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Items: 1 to 50 of 73


OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome.

Xu R, Brawner AT, Li S, Liu JJ, Kim H, Xue H, Pang ZP, Kim WY, Hart RP, Liu Y, Jiang P.

Cell Stem Cell. 2019 Jun 6;24(6):908-926.e8. doi: 10.1016/j.stem.2019.04.014. Epub 2019 May 23.


Synaptic Regulation by OPRM1 Variants in Reward Neurocircuitry.

Popova D, Desai N, Blendy JA, Pang ZP.

J Neurosci. 2019 Jul 17;39(29):5685-5696. doi: 10.1523/JNEUROSCI.2317-18.2019. Epub 2019 May 20.


Cell type- and pathway-specific synaptic regulation of orexin neurocircuitry.

Liu JJ, Mirabella VR, Pang ZP.

Brain Res. 2018 Oct 5. pii: S0006-8993(18)30507-9. doi: 10.1016/j.brainres.2018.10.003. [Epub ahead of print]


Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics.

Fantuzzo JA, Hart RP, Zahn JD, Pang ZP.

Dev Dyn. 2019 Jan;248(1):65-77. doi: 10.1002/dvdy.24665. Epub 2018 Sep 12. Review.


Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook.

Scarnati MS, Halikere A, Pang ZP.

Alcohol. 2019 Feb;74:83-93. doi: 10.1016/j.alcohol.2018.03.008. Epub 2018 Mar 31. Review.


hsa-let-7c miRNA Regulates Synaptic and Neuronal Function in Human Neurons.

McGowan H, Mirabella VR, Hamod A, Karakhanyan A, Mlynaryk N, Moore JC, Tischfield JA, Hart RP, Pang ZP.

Front Synaptic Neurosci. 2018 Jul 17;10:19. doi: 10.3389/fnsyn.2018.00019. eCollection 2018.


Open chromatin dynamics reveals stage-specific transcriptional networks in hiPSC-based neurodevelopmental model.

Zhang S, Moy W, Zhang H, Leites C, McGowan H, Shi J, Sanders AR, Pang ZP, Gejman PV, Duan J.

Stem Cell Res. 2018 May;29:88-98. doi: 10.1016/j.scr.2018.03.014. Epub 2018 Mar 31.


Intellicount: High-Throughput Quantification of Fluorescent Synaptic Protein Puncta by Machine Learning.

Fantuzzo JA, Mirabella VR, Hamod AH, Hart RP, Zahn JD, Pang ZP.

eNeuro. 2017 Dec 6;4(6). pii: ENEURO.0219-17.2017. doi: 10.1523/ENEURO.0219-17.2017. eCollection 2017 Nov-Dec.


Presynaptic Regulation of Leptin in a Defined Lateral Hypothalamus-Ventral Tegmental Area Neurocircuitry Depends on Energy State.

Liu JJ, Bello NT, Pang ZP.

J Neurosci. 2017 Dec 6;37(49):11854-11866. doi: 10.1523/JNEUROSCI.1942-17.2017. Epub 2017 Oct 31.


Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus.

Liu J, Conde K, Zhang P, Lilascharoen V, Xu Z, Lim BK, Seeley RJ, Zhu JJ, Scott MM, Pang ZP.

Neuron. 2017 Nov 15;96(4):897-909.e5. doi: 10.1016/j.neuron.2017.09.042. Epub 2017 Oct 19.


Calmodulin regulates Cav3 T-type channels at their gating brake.

Chemin J, Taiakina V, Monteil A, Piazza M, Guan W, Stephens RF, Kitmitto A, Pang ZP, Dolphin AC, Perez-Reyes E, Dieckmann T, Guillemette JG, Spafford JD.

J Biol Chem. 2017 Dec 8;292(49):20010-20031. doi: 10.1074/jbc.M117.807925. Epub 2017 Sep 25.


The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family.

Sun N, Nasello C, Deng L, Wang N, Zhang Y, Xu Z, Song Z, Kwan K, King RA, Pang ZP, Xing J, Heiman GA, Tischfield JA.

Mol Psychiatry. 2018 Jun;23(6):1487-1495. doi: 10.1038/mp.2017.179. Epub 2017 Sep 12.


Paraventricular Thalamic Control of Food Intake and Reward: Role of Glucagon-Like Peptide-1 Receptor Signaling.

Ong ZY, Liu JJ, Pang ZP, Grill HJ.

Neuropsychopharmacology. 2017 Nov;42(12):2387-2397. doi: 10.1038/npp.2017.150. Epub 2017 Jul 19.


Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.

Forrest MP, Zhang H, Moy W, McGowan H, Leites C, Dionisio LE, Xu Z, Shi J, Sanders AR, Greenleaf WJ, Cowan CA, Pang ZP, Gejman PV, Penzes P, Duan J.

Cell Stem Cell. 2017 Sep 7;21(3):305-318.e8. doi: 10.1016/j.stem.2017.07.008. Epub 2017 Aug 10.


μNeurocircuitry: Establishing in vitro models of neurocircuits with human neurons.

Fantuzzo JA, De Filippis L, McGowan H, Yang N, Ng YH, Halikere A, Liu JJ, Hart RP, Wernig M, Zahn JD, Pang ZP.

Technology (Singap World Sci). 2017 Jun;5(2):87-97. doi: 10.1142/S2339547817500054.


Erratum: BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.

Lim CS, Kang X, Mirabella V, Zhang H, Bu Q, Araki Y, Hoang ET, Wang S, Shen Y, Choi S, Kaang BK, Chang Q, Pang ZP, Huganir RL, Zhu JJ.

Genes Dev. 2017 Apr 15;31(8):846. doi: 10.1101/gad.300863.117. No abstract available.


BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.

Lim CS, Kang X, Mirabella V, Zhang H, Bu Q, Araki Y, Hoang ET, Wang S, Shen Y, Choi S, Kaang BK, Chang Q, Pang ZP, Huganir RL, Zhu JJ.

Genes Dev. 2017 Mar 15;31(6):537-552. doi: 10.1101/gad.294413.116. Erratum in: Genes Dev. 2017 Apr 15;31(8):846.


Polymer brain-nanotherapeutics for multipronged inhibition of microglial α-synuclein aggregation, activation, and neurotoxicity.

Bennett NK, Chmielowski R, Abdelhamid DS, Faig JJ, Francis N, Baum J, Pang ZP, Uhrich KE, Moghe PV.

Biomaterials. 2016 Dec;111:179-189. doi: 10.1016/j.biomaterials.2016.10.001. Epub 2016 Oct 4.


Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele.

Oni EN, Halikere A, Li G, Toro-Ramos AJ, Swerdel MR, Verpeut JL, Moore JC, Bello NT, Bierut LJ, Goate A, Tischfield JA, Pang ZP, Hart RP.

Sci Rep. 2016 Oct 4;6:34341. doi: 10.1038/srep34341.


Gq Protein-Coupled Membrane-Initiated Estrogen Signaling Rapidly Excites Corticotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus in Female Mice.

Hu P, Liu J, Yasrebi A, Gotthardt JD, Bello NT, Pang ZP, Roepke TA.

Endocrinology. 2016 Sep;157(9):3604-20. doi: 10.1210/en.2016-1191. Epub 2016 Jul 7.


Glucagon-like peptide-1 drives energy metabolism on the synaptic highway.

Liu J, Pang ZP.

FEBS J. 2016 Dec;283(24):4413-4423. doi: 10.1111/febs.13785. Epub 2016 Jul 1. Review.


Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells.

De Filippis L, Halikere A, McGowan H, Moore JC, Tischfield JA, Hart RP, Pang ZP.

Mol Brain. 2016 May 10;9(1):51. doi: 10.1186/s13041-016-0221-7.


Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds.

Carlson AL, Bennett NK, Francis NL, Halikere A, Clarke S, Moore JC, Hart RP, Paradiso K, Wernig M, Kohn J, Pang ZP, Moghe PV.

Nat Commun. 2016 Mar 17;7:10862. doi: 10.1038/ncomms10862.


Regulatory functions and pathological relevance of the MECP2 3'UTR in the central nervous system.

McGowan H, Pang ZP.

Cell Regen (Lond). 2015 Oct 28;4:9. doi: 10.1186/s13619-015-0023-x. eCollection 2015.


Harness the power of endogenous neural stem cells by biomaterials to treat spinal cord injury.

De Filippis L, Südhof TC, Pang ZP.

Sci China Life Sci. 2015 Nov;58(11):1167-8. No abstract available.


Hybrid upconversion nanomaterials for optogenetic neuronal control.

Shah S, Liu JJ, Pasquale N, Lai J, McGowan H, Pang ZP, Lee KB.

Nanoscale. 2015 Oct 28;7(40):16571-7. doi: 10.1039/c5nr03411f.


Endogenous Glucagon-like Peptide-1 Suppresses High-Fat Food Intake by Reducing Synaptic Drive onto Mesolimbic Dopamine Neurons.

Wang XF, Liu JJ, Xia J, Liu J, Mirabella V, Pang ZP.

Cell Rep. 2015 Aug 4;12(5):726-33. doi: 10.1016/j.celrep.2015.06.062. Epub 2015 Jul 23.


High on food: the interaction between the neural circuits for feeding and for reward.

Liu JJ, Mukherjee D, Haritan D, Ignatowska-Jankowska B, Liu J, Citri A, Pang ZP.

Front Biol (Beijing). 2015 Apr;10(2):165-176. doi: 10.1007/s11515-015-1348-0. Epub 2015 Feb 10.


Insulin-stimulated leptin secretion requires calcium and PI3K/Akt activation.

Wang Y, Ali Y, Lim CY, Hong W, Pang ZP, Han W.

Biochem J. 2014 Mar 15;458(3):491-8. doi: 10.1042/BJ20131176.


Motor neuropathy-associated mutation impairs Seipin functions in neurotransmission.

Wei S, Soh SL, Xia J, Ong WY, Pang ZP, Han W.

J Neurochem. 2014 Apr;129(2):328-38. doi: 10.1111/jnc.12638. Epub 2014 Jan 8.


Lipid-anchored SNAREs lacking transmembrane regions fully support membrane fusion during neurotransmitter release.

Zhou P, Bacaj T, Yang X, Pang ZP, Südhof TC.

Neuron. 2013 Oct 16;80(2):470-83. doi: 10.1016/j.neuron.2013.09.010. Epub 2013 Oct 10.


Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ.

Pertsinidis A, Mukherjee K, Sharma M, Pang ZP, Park SR, Zhang Y, Brunger AT, Südhof TC, Chu S.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2812-20. doi: 10.1073/pnas.1310654110. Epub 2013 Jul 2.


Motor neuron degeneration in a mouse model of seipinopathy.

Guo J, Qiu W, Soh SL, Wei S, Radda GK, Ong WY, Pang ZP, Han W.

Cell Death Dis. 2013 Mar 7;4:e535. doi: 10.1038/cddis.2013.64.


Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion.

Zhou P, Pang ZP, Yang X, Zhang Y, Rosenmund C, Bacaj T, Südhof TC.

EMBO J. 2013 Jan 9;32(1):159-71. doi: 10.1038/emboj.2012.307. Epub 2012 Nov 27.


Seipin regulates excitatory synaptic transmission in cortical neurons.

Wei S, Soh SL, Qiu W, Yang W, Seah CJ, Guo J, Ong WY, Pang ZP, Han W.

J Neurochem. 2013 Feb;124(4):478-89. doi: 10.1111/jnc.12099. Epub 2012 Dec 27.


Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission.

Xu W, Morishita W, Buckmaster PS, Pang ZP, Malenka RC, Südhof TC.

Neuron. 2012 Mar 8;73(5):990-1001. doi: 10.1016/j.neuron.2011.12.036.


Comprehensive qPCR profiling of gene expression in single neuronal cells.

Citri A, Pang ZP, Südhof TC, Wernig M, Malenka RC.

Nat Protoc. 2011 Dec 22;7(1):118-27. doi: 10.1038/nprot.2011.430.


Induced neuronal cells: how to make and define a neuron.

Yang N, Ng YH, Pang ZP, Südhof TC, Wernig M.

Cell Stem Cell. 2011 Dec 2;9(6):517-25. doi: 10.1016/j.stem.2011.11.015. Review.


Direct lineage conversion of terminally differentiated hepatocytes to functional neurons.

Marro S, Pang ZP, Yang N, Tsai MC, Qu K, Chang HY, Südhof TC, Wernig M.

Cell Stem Cell. 2011 Oct 4;9(4):374-82. doi: 10.1016/j.stem.2011.09.002. Epub 2011 Sep 29.


Up-regulation of A-type potassium currents protects neurons against cerebral ischemia.

Deng P, Pang ZP, Lei Z, Shikano S, Xiong Q, Harvey BK, London B, Wang Y, Li M, Xu ZC.

J Cereb Blood Flow Metab. 2011 Sep;31(9):1823-35. doi: 10.1038/jcbfm.2011.88. Epub 2011 Jun 15.


Induction of human neuronal cells by defined transcription factors.

Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, Citri A, Sebastiano V, Marro S, Südhof TC, Wernig M.

Nature. 2011 May 26;476(7359):220-3. doi: 10.1038/nature10202.


Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism.

Pang ZP, Bacaj T, Yang X, Zhou P, Xu W, Südhof TC.

Neuron. 2011 Apr 28;70(2):244-51. doi: 10.1016/j.neuron.2011.03.011.


Testing the SNARE/SM protein model of membrane fusion.

Bacaj T, Pang ZP, Südhof TC.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22365-6. doi: 10.1073/pnas.1017268108. Epub 2010 Dec 17. No abstract available.


Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix.

Yang X, Kaeser-Woo YJ, Pang ZP, Xu W, Südhof TC.

Neuron. 2010 Dec 9;68(5):907-20. doi: 10.1016/j.neuron.2010.11.001.


The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses.

Sun T, Wu XS, Xu J, McNeil BD, Pang ZP, Yang W, Bai L, Qadri S, Molkentin JD, Yue DT, Wu LG.

J Neurosci. 2010 Sep 1;30(35):11838-47. doi: 10.1523/JNEUROSCI.1481-10.2010.


Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.

Pang ZP, Xu W, Cao P, Südhof TC.

J Biol Chem. 2010 Oct 29;285(44):33930-9. doi: 10.1074/jbc.M110.150151. Epub 2010 Aug 20.


Cell biology of Ca2+-triggered exocytosis.

Pang ZP, Südhof TC.

Curr Opin Cell Biol. 2010 Aug;22(4):496-505. doi: 10.1016/ Epub 2010 Jun 3. Review.


Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II.

Pang ZP, Cao P, Xu W, Südhof TC.

J Neurosci. 2010 Mar 17;30(11):4132-42. doi: 10.1523/JNEUROSCI.3129-09.2010.


Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.

Shin OH, Lu J, Rhee JS, Tomchick DR, Pang ZP, Wojcik SM, Camacho-Perez M, Brose N, Machius M, Rizo J, Rosenmund C, Südhof TC.

Nat Struct Mol Biol. 2010 Mar;17(3):280-8. doi: 10.1038/nsmb.1758. Epub 2010 Feb 14.

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