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Amphiregulin in intestinal acute graft-versus-host disease: a possible diagnostic and prognostic aid.

Amin K, Yaqoob U, Schultz B, Vaughn BP, Khoruts A, Howard JR, DeFor TE, Forster C, Meyer C, Gandhi I, Weisdorf DJ, Rashidi A, MacMillan ML, Blazar BR, Panoskaltsis-Mortari A, Holtan SG.

Mod Pathol. 2018 Nov 13. doi: 10.1038/s41379-018-0170-z. [Epub ahead of print]


The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease.

McDonald-Hyman C, Muller JT, Loschi M, Thangavelu G, Saha A, Kumari S, Reichenbach DK, Smith MJ, Zhang G, Koehn BH, Lin J, Mitchell JS, Fife BT, Panoskaltsis-Mortari A, Feser CJ, Kirchmeier AK, Osborn MJ, Hippen KL, Kelekar A, Serody JS, Turka LA, Munn DH, Chi H, Neubert TA, Dustin ML, Blazar BR.

J Clin Invest. 2018 Oct 1;128(10):4604-4621. doi: 10.1172/JCI95713. Epub 2018 Aug 14.


CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates.

Watkins BK, Tkachev V, Furlan SN, Hunt DJ, Betz K, Yu A, Brown M, Poirier N, Zheng HB, Taraseviciute A, Colonna L, Mary C, Blancho G, Soulillou JP, Panoskaltsis-Mortari A, Sharma P, Garcia A, Strobert E, Hamby K, Garrett A, Deane T, Blazar BR, Vanhove B, Kean LS.

J Clin Invest. 2018 Aug 31;128(9):3991-4007. doi: 10.1172/JCI98793. Epub 2018 Aug 13.


Amphiregulin modifies the Minnesota Acute Graft-versus-Host Disease Risk Score: results from BMT CTN 0302/0802.

Holtan SG, DeFor TE, Panoskaltsis-Mortari A, Khera N, Levine JE, Flowers MED, Lee SJ, Inamoto Y, Chen GL, Mayer S, Arora M, Palmer J, Cutler CS, Arai S, Lazaryan A, Newell LF, Jagasia MH, Pusic I, Wood WA, Renteria AS, Yanik G, Hogan WJ, Hexner E, Ayuk F, Holler E, Bunworasate U, Efebera YA, Ferrara JLM, Pidala J, Howard A, Wu J, Bolaños-Meade J, Ho V, Alousi A, Blazar BR, Weisdorf DJ, MacMillan ML.

Blood Adv. 2018 Aug 14;2(15):1882-1888. doi: 10.1182/bloodadvances.2018017343.


Proopiomelanocortin (POMC) sequencing and developmental delay: Preliminary evidence for a SNP in the 3' UTR region of the POMC gene-Possible relevance for biological risk and self-injurious behavior.

Damerow JA, Tervo RC, Ehrhardt M, Panoskaltsis-Mortari A, Symons FJ.

Dev Psychopathol. 2018 Jul 16:1-6. doi: 10.1017/S0954579418000718. [Epub ahead of print]


Lung transplant after prolonged ex vivo lung perfusion: predictors of allograft function in swine.

Spratt JR, Mattison LM, Iaizzo PA, Meyer C, Brown RZ, Iles T, Panoskaltsis-Mortari A, Loor G.

Transpl Int. 2018 Dec;31(12):1405-1417. doi: 10.1111/tri.13315. Epub 2018 Jul 31.


Co-opting of by patient-funded studies.

Wagner DE, Turner L, Panoskaltsis-Mortari A, Weiss DJ, Ikonomou L.

Lancet Respir Med. 2018 Aug;6(8):579-581. doi: 10.1016/S2213-2600(18)30242-X. Epub 2018 Jun 19. No abstract available.


Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice.

Pennell CA, Barnum JL, McDonald-Hyman CS, Panoskaltsis-Mortari A, Riddle MJ, Xiong Z, Loschi M, Thangavelu G, Campbell HM, Storlie MD, Refaeli Y, Furlan SN, Jensen MC, Kean LS, Miller JS, Tolar J, Osborn MJ, Blazar BR.

Mol Ther. 2018 Jun 6;26(6):1423-1434. doi: 10.1016/j.ymthe.2018.04.006. Epub 2018 Apr 7.


Association of Cerebrospinal Fluid Biomarkers of Central Nervous System Injury With Neurocognitive and Brain Imaging Outcomes in Children Receiving Chemotherapy for Acute Lymphoblastic Leukemia.

Cheung YT, Khan RB, Liu W, Brinkman TM, Edelmann MN, Reddick WE, Pei D, Panoskaltsis-Mortari A, Srivastava D, Cheng C, Robison LL, Hudson MM, Pui CH, Krull KR.

JAMA Oncol. 2018 Jul 12;4(7):e180089. doi: 10.1001/jamaoncol.2018.0089. Epub 2018 Jul 12.


Targeted afferent renal denervation reduces arterial pressure but not renal inflammation in established DOCA-salt hypertension in the rat.

Banek CT, Gauthier MM, Baumann DC, Van Helden D, Asirvatham-Jeyaraj N, Panoskaltsis-Mortari A, Fink GD, Osborn JW.

Am J Physiol Regul Integr Comp Physiol. 2018 Jun 1;314(6):R883-R891. doi: 10.1152/ajpregu.00416.2017. Epub 2018 Mar 7.


Initial Observations of Salivary Brain-Derived Neurotrophic Factor Levels in Rett Syndrome.

Byiers B, Barney C, Ehrhardt M, Panoskaltsis-Mortari A, Feyma T, Beisang A, Symons FJ.

Pediatr Neurol. 2018 Mar;80:88-89. doi: 10.1016/j.pediatrneurol.2017.11.005. Epub 2017 Dec 8. No abstract available.


Haploidentical natural killer cells induce remissions in non-Hodgkin lymphoma patients with low levels of immune-suppressor cells.

Bachanova V, Sarhan D, DeFor TE, Cooley S, Panoskaltsis-Mortari A, Blazar BR, Curtsinger JM, Burns L, Weisdorf DJ, Miller JS.

Cancer Immunol Immunother. 2018 Mar;67(3):483-494. doi: 10.1007/s00262-017-2100-1. Epub 2017 Dec 7.


Cytokine Profiles of Severe Influenza Virus-Related Complications in Children.

Fiore-Gartland A, Panoskaltsis-Mortari A, Agan AA, Mistry AJ, Thomas PG, Matthay MA; PALISI PICFlu Investigators, Hertz T, Randolph AG.

Front Immunol. 2017 Nov 6;8:1423. doi: 10.3389/fimmu.2017.01423. eCollection 2017.


Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes.

Burwitz BJ, Wu HL, Abdulhaqq S, Shriver-Munsch C, Swanson T, Legasse AW, Hammond KB, Junell SL, Reed JS, Bimber BN, Greene JM, Webb GM, Northrup M, Laub W, Kievit P, MacAllister R, Axthelm MK, Ducore R, Lewis A, Colgin LMA, Hobbs T, Martin LD, Ferguson B, Thomas CR Jr, Panoskaltsis-Mortari A, Meyers G, Stanton JJ, Maziarz RT, Sacha JB.

Nat Commun. 2017 Nov 10;8(1):1418. doi: 10.1038/s41467-017-01631-z.


Donor and recipient plasma follistatin levels are associated with acute GvHD in Blood and Marrow Transplant Clinical Trials Network 0402.

Turcotte LM, DeFor TE, Newell LF, Cutler CS, Verneris MR, Wu J, Howard A, MacMillan ML, Antin JH, Vercellotti GM, Slungaard A, Blazar BR, Weisdorf DJ, Panoskaltsis-Mortari A, Holtan SG.

Bone Marrow Transplant. 2018 Jan;53(1):64-68. doi: 10.1038/bmt.2017.236. Epub 2017 Oct 23.


Mesenchymal stem cells in the pathogenesis and treatment of bronchopulmonary dysplasia: a clinical review.

Simones AA, Beisang DJ, Panoskaltsis-Mortari A, Roberts KD.

Pediatr Res. 2018 Jan;83(1-2):308-317. doi: 10.1038/pr.2017.237. Epub 2017 Oct 25. Review.


Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant.

Tkachev V, Furlan SN, Watkins B, Hunt DJ, Zheng HB, Panoskaltsis-Mortari A, Betz K, Brown M, Schell JB, Zeleski K, Yu A, Kirby I, Cooley S, Miller JS, Blazar BR, Casson D, Bland-Ward P, Kean LS.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaan3085. doi: 10.1126/scitranslmed.aan3085.


Early assessment of dosimetric and biological differences of total marrow irradiation versus total body irradiation in rodents.

Hui S, Takahashi Y, Holtan SG, Azimi R, Seelig D, Yagi M, Ingvalson J, Alaei P, Sharkey L, Kodal B, Peterson N, Meyer C, Godin L, Ehrhardt M, Storme G, Zhou D, Panoskaltsis-Mortari A.

Radiother Oncol. 2017 Sep;124(3):468-474. doi: 10.1016/j.radonc.2017.07.018. Epub 2017 Aug 1.


Tracheal Cartilage Isolation and Decellularization.

Galliger Z, Panoskaltsis-Mortari A.

Methods Mol Biol. 2018;1577:155-160. doi: 10.1007/7651_2017_52.


Decellularization of Intact Lung Tissue Through Vasculature and Airways Using Negative and Positive Pressure.

Skolasinski S, Panoskaltsis-Mortari A.

Methods Mol Biol. 2018;1577:307-315. doi: 10.1007/7651_2017_32.


Low EGF in myeloablative allotransplantation: association with severe acute GvHD in BMT CTN 0402.

Holtan SG, Newell LF, Cutler C, Verneris MR, DeFor TE, Wu J, Howard A, MacMillan ML, Antin JH, Blazar BR, Weisdorf DJ, Panoskaltsis-Mortari A.

Bone Marrow Transplant. 2017 Sep;52(9):1300-1303. doi: 10.1038/bmt.2017.89. Epub 2017 Jun 5.


An experimental study of the recovery of injured porcine lungs with prolonged normothermic cellular ex vivo lung perfusion following donation after circulatory death.

Spratt JR, Mattison LM, Iaizzo PA, Brown RZ, Helms H, Iles TL, Howard B, Panoskaltsis-Mortari A, Loor G.

Transpl Int. 2017 Sep;30(9):932-944. doi: 10.1111/tri.12981. Epub 2017 Jul 19.


Large-conductance Ca2+ -activated K+ channel activation by apical P2Y receptor agonists requires hydrocortisone in differentiated airway epithelium.

Zaidman NA, Panoskaltsis-Mortari A, O'Grady SM.

J Physiol. 2017 Jul 15;595(14):4631-4645. doi: 10.1113/JP274200. Epub 2017 Jun 11.


Soluble MICA is elevated in pancreatic cancer: Results from a population based case-control study.

Onyeaghala G, Nelson HH, Thyagarajan B, Linabery AM, Panoskaltsis-Mortari A, Gross M, Anderson KE, Prizment AE.

Mol Carcinog. 2017 Sep;56(9):2158-2164. doi: 10.1002/mc.22667. Epub 2017 May 24.


Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop.

Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR.

JCI Insight. 2017 May 4;2(9). pii: 93121. doi: 10.1172/jci.insight.93121. [Epub ahead of print] Review.


Impact of sleep, fatigue, and systemic inflammation on neurocognitive and behavioral outcomes in long-term survivors of childhood acute lymphoblastic leukemia.

Cheung YT, Brinkman TM, Mulrooney DA, Mzayek Y, Liu W, Banerjee P, Panoskaltsis-Mortari A, Srivastava D, Pui CH, Robison LL, Hudson MM, Krull KR.

Cancer. 2017 Sep 1;123(17):3410-3419. doi: 10.1002/cncr.30742. Epub 2017 Apr 27.


Invariant natural killer T cells ameliorate murine chronic GVHD by expanding donor regulatory T cells.

Du J, Paz K, Thangavelu G, Schneidawind D, Baker J, Flynn R, Duramad O, Feser C, Panoskaltsis-Mortari A, Negrin RS, Blazar BR.

Blood. 2017 Jun 8;129(23):3121-3125. doi: 10.1182/blood-2016-11-752444. Epub 2017 Apr 17.


Unproven Stem Cell Treatments for Lung Disease-An Emerging Public Health Problem.

Ikonomou L, Panoskaltsis-Mortari A, Wagner DE, Freishtat RJ, Weiss DJ; American Thoracic Society Respiratory Cell and Molecular Biology Assembly Stem Cell Working Group.

Am J Respir Crit Care Med. 2017 Apr 1;195(7):P13-P14. doi: 10.1164/rccm.1957P13. No abstract available.


Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production.

Du J, Paz K, Flynn R, Vulic A, Robinson TM, Lineburg KE, Alexander KA, Meng J, Roy S, Panoskaltsis-Mortari A, Loschi M, Hill GR, Serody JS, Maillard I, Miklos D, Koreth J, Cutler CS, Antin JH, Ritz J, MacDonald KP, Schacker TW, Luznik L, Blazar BR.

Blood. 2017 May 4;129(18):2570-2580. doi: 10.1182/blood-2017-01-758854. Epub 2017 Mar 2.


Targeting the Canonical Nuclear Factor-κB Pathway with a High-Potency IKK2 Inhibitor Improves Outcomes in a Mouse Model of Idiopathic Pneumonia Syndrome.

Fowler KA, Jania CM, Tilley SL, Panoskaltsis-Mortari A, Baldwin AS, Serody JS, Coghill JM.

Biol Blood Marrow Transplant. 2017 Apr;23(4):569-580. doi: 10.1016/j.bbmt.2017.01.083. Epub 2017 Feb 1.


Prolonged EVLP Using OCS Lung: Cellular and Acellular Perfusates.

Loor G, Howard BT, Spratt JR, Mattison LM, Panoskaltsis-Mortari A, Brown RZ, Iles TL, Meyer CM, Helms HR, Price A, Iaizzo PA.

Transplantation. 2017 Oct;101(10):2303-2311. doi: 10.1097/TP.0000000000001616.


Low day +100 serum epidermal growth factor levels are associated with acute GvHD after allogeneic hematopoietic cell transplantation.

He F, Verneris MR, Cooley S, Blazar BR, MacMillan ML, Newell LF, Panoskaltsis-Mortari A, DeFor T, Weisdorf DJ, Holtan SG.

Bone Marrow Transplant. 2017 Feb;52(2):301-303. doi: 10.1038/bmt.2016.261. Epub 2016 Nov 21. No abstract available.


Induction of Major Histocompatibility Complex-mismatched Mouse Lung Allograft Acceptance With Combined Donor Bone Marrow: Lung Transplant Using a 12-Hour Nonmyeloablative Conditioning Regimen.

Dodd-O JM, Ganguly S, Vulic A, Panoskaltsis-Mortari A, McDyer JF, Luznik L.

Transplantation. 2016 Dec;100(12):e140-e146. doi: 10.1097/TP.0000000000001480.


Preclinical Testing of Antihuman CD28 Fab' Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease.

Hippen KL, Watkins B, Tkachev V, Lemire AM, Lehnen C, Riddle MJ, Singh K, Panoskaltsis-Mortari A, Vanhove B, Tolar J, Kean LS, Blazar BR.

Transplantation. 2016 Dec;100(12):2630-2639. doi: 10.1097/TP.0000000000001465.


Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells.

Furlan SN, Watkins B, Tkachev V, Cooley S, Panoskaltsis-Mortari A, Betz K, Brown M, Hunt DJ, Schell JB, Zeleski K, Yu A, Giver CR, Waller EK, Miller JS, Blazar BR, Kean LS.

Blood. 2016 Nov 24;128(21):2568-2579. Epub 2016 Oct 6.


Late acute graft-versus-host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors.

Holtan SG, Khera N, Levine JE, Chai X, Storer B, Liu HD, Inamoto Y, Chen GL, Mayer S, Arora M, Palmer J, Flowers MED, Cutler CS, Lukez A, Arai S, Lazaryan A, Newell LF, Krupski C, Jagasia MH, Pusic I, Wood W, Renteria AS, Yanik G, Hogan WJ, Hexner E, Ayuk F, Holler E, Watanaboonyongcharoen P, Efebera YA, Ferrara JLM, Panoskaltsis-Mortari A, Weisdorf D, Lee SJ, Pidala J.

Blood. 2016 Nov 10;128(19):2350-2358. doi: 10.1182/blood-2015-09-669846. Epub 2016 Sep 13.


Renal Denervation Normalizes Arterial Pressure With No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice.

Asirvatham-Jeyaraj N, Fiege JK, Han R, Foss J, Banek CT, Burbach BJ, Razzoli M, Bartolomucci A, Shimizu Y, Panoskaltsis-Mortari A, Osborn JW.

Hypertension. 2016 Oct;68(4):929-36. doi: 10.1161/HYPERTENSIONAHA.116.07993. Epub 2016 Aug 22.


The Global Emergence of Unregulated Stem Cell Treatments for Respiratory Diseases. Professional Societies Need to Act.

Ikonomou L, Freishtat RJ, Wagner DE, Panoskaltsis-Mortari A, Weiss DJ.

Ann Am Thorac Soc. 2016 Aug;13(8):1205-7. doi: 10.1513/AnnalsATS.201604-277ED. No abstract available.


Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner.

McDonald-Hyman C, Flynn R, Panoskaltsis-Mortari A, Peterson N, MacDonald KP, Hill GR, Luznik L, Serody JS, Murphy WJ, Maillard I, Munn DH, Turka LA, Koreth J, Cutler CS, Soiffer RJ, Antin JH, Ritz J, Blazar BR.

Blood. 2016 Aug 18;128(7):1013-7. doi: 10.1182/blood-2016-05-715896. Epub 2016 Jul 6.


Differentiation of human bronchial epithelial cells: role of hydrocortisone in development of ion transport pathways involved in mucociliary clearance.

Zaidman NA, Panoskaltsis-Mortari A, O'Grady SM.

Am J Physiol Cell Physiol. 2016 Aug 1;311(2):C225-36. doi: 10.1152/ajpcell.00073.2016. Epub 2016 Jun 15.


Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.

Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, Ranganathan P, Devine SM, Burrill JS, Guo L, Sacristan C, Snyder NW, Blair IA, Milone MC, Dustin ML, Riley JL, Bernlohr DA, Murphy WJ, Fife BT, Munn DH, Miller JS, Serody JS, Freeman GJ, Sharpe AH, Turka LA, Blazar BR.

J Clin Invest. 2016 Jul 1;126(7):2642-60. doi: 10.1172/JCI85796. Epub 2016 Jun 13.


Proteome Profiling in Lung Injury after Hematopoietic Stem Cell Transplantation.

Bhargava M, Viken KJ, Dey S, Steinbach MS, Wu B, Jagtap PD, Higgins L, Panoskaltsis-Mortari A, Weisdorf DJ, Kumar V, Arora M, Bitterman PB, Ingbar DH, Wendt CH.

Biol Blood Marrow Transplant. 2016 Aug;22(8):1383-1390. doi: 10.1016/j.bbmt.2016.04.021. Epub 2016 May 5.


Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism.

Flynn R, Paz K, Du J, Reichenbach DK, Taylor PA, Panoskaltsis-Mortari A, Vulic A, Luznik L, MacDonald KK, Hill GR, Nyuydzefe MS, Weiss JM, Chen W, Trzeciak A, Serody JS, Aguilar EG, Murphy WJ, Maillard I, Munn D, Koreth J, Cutler CS, Antin JH, Ritz J, Waksal SD, Zanin-Zhorov A, Blazar BR.

Blood. 2016 Apr 28;127(17):2144-54. doi: 10.1182/blood-2015-10-678706. Epub 2016 Mar 16.


Decreased Laminin Expression by Human Lung Epithelial Cells and Fibroblasts Cultured in Acellular Lung Scaffolds from Aged Mice.

Godin LM, Sandri BJ, Wagner DE, Meyer CM, Price AP, Akinnola I, Weiss DJ, Panoskaltsis-Mortari A.

PLoS One. 2016 Mar 8;11(3):e0150966. doi: 10.1371/journal.pone.0150966. eCollection 2016.


IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function.

Vallera DA, Felices M, McElmurry R, McCullar V, Zhou X, Schmohl JU, Zhang B, Lenvik AJ, Panoskaltsis-Mortari A, Verneris MR, Tolar J, Cooley S, Weisdorf DJ, Blazar BR, Miller JS.

Clin Cancer Res. 2016 Jul 15;22(14):3440-50. doi: 10.1158/1078-0432.CCR-15-2710. Epub 2016 Feb 4.


Urinary-derived human chorionic gonadotropin to induce tolerance and promote healing in steroid-refractory GvHD.

Holtan SG, Panoskaltsis-Mortari A.

Bone Marrow Transplant. 2016 Jan;51(1):142-3. doi: 10.1038/bmt.2015.220. Epub 2015 Sep 21. No abstract available.


Differential Induction of Type I and Type III Interferons by Swine and Human Origin H1N1 Influenza A Viruses in Porcine Airway Epithelial Cells.

Krishna VD, Roach E, Zaidman NA, Panoskaltsis-Mortari A, Rotschafer JH, O'Grady SM, Cheeran MC.

PLoS One. 2015 Sep 18;10(9):e0138704. doi: 10.1371/journal.pone.0138704. eCollection 2015.


Critically Ill Children Have Low Vitamin D-Binding Protein, Influencing Bioavailability of Vitamin D.

Madden K, Feldman HA, Chun RF, Smith EM, Sullivan RM, Agan AA, Keisling SM, Panoskaltsis-Mortari A, Randolph AG.

Ann Am Thorac Soc. 2015 Nov;12(11):1654-61. doi: 10.1513/AnnalsATS.201503-160OC.


Effect of oral and vaginal hormonal contraceptives on inflammatory blood biomarkers.

Divani AA, Luo X, Datta YH, Flaherty JD, Panoskaltsis-Mortari A.

Mediators Inflamm. 2015;2015:379501. doi: 10.1155/2015/379501. Epub 2015 Mar 16.


Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease.

Flynn R, Allen JL, Luznik L, MacDonald KP, Paz K, Alexander KA, Vulic A, Du J, Panoskaltsis-Mortari A, Taylor PA, Poe JC, Serody JS, Murphy WJ, Hill GR, Maillard I, Koreth J, Cutler CS, Soiffer RJ, Antin JH, Ritz J, Chao NJ, Clynes RA, Sarantopoulos S, Blazar BR.

Blood. 2015 Jun 25;125(26):4085-94. doi: 10.1182/blood-2014-08-595470. Epub 2015 Apr 7.

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