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Items: 1 to 50 of 190

1.

Cell death induced autophagy contributes to terminal differentiation of skin and skin appendages.

Koenig U, Robenek H, Barresi C, Brandstetter M, Resch GP, Gröger M, Pap T, Hartmann C.

Autophagy. 2019 Aug 4:1-14. doi: 10.1080/15548627.2019.1646552. [Epub ahead of print]

PMID:
31379249
2.

IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes : JAKinibs suppress the interferon response in RA-FLSs.

Bonelli M, Dalwigk K, Platzer A, Olmos Calvo I, Hayer S, Niederreiter B, Holinka J, Sevelda F, Pap T, Steiner G, Superti-Furga G, Smolen JS, Kiener HP, Karonitsch T.

Exp Mol Med. 2019 Jul 8;51(7):75. doi: 10.1038/s12276-019-0267-6.

PMID:
31285419
3.

The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts.

Diller M, Frommer K, Dankbar B, Tarner I, Hülser ML, Tsiklauri L, Hasseli R, Sauerbier M, Pap T, Rehart S, Müller-Ladner U, Neumann E.

Arthritis Res Ther. 2019 Jun 10;21(1):144. doi: 10.1186/s13075-019-1926-7.

4.

FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synoviocytes.

Brandstetter B, Dalwigk K, Platzer A, Niederreiter B, Kartnig F, Fischer A, Vladimer GI, Byrne RA, Sevelda F, Holinka J, Pap T, Steiner G, Superti-Furga G, Smolen JS, Kiener HP, Karonitsch T.

Lab Invest. 2019 May;99(5):648-658. doi: 10.1038/s41374-018-0184-7. Epub 2019 Jan 24.

PMID:
30679758
5.

Notch Signaling Activity Determines Uptake and Biological Effect of Imatinib in Systemic Sclerosis Dermal Fibroblasts.

Harrach S, Barz V, Pap T, Pavenstädt H, Schlatter E, Edemir B, Distler J, Ciarimboli G, Bertrand J.

J Invest Dermatol. 2019 Feb;139(2):439-447. doi: 10.1016/j.jid.2018.08.021. Epub 2018 Sep 28.

PMID:
30273596
6.

Syndecan-4 Modulates Epithelial Gut Barrier Function and Epithelial Regeneration in Experimental Colitis.

Fröhling M, Tepasse P, Intemann J, Sambale M, Sherwood J, Paruzel P, Tiemeyer NM, Nowacki TM, Brückner M, Mennigen R, Lügering A, Echtermeyer F, Pap T, Stratis A, Bettenworth D.

Inflamm Bowel Dis. 2018 Nov 29;24(12):2579-2589. doi: 10.1093/ibd/izy248.

PMID:
30053064
7.

Apolipoprotein B binds to enolase-1 and aggravates inflammation in rheumatoid arthritis.

Lee JY, Kang MJ, Choi JY, Park JS, Park JK, Lee EY, Lee EB, Pap T, Yi EC, Song YW.

Ann Rheum Dis. 2018 Oct;77(10):1480-1489. doi: 10.1136/annrheumdis-2018-213444. Epub 2018 Jul 11.

PMID:
29997113
8.

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation.

Karonitsch T, Kandasamy RK, Kartnig F, Herdy B, Dalwigk K, Niederreiter B, Holinka J, Sevelda F, Windhager R, Bilban M, Weichhart T, Säemann M, Pap T, Steiner G, Smolen JS, Kiener HP, Superti-Furga G.

Cell Rep. 2018 May 15;23(7):2157-2167. doi: 10.1016/j.celrep.2018.04.044.

9.

[Mutual influence of immune system and bones].

Kamradt T, Amling M, Dankbar B, Dudeck A, Gunzer M, Ignatius A, Krönke G, Kubatzky K, Pap T, Prinz I, Schett G, Schinke T, Tuckermann J, Waisman A.

Z Rheumatol. 2018 May;77(Suppl 1):8-11. doi: 10.1007/s00393-018-0454-1. Review. German. No abstract available.

PMID:
29675686
10.

Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation.

Vogl T, Stratis A, Wixler V, Völler T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Fröhling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schäfers M, Ludwig S, Stoll M, Leanderson T, Schultze JL, König S, Pap T, Roth J.

J Clin Invest. 2018 May 1;128(5):1852-1866. doi: 10.1172/JCI89867. Epub 2018 Apr 3.

11.

Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage.

Held A, Glas A, Dietrich L, Bollmann M, Brandstädter K, Grossmann TN, Lohmann CH, Pap T, Bertrand J.

Osteoarthritis Cartilage. 2018 Jun;26(6):818-823. doi: 10.1016/j.joca.2018.02.908. Epub 2018 Mar 17.

12.

Targeted inhibition of Janus kinases abates interfon gamma-induced invasive behaviour of fibroblast-like synoviocytes.

Karonitsch T, Beckmann D, Dalwigk K, Niederreiter B, Studenic P, Byrne RA, Holinka J, Sevelda F, Korb-Pap A, Steiner G, Smolen JS, Pap T, Kiener HP.

Rheumatology (Oxford). 2018 Mar 1;57(3):572-577. doi: 10.1093/rheumatology/kex426.

PMID:
29228301
13.

Dose-dependent effect of parathyroid hormone on fracture healing and bone formation in mice.

Milstrey A, Wieskoetter B, Hinze D, Grueneweller N, Stange R, Pap T, Raschke M, Garcia P.

J Surg Res. 2017 Dec;220:327-335. doi: 10.1016/j.jss.2017.07.019. Epub 2017 Aug 18.

PMID:
29180199
14.

[Psoriasis vs. psoriatic arthritis : Similarities and differences in the pathophysiology].

Pap T, Sunderkötter C.

Z Rheumatol. 2017 Aug;76(6):477-483. doi: 10.1007/s00393-017-0342-0. German.

PMID:
28664285
15.

Importance of the novel organic cation transporter 1 for tyrosine kinase inhibition by saracatinib in rheumatoid arthritis synovial fibroblasts.

Harrach S, Edemir B, Schmidt-Lauber C, Pap T, Bertrand J, Ciarimboli G.

Sci Rep. 2017 Apr 28;7(1):1258. doi: 10.1038/s41598-017-01438-4.

16.

The role of stromal cells in inflammatory bone loss.

Wehmeyer C, Pap T, Buckley CD, Naylor AJ.

Clin Exp Immunol. 2017 Jul;189(1):1-11. doi: 10.1111/cei.12979. Epub 2017 May 18. Review.

17.

Structural cartilage damage attracts circulating rheumatoid arthritis synovial fibroblasts into affected joints.

Hillen J, Geyer C, Heitzmann M, Beckmann D, Krause A, Winkler I, Pavenstädt H, Bremer C, Pap T, Korb-Pap A.

Arthritis Res Ther. 2017 Feb 28;19(1):40. doi: 10.1186/s13075-017-1245-9.

18.

Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis.

Sanchez C, Bay-Jensen AC, Pap T, Dvir-Ginzberg M, Quasnichka H, Barrett-Jolley R, Mobasheri A, Henrotin Y.

Osteoarthritis Cartilage. 2017 Aug;25(8):1199-1209. doi: 10.1016/j.joca.2017.02.797. Epub 2017 Feb 20. Review.

19.

Smad-dependent mechanisms of inflammatory bone destruction.

Fennen M, Pap T, Dankbar B.

Arthritis Res Ther. 2016 Dec 1;18(1):279. Review.

20.

Stable activation of fibroblasts in rheumatic arthritis-causes and consequences.

Korb-Pap A, Bertrand J, Sherwood J, Pap T.

Rheumatology (Oxford). 2016 Dec;55(suppl 2):ii64-ii67. Review.

PMID:
27856663
21.

MATE1 regulates cellular uptake and sensitivity to imatinib in CML patients.

Harrach S, Schmidt-Lauber C, Pap T, Pavenstädt H, Schlatter E, Schmidt E, Berdel WE, Schulze U, Edemir B, Jeromin S, Haferlach T, Ciarimboli G, Bertrand J.

Blood Cancer J. 2016 Sep 16;6:e470. doi: 10.1038/bcj.2016.79.

22.

[Fibroblastic modulators of bone destruction].

Dankbar B, Pap T.

Z Rheumatol. 2016 Aug;75(6):534-6. doi: 10.1007/s00393-016-0160-9. Review. German. No abstract available.

PMID:
27418056
23.

Articular cartilage calcification of the hip and knee is highly prevalent, independent of age but associated with histological osteoarthritis: evidence for a systemic disorder.

Hawellek T, Hubert J, Hischke S, Krause M, Bertrand J, Pap T, Püschel K, Rüther W, Niemeier A.

Osteoarthritis Cartilage. 2016 Dec;24(12):2092-2099. doi: 10.1016/j.joca.2016.06.020. Epub 2016 Jul 5.

24.

Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin.

Gronau T, Krüger K, Prein C, Aszodi A, Gronau I, Iozzo RV, Mooren FC, Clausen-Schaumann H, Bertrand J, Pap T, Bruckner P, Dreier R.

Ann Rheum Dis. 2017 Feb;76(2):442-449. doi: 10.1136/annrheumdis-2016-209319. Epub 2016 Jul 4.

PMID:
27377816
25.

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Göbel K, Pankratz S, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG.

Nat Commun. 2016 May 18;7:11626. doi: 10.1038/ncomms11626.

26.

Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction.

Wehmeyer C, Frank S, Beckmann D, Böttcher M, Cromme C, König U, Fennen M, Held A, Paruzel P, Hartmann C, Stratis A, Korb-Pap A, Kamradt T, Kramer I, van den Berg W, Kneissel M, Pap T, Dankbar B.

Sci Transl Med. 2016 Mar 16;8(330):330ra35. doi: 10.1126/scitranslmed.aac4351. Epub 2016 Mar 16.

PMID:
27089204
27.

Articular cartilage calcification of the humeral head is highly prevalent and associated with osteoarthritis in the general population.

Hawellek T, Hubert J, Hischke S, Vettorazzi E, Wegscheider K, Bertrand J, Pap T, Krause M, Püschel K, Rüther W, Niemeier A.

J Orthop Res. 2016 Nov;34(11):1984-1990. doi: 10.1002/jor.23227. Epub 2016 Apr 6.

28.

OCT angiography in the mouse: A novel evaluation method for vascular pathologies of the mouse retina.

Alnawaiseh M, Rosentreter A, Hillmann A, Alex AF, Niekämper D, Heiduschka P, Pap T, Eter N.

Exp Eye Res. 2016 Apr;145:417-423. doi: 10.1016/j.exer.2016.02.012. Epub 2016 Mar 2.

PMID:
26946073
29.

Osteoarthrose--nur symptomatische oder auch kausale Therapie?

Pap T.

Drug Res (Stuttg). 2015 Nov;65 Suppl 1:S11-2. doi: 10.1055/s-0035-1558062. Epub 2015 Nov 4. German. No abstract available.

30.

[OVERLOAD of joints and its role in osteoarthritis. Towards understanding and preventing progression of primary osteoarthritis].

Willie BM, Pap T, Perka C, Schmidt CO, Eckstein F, Arampatzis A, Hege HC, Madry H, Vortkamp A, Duda GN.

Z Rheumatol. 2015 Sep;74(7):618-21. doi: 10.1007/s00393-015-1649-3. German. No abstract available.

PMID:
26334971
31.

Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice.

Dankbar B, Fennen M, Brunert D, Hayer S, Frank S, Wehmeyer C, Beckmann D, Paruzel P, Bertrand J, Redlich K, Koers-Wunrau C, Stratis A, Korb-Pap A, Pap T.

Nat Med. 2015 Sep;21(9):1085-90. doi: 10.1038/nm.3917. Epub 2015 Aug 3.

PMID:
26236992
32.

OVERLOAD of joints and its role in osteoarthritis : Towards understanding and preventing progression of primary osteoarthritis. English version.

Willie BM, Pap T, Perka C, Schmidt CO, Eckstein F, Arampatzis A, Hege HC, Madry H, Vortkamp A, Duda GN.

Z Rheumatol. 2017 Mar;76(Suppl 1):1-4. doi: 10.1007/s00393-014-1561-2. No abstract available.

PMID:
26224533
33.

Cartilage damage in osteoarthritis and rheumatoid arthritis--two unequal siblings.

Pap T, Korb-Pap A.

Nat Rev Rheumatol. 2015 Oct;11(10):606-15. doi: 10.1038/nrrheum.2015.95. Epub 2015 Jul 21. Review.

PMID:
26195338
34.

Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation.

Polte T, Petzold S, Bertrand J, Schütze N, Hinz D, Simon JC, Lehmann I, Echtermeyer F, Pap T, Averbeck M.

Nat Commun. 2015 Jul 13;6:7554. doi: 10.1038/ncomms8554.

PMID:
26165408
35.

ER Stress During the Pubertal Growth Spurt Results in Impaired Long-Bone Growth in Chondrocyte-Specific ERp57 Knockout Mice.

Linz A, Knieper Y, Gronau T, Hansen U, Aszodi A, Garbi N, Hämmerling GJ, Pap T, Bruckner P, Dreier R.

J Bone Miner Res. 2015 Aug;30(8):1481-93. doi: 10.1002/jbmr.2484. Epub 2015 Jun 16.

36.

[Fibroblasts as pathogenic cells in rheumatic inflammation].

Schönfeld C, Pap T, Neumann E, Müller-Ladner U.

Z Rheumatol. 2015 Feb;74(1):33-8. doi: 10.1007/s00393-014-1439-3. Review. German.

PMID:
25676126
37.

Deficiency of fibroblast activation protein alpha ameliorates cartilage destruction in inflammatory destructive arthritis.

Wäldele S, Koers-Wunrau C, Beckmann D, Korb-Pap A, Wehmeyer C, Pap T, Dankbar B.

Arthritis Res Ther. 2015 Jan 20;17:12. doi: 10.1186/s13075-015-0524-6.

38.

Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib.

Hochberg MC, Martel-Pelletier J, Monfort J, Möller I, Castillo JR, Arden N, Berenbaum F, Blanco FJ, Conaghan PG, Doménech G, Henrotin Y, Pap T, Richette P, Sawitzke A, du Souich P, Pelletier JP; MOVES Investigation Group.

Ann Rheum Dis. 2016 Jan;75(1):37-44. doi: 10.1136/annrheumdis-2014-206792. Epub 2015 Jan 14.

39.

Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2.

Höfling S, Scharnert J, Cromme C, Bertrand J, Pap T, Schmidt MA, Rüter C.

Virulence. 2014;5(7):761-71. doi: 10.4161/viru.29062.

40.

A homeostatic function of CXCR2 signalling in articular cartilage.

Sherwood J, Bertrand J, Nalesso G, Poulet B, Pitsillides A, Brandolini L, Karystinou A, De Bari C, Luyten FP, Pitzalis C, Pap T, Dell'Accio F.

Ann Rheum Dis. 2015 Dec;74(12):2207-15. doi: 10.1136/annrheumdis-2014-205546. Epub 2014 Aug 18.

41.

FHL2 regulates the resolution of tissue damage in chronic inflammatory arthritis.

Wixler V, Cromme C, Retser E, Meyer LH, Smyth N, Mühlenberg K, Korb-Pap A, Koers-Wunrau C, Sotsios Y, Bassel-Duby R, Baeten D, Tak PP, Niederreiter B, Redlich K, Bertrand J, Skryabin BV, Ludwig S, Pap T.

Ann Rheum Dis. 2015 Dec;74(12):2216-23. doi: 10.1136/annrheumdis-2013-205061. Epub 2014 Aug 14.

PMID:
25125695
42.

Influence of antiTNF-alpha antibody treatment on fracture healing under chronic inflammation.

Timmen M, Hidding H, Wieskötter B, Baum W, Pap T, Raschke MJ, Schett G, Zwerina J, Stange R.

BMC Musculoskelet Disord. 2014 May 29;15:184. doi: 10.1186/1471-2474-15-184.

43.

Cell surface-bound TIMP3 induces apoptosis in mesenchymal Cal78 cells through ligand-independent activation of death receptor signaling and blockade of survival pathways.

Koers-Wunrau C, Wehmeyer C, Hillmann A, Pap T, Dankbar B.

PLoS One. 2013 Jul 24;8(7):e70709. doi: 10.1371/journal.pone.0070709. Print 2013.

44.

Doxycycline-induced expression of transgenic human tumor necrosis factor α in adult mice results in psoriasis-like arthritis.

Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent PL, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V.

Arthritis Rheum. 2013 Sep;65(9):2290-300. doi: 10.1002/art.38026.

45.

Age-related bone deterioration is diminished by disrupted collagen sensing in integrin α2β1 deficient mice.

Stange R, Kronenberg D, Timmen M, Everding J, Hidding H, Eckes B, Hansen U, Holtkamp M, Karst U, Pap T, Raschke MJ.

Bone. 2013 Sep;56(1):48-54. doi: 10.1016/j.bone.2013.05.003. Epub 2013 May 13.

PMID:
23680479
46.

TRPC6 regulates CXCR2-mediated chemotaxis of murine neutrophils.

Lindemann O, Umlauf D, Frank S, Schimmelpfennig S, Bertrand J, Pap T, Hanley PJ, Fabian A, Dietrich A, Schwab A.

J Immunol. 2013 Jun 1;190(11):5496-505. doi: 10.4049/jimmunol.1201502. Epub 2013 May 1.

47.

Translational 18F-FDG PET/CT imaging to monitor lesion activity in intestinal inflammation.

Bettenworth D, Reuter S, Hermann S, Weckesser M, Kerstiens L, Stratis A, Nowacki TM, Ross M, Lenze F, Edemir B, Maaser C, Pap T, Koschmieder S, Heidemann J, Schäfers M, Lügering A.

J Nucl Med. 2013 May;54(5):748-55. doi: 10.2967/jnumed.112.112623. Epub 2013 Mar 20.

48.

Regulation of matrixmetalloproteinase-3 and matrixmetalloproteinase-13 by SUMO-2/3 through the transcription factor NF-κB.

Frank S, Peters MA, Wehmeyer C, Strietholt S, Koers-Wunrau C, Bertrand J, Heitzmann M, Hillmann A, Sherwood J, Seyfert C, Gay S, Pap T.

Ann Rheum Dis. 2013 Nov;72(11):1874-81. doi: 10.1136/annrheumdis-2012-202080. Epub 2013 Feb 16.

49.

Transport mechanisms and their pathology-induced regulation govern tyrosine kinase inhibitor delivery in rheumatoid arthritis.

Schmidt-Lauber C, Harrach S, Pap T, Fischer M, Victor M, Heitzmann M, Hansen U, Fobker M, Brand SM, Sindic A, Pavenstädt H, Edemir B, Schlatter E, Bertrand J, Ciarimboli G.

PLoS One. 2012;7(12):e52247. doi: 10.1371/journal.pone.0052247. Epub 2012 Dec 20.

50.

Syndecan 4 supports bone fracture repair, but not fetal skeletal development, in mice.

Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Timmen M, Bruckner P, Dell'Accio F, Raschke MJ, Pap T, Dreier R.

Arthritis Rheum. 2013 Mar;65(3):743-52. doi: 10.1002/art.37817.

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