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Items: 50


Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production.

Guidi A, Saccoccia F, Gennari N, Gimmelli R, Nizi E, Lalli C, Paonessa G, Papoff G, Bresciani A, Ruberti G.

Parasit Vectors. 2018 Dec 27;11(1):668. doi: 10.1186/s13071-018-3268-8.


Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro.

Ferrigno F, Biancofiore I, Malancona S, Ponzi S, Paonessa G, Graziani R, Bresciani A, Gennari N, Di Marco A, Kaiser M, Summa V, Harper S, Ontoria JM.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3689-3692. doi: 10.1016/j.bmcl.2018.10.028. Epub 2018 Oct 22.


Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins.

Nizi E, Sferrazza A, Fabbrini D, Nardi V, Andreini M, Graziani R, Gennari N, Bresciani A, Paonessa G, Harper S.

Bioorg Med Chem Lett. 2018 May 15;28(9):1540-1544. doi: 10.1016/j.bmcl.2018.03.069. Epub 2018 Mar 26.


Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs.

Ontoria JM, Paonessa G, Ponzi S, Ferrigno F, Nizi E, Biancofiore I, Malancona S, Graziani R, Roberts D, Willis P, Bresciani A, Gennari N, Cecchetti O, Monteagudo E, Orsale MV, Veneziano M, Di Marco A, Cellucci A, Laufer R, Altamura S, Summa V, Harper S.

ACS Med Chem Lett. 2016 Mar 5;7(5):454-9. doi: 10.1021/acsmedchemlett.5b00468. eCollection 2016 May 12.


Synthesis and anti-hepatitis C virus activity of novel ethyl 1H-indole-3-carboxylates in vitro.

Sellitto G, Faruolo A, de Caprariis P, Altamura S, Paonessa G, Ciliberto G.

Bioorg Med Chem. 2010 Aug 15;18(16):6143-8. doi: 10.1016/j.bmc.2010.06.058. Epub 2010 Jun 22.


Role of scavenger receptor class B type I in hepatitis C virus entry: kinetics and molecular determinants.

Catanese MT, Ansuini H, Graziani R, Huby T, Moreau M, Ball JK, Paonessa G, Rice CM, Cortese R, Vitelli A, Nicosia A.

J Virol. 2010 Jan;84(1):34-43. doi: 10.1128/JVI.02199-08.


Naturally occurring hepatitis C virus subgenomic deletion mutants replicate efficiently in Huh-7 cells and are trans-packaged in vitro to generate infectious defective particles.

Pacini L, Graziani R, Bartholomew L, De Francesco R, Paonessa G.

J Virol. 2009 Sep;83(18):9079-93. doi: 10.1128/JVI.00308-09. Epub 2009 Jul 8.


Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors.

Rydberg EH, Cellucci A, Bartholomew L, Mattu M, Barbato G, Ludmerer SW, Graham DJ, Altamura S, Paonessa G, De Francesco R, Migliaccio G, Carfí A.

J Mol Biol. 2009 Jul 31;390(5):1048-59. doi: 10.1016/j.jmb.2009.06.012. Epub 2009 Jun 6.


High-avidity monoclonal antibodies against the human scavenger class B type I receptor efficiently block hepatitis C virus infection in the presence of high-density lipoprotein.

Catanese MT, Graziani R, von Hahn T, Moreau M, Huby T, Paonessa G, Santini C, Luzzago A, Rice CM, Cortese R, Vitelli A, Nicosia A.

J Virol. 2007 Aug;81(15):8063-71. Epub 2007 May 16.


Development of humanized mice for the study of hepatitis C virus infection.

Turrini P, Sasso R, Germoni S, Marcucci I, Celluci A, Di Marco A, Marra E, Paonessa G, Eutropi A, Laufer R, Migliaccio G, Padron J.

Transplant Proc. 2006 May;38(4):1181-4.


HCV antiviral resistance: the impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase.

Tomei L, Altamura S, Paonessa G, De Francesco R, Migliaccio G.

Antivir Chem Chemother. 2005;16(4):225-45. Review.


Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase.

Harper S, Avolio S, Pacini B, Di Filippo M, Altamura S, Tomei L, Paonessa G, Di Marco S, Carfi A, Giuliano C, Padron J, Bonelli F, Migliaccio G, De Francesco R, Laufer R, Rowley M, Narjes F.

J Med Chem. 2005 Jul 14;48(14):4547-57.


Human hepatocytes in mice receiving pre-immune injection with human cord blood cells.

Turrini P, Monego G, Gonzalez J, Cicuzza S, Bonanno G, Zelano G, Rosenthal N, Paonessa G, Laufer R, Padron J.

Biochem Biophys Res Commun. 2005 Jan 7;326(1):66-73.


Conventional protein kinase C inhibition prevents alpha interferon-mediated hepatitis C virus replicon clearance by impairing STAT activation.

Fimia GM, Evangelisti C, Alonzi T, Romani M, Fratini F, Paonessa G, Ippolito G, Tripodi M, Piacentini M.

J Virol. 2004 Dec;78(23):12809-16.


Dominant negative effect of wild-type NS5A on NS5A-adapted subgenomic hepatitis C virus RNA replicon.

Graziani R, Paonessa G.

J Gen Virol. 2004 Jul;85(Pt 7):1867-75.


In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor.

Trozzi C, Bartholomew L, Ceccacci A, Biasiol G, Pacini L, Altamura S, Narjes F, Muraglia E, Paonessa G, Koch U, De Francesco R, Steinkuhler C, Migliaccio G.

J Virol. 2003 Mar;77(6):3669-79.


Persistent replication of hepatitis C virus replicons expressing the beta-lactamase reporter in subpopulations of highly permissive Huh7 cells.

Murray EM, Grobler JA, Markel EJ, Pagnoni MF, Paonessa G, Simon AJ, Flores OA.

J Virol. 2003 Mar;77(5):2928-35.


High circulating levels of biologically inactive IL-6/SIL-6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to gp130.

Pignatti P, Ciapponi L, Galle P, Hansen MB, Massa M, Meazza C, Paonessa G, Novick D, Ciliberto G, Martini A, De Benedetti F.

Clin Exp Immunol. 2003 Feb;131(2):355-63.


Cell clones selected from the Huh7 human hepatoma cell line support efficient replication of a subgenomic GB virus B replicon.

De Tomassi A, Pizzuti M, Graziani R, Sbardellati A, Altamura S, Paonessa G, Traboni C.

J Virol. 2002 Aug;76(15):7736-46.


Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions.

Dahmen H, Horsten U, Küster A, Jacques Y, Minvielle S, Kerr IM, Ciliberto G, Paonessa G, Heinrich PC, Müller-Newen G.

Biochem J. 1998 May 1;331 ( Pt 3):695-702.


Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist.

Ciapponi L, Maione D, Scoumanne A, Costa P, Hansen MB, Svenson M, Bendtzen K, Alonzi T, Paonessa G, Cortese R, Ciliberto G, Savino R.

Nat Biotechnol. 1997 Oct;15(10):997-1001.


Agonistic and antagonistic variants of ciliary neurotrophic factor (CNTF) reveal functional differences between membrane-bound and soluble CNTF alpha-receptor.

Di Marco A, Gloaguen I, Demartis A, Saggio I, Graziani R, Paonessa G, Laufer R.

J Biol Chem. 1997 Sep 12;272(37):23069-75.


Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance.

Gloaguen I, Costa P, Demartis A, Lazzaro D, Di Marco A, Graziani R, Paonessa G, Chen F, Rosenblum CI, Van der Ploeg LH, Cortese R, Ciliberto G, Laufer R.

Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6456-61.


Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.

Di Marco A, Gloaguen I, Graziani R, Paonessa G, Saggio I, Hudson KR, Laufer R.

Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9247-52.


Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells.

Sporeno E, Savino R, Ciapponi L, Paonessa G, Cabibbo A, Lahm A, Pulkki K, Sun RX, Toniatti C, Klein B, Ciliberto G.

Blood. 1996 Jun 1;87(11):4510-9.


Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1.

Benigni F, Fantuzzi G, Sacco S, Sironi M, Pozzi P, Dinarello CA, Sipe JD, Poli V, Cappelletti M, Paonessa G, Pennica D, Panayotatos N, Ghezzi P.

Blood. 1996 Mar 1;87(5):1851-4.


Monovalent phage display of human interleukin (hIL)-6: selection of superbinder variants from a complex molecular repertoire in the hIL-6 D-helix.

Cabibbo A, Sporeno E, Toniatti C, Altamura S, Savino R, Paonessa G, Ciliberto G.

Gene. 1995 Dec 29;167(1-2):41-7.


Definition of a composite binding site for gp130 in human interleukin-6.

Ciapponi L, Graziani R, Paonessa G, Lahm A, Ciliberto G, Savino R.

J Biol Chem. 1995 Dec 29;270(52):31249-54.


In vitro binding of ciliary neurotrophic factor to its receptors: evidence for the formation of an IL-6-type hexameric complex.

De Serio A, Graziani R, Laufer R, Ciliberto G, Paonessa G.

J Mol Biol. 1995 Dec 15;254(5):795-800.


The molecular design of human IL-6 receptor antagonists.

Lahm A, Savino R, Salvati AL, Cabibbo A, Ciapponi L, Demartis A, Toniatti C, Paonessa G, Altamura S, Ciliberto G.

Ann N Y Acad Sci. 1995 Jul 21;762:136-50; discussion 150-1. No abstract available.


Interleukin-6 (IL-6) antagonism by soluble IL-6 receptor alpha mutated in the predicted gp130-binding interface.

Salvati AL, Lahm A, Paonessa G, Ciliberto G, Toniatti C.

J Biol Chem. 1995 May 19;270(20):12242-9.


Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

Paonessa G, Graziani R, De Serio A, Savino R, Ciapponi L, Lahm A, Salvati AL, Toniatti C, Ciliberto G.

EMBO J. 1995 May 1;14(9):1942-51.


Nonradioactive receptor binding assay for ciliary neurotrophic factor.

Saggio I, Paonessa G, Gloaguen I, Graziani R, De Serio A, Laufer R.

Anal Biochem. 1994 Sep;221(2):387-91.


Production and structural characterization of amino terminally histidine tagged human oncostatin M in E. coli.

Sporeno E, Barbato G, Graziani R, Pucci P, Nitti G, Paonessa G.

Cytokine. 1994 May;6(3):255-64.


Oncostatin M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin M receptors.

Sporeno E, Paonessa G, Salvati AL, Graziani R, Delmastro P, Ciliberto G, Toniatti C.

J Biol Chem. 1994 Apr 15;269(15):10991-5.


Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.

Savino R, Lahm A, Salvati AL, Ciapponi L, Sporeno E, Altamura S, Paonessa G, Toniatti C, Ciliberto G.

EMBO J. 1994 Mar 15;13(6):1357-67.


Chimpanzee DNA profiles on trial.

Pascali VL, Destro Bisol G, Dobosz M, d'Aloja E, Paonessa G, Mereu U.

Nature. 1994 Feb 24;367(6465):692-3. No abstract available.


Specific recognition of cruciform DNA by nuclear protein HMG1.

Bianchi ME, Beltrame M, Paonessa G.

Science. 1989 Feb 24;243(4894 Pt 1):1056-9.


Purification of a NF1-like DNA-binding protein from rat liver and cloning of the corresponding cDNA.

Paonessa G, Gounari F, Frank R, Cortese R.

EMBO J. 1988 Oct;7(10):3115-23.


Two distinct factors interact with the promoter regions of several liver-specific genes.

Hardon EM, Frain M, Paonessa G, Cortese R.

EMBO J. 1988 Jun;7(6):1711-9.


Nucleotide sequence of rat liver HMG1 cDNA.

Paonessa G, Frank R, Cortese R.

Nucleic Acids Res. 1987 Nov 11;15(21):9077. No abstract available.


Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin gene.

De Simone V, Ciliberto G, Hardon E, Paonessa G, Palla F, Lundberg L, Cortese R.

EMBO J. 1987 Sep;6(9):2759-66.


Structural analysis of the X-linked gene encoding human glucose 6-phosphate dehydrogenase.

Martini G, Toniolo D, Vulliamy T, Luzzatto L, Dono R, Viglietto G, Paonessa G, D'Urso M, Persico MG.

EMBO J. 1986 Aug;5(8):1849-55.


Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5' non-coding region.

Persico MG, Viglietto G, Martini G, Toniolo D, Paonessa G, Moscatelli C, Dono R, Vulliamy T, Luzzatto L, D'Urso M.

Nucleic Acids Res. 1986 Mar 25;14(6):2511-22. Erratum in: Nucleic Acids Res 1986 Oct 10;14(19):7822.


Transglutaminase-mediated modifications of the rat sperm surface in vitro.

Paonessa G, Metafora S, Tajana G, Abrescia P, De Santis A, Gentile V, Porta R.

Science. 1984 Nov 16;226(4676):852-5.


The 11S rat seminal vesicle mRNA directs the in vitro synthesis of two precursors of the major secretory protein IV.

Metafora S, Guardiola J, Paonessa G, Abrescia P.

Nucleic Acids Res. 1984 Feb 24;12(4):1901-10.

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