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Items: 1 to 50 of 90

1.

Hepcidin Therapeutics.

Katsarou A, Pantopoulos K.

Pharmaceuticals (Basel). 2018 Nov 21;11(4). pii: E127. doi: 10.3390/ph11040127. Review.

2.

Inherited Disorders of Iron Overload.

Pantopoulos K.

Front Nutr. 2018 Oct 29;5:103. doi: 10.3389/fnut.2018.00103. eCollection 2018. Review.

3.

Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling.

Fillebeen C, Wilkinson N, Charlebois E, Katsarou A, Wagner J, Pantopoulos K.

Blood. 2018 Oct 25;132(17):1829-1841. doi: 10.1182/blood-2018-03-841197. Epub 2018 Sep 13.

PMID:
30213871
4.

Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model.

Garcia-Santos D, Hamdi A, Saxova Z, Fillebeen C, Pantopoulos K, Horvathova M, Ponka P.

Blood. 2018 Jan 11;131(2):236-246. doi: 10.1182/blood-2017-07-798728. Epub 2017 Nov 27.

PMID:
29180398
5.

Serpinb3 is overexpressed in the liver in presence of iron overload.

Turato C, Kent P, Sebastiani G, Cannito S, Morello E, Terrin L, Biasiolo A, Simonato D, Parola M, Pantopoulos K, Pontisso P.

J Investig Med. 2018 Jan;66(1):32-38. doi: 10.1136/jim-2017-000473. Epub 2017 Sep 20.

PMID:
28935635
6.

Systemic iron homeostasis and erythropoiesis.

Papanikolaou G, Pantopoulos K.

IUBMB Life. 2017 Jun;69(6):399-413. doi: 10.1002/iub.1629. Epub 2017 Apr 6. Review.

7.

Pharmacological Targeting of the Hepcidin/Ferroportin Axis.

Sebastiani G, Wilkinson N, Pantopoulos K.

Front Pharmacol. 2016 Jun 21;7:160. doi: 10.3389/fphar.2016.00160. eCollection 2016. Review.

8.

Response to: Dietary and pharmacological factors affecting iron absorption in mice and man.

Fillebeen C, Gkouvatsos K, Fragoso G, Calvé A, Garcia-Santos D, Buffler M, Becker C, Schümann K, Ponka P, Santos MM, Pantopoulos K.

Haematologica. 2016 Mar;101(3):e122. doi: 10.3324/haematol.2015.139741. No abstract available.

9.

Mice are poor heme absorbers and do not require intestinal Hmox1 for dietary heme iron assimilation.

Fillebeen C, Gkouvatsos K, Fragoso G, Calvé A, Garcia-Santos D, Buffler M, Becker C, Schümann K, Ponka P, Santos MM, Pantopoulos K.

Haematologica. 2015 Sep;100(9):e334-7. doi: 10.3324/haematol.2015.126870. Epub 2015 May 14. No abstract available.

10.

Iron regulation of hepcidin through Hfe and Hjv: Common or distinct pathways?

Pantopoulos K.

Hepatology. 2015 Dec;62(6):1922-3. doi: 10.1002/hep.27777. Epub 2015 Apr 8. No abstract available.

PMID:
25761647
11.

TfR2 links iron metabolism and erythropoiesis.

Pantopoulos K.

Blood. 2015 Feb 12;125(7):1055-6. doi: 10.1182/blood-2014-12-617571. No abstract available.

12.

Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.

Kent P, Wilkinson N, Constante M, Fillebeen C, Gkouvatsos K, Wagner J, Buffler M, Becker C, Schümann K, Santos MM, Pantopoulos K.

J Mol Med (Berl). 2015 May;93(5):489-98. doi: 10.1007/s00109-015-1253-7. Epub 2015 Jan 23.

PMID:
25609138
13.

Electrophoretic mobility shift assay (EMSA) for the study of RNA-protein interactions: the IRE/IRP example.

Fillebeen C, Wilkinson N, Pantopoulos K.

J Vis Exp. 2014 Dec 3;(94). doi: 10.3791/52230.

14.

A high-fat diet modulates iron metabolism but does not promote liver fibrosis in hemochromatotic Hjv⁻/⁻ mice.

Padda RS, Gkouvatsos K, Guido M, Mui J, Vali H, Pantopoulos K.

Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G251-61. doi: 10.1152/ajpgi.00137.2014. Epub 2014 Dec 11.

15.

NTBI unveiled by chelatable fluorescent beads.

Sebastiani G, Pantopoulos K.

Biochem J. 2014 Nov 1;463(3):e7-9. doi: 10.1042/BJ20141083.

PMID:
25301074
16.

Chronic hepatitis C and liver fibrosis.

Sebastiani G, Gkouvatsos K, Pantopoulos K.

World J Gastroenterol. 2014 Aug 28;20(32):11033-53. doi: 10.3748/wjg.v20.i32.11033. Review.

17.

The IRP/IRE system in vivo: insights from mouse models.

Wilkinson N, Pantopoulos K.

Front Pharmacol. 2014 Jul 28;5:176. doi: 10.3389/fphar.2014.00176. eCollection 2014. Review.

18.

Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels.

Gkouvatsos K, Fillebeen C, Daba A, Wagner J, Sebastiani G, Pantopoulos K.

PLoS One. 2014 Jan 7;9(1):e85530. doi: 10.1371/journal.pone.0085530. eCollection 2014.

19.

Hepatitis C virus infection causes iron deficiency in Huh7.5.1 cells.

Fillebeen C, Pantopoulos K.

PLoS One. 2013 Dec 13;8(12):e83307. doi: 10.1371/journal.pone.0083307. eCollection 2013.

20.

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.

Wilkinson N, Pantopoulos K.

Blood. 2013 Aug 29;122(9):1658-68. doi: 10.1182/blood-2013-03-492454. Epub 2013 Jun 18.

21.

Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera.

Chachami G, Lyberopoulou A, Kalousi A, Paraskeva E, Pantopoulos K, Simos G.

Biochem Biophys Res Commun. 2013 Jun 14;435(4):540-5. doi: 10.1016/j.bbrc.2013.04.085. Epub 2013 May 8.

PMID:
23665013
22.

Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment.

Song W, Zukor H, Lin SH, Liberman A, Tavitian A, Mui J, Vali H, Fillebeen C, Pantopoulos K, Wu TD, Guerquin-Kern JL, Schipper HM.

J Neurochem. 2012 Oct;123(2):325-36. doi: 10.1111/j.1471-4159.2012.07914.x. Epub 2012 Sep 3.

23.

Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing.

Daba A, Gkouvatsos K, Sebastiani G, Pantopoulos K.

J Mol Med (Berl). 2013 Jan;91(1):95-102. doi: 10.1007/s00109-012-0937-5. Epub 2012 Jul 31.

PMID:
22847740
24.

Mechanisms of mammalian iron homeostasis.

Pantopoulos K, Porwal SK, Tartakoff A, Devireddy L.

Biochemistry. 2012 Jul 24;51(29):5705-24. doi: 10.1021/bi300752r. Epub 2012 Jul 9. Review.

25.

Alternative ferritin mRNA translation via internal initiation.

Daba A, Koromilas AE, Pantopoulos K.

RNA. 2012 Mar;18(3):547-56. doi: 10.1261/rna.029322.111. Epub 2012 Jan 23. Erratum in: RNA. 2012 Jun;18(6):1307.

26.
27.

Regulation of iron transport and the role of transferrin.

Gkouvatsos K, Papanikolaou G, Pantopoulos K.

Biochim Biophys Acta. 2012 Mar;1820(3):188-202. doi: 10.1016/j.bbagen.2011.10.013. Epub 2011 Nov 4. Review.

PMID:
22085723
28.

Accelerated CCl4-induced liver fibrosis in Hjv-/- mice, associated with an oxidative burst and precocious profibrogenic gene expression.

Sebastiani G, Gkouvatsos K, Maffettone C, Busatto G, Guido M, Pantopoulos K.

PLoS One. 2011;6(9):e25138. doi: 10.1371/journal.pone.0025138. Epub 2011 Sep 22.

29.

Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice.

Sebastiani G, Pantopoulos K.

Metallomics. 2011 Oct;3(10):971-86. doi: 10.1039/c1mt00082a. Epub 2011 Sep 7. Review.

PMID:
21901209
30.

Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin.

Gkouvatsos K, Wagner J, Papanikolaou G, Sebastiani G, Pantopoulos K.

Hepatology. 2011 Nov;54(5):1800-7. doi: 10.1002/hep.24547. Epub 2011 Aug 24.

PMID:
21748766
31.

Regulation of cellular iron metabolism.

Wang J, Pantopoulos K.

Biochem J. 2011 Mar 15;434(3):365-81. doi: 10.1042/BJ20101825. Review.

32.

Redox control of iron regulatory protein 2 stability.

Hausmann A, Lee J, Pantopoulos K.

FEBS Lett. 2011 Feb 18;585(4):687-92. doi: 10.1016/j.febslet.2011.01.036. Epub 2011 Feb 1.

33.

eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}.

Papadakis AI, Paraskeva E, Peidis P, Muaddi H, Li S, Raptis L, Pantopoulos K, Simos G, Koromilas AE.

Cancer Res. 2010 Oct 15;70(20):7820-9. doi: 10.1158/0008-5472.CAN-10-0215. Epub 2010 Oct 5.

34.

Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells.

Fillebeen C, Pantopoulos K.

J Hepatol. 2010 Dec;53(6):995-9. doi: 10.1016/j.jhep.2010.04.044. Epub 2010 Aug 1.

PMID:
20813419
35.

Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert.

Maffettone C, Chen G, Drozdov I, Ouzounis C, Pantopoulos K.

PLoS One. 2010 Apr 13;5(4):e10163. doi: 10.1371/journal.pone.0010163.

36.

Iron absorption and distribution in TNF(DeltaARE/+) mice, a model of chronic inflammation.

Schümann K, Herbach N, Kerling C, Seifert M, Fillebeen C, Prysch I, Reich J, Weiss G, Pantopoulos K.

J Trace Elem Med Biol. 2010 Jan;24(1):58-66. doi: 10.1016/j.jtemb.2009.10.002. Epub 2009 Nov 17.

PMID:
20122582
37.

HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues.

Zukor H, Song W, Liberman A, Mui J, Vali H, Fillebeen C, Pantopoulos K, Wu TD, Guerquin-Kern JL, Schipper HM.

J Neurochem. 2009 May;109(3):776-91. doi: 10.1111/j.1471-4159.2009.06007.x. Epub 2009 Feb 24.

38.

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.

Zimmer M, Ebert BL, Neil C, Brenner K, Papaioannou I, Melas A, Tolliday N, Lamb J, Pantopoulos K, Golub T, Iliopoulos O.

Mol Cell. 2008 Dec 26;32(6):838-48. doi: 10.1016/j.molcel.2008.12.004.

39.

Function of the hemochromatosis protein HFE: Lessons from animal models.

Pantopoulos K.

World J Gastroenterol. 2008 Dec 7;14(45):6893-901.

40.

A role for lysosomes in the turnover of human iron regulatory protein 2.

Dycke C, Charbonnier P, Pantopoulos K, Moulis JM.

Int J Biochem Cell Biol. 2008;40(12):2826-32. doi: 10.1016/j.biocel.2008.05.015. Epub 2008 Jun 5.

PMID:
18582596
41.

Iron regulatory and bactericidal properties of human recombinant hepcidin expressed in Pichia pastoris.

Koliaraki V, Marinou M, Samiotaki M, Panayotou G, Pantopoulos K, Mamalaki A.

Biochimie. 2008 May;90(5):726-35. doi: 10.1016/j.biochi.2008.01.012. Epub 2008 Feb 6.

PMID:
18295606
42.

Oxidative stress and iron homeostasis: mechanistic and health aspects.

Galaris D, Pantopoulos K.

Crit Rev Clin Lab Sci. 2008;45(1):1-23. doi: 10.1080/10408360701713104 . Review.

PMID:
18293179
43.

Insights on regulation and function of the iron regulatory protein 1 (IRP1).

Wang J, Chen G, Filebeen C, Pantopoulos K.

Hemoglobin. 2008;32(1-2):109-15. doi: 10.1080/03630260701680326.

PMID:
18274988
44.

Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity.

Wang J, Chen G, Lee J, Pantopoulos K.

BMC Mol Biol. 2008 Jan 28;9:15. doi: 10.1186/1471-2199-9-15.

45.

Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein.

Dycke C, Bougault C, Gaillard J, Andrieu JP, Pantopoulos K, Moulis JM.

Biochem J. 2007 Dec 15;408(3):429-39.

46.

Sustained hydrogen peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network.

Andriopoulos B, Hegedüsch S, Mangin J, Riedel HD, Hebling U, Wang J, Pantopoulos K, Mueller S.

J Biol Chem. 2007 Jul 13;282(28):20301-8. Epub 2007 May 21.

47.

Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells.

Fillebeen C, Muckenthaler M, Andriopoulos B, Bisaillon M, Mounir Z, Hentze MW, Koromilas AE, Pantopoulos K.

J Hepatol. 2007 Jul;47(1):12-22. Epub 2007 Mar 2.

PMID:
17399844
48.

Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway.

Wang J, Fillebeen C, Chen G, Biederbick A, Lill R, Pantopoulos K.

Mol Cell Biol. 2007 Apr;27(7):2423-30. Epub 2007 Jan 22.

49.

Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts.

Chen G, Fillebeen C, Wang J, Pantopoulos K.

Carcinogenesis. 2007 Apr;28(4):785-91. Epub 2006 Nov 24.

50.

In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin.

Nie G, Chen G, Sheftel AD, Pantopoulos K, Ponka P.

Blood. 2006 Oct 1;108(7):2428-34. Epub 2006 Jun 6.

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