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Items: 1 to 50 of 217

1.

Gelsemium poisoning mediated by the non-toxic plant Cassytha filiformis parasitizing Gelsemium elegans.

Cheung WL, Law CY, Lee HCH, Tang CO, Lam YH, Ng SW, Chan SS, Chow TC, Pang KS, Mak TWL.

Toxicon. 2018 Nov;154:42-49. doi: 10.1016/j.toxicon.2018.09.009. Epub 2018 Sep 28.

PMID:
30273705
2.

Finding Tmax and Cmax in Multicompartmental Models.

Han YR, Lee PI, Pang KS.

Drug Metab Dispos. 2018 Nov;46(11):1796-1804. doi: 10.1124/dmd.118.082636. Epub 2018 Aug 22.

PMID:
30135243
3.

Strategies and limitations associated with in vitro characterization of vitamin D receptor activators.

Bukuroshi P, Saitoh H, Magomedova L, Cummins CL, Chow EC, Li AP, Pang KS.

Biochem Pharmacol. 2018 Sep;155:547-561. doi: 10.1016/j.bcp.2018.07.015. Epub 2018 Jul 18.

PMID:
30028992
4.

Potencies of vitamin D analogs, 1α-hydroxyvitamin D3 , 1α-hydroxyvitamin D2 and 25-hydroxyvitamin D3 , in lowering cholesterol in hypercholesterolemic mice in vivo.

Quach HP, Dzekic T, Bukuroshi P, Pang KS.

Biopharm Drug Dispos. 2018 Apr;39(4):196-204. doi: 10.1002/bdd.2126.

PMID:
29488238
5.

Tranexamic Acid Dosing for Cardiac Surgical Patients With Chronic Renal Dysfunction: A New Dosing Regimen.

Jerath A, Yang QJ, Pang KS, Looby N, Reyes-Garces N, Vasiljevic T, Bojko B, Pawliszyn J, Wijeysundera D, Beattie WS, Yau TM, Wąsowicz M.

Anesth Analg. 2018 Jan 5. doi: 10.1213/ANE.0000000000002724. [Epub ahead of print]

PMID:
29309319
6.

Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.

Quach HP, Noh K, Hoi SY, Bruinsma A, Groothuis GMM, Li AP, Chow ECY, Pang KS.

Biopharm Drug Dispos. 2018 Feb;39(2):99-115. doi: 10.1002/bdd.2118. Epub 2018 Jan 30.

PMID:
29243851
7.

Commentary on "The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio".

Rowland M, Pang KS.

Clin Pharmacol Ther. 2018 Mar;103(3):386-388. doi: 10.1002/cpt.921. Epub 2017 Nov 14.

PMID:
29134634
8.

Highlighting Vitamin D Receptor-Targeted Activities of 1α,25-Dihydroxyvitamin D3 in Mice via Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling.

Yang QJ, Bukuroshi P, Quach HP, Chow ECY, Pang KS.

Drug Metab Dispos. 2018 Jan;46(1):75-87. doi: 10.1124/dmd.117.077271. Epub 2017 Oct 30.

PMID:
29084783
9.

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice.

Zhang RX, Zhang T, Chen K, Cheng J, Lai P, Rauth AM, Pang KS, Wu XY.

J Vis Exp. 2017 Oct 5;(128). doi: 10.3791/56159.

PMID:
29053672
10.

Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist.

Kusuhara H, Obach RS, Rostami-Hodjegan A, Pang KS, Hammarlund-Udenaes M, Derendorf H, Artursson P, Huang SM, Suzuki H, Terasaki T.

J Pharm Sci. 2017 Sep;106(9):2188-2194. doi: 10.1016/j.xphs.2017.04.072. Epub 2017 May 4. No abstract available.

PMID:
28479350
11.

Revisiting the role of gut wall in the fate of orally administered drugs: Why now and to what effect?

Rostami-Hodjegan A, Tamai I, Pang KS.

Biopharm Drug Dispos. 2017 Mar;38(2):87-93. doi: 10.1002/bdd.2071. No abstract available.

PMID:
28317174
12.

Comparing early liver graft function from heart beating and living-donors: A pilot study aiming to identify new biomarkers of liver injury.

Yang QJ, Kluger M, Goryński K, Pawliszyn J, Bojko B, Yu AM, Noh K, Selzner M, Jerath A, McCluskey S, Pang KS, Wąsowicz M.

Biopharm Drug Dispos. 2017 Jul;38(5):326-339. doi: 10.1002/bdd.2066. Epub 2017 Apr 6.

PMID:
28102538
13.

Unequivocal evidence supporting the segregated flow intestinal model that discriminates intestine versus liver first-pass removal with PBPK modeling.

Pang KS, Yang QJ, Noh K.

Biopharm Drug Dispos. 2017 Apr;38(3):231-250. doi: 10.1002/bdd.2056. Epub 2017 Mar 28.

PMID:
27977852
14.

Physiologically based pharmacokinetic modeling revealed minimal codeine intestinal metabolism in first-pass removal in rats.

Noh K, Chen S, Yang QJ, Pang KS.

Biopharm Drug Dispos. 2017 Jan;38(1):50-74. doi: 10.1002/bdd.2051.

PMID:
27925239
15.

Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.

Chow EC, Quach HP, Zhang Y, Wang JZ, Evans DC, Li AP, Silva J, Tirona RG, Lai Y, Pang KS.

J Pharmacol Exp Ther. 2017 Jan;360(1):174-191. Epub 2016 Oct 27.

16.

Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.

Chow EC, Wang JZ, Quach HP, Tang H, Evans DC, Li AP, Silva J, Pang KS.

Drug Metab Dispos. 2016 Sep;44(9):1524-35. doi: 10.1124/dmd.116.070060. Epub 2016 Jun 24.

17.
18.

Polymer-lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin-mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tumor.

Zhang RX, Cai P, Zhang T, Chen K, Li J, Cheng J, Pang KS, Adissu HA, Rauth AM, Wu XY.

Nanomedicine. 2016 Jul;12(5):1279-90. doi: 10.1016/j.nano.2015.12.383. Epub 2016 Jan 7.

PMID:
26772427
19.

Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice.

Ramakrishnan V, Yang QJ, Quach HP, Cao Y, Chow EC, Mager DE, Pang KS.

Drug Metab Dispos. 2016 Feb;44(2):189-208. doi: 10.1124/dmd.115.067033. Epub 2015 Nov 19.

20.

Response to letter to the editor on "fractional clearance for verapamil N-demethylation in the isolated rat liver preparation".

Pang KS, Yang QJ.

Drug Metab Dispos. 2015 Jul;43(7):1058-9. doi: 10.1124/dmd.115.065227. Epub 2015 May 11. No abstract available.

21.

PKPD modelling to predict altered disposition of 1α,25-dihydroxyvitamin D3 in mice due to dose-dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation.

Quach HP, Yang QJ, Chow EC, Mager DE, Hoi SY, Pang KS.

Br J Pharmacol. 2015 Jul;172(14):3611-26. doi: 10.1111/bph.13153. Epub 2015 May 15.

22.

Pharmacokinetic modeling of tranexamic acid for patients undergoing cardiac surgery with normal renal function and model simulations for patients with renal impairment.

Yang QJ, Jerath A, Bies RR, Wąsowicz M, Pang KS.

Biopharm Drug Dispos. 2015 Jul;36(5):294-307. doi: 10.1002/bdd.1941. Epub 2015 Apr 21.

23.
24.

Dealing with the complex drug-drug interactions: towards mechanistic models.

Varma MV, Pang KS, Isoherranen N, Zhao P.

Biopharm Drug Dispos. 2015 Mar;36(2):71-92. doi: 10.1002/bdd.1934. Epub 2015 Feb 10. Review.

PMID:
25545151
25.

Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats.

Durk MR, Fan J, Sun H, Yang Y, Pang H, Pang KS, de Lannoy IA.

Pharm Res. 2015 Mar;32(3):1128-40. doi: 10.1007/s11095-014-1524-y. Epub 2014 Oct 16.

PMID:
25319098
26.

Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat.

Kim YC, Kim IB, Noh CK, Quach HP, Yoon IS, Chow ECY, Kim M, Jin HE, Cho KH, Chung SJ, Pang KS, Maeng HJ.

J Pharm Sci. 2014 Nov;103(11):3793-3805. doi: 10.1002/jps.24195. Epub 2014 Sep 29.

PMID:
25266751
27.

1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease.

Durk MR, Han K, Chow EC, Ahrens R, Henderson JT, Fraser PE, Pang KS.

J Neurosci. 2014 May 21;34(21):7091-101. doi: 10.1523/JNEUROSCI.2711-13.2014.

28.

Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.

Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS.

Gastroenterology. 2014 Apr;146(4):1048-59. doi: 10.1053/j.gastro.2013.12.027. Epub 2013 Dec 21.

PMID:
24365583
29.

Budd-Chiari syndrome secondary to toxic pyrrolizidine alkaloid exposure.

Wu JS, Poon WT, Ma CK, Chen ML, Pang KS, Mak TW, Chan HB.

Hong Kong Med J. 2013 Dec;19(6):553-5. doi: 10.12809/hkmj133779.

30.

Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice.

Chow EC, Durk MR, Maeng HJ, Pang KS.

Biopharm Drug Dispos. 2013 Oct;34(7):402-16. doi: 10.1002/bdd.1856. Epub 2013 Sep 16. Erratum in: Biopharm Drug Dispos. 2014 Mar;35(2):134.

PMID:
23897575
31.

ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans.

Zamek-Gliszczynski MJ, Lee CA, Poirier A, Bentz J, Chu X, Ellens H, Ishikawa T, Jamei M, Kalvass JC, Nagar S, Pang KS, Korzekwa K, Swaan PW, Taub ME, Zhao P, Galetin A; International Transporter Consortium.

Clin Pharmacol Ther. 2013 Jul;94(1):64-79. doi: 10.1038/clpt.2013.45. Epub 2013 Feb 25. Review.

32.

Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice.

Chow EC, Quach HP, Vieth R, Pang KS.

Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E977-89. doi: 10.1152/ajpendo.00489.2012. Epub 2013 Mar 12.

33.

1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.

Durk MR, Chan GN, Campos CR, Peart JC, Chow EC, Lee E, Cannon RE, Bendayan R, Miller DS, Pang KS.

J Neurochem. 2012 Dec;123(6):944-53. doi: 10.1111/jnc.12041. Epub 2012 Nov 1.

34.

Why we need proper PBPK models to examine intestine and liver oral drug absorption.

Chow EC, Pang KS.

Curr Drug Metab. 2013 Jan;14(1):57-79. Review.

PMID:
22935069
35.

Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass.

Sharma V, Fan J, Jerath A, Pang KS, Bojko B, Pawliszyn J, Karski JM, Yau T, McCluskey S, Wąsowicz M.

Anaesthesia. 2012 Nov;67(11):1242-50. doi: 10.1111/j.1365-2044.2012.07266.x. Epub 2012 Jul 24.

37.

Effects of 1α,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells.

Maeng HJ, Chapy H, Zaman S, Pang KS.

Eur J Pharm Sci. 2012 Jun 14;46(3):149-66. doi: 10.1016/j.ejps.2012.02.018. Epub 2012 Mar 3.

PMID:
22387228
38.

Physiologically based pharmacokinetic (PBPK) modeling: it is here to stay!

Rostami-Hodjegan A, Tamai I, Pang KS.

Biopharm Drug Dispos. 2012 Mar;33(2):47-50. doi: 10.1002/bdd.1776. Epub 2012 Mar 5. No abstract available.

PMID:
22351594
39.

Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice.

Grillo JA, Zhao P, Bullock J, Booth BP, Lu M, Robie-Suh K, Berglund EG, Pang KS, Rahman A, Zhang L, Lesko LJ, Huang SM.

Biopharm Drug Dispos. 2012 Mar;33(2):99-110. doi: 10.1002/bdd.1771. Epub 2012 Mar 4.

PMID:
22270945
40.

Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation.

Zhao P, Vieira Mde L, Grillo JA, Song P, Wu TC, Zheng JH, Arya V, Berglund EG, Atkinson AJ Jr, Sugiyama Y, Pang KS, Reynolds KS, Abernethy DR, Zhang L, Lesko LJ, Huang SM.

J Clin Pharmacol. 2012 Jan;52(1 Suppl):91S-108S. doi: 10.1177/0091270011415528.

PMID:
22232759
41.

Fraction absorbed (Fabs ): different connotations and confusion for the literature?

Pang KS, Rostami-Hodjegan A.

Biopharm Drug Dispos. 2011 Jul;32(5):301-2. doi: 10.1002/bdd.758. Epub 2011 Jun 1. No abstract available.

PMID:
21630284
42.
43.

1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac.

Maeng HJ, Durk MR, Chow EC, Ghoneim R, Pang KS.

Biopharm Drug Dispos. 2011 Mar;32(2):112-25. doi: 10.1002/bdd.742. Epub 2011 Jan 14.

PMID:
21341280
44.

PBPK modeling of intestinal and liver enzymes and transporters in drug absorption and sequential metabolism.

Fan J, Chen S, Chow EC, Pang KS.

Curr Drug Metab. 2010 Nov;11(9):743-61. Review.

PMID:
21189137
45.

Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion.

Pang KS, Durk MR.

J Pharmacokinet Pharmacodyn. 2010 Dec;37(6):591-615. doi: 10.1007/s10928-010-9185-x. Epub 2010 Dec 14. Review.

PMID:
21153869
46.

Comparative effects of doxercalciferol (1α-hydroxyvitamin D₂) versus calcitriol (1α,25-dihydroxyvitamin D₃) on the expression of transporters and enzymes in the rat in vivo.

Chow EC, Sondervan M, Jin C, Groothuis GM, Pang KS.

J Pharm Sci. 2011 Apr;100(4):1594-604. doi: 10.1002/jps.22366. Epub 2010 Oct 21.

PMID:
20967888
47.

Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells.

Fan J, Maeng HJ, Du Y, Kwan D, Pang KS.

Eur J Pharm Sci. 2011 Jan 18;42(1-2):19-29. doi: 10.1016/j.ejps.2010.10.001. Epub 2010 Oct 16.

PMID:
20955791
48.

The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices.

Khan AA, Chow EC, Porte RJ, Pang KS, Groothuis GM.

Toxicol In Vitro. 2011 Feb;25(1):80-90. doi: 10.1016/j.tiv.2010.09.011. Epub 2010 Oct 1.

PMID:
20888898
49.

Interplay of transporters and enzymes in the Caco-2 cell monolayer: I. effect of altered apical secretion.

Fan J, Maeng HJ, Pang KS.

Biopharm Drug Dispos. 2010 May;31(4):215-27. doi: 10.1002/bdd.704.

PMID:
20437461
50.

Physiological modeling to understand the impact of enzymes and transporters on drug and metabolite data and bioavailability estimates.

Sun H, Pang KS.

Pharm Res. 2010 Jul;27(7):1237-54. doi: 10.1007/s11095-010-0049-2. Epub 2010 Apr 6.

PMID:
20372987

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