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Items: 31


Understanding the genetics behind complex human disease with large-scale iPSC collections.

Yamasaki AE, Panopoulos AD, Belmonte JCI.

Genome Biol. 2017 Jul 20;18(1):135. doi: 10.1186/s13059-017-1276-1.


High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells.

D'Antonio M, Woodruff G, Nathanson JL, D'Antonio-Chronowska A, Arias A, Matsui H, Williams R, Herrera C, Reyna SM, Yeo GW, Goldstein LSB, Panopoulos AD, Frazer KA.

Stem Cell Reports. 2017 Apr 11;8(4):1101-1111. doi: 10.1016/j.stemcr.2017.03.011.


iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types.

Panopoulos AD, D'Antonio M, Benaglio P, Williams R, Hashem SI, Schuldt BM, DeBoever C, Arias AD, Garcia M, Nelson BC, Harismendy O, Jakubosky DA, Donovan MKR, Greenwald WW, Farnam K, Cook M, Borja V, Miller CA, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Aguirre A, McGarry TJ, Matsui H, Li H, Reyna J, Rao F, O'Connor DT, Yeo GW, Evans SM, Chi NC, Jepsen K, Nariai N, Müller FJ, Goldstein LSB, Izpisua Belmonte JC, Adler E, Loring JF, Berggren WT, D'Antonio-Chronowska A, Smith EN, Frazer KA.

Stem Cell Reports. 2017 Apr 11;8(4):1086-1100. doi: 10.1016/j.stemcr.2017.03.012.


Aberrant DNA Methylation in Human iPSCs Associates with MYC-Binding Motifs in a Clone-Specific Manner Independent of Genetics.

Panopoulos AD, Smith EN, Arias AD, Shepard PJ, Hishida Y, Modesto V, Diffenderfer KE, Conner C, Biggs W, Sandoval E, D'Antonio-Chronowska A, Berggren WT, Izpisua Belmonte JC, Frazer KA.

Cell Stem Cell. 2017 Apr 6;20(4):505-517.e6. doi: 10.1016/j.stem.2017.03.010.


Brief Report: Oxidative Stress Mediates Cardiomyocyte Apoptosis in a Human Model of Danon Disease and Heart Failure.

Hashem SI, Perry CN, Bauer M, Han S, Clegg SD, Ouyang K, Deacon DC, Spinharney M, Panopoulos AD, Izpisua Belmonte JC, Frazer KA, Chen J, Gong Q, Zhou Z, Chi NC, Adler ED.

Stem Cells. 2015 Jul;33(7):2343-50. doi: 10.1002/stem.2015. Epub 2015 May 13.


Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming.

Ruiz S, Gore A, Li Z, Panopoulos AD, Montserrat N, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Schöler HR, Zhang K, Izpisua Belmonte JC.

Nat Commun. 2013;4:1382. doi: 10.1038/ncomms2381.


Generation of a drug-inducible reporter system to study cell reprogramming in human cells.

Ruiz S, Panopoulos AD, Montserrat N, Multon MC, Daury A, Rocher C, Spanakis E, Batchelder EM, Orsini C, Deleuze JF, Izpisua Belmonte JC.

J Biol Chem. 2012 Nov 23;287(48):40767-78. doi: 10.1074/jbc.M112.384024. Epub 2012 Sep 27.


Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells.

Ruiz S, Diep D, Gore A, Panopoulos AD, Montserrat N, Plongthongkum N, Kumar S, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Kan NG, Schöler HR, Mercola M, Zhang K, Izpisua Belmonte JC.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16196-201. doi: 10.1073/pnas.1202352109. Epub 2012 Sep 18.


Induced pluripotent stem cells in clinical hematology: potentials, progress, and remaining obstacles.

Panopoulos AD, Belmonte JC.

Curr Opin Hematol. 2012 Jul;19(4):256-60. doi: 10.1097/MOH.0b013e328353c78f. Review.


The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming.

Panopoulos AD, Yanes O, Ruiz S, Kida YS, Diep D, Tautenhahn R, Herrerías A, Batchelder EM, Plongthongkum N, Lutz M, Berggren WT, Zhang K, Evans RM, Siuzdak G, Izpisua Belmonte JC.

Cell Res. 2012 Jan;22(1):168-77. doi: 10.1038/cr.2011.177. Epub 2011 Nov 8.


Anaerobicizing into pluripotency.

Panopoulos AD, Izpisua Belmonte JC.

Cell Metab. 2011 Aug 3;14(2):143-4. doi: 10.1016/j.cmet.2011.07.003.


Rapid and highly efficient generation of induced pluripotent stem cells from human umbilical vein endothelial cells.

Panopoulos AD, Ruiz S, Yi F, Herrerías A, Batchelder EM, Izpisua Belmonte JC.

PLoS One. 2011;6(5):e19743. doi: 10.1371/journal.pone.0019743. Epub 2011 May 16.


iPSCs: induced back to controversy.

Panopoulos AD, Ruiz S, Izpisua Belmonte JC.

Cell Stem Cell. 2011 Apr 8;8(4):347-8. doi: 10.1016/j.stem.2011.03.003.


Somatic coding mutations in human induced pluripotent stem cells.

Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K.

Nature. 2011 Mar 3;471(7336):63-7. doi: 10.1038/nature09805.


Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome.

Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Yates J 3rd, Izpisua Belmonte JC.

Nature. 2011 Apr 14;472(7342):221-5. doi: 10.1038/nature09879. Epub 2011 Feb 23.


High-efficient generation of induced pluripotent stem cells from human astrocytes.

Ruiz S, Brennand K, Panopoulos AD, Herrerías A, Gage FH, Izpisua-Belmonte JC.

PLoS One. 2010 Dec 9;5(12):e15526. doi: 10.1371/journal.pone.0015526.


A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity.

Ruiz S, Panopoulos AD, Herrerías A, Bissig KD, Lutz M, Berggren WT, Verma IM, Izpisua Belmonte JC.

Curr Biol. 2011 Jan 11;21(1):45-52. doi: 10.1016/j.cub.2010.11.049. Epub 2010 Dec 17.


STAT3 controls myeloid progenitor growth during emergency granulopoiesis.

Zhang H, Nguyen-Jackson H, Panopoulos AD, Li HS, Murray PJ, Watowich SS.

Blood. 2010 Oct 7;116(14):2462-71. doi: 10.1182/blood-2009-12-259630. Epub 2010 Jun 25.


STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction.

Nguyen-Jackson H, Panopoulos AD, Zhang H, Li HS, Watowich SS.

Blood. 2010 Apr 22;115(16):3354-63. doi: 10.1182/blood-2009-08-240317. Epub 2010 Feb 25.


Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways.

Kelber JA, Panopoulos AD, Shani G, Booker EC, Belmonte JC, Vale WW, Gray PC.

Oncogene. 2009 Jun 18;28(24):2324-36. doi: 10.1038/onc.2009.97. Epub 2009 May 4.


CCR6 regulates the migration of inflammatory and regulatory T cells.

Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, Pappu B, Martin-Orozco N, Kang HS, Ma L, Panopoulos AD, Craig S, Watowich SS, Jetten AM, Tian Q, Dong C.

J Immunol. 2008 Dec 15;181(12):8391-401.


Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis.

Panopoulos AD, Watowich SS.

Cytokine. 2008 Jun;42(3):277-88. doi: 10.1016/j.cyto.2008.03.002. Epub 2008 Apr 8. Review.


T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma.

Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C.

Immunity. 2008 Jan;28(1):29-39. doi: 10.1016/j.immuni.2007.11.016. Epub 2007 Dec 27.


Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.

El Kasmi KC, Smith AM, Williams L, Neale G, Panopoulos AD, Watowich SS, Häcker H, Foxwell BM, Murray PJ.

J Immunol. 2007 Dec 1;179(11):7215-9. Erratum in: J Immunol. 2008 Mar 1;180(5):3612. Panopolous, Athanasia [corrected to Panopoulos, Athanasia D].


Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.

Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C.

Nature. 2007 Jul 26;448(7152):480-3. Epub 2007 Jun 20.


Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia.

Kile BT, Panopoulos AD, Stirzaker RA, Hacking DF, Tahtamouni LH, Willson TA, Mielke LA, Henley KJ, Zhang JG, Wicks IP, Stevenson WS, Nurden P, Watowich SS, Justice MJ.

Blood. 2007 Oct 1;110(7):2371-80. Epub 2007 May 21.


STAT3 regulates cytokine-mediated generation of inflammatory helper T cells.

Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C.

J Biol Chem. 2007 Mar 30;282(13):9358-63. Epub 2007 Feb 3.


STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils.

Panopoulos AD, Zhang L, Snow JW, Jones DM, Smith AM, El Kasmi KC, Liu F, Goldsmith MA, Link DC, Murray PJ, Watowich SS.

Blood. 2006 Dec 1;108(12):3682-90. Epub 2006 Aug 3.


IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages.

Butcher BA, Kim L, Panopoulos AD, Watowich SS, Murray PJ, Denkers EY.

J Immunol. 2005 Mar 15;174(6):3148-52.


Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1.

Panopoulos AD, Bartos D, Zhang L, Watowich SS.

J Biol Chem. 2002 May 24;277(21):19001-7. Epub 2002 Mar 11.


Structure-activity relationships for 5-substituted 1-phenylbenzimidazoles as selective inhibitors of the platelet-derived growth factor receptor.

Palmer BD, Kraker AJ, Hartl BG, Panopoulos AD, Panek RL, Batley BL, Lu GH, Trumpp-Kallmeyer S, Showalter HD, Denny WA.

J Med Chem. 1999 Jul 1;42(13):2373-82.


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