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Items: 1 to 50 of 72

1.

Suppression of Hepatocellular Carcinoma by Mycophenolic Acid in Experimental Models and in Patients.

Chen K, Sheng J, Ma B, Cao W, Hernanda PY, Liu J, Boor PPC, Tjon ASW, Felczak K, Sprengers D, Pankiewicz KW, Metselaar HJ, Ma Z, Kwekkeboom J, Peppelenbosch MP, Pan Q.

Transplantation. 2019 May;103(5):929-937. doi: 10.1097/TP.0000000000002647.

PMID:
30747839
2.

Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication.

Dang W, Yin Y, Wang Y, Wang W, Su J, Sprengers D, van der Laan LJW, Felczak K, Pankiewicz KW, Chang KO, Koopmans MPG, Metselaar HJ, Peppelenbosch MP, Pan Q.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01095-17. doi: 10.1128/AAC.01095-17. Print 2017 Nov.

3.

Mycophenolic acid potently inhibits rotavirus infection with a high barrier to resistance development.

Yin Y, Wang Y, Dang W, Xu L, Su J, Zhou X, Wang W, Felczak K, van der Laan LJ, Pankiewicz KW, van der Eijk AA, Bijvelds M, Sprengers D, de Jonge H, Koopmans MP, Metselaar HJ, Peppelenbosch MP, Pan Q.

Antiviral Res. 2016 Sep;133:41-9. doi: 10.1016/j.antiviral.2016.07.017. Epub 2016 Jul 25.

PMID:
27468950
4.

Cross Talk between Nucleotide Synthesis Pathways with Cellular Immunity in Constraining Hepatitis E Virus Replication.

Wang Y, Wang W, Xu L, Zhou X, Shokrollahi E, Felczak K, van der Laan LJ, Pankiewicz KW, Sprengers D, Raat NJ, Metselaar HJ, Peppelenbosch MP, Pan Q.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2834-48. doi: 10.1128/AAC.02700-15. Print 2016 May.

5.

Nucleoside/tide Analogues in Modern Drug Design.

Pankiewicz KW.

Curr Med Chem. 2015;22(34):3864-5. No abstract available.

PMID:
26597060
6.

Nicotinamide Adenine Dinucleotide Based Therapeutics, Update.

Pankiewicz KW, Petrelli R, Singh R, Felczak K.

Curr Med Chem. 2015;22(34):3991-4028. Review.

PMID:
26295463
7.

NAD-based inhibitors with anticancer potential.

Felczak K, Vince R, Pankiewicz KW.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):332-6. doi: 10.1016/j.bmcl.2013.11.005. Epub 2013 Nov 14.

PMID:
24269162
8.

A second target of benzamide riboside: dihydrofolate reductase.

Roussel B, Johnson-Farley N, Kerrigan JE, Scotto KW, Banerjee D, Felczak K, Pankiewicz KW, Gounder M, Lin H, Abali EE, Bertino JR.

Cancer Biol Ther. 2012 Nov;13(13):1290-8. doi: 10.4161/cbt.21786. Epub 2012 Sep 6.

9.

Synthesis of methylenebis(phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide.

Felczak K, Pankiewicz KW.

Nucleosides Nucleotides Nucleic Acids. 2011 Jul-Aug;30(7-8):512-23. doi: 10.1080/15257770.2011.575909.

PMID:
21888543
10.

NAD and its role in biology and medicine.

Pankiewicz KW.

Curr Med Chem. 2011;18(13):1890. No abstract available.

PMID:
21517782
11.

Rehab of NAD(P)-dependent enzymes with NAD(P)-based inhibitors.

Felczak K, Pankiewicz KW.

Curr Med Chem. 2011;18(13):1891-908. Review.

PMID:
21517781
12.

Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.

Felczak K, Chen L, Wilson D, Williams J, Vince R, Petrelli R, Jayaram HN, Kusumanchi P, Kumar M, Pankiewicz KW.

Bioorg Med Chem. 2011 Mar 1;19(5):1594-605. doi: 10.1016/j.bmc.2011.01.042. Epub 2011 Jan 27.

PMID:
21324702
13.

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure.

Chen L, Petrelli R, Gao G, Wilson DJ, McLean GT, Jayaram HN, Sham YY, Pankiewicz KW.

Bioorg Med Chem. 2010 Aug 15;18(16):5950-64. doi: 10.1016/j.bmc.2010.06.081. Epub 2010 Jul 1.

PMID:
20650640
14.

Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis.

Chen L, Wilson DJ, Xu Y, Aldrich CC, Felczak K, Sham YY, Pankiewicz KW.

J Med Chem. 2010 Jun 24;53(12):4768-78. doi: 10.1021/jm100424m.

15.

Prodrug activation by Cryptosporidium thymidine kinase.

Sun XE, Sharling L, Muthalagi M, Mudeppa DG, Pankiewicz KW, Felczak K, Rathod PK, Mead J, Striepen B, Hedstrom L.

J Biol Chem. 2010 May 21;285(21):15916-22. doi: 10.1074/jbc.M110.101543. Epub 2010 Mar 15.

16.

Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.

Petrelli R, Sham YY, Chen L, Felczak K, Bennett E, Wilson D, Aldrich C, Yu JS, Cappellacci L, Franchetti P, Grifantini M, Mazzola F, Di Stefano M, Magni G, Pankiewicz KW.

Bioorg Med Chem. 2009 Aug 1;17(15):5656-64. doi: 10.1016/j.bmc.2009.06.013. Epub 2009 Jun 13.

PMID:
19596199
17.

Technical aspects of imaging and transfemoral arterial treatment of N1-S1 tumors in rats: an appropriate model to test the biology and therapeutic response to transarterial treatments of liver cancers.

Ju S, McLennan G, Bennett SL, Liang Y, Bonnac L, Pankiewicz KW, Jayaram HN.

J Vasc Interv Radiol. 2009 Mar;20(3):410-4. doi: 10.1016/j.jvir.2008.12.408. Epub 2009 Jan 23.

PMID:
19167243
18.

A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor.

Zou G, Puig-Basagoiti F, Zhang B, Qing M, Chen L, Pankiewicz KW, Felczak K, Yuan Z, Shi PY.

Virology. 2009 Feb 5;384(1):242-52. doi: 10.1016/j.virol.2008.11.003. Epub 2008 Dec 5.

19.

Mycophenolic acid analogs with a modified metabolic profile.

Chen L, Wilson DJ, Labello NP, Jayaram HN, Pankiewicz KW.

Bioorg Med Chem. 2008 Oct 15;16(20):9340-5. doi: 10.1016/j.bmc.2008.08.062. Epub 2008 Aug 29.

PMID:
18809333
20.

Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase.

Chen L, Petrelli R, Olesiak M, Wilson DJ, Labello NP, Pankiewicz KW.

Bioorg Med Chem. 2008 Aug 1;16(15):7462-9. doi: 10.1016/j.bmc.2008.06.003. Epub 2008 Jun 10.

PMID:
18583139
21.

Synthesis of methylenebis(phosphonate) analogs of dinucleotide pyrophosphates.

Pankiewicz KW, Gao G, Patterson SE.

Curr Protoc Nucleic Acid Chem. 2006 Apr;Chapter 13:Unit 13.5. doi: 10.1002/0471142700.nc1305s24.

PMID:
18428948
22.

Nucleoside-5'-phosphoimidazolides: reagents for facile synthesis of dinucleoside pyrophosphates.

Chen L, Rejman D, Bonnac L, Pankiewicz KW, Patterson SE.

Curr Protoc Nucleic Acid Chem. 2006 Jan;Chapter 13:Unit 13.4. doi: 10.1002/0471142700.nc1304s23.

PMID:
18428947
23.

Nicotinamide adenine dinucleotide based therapeutics.

Chen L, Petrelli R, Felczak K, Gao G, Bonnac L, Yu JS, Bennett EM, Pankiewicz KW.

Curr Med Chem. 2008;15(7):650-70. Review.

PMID:
18336280
24.

Efficient synthesis of benzamide riboside, a potential anticancer agent.

Bonnac LF, Gao GY, Chen L, Patterson SE, Jayaram HN, Pankiewicz KW.

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1249-53.

PMID:
18066762
25.

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.

Chen L, Wilson D, Jayaram HN, Pankiewicz KW.

J Med Chem. 2007 Dec 27;50(26):6685-91. Epub 2007 Nov 27.

PMID:
18038969
26.

Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.

Chen L, Gao G, Felczak K, Bonnac L, Patterson SE, Wilson D, Bennett EM, Jayaram HN, Hedstrom L, Pankiewicz KW.

J Med Chem. 2007 Nov 15;50(23):5743-51. Epub 2007 Oct 24.

PMID:
17958343
27.

Recent development of IMP dehydrogenase inhibitors for the treatment of cancer.

Chen L, Pankiewicz KW.

Curr Opin Drug Discov Devel. 2007 Jul;10(4):403-12. Review.

PMID:
17659481
28.

Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis.

Bonnac L, Gao GY, Chen L, Felczak K, Bennett EM, Xu H, Kim T, Liu N, Oh H, Tonge PJ, Pankiewicz KW.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4588-91. Epub 2007 May 31.

PMID:
17560106
29.

Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor.

Chen L, Gao G, Bonnac L, Wilson DJ, Bennett EM, Jayaram HN, Pankiewicz KW.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3152-5. Epub 2007 Mar 15.

PMID:
17395461
30.

Phosphonoxins: rational design and discovery of a potent nucleotide anti-Giardia agent.

Suk DH, Rejman D, Dykstra CC, Pohl R, Pankiewicz KW, Patterson SE.

Bioorg Med Chem Lett. 2007 May 15;17(10):2811-6. Epub 2007 Feb 25.

PMID:
17360182
31.

Rational design and synthesis of novel nucleotide anti-Giardia agents.

Suk DH, Bonnac L, Dykstra CC, Pankiewicz KW, Patterson SE.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):2064-7. Epub 2007 Jan 17.

PMID:
17258459
32.

Probing binding requirements of NAD kinase with modified substrate (NAD) analogues.

Bonnac L, Chen L, Pathak R, Gao G, Ming Q, Bennett E, Felczak K, Kullberg M, Patterson SE, Mazzola F, Magni G, Pankiewicz KW.

Bioorg Med Chem Lett. 2007 Mar 15;17(6):1512-5. Epub 2007 Jan 17.

PMID:
17258457
33.

Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase.

Rejman D, Olesiak M, Chen L, Patterson SE, Wilson D, Jayaram HN, Hedstrom L, Pankiewicz KW.

J Med Chem. 2006 Aug 10;49(16):5018-22.

PMID:
16884314
34.

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.

Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Stuyver LJ, Schinazi RF, Otto MJ, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):957-60.

PMID:
16248071
35.

Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides.

Shi J, Du J, Ma T, Pankiewicz KW, Patterson SE, Hassan AE, Tharnish PM, McBrayer TR, Lostia S, Stuyver LJ, Watanabe KA, Chu CK, Schinazi RF, Otto MJ.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):875-9.

PMID:
16248053
36.

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

Clark JL, Hollecker L, Mason JC, Stuyver LJ, Tharnish PM, Lostia S, McBrayer TR, Schinazi RF, Watanabe KA, Otto MJ, Furman PA, Stec WJ, Patterson SE, Pankiewicz KW.

J Med Chem. 2005 Aug 25;48(17):5504-8.

PMID:
16107149
37.

Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.

Shi J, Du J, Ma T, Pankiewicz KW, Patterson SE, Tharnish PM, McBrayer TR, Stuyver LJ, Otto MJ, Chu CK, Schinazi RF, Watanabe KA.

Bioorg Med Chem. 2005 Mar 1;13(5):1641-52.

PMID:
15698782
38.

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Sidwell RW, Stuyver LJ, Otto MJ, Schinazi RF, Watanabe KA.

J Med Chem. 2004 Nov 18;47(24):6100-3.

PMID:
15537363
39.

Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.

Pankiewicz KW, Patterson SE, Black PL, Jayaram HN, Risal D, Goldstein BM, Stuyver LJ, Schinazi RF.

Curr Med Chem. 2004 Apr;11(7):887-900. Review.

PMID:
15083807
40.

Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites.

Stuyver LJ, McBrayer TR, Tharnish PM, Hassan AE, Chu CK, Pankiewicz KW, Watanabe KA, Schinazi RF, Otto MJ.

J Virol. 2003 Oct;77(19):10689-94.

41.

Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents.

Stuyver LJ, Lostia S, Patterson SE, Clark JL, Watanabe KA, Otto MJ, Pankiewicz KW.

Antivir Chem Chemother. 2002 Nov;13(6):345-52.

PMID:
12718406
42.

The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside.

Pankiewicz KW, Watanabe KA, Lesiak-Watanabe K, Goldstein BM, Jayaram HN.

Curr Med Chem. 2002 Apr;9(7):733-41.

PMID:
11966436
43.

Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia.

Pankiewicz KW, Lesiak-Watanabe KB, Watanabe KA, Patterson SE, Jayaram HN, Yalowitz JA, Miller MD, Seidman M, Majumdar A, Prehna G, Goldstein BM.

J Med Chem. 2002 Jan 31;45(3):703-12.

PMID:
11806722
44.

Raman spectroscopy of uracil DNA glycosylase-DNA complexes: insights into DNA damage recognition and catalysis.

Dong J, Drohat AC, Stivers JT, Pankiewicz KW, Carey PR.

Biochemistry. 2000 Oct 31;39(43):13241-50.

PMID:
11052677
45.

Fluorinated nucleosides.

Pankiewicz KW.

Carbohydr Res. 2000 Jul 10;327(1-2):87-105. Review.

PMID:
10968677
46.

Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187.

Drohat AC, Xiao G, Tordova M, Jagadeesh J, Pankiewicz KW, Watanabe KA, Gilliland GL, Stivers JT.

Biochemistry. 1999 Sep 14;38(37):11876-86.

PMID:
10508390
47.

Novel mycophenolic adenine bis(phosphonate)s as potent anticancer agents and inducers of cells differentiation.

Pankiewicz KW, Lesiak-Watanabe K.

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):927-32.

PMID:
10432711
48.

Novel mycophenolic adenine bis(phosphonate)s as potential immunosuppressants.

Pankiewicz KW, Lesiak-Watanabe K, Watanabe KA, Malinowski K.

Curr Med Chem. 1999 Jul;6(7):629-34.

PMID:
10390605
49.

Synthesis of a novel C-nucleoside, 2-amino-7-(2-deoxy-beta-D-erythro- pentofuranosyl)-3H,5H-pyrrolo-[3,2-d]pyrimidin-4-one (2'-deoxy-9-deazaguanosine).

Gibson ES, Lesiak K, Watanabe KA, Gudas LJ, Pankiewicz KW.

Nucleosides Nucleotides. 1999 Mar;18(3):363-76.

PMID:
10358941
50.

Kinetic mechanism of damage site recognition and uracil flipping by Escherichia coli uracil DNA glycosylase.

Stivers JT, Pankiewicz KW, Watanabe KA.

Biochemistry. 1999 Jan 19;38(3):952-63.

PMID:
9893991

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