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Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.

Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJ.

Sci Signal. 2018 Sep 25;11(549). pii: eaat7650. doi: 10.1126/scisignal.aat7650.


G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor.

Choi M, Staus DP, Wingler LM, Ahn S, Pani B, Capel WD, Lefkowitz RJ.

Sci Signal. 2018 Aug 21;11(544). pii: eaar7084. doi: 10.1126/scisignal.aar7084.


GPCR signaling: conformational activation of arrestins.

Kahsai AW, Pani B, Lefkowitz RJ.

Cell Res. 2018 Aug;28(8):783-784. doi: 10.1038/s41422-018-0067-x. No abstract available.


Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.

Ahn S, Pani B, Kahsai AW, Olsen EK, Husemoen G, Vestergaard M, Jin L, Zhao S, Wingler LM, Rambarat PK, Simhal RK, Xu TT, Sun LD, Shim PJ, Staus DP, Huang LY, Franch T, Chen X, Lefkowitz RJ.

Mol Pharmacol. 2018 Aug;94(2):850-861. doi: 10.1124/mol.118.111948. Epub 2018 May 16.


New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease.

Ekimova IV, Plaksina DV, Pastukhov YF, Lapshina KV, Lazarev VF, Mikhaylova ER, Polonik SG, Pani B, Margulis BA, Guzhova IV, Nudler E.

Exp Neurol. 2018 Aug;306:199-208. doi: 10.1016/j.expneurol.2018.04.012. Epub 2018 Apr 26.


Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.

Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3834-3839. doi: 10.1073/pnas.1722336115. Epub 2018 Mar 26.


Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function.

Bollimuntha S, Pani B, Singh BB.

Adv Exp Med Biol. 2017;993:535-556. doi: 10.1007/978-3-319-57732-6_27. Review.


Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.

Liu X, Ahn S, Kahsai AW, Meng KC, Latorraca NR, Pani B, Venkatakrishnan AJ, Masoudi A, Weis WI, Dror RO, Chen X, Lefkowitz RJ, Kobilka BK.

Nature. 2017 Aug 24;548(7668):480-484. doi: 10.1038/nature23652. Epub 2017 Aug 16.


Mechanistic insights into transcription coupled DNA repair.

Pani B, Nudler E.

DNA Repair (Amst). 2017 Aug;56:42-50. doi: 10.1016/j.dnarep.2017.06.006. Epub 2017 Jun 9. Review.


Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress.

Gusarov I, Pani B, Gautier L, Smolentseva O, Eremina S, Shamovsky I, Katkova-Zhukotskaya O, Mironov A, Nudler E.

Nat Commun. 2017 Jun 19;8:15868. doi: 10.1038/ncomms15868.


Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.

Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, Burnett MB, Lamerdin JE, Bassoni DL, Gavino BJ, Husemoen G, Olsen EK, Franch T, Costanzi S, Chen X, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713. doi: 10.1073/pnas.1620645114. Epub 2017 Jan 27.


A Magic Spot in Genome Maintenance.

Rasouly A, Pani B, Nudler E.

Trends Genet. 2017 Jan;33(1):58-67. doi: 10.1016/j.tig.2016.11.002. Epub 2016 Dec 5. Review.


GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.

Thomsen ARB, Plouffe B, Cahill TJ 3rd, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ.

Cell. 2016 Aug 11;166(4):907-919. doi: 10.1016/j.cell.2016.07.004. Epub 2016 Aug 4.


Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.

Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ.

Nature. 2016 Jul 21;535(7612):448-52. Epub 2016 Jul 13.


Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.

Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, Alam SM, Sullenger BA, Lefkowitz RJ.

Nat Chem Biol. 2016 Sep;12(9):709-16. doi: 10.1038/nchembio.2126. Epub 2016 Jul 11.


The translation elongation factor eEF1A1 couples transcription to translation during heat shock response.

Vera M, Pani B, Griffiths LA, Muchardt C, Abbott CM, Singer RH, Nudler E.

Elife. 2014 Sep 16;3:e03164. doi: 10.7554/eLife.03164.


Helminth induced suppression of macrophage activation is correlated with inhibition of calcium channel activity.

Chauhan A, Sun Y, Pani B, Quenumzangbe F, Sharma J, Singh BB, Mishra BB.

PLoS One. 2014 Jul 11;9(7):e101023. doi: 10.1371/journal.pone.0101023. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e111349.


The moonlighting function of bacteriophage P4 capsid protein, Psu, as a transcription antiterminator.

Ranjan A, Banerjee R, Pani B, Sen U, Sen R.

Bacteriophage. 2013 Apr 1;3(2):e25657.


Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1.

Pani B, Liu X, Bollimuntha S, Cheng KT, Niesman IR, Zheng C, Achen VR, Patel HH, Ambudkar IS, Singh BB.

J Cell Sci. 2013 Jan 15;126(Pt 2):667-75. doi: 10.1242/jcs.118943. Epub 2012 Nov 30.


The first structure of polarity suppression protein, Psu from enterobacteria phage P4, reveals a novel fold and a knotted dimer.

Banerjee R, Nath S, Ranjan A, Khamrui S, Pani B, Sen R, Sen U.

J Biol Chem. 2012 Dec 28;287(53):44667-75. doi: 10.1074/jbc.M112.423202. Epub 2012 Nov 12.


The TR (i)P to Ca²⁺ signaling just got STIMy: an update on STIM1 activated TRPC channels.

Pani B, Bollimuntha S, Singh BB.

Front Biosci (Landmark Ed). 2012 Jan 1;17:805-23. Review.


Effect of cell swelling on ER/PM junctional interactions and channel assembly involved in SOCE.

Liu X, Ong HL, Pani B, Johnson K, Swaim WB, Singh B, Ambudkar I.

Cell Calcium. 2010 Jun;47(6):491-9. doi: 10.1016/j.ceca.2010.04.002. Epub 2010 May 20.


Crystallization and preliminary X-ray analysis of Psu, an inhibitor of the bacterial transcription terminator Rho.

Khamrui S, Ranjan A, Pani B, Sen R, Sen U.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Feb 1;66(Pt 2):204-6. doi: 10.1107/S1744309109053846. Epub 2010 Jan 28.


Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1.

Pani B, Ong HL, Brazer SC, Liu X, Rauser K, Singh BB, Ambudkar IS.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20087-92. doi: 10.1073/pnas.0905002106. Epub 2009 Nov 6.


Interaction surface of bacteriophage P4 protein Psu required for complex formation with the transcription terminator Rho.

Pani B, Ranjan A, Sen R.

J Mol Biol. 2009 Jun 19;389(4):647-60. doi: 10.1016/j.jmb.2009.04.052. Epub 2009 May 3.


Lipid rafts/caveolae as microdomains of calcium signaling.

Pani B, Singh BB.

Cell Calcium. 2009 Jun;45(6):625-33. doi: 10.1016/j.ceca.2009.02.009. Epub 2009 Mar 25. Review.


Lipid rafts determine clustering of STIM1 in endoplasmic reticulum-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE).

Pani B, Ong HL, Liu X, Rauser K, Ambudkar IS, Singh BB.

J Biol Chem. 2008 Jun 20;283(25):17333-40. doi: 10.1074/jbc.M800107200. Epub 2008 Apr 22.


Solid-state laser pumping with a planar compound parabolic concentrator.

Panteli DV, Pani BM, Beli LZ.

Appl Opt. 1997 Oct 20;36(30):7730-40.


Darier's disease: a calcium-signaling perspective.

Pani B, Singh BB.

Cell Mol Life Sci. 2008 Jan;65(2):205-11. Review.


Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice.

Liu X, Cheng KT, Bandyopadhyay BC, Pani B, Dietrich A, Paria BC, Swaim WD, Beech D, Yildrim E, Singh BB, Birnbaumer L, Ambudkar IS.

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17542-7. Epub 2007 Oct 23.


Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components.

Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Ambudkar IS.

J Biol Chem. 2007 Mar 23;282(12):9105-16. Epub 2007 Jan 15. Erratum in: J Biol Chem. 2007 Sep 14;282(37):27556. Gill, Donald [corrected to Gill, Donald L].


Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease.

Pani B, Cornatzer E, Cornatzer W, Shin DM, Pittelkow MR, Hovnanian A, Ambudkar IS, Singh BB.

Mol Biol Cell. 2006 Oct;17(10):4446-58. Epub 2006 Aug 9.


Mechanism of inhibition of Rho-dependent transcription termination by bacteriophage P4 protein Psu.

Pani B, Banerjee S, Chalissery J, Muralimohan A, Loganathan RM, Suganthan RB, Sen R.

J Biol Chem. 2006 Sep 8;281(36):26491-500. Epub 2006 Jul 7. Erratum in: J Biol Chem. 2009 Sep 11;284(37):25459. Abishek, Muralimohan [corrected to Muralimohan, Abishek].


Expression and characterization of human-elastin-repeat-based temperature-responsive protein polymers for biotechnological purposes.

Bandiera A, Taglienti A, Micali F, Pani B, Tamaro M, Crescenzi V, Manzini G.

Biotechnol Appl Biochem. 2005 Dec;42(Pt 3):247-56.


Mechanically induced ATP release from human osteoblastic cells.

Romanello M, Pani B, Bicego M, D'Andrea P.

Biochem Biophys Res Commun. 2001 Dec 21;289(5):1275-81.


Molecular interactions of ruthenium complexes in isolated mammalian nuclei and cytotoxicity on V79 cells in culture.

Barca A, Pani B, Tamaro M, Russo E.

Mutat Res. 1999 Jan 25;423(1-2):171-81.


DNA damage and cytotoxicity induced in mammalian cells by a tetramethylfuroquinolinone derivative.

Marzano C, Severin E, Pani B, Guiotto A, Bordin F.

Environ Mol Mutagen. 1997;29(3):256-64.


DNA damage and topoisomerase II inhibition induced by a benzopsoralen derivative.

Pani B, Barbisin M, Russo E, Tamaro M, Baccichetti F, Carlassare F, Marzano C, Rodighiero P, Bordin F.

Mutat Res. 1994 Dec 1;311(2):277-85.


6-Methylangelicins: new monofunctional photochemotherapeutic agents for psoriasis.

Cristofolini M, Recchia G, Boi S, Piscioli F, Bordin F, Baccichetti F, Carlassare F, Tamaro M, Pani B, Baburdi N, et al.

Br J Dermatol. 1990 Apr;122(4):513-24.


Butyrate effect on nuclear proteins of two Chinese hamster cell lines.

Giancotti V, Pani B, D'Andrea P, Symmons P.

Exp Cell Res. 1988 Jan;174(1):34-40.


Elevated levels of a specific class of nuclear phosphoproteins in cells transformed with v-ras and v-mos oncogenes and by cotransfection with c-myc and polyoma middle T genes.

Giancotti V, Pani B, D'Andrea P, Berlingieri MT, Di Fiore PP, Fusco A, Vecchio G, Philp R, Crane-Robinson C, Nicolas RH, et al.

EMBO J. 1987 Jul;6(7):1981-7.


Histone and nonhistone proteins from normal and virus-transformed rat thyroid epithelial cells.

Giancotti V, Pani B, D'Andrea P, Berlingieri MT, Di Fiore PP, Fusco A, Vecchio G, Crane-Robinson C, Goodwin GH.

Basic Appl Histochem. 1987;31(3):229-38.


Mutagenic activity of four furocoumarins: angelicin, 4,5'-dimethyl-angelicin, psoralen and 8-methyl-psoralen on V79 Chinese hamster cells.

Babudri N, Pani B, Venturini S, Monti-Bragadin C.

J Environ Pathol Toxicol Oncol. 1986 Sep-Dec;7(1-2):123-9.


Genotoxic activity of some water-soluble derivatives of 5-methoxypsoralen and 8-methoxypsoralen.

Tamaro M, Gastaldi S, Carlassare F, Babudri N, Pani B.

Carcinogenesis. 1986 Apr;7(4):605-9.


Lack of effect of glutathione depletion on cytotoxicity, mutagenicity and DNA damage produced by doxorubicin in cultured cells.

Capranico G, Babudri N, Casciarri G, Dolzani L, Gambetta RA, Longoni E, Pani B, Soranzo C, Zunino F.

Chem Biol Interact. 1986 Feb;57(2):189-201.


Mutagenic and cytotoxic activity of doxorubicin and daunorubicin derivatives on prokaryotic and eukaryotic cells.

Babudri N, Pani B, Tamaro M, Monti-Bragadin C, Zunino F.

Br J Cancer. 1984 Jul;50(1):91-6.


Mutagenicity test of extracts of airborne dust from the municipal incinerator of Trieste.

Pani B, Laureni U, Babudri N, Collareta A, Venturini S, Ferri R, Carrozzi M, Burlini F, Monti-Bragadin C.

Environ Mutagen. 1983;5(1):23-32.


The child-rearing attitudes of the parents of (male and female) schizophrenics.

Pani B, Nandi DN.

Indian J Psychiatry. 1982 Apr;24(2):147-54.

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