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Items: 1 to 50 of 60

1.

Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1).

Koumantou D, Barnea E, Martin-Esteban A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Pratsinis H, Georgiadis D, Stern LJ, Admon A, Stratikos E.

Cancer Immunol Immunother. 2019 Aug;68(8):1245-1261. doi: 10.1007/s00262-019-02358-0. Epub 2019 Jun 20.

PMID:
31222486
2.

Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors.

Zouridakis M, Papakyriakou A, Ivanov IA, Kasheverov IE, Tsetlin V, Tzartos S, Giastas P.

Front Pharmacol. 2019 May 1;10:474. doi: 10.3389/fphar.2019.00474. eCollection 2019.

3.

Identification of Novel Melanin Synthesis Inhibitors From Crataegus pycnoloba Using an in Vivo Zebrafish Phenotypic Assay.

Agalou A, Thrapsianiotis M, Angelis A, Papakyriakou A, Skaltsounis AL, Aligiannis N, Beis D.

Front Pharmacol. 2018 Mar 26;9:265. doi: 10.3389/fphar.2018.00265. eCollection 2018.

4.

The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.

Papakyriakou A, Reeves E, Beton M, Mikolajek H, Douglas L, Cooper G, Elliott T, Werner JM, James E.

J Biol Chem. 2018 May 18;293(20):7538-7548. doi: 10.1074/jbc.RA117.000313. Epub 2018 Mar 29.

5.

Structures of the Peptidoglycan N-Acetylglucosamine Deacetylase Bc1974 and Its Complexes with Zinc Metalloenzyme Inhibitors.

Giastas P, Andreou A, Papakyriakou A, Koutsioulis D, Balomenou S, Tzartos SJ, Bouriotis V, Eliopoulos EE.

Biochemistry. 2018 Feb 6;57(5):753-763. doi: 10.1021/acs.biochem.7b00919. Epub 2018 Jan 5.

PMID:
29257674
6.

Direct modulation of T-box riboswitch-controlled transcription by protein synthesis inhibitors.

Stamatopoulou V, Apostolidi M, Li S, Lamprinou K, Papakyriakou A, Zhang J, Stathopoulos C.

Nucleic Acids Res. 2017 Sep 29;45(17):10242-10258. doi: 10.1093/nar/gkx663.

7.

Molecular recognition of N-acetyltryptophan enantiomers by β-cyclodextrin.

Chatziefthimiou SD, Inclán M, Giastas P, Papakyriakou A, Yannakopoulou K, Mavridis IM.

Beilstein J Org Chem. 2017 Aug 9;13:1572-1582. doi: 10.3762/bjoc.13.157. eCollection 2017.

8.

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases.

Papakyriakou A, Stratikos E.

Front Immunol. 2017 Aug 7;8:946. doi: 10.3389/fimmu.2017.00946. eCollection 2017. Review.

9.

Aqueous Solubility Enhancement for Bioassays of Insoluble Inhibitors and QSPR Analysis: A TNF-α Study.

Mettou A, Papaneophytou C, Melagraki G, Maranti A, Liepouri F, Alexiou P, Papakyriakou A, Couladouros E, Eliopoulos E, Afantitis A, Kontopidis G.

SLAS Discov. 2018 Jan;23(1):84-93. doi: 10.1177/2472555217712507. Epub 2017 Jun 6.

PMID:
28586633
10.

Targeting of the breast cancer microenvironment with a potent and linkable oxindole based antiangiogenic small molecule.

Argyros O, Karampelas T, Varela A, Asvos X, Papakyriakou A, Agalou A, Beis D, Davos CH, Fokas D, Tamvakopoulos C.

Oncotarget. 2017 Jun 6;8(23):37250-37262. doi: 10.18632/oncotarget.16763.

11.

Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.

Mpakali A, Giastas P, Deprez-Poulain R, Papakyriakou A, Koumantou D, Gealageas R, Tsoukalidou S, Vourloumis D, Mavridis IM, Stratikos E, Saridakis E.

ACS Med Chem Lett. 2017 Feb 21;8(3):333-337. doi: 10.1021/acsmedchemlett.6b00505. eCollection 2017 Mar 9.

12.

Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.

Mpakali A, Saridakis E, Harlos K, Zhao Y, Kokkala P, Georgiadis D, Giastas P, Papakyriakou A, Stratikos E.

J Med Chem. 2017 Apr 13;60(7):2963-2972. doi: 10.1021/acs.jmedchem.6b01890. Epub 2017 Apr 3.

PMID:
28328206
13.

The Pivotal Role of Protein Phosphorylation in the Control of Yeast Central Metabolism.

Vlastaridis P, Papakyriakou A, Chaliotis A, Stratikos E, Oliver SG, Amoutzias GD.

G3 (Bethesda). 2017 Apr 3;7(4):1239-1249. doi: 10.1534/g3.116.037218.

14.

Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.

Stamogiannos A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Georgiadis D, Stern LJ, Stratikos E.

Biochemistry. 2017 Mar 14;56(10):1546-1558. doi: 10.1021/acs.biochem.6b01170. Epub 2017 Mar 2.

15.

Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides.

Kokkala P, Mpakali A, Mauvais FX, Papakyriakou A, Daskalaki I, Petropoulou I, Kavvalou S, Papathanasopoulou M, Agrotis S, Fonsou TM, van Endert P, Stratikos E, Georgiadis D.

J Med Chem. 2016 Oct 13;59(19):9107-9123. Epub 2016 Sep 20.

PMID:
27606717
16.

Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development.

Anastasakis D, Skeparnias I, Shaukat AN, Grafanaki K, Kanellou A, Taraviras S, Papachristou DJ, Papakyriakou A, Stathopoulos C.

Nucleic Acids Res. 2016 Oct 14;44(18):8908-8920. Epub 2016 Aug 11.

17.

Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.

Stamogiannos A, Papakyriakou A, Mauvais FX, van Endert P, Stratikos E.

ACS Med Chem Lett. 2016 May 31;7(7):681-5. doi: 10.1021/acsmedchemlett.6b00084. eCollection 2016 Jul 14.

18.

Comparative Experimental and Computational Study of Monoalkyl Chain Phosphatidylcholine-Containing Thermoresponsive Liposomes.

Eleftheriou K, Sideratou Z, Thanassoulas A, Papakyriakou A, Tsiourvas D.

J Phys Chem B. 2016 Jun 23;120(24):5417-28. doi: 10.1021/acs.jpcb.6b02783. Epub 2016 Jun 9.

PMID:
27280363
19.

Peptide-Drug Conjugate GnRH-Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth.

Argyros O, Karampelas T, Asvos X, Varela A, Sayyad N, Papakyriakou A, Davos CH, Tzakos AG, Fokas D, Tamvakopoulos C.

Cancer Res. 2016 Mar 1;76(5):1181-92. doi: 10.1158/0008-5472.CAN-15-2138. Epub 2015 Dec 8.

20.

Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs.

Nicolaou KC, Vourloumis D, Totokotsopoulos S, Papakyriakou A, Karsunky H, Fernando H, Gavrilyuk J, Webb D, Stepan AF.

ChemMedChem. 2016 Jan 5;11(1):31-7. doi: 10.1002/cmdc.201500510. Epub 2015 Nov 20.

PMID:
26585829
21.

Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing.

Mpakali A, Saridakis E, Harlos K, Zhao Y, Papakyriakou A, Kokkala P, Georgiadis D, Stratikos E.

J Immunol. 2015 Sep 15;195(6):2842-51. doi: 10.4049/jimmunol.1501103. Epub 2015 Aug 10.

22.

Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.

Stamogiannos A, Koumantou D, Papakyriakou A, Stratikos E.

Mol Immunol. 2015 Oct;67(2 Pt B):426-35. doi: 10.1016/j.molimm.2015.07.010. Epub 2015 Jul 26.

PMID:
26224046
23.

Molecular interaction of α-conotoxin RgIA with the rat α9α10 nicotinic acetylcholine receptor.

Azam L, Papakyriakou A, Zouridakis M, Giastas P, Tzartos SJ, McIntosh JM.

Mol Pharmacol. 2015 May;87(5):855-64. doi: 10.1124/mol.114.096511. Epub 2015 Mar 4. Erratum in: Mol Pharmacol. 2016 Oct;90(4):415-7.

24.

Probing the mechanism of allylic substitution of Morita-Baylis-Hillman acetates (MBHAs) by using the silyl phosphonite paradigm: scope and applications of a versatile transformation.

Kalyva M, Zografos AL, Kapourani E, Giambazolias E, Devel L, Papakyriakou A, Dive V, Lazarou YG, Georgiadis D.

Chemistry. 2015 Feb 16;21(8):3278-89. doi: 10.1002/chem.201405626. Epub 2015 Jan 9.

PMID:
25641366
25.

3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties.

Papakyriakou A, Zervoudi E, Tsoukalidou S, Mauvais FX, Sfyroera G, Mastellos DC, van Endert P, Theodorakis EA, Vourloumis D, Stratikos E.

J Med Chem. 2015 Feb 12;58(3):1524-43. doi: 10.1021/jm501867s. Epub 2015 Jan 30.

26.

The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies.

Sharina IG, Sobolevsky M, Papakyriakou A, Rukoyatkina N, Spyroulias GA, Gambaryan S, Martin E.

Br J Pharmacol. 2015 May;172(9):2316-29. doi: 10.1111/bph.13055. Epub 2015 Feb 10.

27.

A zebrafish in vivo phenotypic assay to identify 3-aminothiophene-2-carboxylic acid-based angiogenesis inhibitors.

Papakyriakou A, Kefalos P, Sarantis P, Tsiamantas C, Xanthopoulos KP, Vourloumis D, Beis D.

Assay Drug Dev Technol. 2014 Nov-Dec;12(9-10):527-35. doi: 10.1089/adt.2014.606.

28.

Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects.

Alexiou P, Papakyriakou A, Ntougkos E, Papaneophytou CP, Liepouri F, Mettou A, Katsoulis I, Maranti A, Tsiliouka K, Strongilos A, Chaitidou S, Douni E, Kontopidis G, Kollias G, Couladouros E, Eliopoulos E.

Arch Pharm (Weinheim). 2014 Nov;347(11):798-805. doi: 10.1002/ardp.201400198. Epub 2014 Aug 27.

PMID:
25160057
29.

Novel selective inhibitors of aminopeptidases that generate antigenic peptides.

Papakyriakou A, Zervoudi E, Theodorakis EA, Saveanu L, Stratikos E, Vourloumis D.

Bioorg Med Chem Lett. 2013 Sep 1;23(17):4832-6. doi: 10.1016/j.bmcl.2013.07.024. Epub 2013 Jul 23.

31.

The interaction of the chemotherapeutic drug chlorambucil with human glutathione transferase A1-1: kinetic and structural analysis.

Karpusas M, Axarli I, Chiniadis L, Papakyriakou A, Bethanis K, Scopelitou K, Clonis YD, Labrou NE.

PLoS One. 2013;8(2):e56337. doi: 10.1371/journal.pone.0056337. Epub 2013 Feb 27.

32.

Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor.

Tsoupras AB, Papakyriakou A, Demopoulos CA, Philippopoulos AI.

J Inorg Biochem. 2013 Mar;120:63-73. doi: 10.1016/j.jinorgbio.2012.12.004. Epub 2012 Dec 19.

PMID:
23318288
33.

A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.

Evnouchidou I, Birtley J, Seregin S, Papakyriakou A, Zervoudi E, Samiotaki M, Panayotou G, Giastas P, Petrakis O, Georgiadis D, Amalfitano A, Saridakis E, Mavridis IM, Stratikos E.

J Immunol. 2012 Sep 1;189(5):2383-92. doi: 10.4049/jimmunol.1200918. Epub 2012 Jul 25.

34.

Synthesis of 5,6-spiroethers and evaluation of their affinities for the bacterial A site.

Katsoulis IA, Kythreoti G, Papakyriakou A, Koltsida K, Anastasopoulou P, Stathakis CI, Mavridis I, Cottin T, Saridakis E, Vourloumis D.

Chembiochem. 2011 May 16;12(8):1188-92. doi: 10.1002/cbic.201100076. Epub 2011 May 6. No abstract available.

PMID:
21557427
35.

Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.

Androutsopoulos VP, Ruparelia KC, Papakyriakou A, Filippakis H, Tsatsakis AM, Spandidos DA.

Eur J Med Chem. 2011 Jun;46(6):2586-95. doi: 10.1016/j.ejmech.2011.03.049. Epub 2011 Mar 30.

PMID:
21497957
36.

Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.

Androutsopoulos VP, Papakyriakou A, Vourloumis D, Spandidos DA.

Bioorg Med Chem. 2011 May 1;19(9):2842-9. doi: 10.1016/j.bmc.2011.03.042. Epub 2011 Mar 24.

PMID:
21482471
37.

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.

Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen GS, Drag M, Hattori A, Swevers L, Vourloumis D, Stratikos E.

Biochem J. 2011 Apr 15;435(2):411-20. doi: 10.1042/BJ20102049.

38.

Designed spiro-bicyclic analogues targeting the ribosomal decoding center.

Cottin T, Pyrkotis C, Stathakis CI, Mavridis I, Katsoulis IA, Anastasopoulou P, Kythreoti G, Zografos AL, Nahmias VR, Papakyriakou A, Vourloumis D.

Chembiochem. 2011 Jan 3;12(1):71-87. doi: 10.1002/cbic.201000591.

PMID:
21154494
39.

A computational investigation on the role of glycosylation in the binding of alpha1 nicotinic acetylcholine receptor with two alpha-neurotoxins.

Dimitropoulos N, Papakyriakou A, Dalkas GA, Chasapis CT, Poulas K, Spyroulias GA.

Proteins. 2011 Jan;79(1):142-52. doi: 10.1002/prot.22867.

PMID:
21058296
40.

Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome.

Stathakis CI, Mavridis I, Kythreoti G, Papakyriakou A, Katsoulis IA, Cottin T, Anastasopoulou P, Vourloumis D.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7488-92. doi: 10.1016/j.bmcl.2010.10.001. Epub 2010 Oct 8.

PMID:
21041083
41.

Study of the inclusion of the (R)- and (S)-camphor enantiomers in alpha-cyclodextrin by X-ray crystallography and molecular dynamics.

Kokkinou A, Tsorteki F, Karpusas M, Papakyriakou A, Bethanis K, Mentzafos D.

Carbohydr Res. 2010 May 27;345(8):1034-40. doi: 10.1016/j.carres.2010.03.020. Epub 2010 Mar 20.

PMID:
20378101
42.

A computational approach to the study of the binding mode of dual ACE/NEP inhibitors.

Dimitropoulos N, Papakyriakou A, Dalkas GA, Sturrock ED, Spyroulias GA.

J Chem Inf Model. 2010 Mar 22;50(3):388-96. doi: 10.1021/ci9005047.

PMID:
20170101
43.

Dietary flavonoids in cancer therapy and prevention: substrates and inhibitors of cytochrome P450 CYP1 enzymes.

Androutsopoulos VP, Papakyriakou A, Vourloumis D, Tsatsakis AM, Spandidos DA.

Pharmacol Ther. 2010 Apr;126(1):9-20. doi: 10.1016/j.pharmthera.2010.01.009. Epub 2010 Feb 11. Review.

PMID:
20153368
44.

A new role for Zn(II) aminopeptidases: antigenic peptide generation and destruction.

Evnouchidou I, Papakyriakou A, Stratikos E.

Curr Pharm Des. 2009;15(31):3656-70. Review.

PMID:
19925418
45.

Discovery of potent vascular endothelial growth factor receptor-2 inhibitors.

Papakyriakou A, Katsarou ME, Belimezi M, Karpusas M, Vourloumis D.

ChemMedChem. 2010 Jan;5(1):118-29. doi: 10.1002/cmdc.200900373.

PMID:
19921722
46.

Unnatural rigid scaffolds targeting the bacterial ribosome.

Katsoulis IA, Pyrkotis C, Papakyriakou A, Kythreoti G, Zografos AL, Mavridis I, Nahmias VR, Anastasopoulou P, Vourloumis D.

Chembiochem. 2009 Aug 17;10(12):1969-72. doi: 10.1002/cbic.200900268. No abstract available.

PMID:
19585638
47.

Insights into the anthrax lethal factor-substrate interaction and selectivity using docking and molecular dynamics simulations.

Dalkas GA, Papakyriakou A, Vlamis-Gardikas A, Spyroulias GA.

Protein Sci. 2009 Aug;18(8):1774-85. doi: 10.1002/pro.169.

48.

Conformational dynamics of the EGFR kinase domain reveals structural features involved in activation.

Papakyriakou A, Vourloumis D, Tzortzatou-Stathopoulou F, Karpusas M.

Proteins. 2009 Aug 1;76(2):375-86. doi: 10.1002/prot.22353.

PMID:
19173306
49.

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.

Evnouchidou I, Momburg F, Papakyriakou A, Chroni A, Leondiadis L, Chang SC, Goldberg AL, Stratikos E.

PLoS One. 2008;3(11):e3658. doi: 10.1371/journal.pone.0003658. Epub 2008 Nov 6.

50.

Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors.

Theodossiou TA, Papakyriakou A, Hothersall JS.

Free Radic Biol Med. 2008 Dec 1;45(11):1581-90. doi: 10.1016/j.freeradbiomed.2008.09.015. Epub 2008 Sep 26.

PMID:
18852042

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