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Finnish neuroscience from past to present.

Korpi ER, Lindholm D, Panula P, Tienari PJ, Haltia M.

Eur J Neurosci. 2020 Feb 3. doi: 10.1111/ejn.14693. [Epub ahead of print] No abstract available.


LIN28B affects gene expression at the hypothalamic-pituitary axis and serum testosterone levels.

Leinonen JT, Chen YC, Pennonen J, Lehtonen L, Junna N, Tukiainen T, Panula P, Widén E.

Sci Rep. 2019 Dec 2;9(1):18060. doi: 10.1038/s41598-019-54475-6.


Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine-deficient mice.

Abdurakhmanova S, Semenova S, Piepponen TP, Panula P.

Genes Brain Behav. 2019 Nov;18(8):e12595. doi: 10.1111/gbb.12595. Epub 2019 Jul 17.


Regeneration of Dopaminergic Neurons in Adult Zebrafish Depends on Immune System Activation and Differs for Distinct Populations.

Caldwell LJ, Davies NO, Cavone L, Mysiak KS, Semenova SA, Panula P, Armstrong JD, Becker CG, Becker T.

J Neurosci. 2019 Jun 12;39(24):4694-4713. doi: 10.1523/JNEUROSCI.2706-18.2019. Epub 2019 Apr 4.


Histamine, histamine H3 receptor, and alcohol use disorder.

Panula P.

Br J Pharmacol. 2020 Feb;177(3):634-641. doi: 10.1111/bph.14634. Epub 2019 Apr 10. Review.


Neurotrophin receptor Ntrk2b function in the maintenance of dopamine and serotonin neurons in zebrafish.

Sahu MP, Pazos-Boubeta Y, Pajanoja C, Rozov S, Panula P, Castrén E.

Sci Rep. 2019 Feb 14;9(1):2036. doi: 10.1038/s41598-019-39347-3.


Transient modification of lin28b expression - Permanent effects on zebrafish growth.

Leinonen JT, Chen YC, Tukiainen T, Panula P, Widén E.

Mol Cell Endocrinol. 2019 Jan 5;479:61-70. doi: 10.1016/j.mce.2018.09.001. Epub 2018 Sep 7.


Embryonic exposure to valproic acid affects the histaminergic system and the social behaviour of adult zebrafish (Danio rerio).

Baronio D, Puttonen HAJ, Sundvik M, Semenova S, Lehtonen E, Panula P.

Br J Pharmacol. 2018 Mar;175(5):797-809. doi: 10.1111/bph.14124. Epub 2018 Jan 23.


Salsolinol: an Unintelligible and Double-Faced Molecule-Lessons Learned from In Vivo and In Vitro Experiments.

Kurnik-Łucka M, Panula P, Bugajski A, Gil K.

Neurotox Res. 2018 Feb;33(2):485-514. doi: 10.1007/s12640-017-9818-6. Epub 2017 Oct 23. Review.


Guidelines for morpholino use in zebrafish.

Stainier DYR, Raz E, Lawson ND, Ekker SC, Burdine RD, Eisen JS, Ingham PW, Schulte-Merker S, Yelon D, Weinstein BM, Mullins MC, Wilson SW, Ramakrishnan L, Amacher SL, Neuhauss SCF, Meng A, Mochizuki N, Panula P, Moens CB.

PLoS Genet. 2017 Oct 19;13(10):e1007000. doi: 10.1371/journal.pgen.1007000. eCollection 2017 Oct. No abstract available.


Knockout of histamine receptor H3 alters adaptation to sudden darkness and monoamine levels in the zebrafish.

Puttonen HAJ, Sundvik M, Semenova S, Shirai Y, Chen YC, Panula P.

Acta Physiol (Oxf). 2018 Mar;222(3). doi: 10.1111/apha.12981. Epub 2017 Nov 6.


Distribution, properties, and inhibitor sensitivity of zebrafish catechol-O-methyl transferases (COMT).

Semenova S, Rozov S, Panula P.

Biochem Pharmacol. 2017 Dec 1;145:147-157. doi: 10.1016/j.bcp.2017.08.017. Epub 2017 Aug 24.


Behavioral and stereological characterization of Hdc KO mice: Relation to Tourette syndrome.

Abdurakhmanova S, Chary K, Kettunen M, Sierra A, Panula P.

J Comp Neurol. 2017 Nov 1;525(16):3476-3487. doi: 10.1002/cne.24279. Epub 2017 Aug 2.


Storage of neural histamine and histaminergic neurotransmission is VMAT2 dependent in the zebrafish.

Puttonen HAJ, Semenova S, Sundvik M, Panula P.

Sci Rep. 2017 Jun 8;7(1):3060. doi: 10.1038/s41598-017-02981-w.


Homeostatic response to sleep/rest deprivation by constant water flow in larval zebrafish in both dark and light conditions.

Aho V, Vainikka M, Puttonen HAJ, Ikonen HMK, Salminen T, Panula P, Porkka-Heiskanen T, Wigren HK.

J Sleep Res. 2017 Jun;26(3):394-400. doi: 10.1111/jsr.12508. Epub 2017 Mar 2.


Narcolepsy patients' blood-based miRNA expression profiling: miRNA expression differences with Pandemrix vaccination.

Mosakhani N, Sarhadi V, Panula P, Partinen M, Knuutila S.

Acta Neurol Scand. 2017 Nov;136(5):462-469. doi: 10.1111/ane.12749. Epub 2017 Mar 1.


Altered Electroencephalographic Activity Associated with Changes in the Sleep-Wakefulness Cycle of C57BL/6J Mice in Response to a Photoperiod Shortening.

Rozov SV, Zant JC, Gurevicius K, Porkka-Heiskanen T, Panula P.

Front Behav Neurosci. 2016 Aug 31;10:168. doi: 10.3389/fnbeh.2016.00168. eCollection 2016.


A Novel Developmental Role for Dopaminergic Signaling to Specify Hypothalamic Neurotransmitter Identity.

Chen YC, Semenova S, Rozov S, Sundvik M, Bonkowsky JL, Panula P.

J Biol Chem. 2016 Oct 14;291(42):21880-21892. Epub 2016 Aug 18.


Effect of Ionic Liquids on Zebrafish (Danio rerio) Viability, Behavior, and Histology; Correlation between Toxicity and Ionic Liquid Aggregation.

Ruokonen SK, Sanwald C, Sundvik M, Polnick S, Vyavaharkar K, Duša F, Holding AJ, King AW, Kilpeläinen I, Lämmerhofer M, Panula P, Wiedmer SK.

Environ Sci Technol. 2016 Jul 5;50(13):7116-25. doi: 10.1021/acs.est.5b06107. Epub 2016 Jun 17.


Histamine receptors.

Haas HL, Panula P.

Neuropharmacology. 2016 Jul;106:1-2. doi: 10.1016/j.neuropharm.2016.04.007. Epub 2016 Apr 14. No abstract available.


Histamine H3 Receptor Regulates Sensorimotor Gating and Dopaminergic Signaling in the Striatum.

Kononoff Vanhanen J, Nuutinen S, Tuominen M, Panula P.

J Pharmacol Exp Ther. 2016 May;357(2):264-72. doi: 10.1124/jpet.115.230771. Epub 2016 Mar 4.


Different Hypothalamic Nicotinic α7 Receptor Expression and Response to Low Nicotine Dose in Alcohol-Preferring and Alcohol-Avoiding Rats.

Nuutinen S, Panula P, Salminen O.

Alcohol Clin Exp Res. 2016 Feb;40(2):329-34. doi: 10.1111/acer.12960.


Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model.

Parmentier R, Zhao Y, Perier M, Akaoka H, Lintunen M, Hou Y, Panula P, Watanabe T, Franco P, Lin JS.

Neuropharmacology. 2016 Jul;106:20-34. doi: 10.1016/j.neuropharm.2015.12.014. Epub 2015 Dec 23.


On the Role of Histamine Receptors in the Regulation of Circadian Rhythms.

Rozov SV, Porkka-Heiskanen T, Panula P.

PLoS One. 2015 Dec 10;10(12):e0144694. doi: 10.1371/journal.pone.0144694. eCollection 2015.


Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.

Keatinge M, Bui H, Menke A, Chen YC, Sokol AM, Bai Q, Ellett F, Da Costa M, Burke D, Gegg M, Trollope L, Payne T, McTighe A, Mortiboys H, de Jager S, Nuthall H, Kuo MS, Fleming A, Schapira AH, Renshaw SA, Highley JR, Chacinska A, Panula P, Burton EA, O'Neill MJ, Bandmann O.

Hum Mol Genet. 2015 Dec 1;24(23):6640-52. doi: 10.1093/hmg/ddv369. Epub 2015 Sep 16.


Effects of acoustic levitation on the development of zebrafish, Danio rerio, embryos.

Sundvik M, Nieminen HJ, Salmi A, Panula P, Hæggström E.

Sci Rep. 2015 Sep 4;5:13596. doi: 10.1038/srep13596.


Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae.

Wang H, Semenova S, Kuusela S, Panula P, Lehtonen S.

FASEB J. 2015 Nov;29(11):4435-48. doi: 10.1096/fj.15-271817. Epub 2015 Jul 13.


Expression change in Angiopoietin-1 underlies change in relative brain size in fish.

Chen YC, Harrison PW, Kotrschal A, Kolm N, Mank JE, Panula P.

Proc Biol Sci. 2015 Jul 7;282(1810). pii: 20150872. doi: 10.1098/rspb.2015.0872.


Histamine H3 receptor antagonist decreases cue-induced alcohol reinstatement in mice.

Nuutinen S, Mäki T, Rozov S, Bäckström P, Hyytiä P, Piepponen P, Panula P.

Neuropharmacology. 2016 Jul;106:156-63. doi: 10.1016/j.neuropharm.2015.06.006. Epub 2015 Jun 21.


International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.

Panula P, Chazot PL, Cowart M, Gutzmer R, Leurs R, Liu WL, Stark H, Thurmond RL, Haas HL.

Pharmacol Rev. 2015 Jul;67(3):601-55. doi: 10.1124/pr.114.010249. Review.


Interactions of the orexin/hypocretin neurones and the histaminergic system.

Sundvik M, Panula P.

Acta Physiol (Oxf). 2015 Feb;213(2):321-33. doi: 10.1111/apha.12432. Epub 2014 Dec 29. Review.


Histamine H3 receptor antagonist JNJ-39220675 modulates locomotor responses but not place conditioning by dopaminergic drugs.

Vanhanen J, Kinnunen M, Nuutinen S, Panula P.

Psychopharmacology (Berl). 2015 Mar;232(6):1143-53. doi: 10.1007/s00213-014-3751-7. Epub 2014 Oct 12.


The tyrosine hydroxylase 2 (TH2) system in zebrafish brain and stress activation of hypothalamic cells.

Semenova SA, Chen YC, Zhao X, Rauvala H, Panula P.

Histochem Cell Biol. 2014 Dec;142(6):619-33. doi: 10.1007/s00418-014-1240-z. Epub 2014 Jul 16.


Amigo adhesion protein regulates development of neural circuits in zebrafish brain.

Zhao X, Kuja-Panula J, Sundvik M, Chen YC, Aho V, Peltola MA, Porkka-Heiskanen T, Panula P, Rauvala H.

J Biol Chem. 2014 Jul 18;289(29):19958-75. doi: 10.1074/jbc.M113.545582. Epub 2014 Jun 5.


Histamine in the brain.

Passani MB, Panula P, Lin JS.

Front Syst Neurosci. 2014 Apr 28;8:64. doi: 10.3389/fnsys.2014.00064. eCollection 2014. No abstract available.


Sept7b is essential for pronephric function and development of left-right asymmetry in zebrafish embryogenesis.

Dash SN, Lehtonen E, Wasik AA, Schepis A, Paavola J, Panula P, Nelson WJ, Lehtonen S.

J Cell Sci. 2014 Apr 1;127(Pt 7):1476-86. doi: 10.1242/jcs.138495. Epub 2014 Feb 4.


Developmental roles of brain histamine.

Panula P, Sundvik M, Karlstedt K.

Trends Neurosci. 2014 Mar;37(3):159-68. doi: 10.1016/j.tins.2014.01.001. Epub 2014 Jan 30. Review.


Periodic properties of the histaminergic system of the mouse brain.

Rozov SV, Zant JC, Karlstedt K, Porkka-Heiskanen T, Panula P.

Eur J Neurosci. 2014 Jan;39(2):218-28. doi: 10.1111/ejn.12397. Epub 2013 Nov 6.


Artificial selection on relative brain size reveals a positive genetic correlation between brain size and proactive personality in the guppy.

Kotrschal A, Lievens EJ, Dahlbom J, Bundsen A, Semenova S, Sundvik M, Maklakov AA, Winberg S, Panula P, Kolm N.

Evolution. 2014 Apr;68(4):1139-49. doi: 10.1111/evo.12341. Epub 2014 Feb 1.


Oxidative stress and regulation of Pink1 in zebrafish (Danio rerio).

Priyadarshini M, Orosco LA, Panula PJ.

PLoS One. 2013 Nov 26;8(11):e81851. doi: 10.1371/journal.pone.0081851. eCollection 2013.


Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.

Decker AR, McNeill MS, Lambert AM, Overton JD, Chen YC, Lorca RA, Johnson NA, Brockerhoff SE, Mohapatra DP, MacArthur H, Panula P, Masino MA, Runnels LW, Cornell RA.

Dev Biol. 2014 Feb 15;386(2):428-39. doi: 10.1016/j.ydbio.2013.11.015. Epub 2013 Nov 27.


The histaminergic network in the brain: basic organization and role in disease.

Panula P, Nuutinen S.

Nat Rev Neurosci. 2013 Jul;14(7):472-87. doi: 10.1038/nrn3526. Review.


A randomized clinical trial of histamine 2 receptor antagonism in treatment-resistant schizophrenia.

Meskanen K, Ekelund H, Laitinen J, Neuvonen PJ, Haukka J, Panula P, Ekelund J.

J Clin Psychopharmacol. 2013 Aug;33(4):472-8. doi: 10.1097/JCP.0b013e3182970490.


Acute ethanol treatment upregulates Th1, Th2, and Hdc in larval zebrafish in stable networks.

Puttonen HA, Sundvik M, Rozov S, Chen YC, Panula P.

Front Neural Circuits. 2013 May 31;7:102. doi: 10.3389/fncir.2013.00102. eCollection 2013.


Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration.

Reimer MM, Norris A, Ohnmacht J, Patani R, Zhong Z, Dias TB, Kuscha V, Scott AL, Chen YC, Rozov S, Frazer SL, Wyatt C, Higashijima S, Patton EE, Panula P, Chandran S, Becker T, Becker CG.

Dev Cell. 2013 Jun 10;25(5):478-91. doi: 10.1016/j.devcel.2013.04.012. Epub 2013 May 23.


Histamine is required for H₃ receptor-mediated alcohol reward inhibition, but not for alcohol consumption or stimulation.

Vanhanen J, Nuutinen S, Lintunen M, Mäki T, Rämö J, Karlstedt K, Panula P.

Br J Pharmacol. 2013 Sep;170(1):177-87. doi: 10.1111/bph.12170.


Expression of histamine receptor genes Hrh3 and Hrh4 in rat brain endothelial cells.

Karlstedt K, Jin C, Panula P.

Br J Pharmacol. 2013 Sep;170(1):58-66. doi: 10.1111/bph.12173.


A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling.

Priyadarshini M, Tuimala J, Chen YC, Panula P.

Neurobiol Dis. 2013 Jun;54:127-38. doi: 10.1016/j.nbd.2013.02.002. Epub 2013 Feb 27.


Presenilin1 regulates histamine neuron development and behavior in zebrafish, danio rerio.

Sundvik M, Chen YC, Panula P.

J Neurosci. 2013 Jan 23;33(4):1589-97. doi: 10.1523/JNEUROSCI.1802-12.2013.


Histamine release in the basal forebrain mediates cortical activation through cholinergic neurons.

Zant JC, Rozov S, Wigren HK, Panula P, Porkka-Heiskanen T.

J Neurosci. 2012 Sep 19;32(38):13244-54.

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