Mar 7;15(3):348-60. doi: 10.1016/j.cmet.2012.02.006.


Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma.

Papandreou I, Denko NC, Olson M, Van Melckebeke H, Lust S, Tam A, Solow-Cordero DE, Bouley DM, Offner F, Niwa M, Koong AC.

Blood. 2011 Jan 27;117(4):1311-4. doi: 10.1182/blood-2010-08-303099. Epub 2010 Nov 16.


Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

Papandreou I, Goliasova T, Denko NC.

Int J Cancer. 2011 Mar 1;128(5):1001-8. doi: 10.1002/ijc.25728. Epub 2010 Dec 7.


Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth.

Spiotto MT, Banh A, Papandreou I, Cao H, Galvez MG, Gurtner GC, Denko NC, Le QT, Koong AC.

Cancer Res. 2010 Jan 1;70(1):78-88. doi: 10.1158/0008-5472.CAN-09-2747. Epub 2009 Dec 22.


Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect.

Chen Y, Cairns R, Papandreou I, Koong A, Denko NC.

PLoS One. 2009 Sep 15;4(9):e7033. doi: 10.1371/journal.pone.0007033.


Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stress.

Verras M, Papandreou I, Lim AL, Denko NC.

Mol Cell Biol. 2008 Dec;28(23):7212-24. doi: 10.1128/MCB.00947-08. Epub 2008 Sep 29.


Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.

Papandreou I, Lim AL, Laderoute K, Denko NC.

Cell Death Differ. 2008 Oct;15(10):1572-81. doi: 10.1038/cdd.2008.84. Epub 2008 Jun 13.


HIF-1alpha in endurance training: suppression of oxidative metabolism.

Mason SD, Rundqvist H, Papandreou I, Duh R, McNulty WJ, Howlett RA, Olfert IM, Sundberg CJ, Denko NC, Poellinger L, Johnson RS.

Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R2059-69. Epub 2007 Sep 12.


Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy.

Cairns RA, Papandreou I, Sutphin PD, Denko NC.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9445-50. Epub 2007 May 15.


HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC.

Cell Metab. 2006 Mar;3(3):187-97.


Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment.

Cairns R, Papandreou I, Denko N.

Mol Cancer Res. 2006 Feb;4(2):61-70. Review.


Sigmoid schwannoma: a rare case.

Fotiadis CI, Kouerinis IA, Papandreou I, Zografos GC, Agapitos G.

World J Gastroenterol. 2005 Aug 28;11(32):5079-81. Review.


Colonic duplication in adults: report of two cases presenting with rectal bleeding.

Fotiadis C, Genetzakis M, Papandreou I, Misiakos EP, Agapitos E, Zografos GC.

World J Gastroenterol. 2005 Aug 28;11(32):5072-4.


Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment.

Papandreou I, Krishna C, Kaper F, Cai D, Giaccia AJ, Denko NC.

Cancer Res. 2005 Apr 15;65(8):3171-8.


Cellular reaction to hypoxia: sensing and responding to an adverse environment.

Papandreou I, Powell A, Lim AL, Denko N.

Mutat Res. 2005 Jan 6;569(1-2):87-100. Review.


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