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Aged dominant negative p38α MAPK mice are resistant to age-dependent decline in adult-neurogenesis and context discrimination fear conditioning.

Cortez I, Bulavin DV, Wu P, McGrath EL, Cunningham KA, Wakamiya M, Papaconstantinou J, Dineley KT.

Behav Brain Res. 2017 Mar 30;322(Pt B):212-222. doi: 10.1016/j.bbr.2016.10.023. Epub 2016 Oct 17.


p38 Mitogen activated protein kinase (MAPK): a new therapeutic target for reducing the risk of adverse pregnancy outcomes.

Menon R, Papaconstantinou J.

Expert Opin Ther Targets. 2016 Dec;20(12):1397-1412. Epub 2016 Aug 4. Review.


8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging.

German P, Saenz D, Szaniszlo P, Aguilera-Aguirre L, Pan L, Hegde ML, Bacsi A, Hajas G, Radak Z, Ba X, Mitra S, Papaconstantinou J, Boldogh I.

Mech Ageing Dev. 2017 Jan;161(Pt A):51-65. doi: 10.1016/j.mad.2016.06.009. Epub 2016 Jun 21.


Amnion-Epithelial-Cell-Derived Exosomes Demonstrate Physiologic State of Cell under Oxidative Stress.

Sheller S, Papaconstantinou J, Urrabaz-Garza R, Richardson L, Saade G, Salomon C, Menon R.

PLoS One. 2016 Jun 22;11(6):e0157614. doi: 10.1371/journal.pone.0157614. eCollection 2016.


IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevity.

Papaconstantinou J, Hsieh CC.

Oncotarget. 2015 Nov 3;6(34):35315-23. doi: 10.18632/oncotarget.6112.


Mitochondrial-generated ROS down regulates insulin signaling via activation of the p38MAPK stress response pathway.

Al-Lahham R, Deford JH, Papaconstantinou J.

Mol Cell Endocrinol. 2016 Jan 5;419:1-11. doi: 10.1016/j.mce.2015.09.013. Epub 2015 Oct 8.


Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways.

Brobey RK, German D, Sonsalla PK, Gurnani P, Pastor J, Hsieh CC, Papaconstantinou J, Foster PP, Kuro-o M, Rosenblatt KP.

PLoS One. 2015 Oct 9;10(10):e0139914. doi: 10.1371/journal.pone.0139914. eCollection 2015.


Attenuation of p38α MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells.

Papaconstantinou J, Wang CZ, Zhang M, Yang S, Deford J, Bulavin DV, Ansari NH.

Aging (Albany NY). 2015 Sep;7(9):718-33.


Topically applied metal chelator reduces thermal injury progression in a rat model of brass comb burn.

Wang CZ, Ayadi AE, Goswamy J, Finnerty CC, Mifflin R, Sousse L, Enkhbaatar P, Papaconstantinou J, Herndon DN, Ansari NH.

Burns. 2015 Dec;41(8):1775-1787. doi: 10.1016/j.burns.2015.08.012. Epub 2015 Sep 29.


HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes.

Bredeson S, Papaconstantinou J, Deford JH, Kechichian T, Syed TA, Saade GR, Menon R.

PLoS One. 2014 Dec 3;9(12):e113799. doi: 10.1371/journal.pone.0113799. eCollection 2014.


Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro.

Menon R, Boldogh I, Hawkins HK, Woodson M, Polettini J, Syed TA, Fortunato SJ, Saade GR, Papaconstantinou J, Taylor RN.

Am J Pathol. 2014 Jun;184(6):1740-51. doi: 10.1016/j.ajpath.2014.02.011. Epub 2014 May 12.


Senescence of primary amniotic cells via oxidative DNA damage.

Menon R, Boldogh I, Urrabaz-Garza R, Polettini J, Syed TA, Saade GR, Papaconstantinou J, Taylor RN.

PLoS One. 2013 Dec 27;8(12):e83416. doi: 10.1371/journal.pone.0083416. eCollection 2013.


Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging.

Lee JS, Ward WO, Ren H, Vallanat B, Darlington GJ, Han ES, Laguna JC, DeFord JH, Papaconstantinou J, Selman C, Corton JC.

Mech Ageing Dev. 2012 Jul;133(7):467-78. doi: 10.1016/j.mad.2012.05.006. Epub 2012 Jun 13.


Ishemia-reperfusion enhances GAPDH nitration in aging skeletal muscle.

Bailey CE, Hammers DW, Deford JH, Dimayuga VL, Amaning JK, Farrar R, Papaconstantinou J.

Aging (Albany NY). 2011 Oct;3(10):1003-17.


Mitochondrial electron transport chain functions in long-lived Ames dwarf mice.

Choksi KB, Nuss JE, DeFord JH, Papaconstantinou J.

Aging (Albany NY). 2011 Aug;3(8):754-67.


Intestinal mitochondrial apoptotic signaling is activated during oxidative stress.

Baregamian N, Song J, Papaconstantinou J, Hawkins HK, Evers BM, Chung DH.

Pediatr Surg Int. 2011 Aug;27(8):871-7. doi: 10.1007/s00383-011-2880-x. Epub 2011 Mar 13.


Activation of senescence and aging characteristics by mitochondrially generated ROS: how are they linked?

Papaconstantinou J, Hsieh CC.

Cell Cycle. 2010 Oct 1;9(19):3831-3. Epub 2010 Oct 11. No abstract available.


The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging.

Hsieh CC, Kuro-o M, Rosenblatt KP, Brobey R, Papaconstantinou J.

Aging (Albany NY). 2010 Sep;2(9):597-611.


alpha1-Acid glycoprotein production in rat dorsal air pouch in response to inflammatory stimuli, dexamethasone and honey bee venom.

Vasileiadou K, Pantazidis G, Papadopoulou K, Ligoudistianou C, Kourelis A, Petrakis S, Masmanidou E, Testa T, Kourounakis AP, Hadjipetrou L, Papaconstantinou J, Yiangou M.

Exp Mol Pathol. 2010 Aug;89(1):63-71. doi: 10.1016/j.yexmp.2010.03.008. Epub 2010 Apr 2.


Oxidative modification and aggregation of creatine kinase from aged mouse skeletal muscle.

Nuss JE, Amaning JK, Bailey CE, DeFord JH, Dimayuga VL, Rabek JP, Papaconstantinou J.

Aging (Albany NY). 2009 May 22;1(6):557-72.


Immunostimulatory activity of potential probiotic yeast strains in the dorsal air pouch system and the gut mucosa.

Kourelis A, Kotzamanidis C, Litopoulou-Tzanetaki E, Papaconstantinou J, Tzanetakis N, Yiangou M.

J Appl Microbiol. 2010 Jul;109(1):260-71. doi: 10.1111/j.1365-2672.2009.04651.x. Epub 2009 Dec 15.


A proteomics analysis of the effects of chronic hemiparetic stroke on troponin T expression in human vastus lateralis.

Rabek JP, Hafer-Macko CE, Amaning JK, Deford JH, Dimayuga VL, Madsen MA, Macko RF, Papaconstantinou J.

J Gerontol A Biol Sci Med Sci. 2009 Aug;64(8):839-49. doi: 10.1093/gerona/glp064. Epub 2009 May 15.


Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination.

Papaconstantinou J.

Mol Cell Endocrinol. 2009 Feb 5;299(1):89-100. doi: 10.1016/j.mce.2008.11.025. Epub 2008 Dec 3. Review.


High-throughput liquid-liquid fractionation of multiple protein post-translational modifications.

Deford JH, Nuss JE, Amaning J, English RD, Tjernlund D, Papaconstantinou J.

J Proteome Res. 2009 Feb;8(2):907-16. doi: 10.1021/pr800519g.


Doppler-guided haemorrhoidal artery ligation, rectoanal repair, sutured haemorrhoidopexy and minimal mucocutaneous excision for grades III-IV haemorrhoids: a multicenter prospective study of safety and efficacy.

Theodoropoulos GE, Sevrisarianos N, Papaconstantinou J, Panoussopoulos SG, Dardamanis D, Stamopoulos P, Bramis K, Spiliotis J, Datsis A, Leandros E.

Colorectal Dis. 2010 Feb;12(2):125-34. doi: 10.1111/j.1463-1318.2008.01739.x. Epub 2009 Nov 14.


Implications of tyrosine phosphoproteomics in cervical carcinogenesis.

Robinson-Bennett BL, Deford J, Diaz-Arrastia C, Levine L, Wang HQ, Hannigan EV, Papaconstantinou J.

J Carcinog. 2008 Jul 17;7:2. doi: 10.1186/1477-3163-7-2.


Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes.

Choksi KB, Nuss JE, Deford JH, Papaconstantinou J.

Free Radic Biol Med. 2008 Sep 15;45(6):826-38. doi: 10.1016/j.freeradbiomed.2008.06.006. Epub 2008 Jun 12.


Age-related alterations in oxidatively damaged proteins of mouse heart mitochondrial electron transport chain complexes.

Choksi KB, Papaconstantinou J.

Free Radic Biol Med. 2008 May 15;44(10):1795-805. doi: 10.1016/j.freeradbiomed.2008.01.032. Epub 2008 Feb 13.


Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers.

Nuss JE, Choksi KB, DeFord JH, Papaconstantinou J.

Biochem Biophys Res Commun. 2008 Jan 11;365(2):355-61. Epub 2007 Nov 9.


Lower levels of F2-isoprostanes in serum and livers of long-lived Ames dwarf mice.

Choksi KB, Roberts LJ 2nd, DeFord JH, Rabek JP, Papaconstantinou J.

Biochem Biophys Res Commun. 2007 Dec 28;364(4):761-4. Epub 2007 Oct 25.


Age-related increases in oxidatively damaged proteins of mouse kidney mitochondrial electron transport chain complexes.

Choksi KB, Nuss JE, Boylston WH, Rabek JP, Papaconstantinou J.

Free Radic Biol Med. 2007 Nov 15;43(10):1423-38. Epub 2007 Aug 15.


Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells.

Bacsi A, Woodberry M, Widger W, Papaconstantinou J, Mitra S, Peterson JW, Boldogh I.

Mitochondrion. 2006 Oct;6(5):235-44. Epub 2006 Aug 3.


Identification of longevity-associated genes in long-lived Snell and Ames dwarf mice.

Boylston WH, DeFord JH, Papaconstantinou J.

Age (Dordr). 2006 Jun;28(2):125-44. doi: 10.1007/s11357-006-9008-6. Epub 2006 Jun 3.


Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice.

Papaconstantinou J, Deford JH, Gerstner A, Hsieh CC, Boylston WH, Guigneaux MM, Flurkey K, Harrison DE.

Mech Ageing Dev. 2005 Jun-Jul;126(6-7):692-704.


Effects of endotoxin on serum chemokines in man.

Schinkel S, Schinkel C, Pollard V, Garofallo R, Heberle H, Reisner P, Papaconstantinou J, Herndon DN.

Eur J Med Res. 2005 Feb 28;10(2):76-80.


Akt/PKB and p38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers.

Hsieh CC, Papaconstantinou J.

Mech Ageing Dev. 2004 Oct-Nov;125(10-11):785-98.


L.S. stone: lens regeneration--contributions to the establishment of an in vivo model of transdifferentiation.

Papaconstantinou J.

J Exp Zool A Comp Exp Biol. 2004 Oct 1;301(10):787-92. No abstract available.


Altered cholesterologenic and lipogenic transcriptional profile in livers of aging Snell dwarf (Pit1dw/dwJ) mice.

Boylston WH, Gerstner A, DeFord JH, Madsen M, Flurkey K, Harrison DE, Papaconstantinou J.

Aging Cell. 2004 Oct;3(5):283-96.


Impaired mitochondrial respiratory chain and bioenergetics during chagasic cardiomyopathy development.

Vyatkina G, Bhatia V, Gerstner A, Papaconstantinou J, Garg N.

Biochim Biophys Acta. 2004 Jun 28;1689(2):162-73.


Altered oxidative stress response of the long-lived Snell dwarf mouse.

Madsen MA, Hsieh CC, Boylston WH, Flurkey K, Harrison D, Papaconstantinou J.

Biochem Biophys Res Commun. 2004 Jun 11;318(4):998-1005.


Gene expression analysis in mitochondria from chagasic mice: alterations in specific metabolic pathways.

Garg N, Gerstner A, Bhatia V, DeFord J, Papaconstantinou J.

Biochem J. 2004 Aug 1;381(Pt 3):743-52. Erratum in: Biochem J. 2004 Nov 1;383(Pt. 3):599.


Oxidatively damaged proteins of heart mitochondrial electron transport complexes.

Choksi KB, Boylston WH, Rabek JP, Widger WR, Papaconstantinou J.

Biochim Biophys Acta. 2004 Mar 2;1688(2):95-101.


Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases.

Szczesny B, Hazra TK, Papaconstantinou J, Mitra S, Boldogh I.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10670-5. Epub 2003 Sep 5.


Comparison of two PCR-based methods and automated DNA sequencing for prop-1 genotyping in Ames dwarf mice.

Gerstner A, DeFord JH, Papaconstantinou J.

Mutat Res. 2003 Jul 25;528(1-2):37-44.


Study of "de novo" malignancies among greek renal transplant recipients.

Zavos G, Bokos J, Papaconstantinou J, Boletis J, Gazouli M, Pappas P, Kostakis A.

Transplant Proc. 2003 Jun;35(4):1399-403.


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