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Identification of functionally important amino acid sequences in cobra venom factor using human C3/Cobra venom factor hybrid proteins.

Hew BE, Fritzinger DC, Pangburn MK, Vogel CW.

Toxicon. 2019 Sep;167:106-116. doi: 10.1016/j.toxicon.2019.06.017. Epub 2019 Jun 15.


SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis.

Ferreira VP, Fazito Vale V, Pangburn MK, Abdeladhim M, Mendes-Sousa AF, Coutinho-Abreu IV, Rasouli M, Brandt EA, Meneses C, Lima KF, Nascimento Araújo R, Pereira MH, Kotsyfakis M, Oliveira F, Kamhawi S, Ribeiro JM, Gontijo NF, Collin N, Valenzuela JG.

Sci Rep. 2016 Jan 13;6:19300. doi: 10.1038/srep19300.


Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans.

Shen L, Frazer-Abel A, Reynolds PR, Giclas PC, Chappell A, Pangburn MK, Younis H, Henry SP.

J Pharmacol Exp Ther. 2014 Dec;351(3):709-17. doi: 10.1124/jpet.114.219378. Epub 2014 Oct 9.


Complement nomenclature 2014.

Kemper C, Pangburn MK, Fishelson Z.

Mol Immunol. 2014 Oct;61(2):56-8. doi: 10.1016/j.molimm.2014.07.004. Epub 2014 Jul 28. Review.


Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis.

Banda NK, Mehta G, Ferreira VP, Cortes C, Pickering MC, Pangburn MK, Arend WP, Holers VM.

J Immunol. 2013 Apr 1;190(7):3560-9. doi: 10.4049/jimmunol.1203271. Epub 2013 Feb 22.


Serine protease PKF of Acinetobacter baumannii results in serum resistance and suppression of biofilm formation.

King LB, Pangburn MK, McDaniel LS.

J Infect Dis. 2013 Apr;207(7):1128-34. doi: 10.1093/infdis/jis939. Epub 2013 Jan 9.


Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

Hadders MA, Bubeck D, Roversi P, Hakobyan S, Forneris F, Morgan BP, Pangburn MK, Llorca O, Lea SM, Gros P.

Cell Rep. 2012 Mar 29;1(3):200-7. doi: 10.1016/j.celrep.2012.02.003. Epub 2012 Feb 23.


The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.

Takeda K, Thurman JM, Tomlinson S, Okamoto M, Shiraishi Y, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Gelfand EW.

J Immunol. 2012 Jan 15;188(2):661-7. doi: 10.4049/jimmunol.1101813. Epub 2011 Dec 14.


Exposing a hidden functional site of C-reactive protein by site-directed mutagenesis.

Singh SK, Thirumalai A, Hammond DJ Jr, Pangburn MK, Mishra VK, Johnson DA, Rusiñol AE, Agrawal A.

J Biol Chem. 2012 Jan 27;287(5):3550-8. doi: 10.1074/jbc.M111.310011. Epub 2011 Dec 9.


Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury.

Renner B, Ferreira VP, Cortes C, Goldberg R, Ljubanovic D, Pangburn MK, Pickering MC, Tomlinson S, Holland-Neidermyer A, Strassheim D, Holers VM, Thurman JM.

Kidney Int. 2011 Jul;80(2):165-73. doi: 10.1038/ki.2011.115. Epub 2011 May 4.


Native properdin binds to Chlamydia pneumoniae and promotes complement activation.

Cortes C, Ferreira VP, Pangburn MK.

Infect Immun. 2011 Feb;79(2):724-31. doi: 10.1128/IAI.00980-10. Epub 2010 Dec 6.


Identification of acidic pH-dependent ligands of pentameric C-reactive protein.

Hammond DJ Jr, Singh SK, Thompson JA, Beeler BW, Rusiñol AE, Pangburn MK, Potempa LA, Agrawal A.

J Biol Chem. 2010 Nov 12;285(46):36235-44. doi: 10.1074/jbc.M110.142026. Epub 2010 Sep 14.


A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration.

Rohrer B, Long Q, Coughlin B, Renner B, Huang Y, Kunchithapautham K, Ferreira VP, Pangburn MK, Gilkeson GS, Thurman JM, Tomlinson S, Holers VM.

Adv Exp Med Biol. 2010;703:137-49. doi: 10.1007/978-1-4419-5635-4_10.


The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells.

Renner B, Coleman K, Goldberg R, Amura C, Holland-Neidermyer A, Pierce K, Orth HN, Molina H, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Thurman JM.

J Immunol. 2010 Sep 1;185(5):3086-94. doi: 10.4049/jimmunol.1000111. Epub 2010 Jul 30.


Complement control protein factor H: the good, the bad, and the inadequate.

Ferreira VP, Pangburn MK, Cortés C.

Mol Immunol. 2010 Aug;47(13):2187-97. doi: 10.1016/j.molimm.2010.05.007. Review.


An evaluation of the role of properdin in alternative pathway activation on Neisseria meningitidis and Neisseria gonorrhoeae.

Agarwal S, Ferreira VP, Cortes C, Pangburn MK, Rice PA, Ram S.

J Immunol. 2010 Jul 1;185(1):507-16. doi: 10.4049/jimmunol.0903598. Epub 2010 Jun 7.


Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement.

Ferreira VP, Cortes C, Pangburn MK.

Immunobiology. 2010 Nov;215(11):932-40. doi: 10.1016/j.imbio.2010.02.002. Epub 2010 Feb 12.


The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.

Ferreira VP, Herbert AP, Cortés C, McKee KA, Blaum BS, Esswein ST, Uhrín D, Barlow PN, Pangburn MK, Kavanagh D.

J Immunol. 2009 Jun 1;182(11):7009-18. doi: 10.4049/jimmunol.0804031.


Discrimination between host and pathogens by the complement system.

Pangburn MK, Ferreira VP, Cortes C.

Vaccine. 2008 Dec 30;26 Suppl 8:I15-21. Review.


Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury.

Thurman JM, Renner B, Kunchithapautham K, Ferreira VP, Pangburn MK, Ablonczy Z, Tomlinson S, Holers VM, Rohrer B.

J Biol Chem. 2009 Jun 19;284(25):16939-47. doi: 10.1074/jbc.M808166200. Epub 2009 Apr 21.


Polyanion-induced self-association of complement factor H.

Pangburn MK, Rawal N, Cortes C, Alam MN, Ferreira VP, Atkinson MA.

J Immunol. 2009 Jan 15;182(2):1061-8.


Denaturation and unfolding of human anaphylatoxin C3a: an unusually low covalent stability of its native disulfide bonds.

Chang JY, Lin CC, Salamanca S, Pangburn MK, Wetsel RA.

Arch Biochem Biophys. 2008 Dec 15;480(2):104-10. doi: 10.1016/ Epub 2008 Sep 30.


Functional characterization of human C3/cobra venom factor hybrid proteins for therapeutic complement depletion.

Fritzinger DC, Hew BE, Thorne M, Pangburn MK, Janssen BJ, Gros P, Vogel CW.

Dev Comp Immunol. 2009;33(1):105-16. doi: 10.1016/j.dci.2008.07.006.


Digestion of native proteins for proteomics using a thermocycler.

Turapov OA, Mukamolova GV, Bottrill AR, Pangburn MK.

Anal Chem. 2008 Aug 1;80(15):6093-9. doi: 10.1021/ac702527b. Epub 2008 Jun 26.


Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.

Hocking HG, Herbert AP, Kavanagh D, Soares DC, Ferreira VP, Pangburn MK, Uhrín D, Barlow PN.

J Biol Chem. 2008 Apr 4;283(14):9475-87. doi: 10.1074/jbc.M709587200. Epub 2008 Feb 5.


Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.

Herbert AP, Deakin JA, Schmidt CQ, Blaum BS, Egan C, Ferreira VP, Pangburn MK, Lyon M, Uhrín D, Barlow PN.

J Biol Chem. 2007 Jun 29;282(26):18960-8. Epub 2007 Mar 13.


Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces.

Ferreira VP, Herbert AP, Hocking HG, Barlow PN, Pangburn MK.

J Immunol. 2006 Nov 1;177(9):6308-16.


Role of the C3b-binding site on C4b-binding protein in regulating classical pathway C5 convertase.

Rawal N, Pangburn MK.

Mol Immunol. 2007 Feb;44(6):1105-14. Epub 2006 Sep 18.


Disease-associated sequence variations in factor H: a structural biology approach.

Herbert AP, Soares DC, Pangburn MK, Barlow PN.

Adv Exp Med Biol. 2006;586:313-27. Review. No abstract available.


Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure.

Herbert AP, Uhrín D, Lyon M, Pangburn MK, Barlow PN.

J Biol Chem. 2006 Jun 16;281(24):16512-20. Epub 2006 Mar 13.


In vivo binding of complement regulator factor H by Streptococcus pneumoniae.

Quin LR, Carmicle S, Dave S, Pangburn MK, Evenhuis JP, McDaniel LS.

J Infect Dis. 2005 Dec 1;192(11):1996-2003. Epub 2005 Oct 26.


A novel vector for the expression of SCR domains in insect cells.

Alam MN, Haque A, Sreedhar M, Pangburn MK.

J Immunol Methods. 2004 Oct;293(1-2):107-13.


Interaction of human factor H with PspC of Streptococcus pneumoniae.

Dave S, Pangburn MK, Pruitt C, McDaniel LS.

Indian J Med Res. 2004 May;119 Suppl:66-73.


Dual roles of PspC, a surface protein of Streptococcus pneumoniae, in binding human secretory IgA and factor H.

Dave S, Carmicle S, Hammerschmidt S, Pangburn MK, McDaniel LS.

J Immunol. 2004 Jul 1;173(1):471-7.


Formation of high affinity C5 convertase of the classical pathway of complement.

Rawal N, Pangburn MK.

J Biol Chem. 2003 Oct 3;278(40):38476-83. Epub 2003 Jul 23.


Structure and function of complement C5 convertase enzymes.

Pangburn MK, Rawal N.

Biochem Soc Trans. 2002 Nov;30(Pt 6):1006-10. Review.


C4bp binding to porin mediates stable serum resistance of Neisseria gonorrhoeae.

Ram S, Cullinane M, Blom AM, Gulati S, McQuillen DP, Boden R, Monks BG, O'Connell C, Elkins C, Pangburn MK, Dahlbäck B, Rice PA.

Int Immunopharmacol. 2001 Mar;1(3):423-32. Review.


Structure/function of C5 convertases of complement.

Rawal N, Pangburn MK.

Int Immunopharmacol. 2001 Mar;1(3):415-22. Review.


PspC, a pneumococcal surface protein, binds human factor H.

Dave S, Brooks-Walter A, Pangburn MK, McDaniel LS.

Infect Immun. 2001 May;69(5):3435-7.


Binding of C4b-binding protein to porin: a molecular mechanism of serum resistance of Neisseria gonorrhoeae.

Ram S, Cullinane M, Blom AM, Gulati S, McQuillen DP, Monks BG, O'Connell C, Boden R, Elkins C, Pangburn MK, Dahlbäck B, Rice PA.

J Exp Med. 2001 Feb 5;193(3):281-95.


Novel mechanism of antibody-independent complement neutralization of herpes simplex virus type 1.

Friedman HM, Wang L, Pangburn MK, Lambris JD, Lubinski J.

J Immunol. 2000 Oct 15;165(8):4528-36.


The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis.

Ram S, Mackinnon FG, Gulati S, McQuillen DP, Vogel U, Frosch M, Elkins C, Guttormsen HK, Wetzler LM, Oppermann M, Pangburn MK, Rice PA.

Mol Immunol. 1999 Sep-Oct;36(13-14):915-28. Review.


Functional role of the noncatalytic subunit of complement C5 convertase.

Rawal N, Pangburn MK.

J Immunol. 2000 Feb 1;164(3):1379-85.


Nephritogenic lambda light chain dimer: a unique human miniautoantibody against complement factor H.

Jokiranta TS, Solomon A, Pangburn MK, Zipfel PF, Meri S.

J Immunol. 1999 Oct 15;163(8):4590-6.


Inhibition of complement by covalent attachment of rosmarinic acid to activated C3b.

Sahu A, Rawal N, Pangburn MK.

Biochem Pharmacol. 1999 Jun 15;57(12):1439-46.


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