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Items: 1 to 50 of 81

1.

Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.

Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi G, Reid CA, King GF, Petrou S.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8077-E8085. doi: 10.1073/pnas.1804764115. Epub 2018 Aug 3.

2.

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold.

Krishnarjuna B, Villegas-Moreno J, Mitchell ML, Csoti A, Peigneur S, Amero C, Pennington MW, Tytgat J, Panyi G, Norton RS.

Toxicon. 2018 Aug;150:50-59. doi: 10.1016/j.toxicon.2018.05.006. Epub 2018 May 19.

PMID:
29772211
3.

Membrane Potential Distinctly Modulates Mobility and Signaling of IL-2 and IL-15 Receptors in T Cells.

Nagy É, Mocsár G, Sebestyén V, Volkó J, Papp F, Tóth K, Damjanovich S, Panyi G, Waldmann TA, Bodnár A, Vámosi G.

Biophys J. 2018 May 22;114(10):2473-2482. doi: 10.1016/j.bpj.2018.04.038. Epub 2018 May 10.

PMID:
29754714
4.

The C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane.

Voros O, Szilagyi O, Balajthy A, Somodi S, Panyi G, Hajdu P.

Sci Rep. 2018 Apr 12;8(1):5937. doi: 10.1038/s41598-018-24159-8.

5.

Sterol Regulation of Voltage-Gated K+ Channels.

Balajthy A, Hajdu P, Panyi G, Varga Z.

Curr Top Membr. 2017;80:255-292. doi: 10.1016/bs.ctm.2017.05.006. Epub 2017 Jul 24. Review.

PMID:
28863820
6.

Pi5 and Pi6, two undescribed peptides from the venom of the scorpion Pandinus imperator and their effects on K+-channels.

Olamendi-Portugal T, Csoti A, Jimenez-Vargas JM, Gomez-Lagunas F, Panyi G, Possani LD.

Toxicon. 2017 Jul;133:136-144. doi: 10.1016/j.toxicon.2017.05.011. Epub 2017 May 11.

PMID:
28502745
7.

Optimization of the Synthesis of Flavone-Amino Acid and Flavone-Dipeptide Hybrids via Buchwald-Hartwig Reaction.

Pajtás D, Kónya K, Kiss-Szikszai A, Džubák P, Pethő Z, Varga Z, Panyi G, Patonay T.

J Org Chem. 2017 May 5;82(9):4578-4587. doi: 10.1021/acs.joc.7b00124. Epub 2017 Apr 25.

PMID:
28441016
8.

A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore.

Tomczak AP, Fernández-Trillo J, Bharill S, Papp F, Panyi G, Stühmer W, Isacoff EY, Pardo LA.

J Gen Physiol. 2017 May 1;149(5):577-593. doi: 10.1085/jgp.201611742. Epub 2017 Mar 30.

9.

Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions.

Fineberg JD, Szanto TG, Panyi G, Covarrubias M.

Sci Rep. 2016 Aug 9;6:31131. doi: 10.1038/srep31131.

10.

7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome.

Balajthy A, Somodi S, Pethő Z, Péter M, Varga Z, Szabó GP, Paragh G, Vígh L, Panyi G, Hajdu P.

Pflugers Arch. 2016 Aug;468(8):1403-18. doi: 10.1007/s00424-016-1851-4. Epub 2016 Jun 17.

PMID:
27315086
11.

Erratum to: Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes.

Pethő Z, Tanner MR, Tajhya RB, Huq R, Laragione T, Panyi G, Gulko PS, Beeton C.

Arthritis Res Ther. 2016 Jun 1;18(1):122. No abstract available.

12.

Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes.

Pethő Z, Tanner MR, Tajhya RB, Huq R, Laragione T, Panyi G, Gulko PS, Beeton C.

Arthritis Res Ther. 2016 May 10;18(1):103. doi: 10.1186/s13075-016-1003-4. Erratum in: Arthritis Res Ther. 2016;18(1):122.

13.

Probing pattern and dynamics of disulfide bridges using synthesis and NMR of an ion channel blocker peptide toxin with multiple diselenide bonds.

Fehér K, Timári I, Rákosi K, Szolomájer J, Illyés TZ, Bartok A, Varga Z, Panyi G, Tóth GK, Kövér KE.

Chem Sci. 2016 Apr 21;7(4):2666-2673. doi: 10.1039/c5sc03995a. Epub 2015 Dec 21.

14.

Isolation, chemical and functional characterization of several new K(+)-channel blocking peptides from the venom of the scorpion Centruroides tecomanus.

Olamendi-Portugal T, Bartok A, Zamudio-Zuñiga F, Balajthy A, Becerril B, Panyi G, Possani LD.

Toxicon. 2016 Jun 1;115:1-12. doi: 10.1016/j.toxicon.2016.02.017. Epub 2016 Feb 26.

PMID:
26921461
15.

The anti-proliferative effect of cation channel blockers in T lymphocytes depends on the strength of mitogenic stimulation.

Petho Z, Balajthy A, Bartok A, Bene K, Somodi S, Szilagyi O, Rajnavolgyi E, Panyi G, Varga Z.

Immunol Lett. 2016 Mar;171:60-9. doi: 10.1016/j.imlet.2016.02.003. Epub 2016 Feb 6.

PMID:
26861999
16.

An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility.

Bartok A, Fehér K, Bodor A, Rákosi K, Tóth GK, Kövér KE, Panyi G, Varga Z.

Sci Rep. 2015 Dec 22;5:18397. doi: 10.1038/srep18397.

17.

Mesenchymal Stromal Cell-Like Cells Set the Balance of Stimulatory and Inhibitory Signals in Monocyte-Derived Dendritic Cells.

Bacskai I, Mázló A, Kis-Tóth K, Szabó A, Panyi G, Sarkadi B, Apáti Á, Rajnavölgyi É.

Stem Cells Dev. 2015 Aug 1;24(15):1805-16. doi: 10.1089/scd.2014.0509. Epub 2015 Apr 29.

PMID:
25808140
18.

Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels.

Bartok A, Toth A, Somodi S, Szanto TG, Hajdu P, Panyi G, Varga Z.

Toxicon. 2014 Sep;87:6-16. doi: 10.1016/j.toxicon.2014.05.002. Epub 2014 May 28.

PMID:
24878374
19.

Structure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi.

Luna-Ramírez K, Bartok A, Restano-Cassulini R, Quintero-Hernández V, Coronas FI, Christensen J, Wright CE, Panyi G, Possani LD.

Mol Pharmacol. 2014 Jul;86(1):28-41. doi: 10.1124/mol.113.090183. Epub 2014 Apr 10.

20.

Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.

Juhász T, Matta C, Katona É, Somogyi C, Takács R, Gergely P, Csernoch L, Panyi G, Tóth G, Reglődi D, Tamás A, Zákány R.

PLoS One. 2014 Mar 18;9(3):e91541. doi: 10.1371/journal.pone.0091541. eCollection 2014.

21.

Ion channels and anti-cancer immunity.

Panyi G, Beeton C, Felipe A.

Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130106. doi: 10.1098/rstb.2013.0106. Print 2014 Mar 19. Review.

22.

OcyKTx2, a new K⁺-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum.

Schwartz EF, Bartok A, Schwartz CA, Papp F, Gómez-Lagunas F, Panyi G, Possani LD.

Peptides. 2013 Aug;46:40-6. doi: 10.1016/j.peptides.2013.04.021. Epub 2013 May 15.

23.

The role of PSD-95 in the rearrangement of Kv1.3 channels to the immunological synapse.

Szilágyi O, Boratkó A, Panyi G, Hajdu P.

Pflugers Arch. 2013 Sep;465(9):1341-53. doi: 10.1007/s00424-013-1256-6. Epub 2013 Apr 4.

PMID:
23553419
24.

Transient receptor potential vanilloid-2 mediates the effects of transient heat shock on endocytosis of human monocyte-derived dendritic cells.

Szöllősi AG, Oláh A, Tóth IB, Papp F, Czifra G, Panyi G, Bíró T.

FEBS Lett. 2013 May 2;587(9):1440-5. doi: 10.1016/j.febslet.2013.03.027. Epub 2013 Mar 28.

25.

Analysis of the K+ current in human CD4+ T lymphocytes in hypercholesterolemic state.

Somodi S, Balajthy A, Szilágyi O, Pethő Z, Harangi M, Paragh G, Panyi G, Hajdu P.

Cell Immunol. 2013 Jan;281(1):20-6. doi: 10.1016/j.cellimm.2013.01.004. Epub 2013 Jan 29.

PMID:
23416720
26.

Membrane microdomain organization, calcium signal, and NFAT activation as an important axis in polarized Th cell function.

Izsepi E, Himer L, Szilagyi O, Hajdu P, Panyi G, Laszlo G, Matko J.

Cytometry A. 2013 Feb;83(2):185-96. doi: 10.1002/cyto.a.22234. Epub 2012 Nov 26.

27.

Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells.

Varga Z, Gurrola-Briones G, Papp F, Rodríguez de la Vega RC, Pedraza-Alva G, Tajhya RB, Gaspar R, Cardenas L, Rosenstein Y, Beeton C, Possani LD, Panyi G.

Mol Pharmacol. 2012 Sep;82(3):372-82. doi: 10.1124/mol.112.078006. Epub 2012 May 23.

28.

Immunology Letters. Introduction.

Erdei A, Sármay G, Kacskovics I, Matkó J, Mocsai A, Panyi G, Prechl J.

Immunol Lett. 2012 Mar 30;143(1):1. No abstract available.

PMID:
22553778
29.

Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes.

Gurrola GB, Hernández-López RA, Rodríguez de la Vega RC, Varga Z, Batista CV, Salas-Castillo SP, Panyi G, del Río-Portilla F, Possani LD.

Biochemistry. 2012 May 15;51(19):4049-61. doi: 10.1021/bi300060n. Epub 2012 May 7.

PMID:
22540187
30.

Switch of voltage-gated K+ channel expression in the plasma membrane of chondrogenic cells affects cytosolic Ca2+-oscillations and cartilage formation.

Varga Z, Juhász T, Matta C, Fodor J, Katona É, Bartok A, Oláh T, Sebe A, Csernoch L, Panyi G, Zákány R.

PLoS One. 2011;6(11):e27957. doi: 10.1371/journal.pone.0027957. Epub 2011 Nov 21.

31.

Voltage-gated sodium channel Nav1.7 maintains the membrane potential and regulates the activation and chemokine-induced migration of a monocyte-derived dendritic cell subset.

Kis-Toth K, Hajdu P, Bacskai I, Szilagyi O, Papp F, Szanto A, Posta E, Gogolak P, Panyi G, Rajnavolgyi E.

J Immunol. 2011 Aug 1;187(3):1273-80. doi: 10.4049/jimmunol.1003345. Epub 2011 Jun 29.

32.

Intact rat superior mesenteric artery endothelium is an electrical syncytium and expresses strong inward rectifier K+ conductance.

Climent B, Zsiros E, Stankevicius E, de la Villa P, Panyi G, Simonsen U, García-Sacristán A, Rivera L.

Biochem Biophys Res Commun. 2011 Jul 8;410(3):501-7. doi: 10.1016/j.bbrc.2011.06.011. Epub 2011 Jun 7.

PMID:
21679686
33.

Effects of the PKC inhibitors chelerythrine and bisindolylmaleimide I (GF 109203X) on delayed rectifier K+ currents.

Harmati G, Papp F, Szentandrássy N, Bárándi L, Ruzsnavszky F, Horváth B, Bányász T, Magyar J, Panyi G, Krasznai Z, Nánási PP.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Feb;383(2):141-8. doi: 10.1007/s00210-010-0584-8. Epub 2010 Dec 1.

PMID:
21120453
34.

Answer to the "comment on functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse" by Stefan Bittner et al. [Immunol. Lett. 125 (Aug 15 (2)) (2009) 156-157].

Hajdú P, Szilágyi O, Tóth A, Krasznai Z, Pocsai K, Panyi G.

Immunol Lett. 2010 Mar 10;129(1):47-9. doi: 10.1016/j.imlet.2009.12.026. Epub 2010 Jan 15. No abstract available.

PMID:
20079762
35.

Ion channels in T lymphocytes: an update on facts, mechanisms and therapeutic targeting in autoimmune diseases.

Varga Z, Hajdu P, Panyi G.

Immunol Lett. 2010 May 4;130(1-2):19-25. doi: 10.1016/j.imlet.2009.12.015. Epub 2009 Dec 21. Review.

PMID:
20026117
36.

Developmental switch of the expression of ion channels in human dendritic cells.

Zsiros E, Kis-Toth K, Hajdu P, Gaspar R, Bielanska J, Felipe A, Rajnavolgyi E, Panyi G.

J Immunol. 2009 Oct 1;183(7):4483-92. doi: 10.4049/jimmunol.0803003. Epub 2009 Sep 11.

37.

Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus.

Papp F, Batista CV, Varga Z, Herceg M, Román-González SA, Gaspar R, Possani LD, Panyi G.

Toxicon. 2009 Sep 15;54(4):379-89. doi: 10.1016/j.toxicon.2009.05.023. Epub 2009 Jun 3.

PMID:
19500613
38.

Functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse.

Tóth A, Szilágyi O, Krasznai Z, Panyi G, Hajdú P.

Immunol Lett. 2009 Jun 30;125(1):15-21. doi: 10.1016/j.imlet.2009.05.004. Epub 2009 May 27.

PMID:
19477198
39.

Potassium channel expression in human CD4+ regulatory and naïve T cells from healthy subjects and multiple sclerosis patients.

Varga Z, Csepany T, Papp F, Fabian A, Gogolak P, Toth A, Panyi G.

Immunol Lett. 2009 Jun 4;124(2):95-101. doi: 10.1016/j.imlet.2009.04.008. Epub 2009 May 3.

PMID:
19409928
40.

A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus.

Corzo G, Papp F, Varga Z, Barraza O, Espino-Solis PG, Rodríguez de la Vega RC, Gaspar R, Panyi G, Possani LD.

Biochem Pharmacol. 2008 Oct 30;76(9):1142-54. doi: 10.1016/j.bcp.2008.08.018. Epub 2008 Aug 22.

PMID:
18786511
41.

Special issue from the International Conference on Molecular Recognition, Pécs; and regional biophysics meeting, Balatonfüred; August 2007 [corrected].

Nyitrai M, Panyi G.

Eur Biophys J. 2008 Sep;37(7):1083-4. doi: 10.1007/s00249-008-0360-6. Epub 2008 Aug 6. No abstract available. Erratum in: Eur Biophys J. 2008 Nov;38(1):127.

42.

Effects of changes in extracellular pH and potassium concentration on Kv1.3 inactivation.

Somodi S, Hajdu P, Gáspár R, Panyi G, Varga Z.

Eur Biophys J. 2008 Sep;37(7):1145-56. doi: 10.1007/s00249-008-0267-2. Epub 2008 Jan 24.

PMID:
18214462
43.

Involvement of membrane channels in autoimmune disorders.

Varga Z, Hajdu P, Panyi G, Gáspár R, Krasznai Z.

Curr Pharm Des. 2007;13(24):2456-68. Review.

PMID:
17692013
44.

Changes in purinoceptor distribution and intracellular calcium levels following noise exposure in the outer hair cells of the guinea pig.

Szucs A, Szappanos H, Batta TJ, Tóth A, Szigeti GP, Panyi G, Csernoch L, Sziklai I.

J Membr Biol. 2006;213(3):135-41. Epub 2007 Apr 28.

PMID:
17468959
45.

Probing the cavity of the slow inactivated conformation of shaker potassium channels.

Panyi G, Deutsch C.

J Gen Physiol. 2007 May;129(5):403-18. Epub 2007 Apr 16.

46.

Nutrition and immune system: certain fatty acids differently modify membrane composition and consequently kinetics of KV1.3 channels of human peripheral lymphocytes.

Székely A, Kitajka K, Panyi G, Márián T, Gáspár R, Krasznai Z.

Immunobiology. 2007;212(3):213-27. Epub 2007 Feb 22.

PMID:
17412288
47.

Cross talk between activation and slow inactivation gates of Shaker potassium channels.

Panyi G, Deutsch C.

J Gen Physiol. 2006 Nov;128(5):547-59. Epub 2006 Oct 16.

48.

K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression.

Panyi G, Possani LD, Rodríguez de la Vega RC, Gáspár R, Varga Z.

Curr Pharm Des. 2006;12(18):2199-220. Review.

PMID:
16787250
49.

Differential expression of potassium currents in Deiters cells of the guinea pig cochlea.

Szucs A, Somodi S, Batta TJ, Tóth A, Szigeti GP, Csernoch L, Panyi G, Sziklai I.

Pflugers Arch. 2006 Jun;452(3):332-41. Epub 2006 Jan 31.

PMID:
16447073
50.

Biophysical and pharmacological aspects of K+ channels in T lymphocytes.

Panyi G.

Eur Biophys J. 2005 Aug;34(6):515-29. Review.

PMID:
16184309

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