Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 35

1.

Metabolic features of cancer cells in NRF2 addiction status.

Okazaki K, Papagiannakopoulos T, Motohashi H.

Biophys Rev. 2020 Feb 28. doi: 10.1007/s12551-020-00659-8. [Epub ahead of print] Review.

2.

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids.

LeBoeuf SE, Wu WL, Karakousi TR, Karadal B, Jackson SR, Davidson SM, Wong KK, Koralov SB, Sayin VI, Papagiannakopoulos T.

Cell Metab. 2020 Feb 4;31(2):339-350.e4. doi: 10.1016/j.cmet.2019.11.012. Epub 2019 Dec 5.

PMID:
31813821
3.

In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma.

Li F, Huang Q, Luster TA, Hu H, Zhang H, Ng WL, Khodadadi-Jamayran A, Wang W, Chen T, Deng J, Ranieri M, Fang Z, Pyon V, Dowling CM, Bagdatlioglu E, Almonte C, Labbe K, Silver H, Rabin AR, Jani K, Tsirigos A, Papagiannakopoulos T, Hammerman PS, Velcheti V, Freeman GJ, Qi J, Miller G, Wong KK.

Cancer Discov. 2020 Feb;10(2):270-287. doi: 10.1158/2159-8290.CD-19-0780. Epub 2019 Nov 19.

4.

Targeting Metabolic Bottlenecks in Lung Cancer.

Sayin VI, LeBoeuf SE, Papagiannakopoulos T.

Trends Cancer. 2019 Aug;5(8):457-459. doi: 10.1016/j.trecan.2019.06.001. Epub 2019 Jun 27.

PMID:
31421901
5.

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.

Lignitto L, LeBoeuf SE, Homer H, Jiang S, Askenazi M, Karakousi TR, Pass HI, Bhutkar AJ, Tsirigos A, Ueberheide B, Sayin VI, Papagiannakopoulos T, Pagano M.

Cell. 2019 Jul 11;178(2):316-329.e18. doi: 10.1016/j.cell.2019.06.003. Epub 2019 Jun 27.

PMID:
31257023
6.

TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.

McLoughlin MR, Orlicky DJ, Prigge JR, Krishna P, Talago EA, Cavigli IR, Eriksson S, Miller CG, Kundert JA, Sayin VI, Sabol RA, Heinemann J, Brandenberger LO, Iverson SV, Bothner B, Papagiannakopoulos T, Shearn CT, Arnér ESJ, Schmidt EE.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11408-11417. doi: 10.1073/pnas.1903244116. Epub 2019 May 16.

7.

Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer.

Hamza B, Ng SR, Prakadan SM, Delgado FF, Chin CR, King EM, Yang LF, Davidson SM, DeGouveia KL, Cermak N, Navia AW, Winter PS, Drake RS, Tammela T, Li CM, Papagiannakopoulos T, Gupta AJ, Shaw Bagnall J, Knudsen SM, Vander Heiden MG, Wasserman SC, Jacks T, Shalek AK, Manalis SR.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2232-2236. doi: 10.1073/pnas.1814102116. Epub 2019 Jan 23.

8.

Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours.

Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K.

Nat Cell Biol. 2018 Oct;20(10):1228. doi: 10.1038/s41556-018-0184-2.

PMID:
30089842
9.

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma.

Snuderl M, Kannan K, Pfaff E, Wang S, Stafford JM, Serrano J, Heguy A, Ray K, Faustin A, Aminova O, Dolgalev I, Stapleton SL, Zagzag D, Chiriboga L, Gardner SL, Wisoff JH, Golfinos JG, Capper D, Hovestadt V, Rosenblum MK, Placantonakis DG, LeBoeuf SE, Papagiannakopoulos TY, Chavez L, Ahsan S, Eberhart CG, Pfister SM, Jones DTW, Karajannis MA.

Nat Commun. 2018 Jul 20;9(1):2868. doi: 10.1038/s41467-018-05029-3.

10.

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours.

Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K.

Nat Cell Biol. 2018 Jul;20(7):775-781. doi: 10.1038/s41556-018-0118-z. Epub 2018 Jun 25. Erratum in: Nat Cell Biol. 2018 Oct;20(10):1228.

11.

Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice.

Petersen DR, Saba LM, Sayin VI, Papagiannakopoulos T, Schmidt EE, Merrill GF, Orlicky DJ, Shearn CT.

PLoS One. 2018 May 25;13(5):e0198139. doi: 10.1371/journal.pone.0198139. eCollection 2018.

12.

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.

Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R.

Mol Cell. 2018 Feb 15;69(4):610-621.e5. doi: 10.1016/j.molcel.2018.01.024.

13.

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis.

Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R.

Nature. 2017 Nov 30;551(7682):639-643. doi: 10.1038/nature24637. Epub 2017 Nov 22.

14.

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.

Romero R, Sayin VI, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T, Papagiannakopoulos T.

Nat Med. 2017 Nov;23(11):1362-1368. doi: 10.1038/nm.4407. Epub 2017 Oct 2.

15.

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.

Sayin VI, LeBoeuf SE, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T.

Elife. 2017 Oct 2;6. pii: e28083. doi: 10.7554/eLife.28083.

16.

Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events.

Ashouri A, Sayin VI, Van den Eynden J, Singh SX, Papagiannakopoulos T, Larsson E.

Nat Commun. 2016 Oct 25;7:13197. doi: 10.1038/ncomms13197.

17.

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.

Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG.

Science. 2016 Sep 9;353(6304):1161-5. doi: 10.1126/science.aaf5171.

18.

Circadian Rhythm Disruption Promotes Lung Tumorigenesis.

Papagiannakopoulos T, Bauer MR, Davidson SM, Heimann M, Subbaraj L, Bhutkar A, Bartlebaugh J, Vander Heiden MG, Jacks T.

Cell Metab. 2016 Aug 9;24(2):324-31. doi: 10.1016/j.cmet.2016.07.001. Epub 2016 Jul 28.

19.

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis.

Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, Baldi P, Jacks T, Sassone-Corsi P.

Cell. 2016 May 5;165(4):896-909. doi: 10.1016/j.cell.2016.04.039.

20.

Application of CRISPR-mediated genome engineering in cancer research.

Sayin VI, Papagiannakopoulos T.

Cancer Lett. 2017 Feb 28;387:10-17. doi: 10.1016/j.canlet.2016.03.029. Epub 2016 Mar 18. Review.

PMID:
27000990
21.

A Modular Assembly Platform for Rapid Generation of DNA Constructs.

Akama-Garren EH, Joshi NS, Tammela T, Chang GP, Wagner BL, Lee DY, Rideout WM 3rd, Papagiannakopoulos T, Xue W, Jacks T.

Sci Rep. 2016 Feb 18;6:16836. doi: 10.1038/srep16836.

22.

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.

Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander Heiden MG.

Cell Metab. 2016 Mar 8;23(3):517-28. doi: 10.1016/j.cmet.2016.01.007. Epub 2016 Feb 4.

23.

Rapid modelling of cooperating genetic events in cancer through somatic genome editing.

Sánchez-Rivera FJ, Papagiannakopoulos T, Romero R, Tammela T, Bauer MR, Bhutkar A, Joshi NS, Subbaraj L, Bronson RT, Xue W, Jacks T.

Nature. 2014 Dec 18;516(7531):428-31. doi: 10.1038/nature13906. Epub 2014 Oct 22.

24.

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.

Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T, Yang A, Dayton TL, Ogino S, Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J, Sesso HD, Gaziano JM, Cochrane BB, Liu S, Wactawski-Wende J, Manson JE, Pollak MN, Kimmelman AC, Souza A, Pierce K, Wang TJ, Gerszten RE, Fuchs CS, Vander Heiden MG, Wolpin BM.

Nat Med. 2014 Oct;20(10):1193-1198. doi: 10.1038/nm.3686. Epub 2014 Sep 28.

25.

CRISPR-mediated direct mutation of cancer genes in the mouse liver.

Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T.

Nature. 2014 Oct 16;514(7522):380-4. doi: 10.1038/nature13589. Epub 2014 Aug 6.

26.

Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing.

McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, Stewart C, Carter SL, Cibulskis K, Bhutkar A, McKenna A, Dooley A, Vernon A, Sougnez C, Malstrom S, Heimann M, Park J, Chen F, Farago AF, Dayton T, Shefler E, Gabriel S, Getz G, Jacks T.

Cell. 2014 Mar 13;156(6):1298-1311. doi: 10.1016/j.cell.2014.02.031.

27.

Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases.

Papagiannakopoulos T, Friedmann-Morvinski D, Neveu P, Dugas JC, Gill RM, Huillard E, Liu C, Zong H, Rowitch DH, Barres BA, Verma IM, Kosik KS.

Oncogene. 2012 Apr 12;31(15):1884-95. doi: 10.1038/onc.2011.380. Epub 2011 Aug 29.

28.

MicroRNA-124: micromanager of neurogenesis.

Papagiannakopoulos T, Kosik KS.

Cell Stem Cell. 2009 May 8;4(5):375-6. doi: 10.1016/j.stem.2009.04.007.

29.

MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.

Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS.

Cell. 2009 May 15;137(4):647-58. doi: 10.1016/j.cell.2009.02.038. Epub 2009 Apr 30.

30.

The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.

Carrettiero DC, Hernandez I, Neveu P, Papagiannakopoulos T, Kosik KS.

J Neurosci. 2009 Feb 18;29(7):2151-61. doi: 10.1523/JNEUROSCI.4660-08.2009.

31.

MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.

Papagiannakopoulos T, Shapiro A, Kosik KS.

Cancer Res. 2008 Oct 1;68(19):8164-72. doi: 10.1158/0008-5472.CAN-08-1305.

32.

MicroRNAs: regulators of oncogenesis and stemness.

Papagiannakopoulos T, Kosik KS.

BMC Med. 2008 Jun 24;6:15. doi: 10.1186/1741-7015-6-15. Review.

33.

Functional analysis of matrix metalloproteinases and tissue inhibitors of metalloproteinases differentially expressed by variants of human HT-1080 fibrosarcoma exhibiting high and low levels of intravasation and metastasis.

Partridge JJ, Madsen MA, Ardi VC, Papagiannakopoulos T, Kupriyanova TA, Quigley JP, Deryugina EI.

J Biol Chem. 2007 Dec 7;282(49):35964-77. Epub 2007 Sep 25.

34.

Detection of a microRNA signal in an in vivo expression set of mRNAs.

Liu T, Papagiannakopoulos T, Puskar K, Qi S, Santiago F, Clay W, Lao K, Lee Y, Nelson SF, Kornblum HI, Doyle F, Petzold L, Shraiman B, Kosik KS.

PLoS One. 2007 Aug 29;2(8):e804.

35.

Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination.

Deryugina EI, Zijlstra A, Partridge JJ, Kupriyanova TA, Madsen MA, Papagiannakopoulos T, Quigley JP.

Cancer Res. 2005 Dec 1;65(23):10959-69.

Supplemental Content

Loading ...
Support Center