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Neutrophil extracellular trap production contributes to pathogenesis in SIV-infected nonhuman primates.

Sivanandham R, Brocca-Cofano E, Krampe N, Falwell E, Venkatraman SMK, Ribeiro RM, Apetrei C, Pandrea I.

J Clin Invest. 2018 Nov 1;128(11):5178-5183. doi: 10.1172/JCI99420. Epub 2018 Oct 15.


The dynamics of simian immunodeficiency virus after depletion of CD8+ cells.

Cardozo EF, Apetrei C, Pandrea I, Ribeiro RM.

Immunol Rev. 2018 Sep;285(1):26-37. doi: 10.1111/imr.12691. Review.


Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques.

Brocca-Cofano E, Xu C, Wetzel KS, Cottrell ML, Policicchio BB, Raehtz KD, Ma D, Dunsmore T, Haret-Richter GS, Musaitif K, Keele BF, Kashuba AD, Collman RG, Pandrea I, Apetrei C.

J Virol. 2018 Aug 16;92(17). pii: e00576-18. doi: 10.1128/JVI.00576-18. Print 2018 Sep 1.


Regulatory T Cells As Potential Targets for HIV Cure Research.

Kleinman AJ, Sivanandham R, Pandrea I, Chougnet CA, Apetrei C.

Front Immunol. 2018 Apr 13;9:734. doi: 10.3389/fimmu.2018.00734. eCollection 2018. Review.


Dynamics of Simian Immunodeficiency Virus Two-Long-Terminal-Repeat Circles in the Presence and Absence of CD8+ Cells.

Policicchio BB, Cardozo EF, Sette P, Xu C, Haret-Richter G, Dunsmore T, Apetrei C, Pandrea I, Ribeiro RM.

J Virol. 2018 Jun 13;92(13). pii: e02100-17. doi: 10.1128/JVI.02100-17. Print 2018 Jul 1.


Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART).

Policicchio BB, Sette P, Xu C, Haret-Richter G, Dunsmore T, Pandrea I, Ribeiro RM, Apetrei C.

PLoS One. 2018 Feb 21;13(2):e0190908. doi: 10.1371/journal.pone.0190908. eCollection 2018.


Pathogenic Correlates of Simian Immunodeficiency Virus-Associated B Cell Dysfunction.

Brocca-Cofano E, Kuhrt D, Siewe B, Xu C, Haret-Richter GS, Craigo J, Labranche C, Montefiori DC, Landay A, Apetrei C, Pandrea I.

J Virol. 2017 Nov 14;91(23). pii: e01051-17. doi: 10.1128/JVI.01051-17. Print 2017 Dec 1.


Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy.

Schechter ME, Andrade BB, He T, Richter GH, Tosh KW, Policicchio BB, Singh A, Raehtz KD, Sheikh V, Ma D, Brocca-Cofano E, Apetrei C, Tracy R, Ribeiro RM, Sher A, Francischetti IMB, Pandrea I, Sereti I.

Sci Transl Med. 2017 Aug 30;9(405). pii: eaam5441. doi: 10.1126/scitranslmed.aam5441.


Modeling aging in HIV infection in nonhuman primates to address an emerging challenge of the post-ART era.

He T, Falwell E, Brocca-Cofano E, Pandrea I.

Curr Opin Virol. 2017 Aug;25:66-75. doi: 10.1016/j.coviro.2017.07.012. Epub 2017 Aug 10. Review.


CXCR6-Mediated Simian Immunodeficiency Virus SIVagmSab Entry into Sabaeus African Green Monkey Lymphocytes Implicates Widespread Use of Non-CCR5 Pathways in Natural Host Infections.

Wetzel KS, Yi Y, Elliott STC, Romero D, Jacquelin B, Hahn BH, Muller-Trutwin M, Apetrei C, Pandrea I, Collman RG.

J Virol. 2017 Jan 31;91(4). pii: e01626-16. doi: 10.1128/JVI.01626-16. Print 2017 Feb 15.


Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes.

He T, Brocca-Cofano E, Policicchio BB, Sivanandham R, Gautam R, Raehtz KD, Xu C, Pandrea I, Apetrei C.

J Immunol. 2016 Dec 15;197(12):4535-4539. Epub 2016 Nov 11.


Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rhesus Macaque Controllers.

Policicchio BB, Xu C, Brocca-Cofano E, Raehtz KD, He T, Ma D, Li H, Sivanandham R, Haret-Richter GS, Dunsmore T, Trichel A, Mellors JW, Hahn BH, Shaw GM, Ribeiro RM, Pandrea I, Apetrei C.

PLoS Pathog. 2016 Sep 15;12(9):e1005879. doi: 10.1371/journal.ppat.1005879. eCollection 2016 Sep.


Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques.

Li H, Wang S, Kong R, Ding W, Lee FH, Parker Z, Kim E, Learn GH, Hahn P, Policicchio B, Brocca-Cofano E, Deleage C, Hao X, Chuang GY, Gorman J, Gardner M, Lewis MG, Hatziioannou T, Santra S, Apetrei C, Pandrea I, Alam SM, Liao HX, Shen X, Tomaras GD, Farzan M, Chertova E, Keele BF, Estes JD, Lifson JD, Doms RW, Montefiori DC, Haynes BF, Sodroski JG, Kwong PD, Hahn BH, Shaw GM.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3413-22. doi: 10.1073/pnas.1606636113. Epub 2016 May 31.


Animal Models for HIV Cure Research.

Policicchio BB, Pandrea I, Apetrei C.

Front Immunol. 2016 Jan 28;7:12. doi: 10.3389/fimmu.2016.00012. eCollection 2016. Review.


Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques.

Pandrea I, Xu C, Stock JL, Frank DN, Ma D, Policicchio BB, He T, Kristoff J, Cornell E, Haret-Richter GS, Trichel A, Ribeiro RM, Tracy R, Wilson C, Landay AL, Apetrei C.

PLoS Pathog. 2016 Jan 14;12(1):e1005384. doi: 10.1371/journal.ppat.1005384. eCollection 2016 Jan.


Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques.

Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A, Dunham RM, Fadrosh DW, Lin DL, Faruqi AA, Huang Y, Apetrei C, Pandrea I, Hecht FM, Pilcher CD, Klatt NR, Brenchley JM, Lynch SV, McCune JM.

Cell Rep. 2015 Nov 24;13(8):1589-97. doi: 10.1016/j.celrep.2015.10.026. Epub 2015 Nov 12.


Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection.

Hao XP, Lucero CM, Turkbey B, Bernardo ML, Morcock DR, Deleage C, Trubey CM, Smedley J, Klatt NR, Giavedoni LD, Kristoff J, Xu A, Del Prete GQ, Keele BF, Rao SS, Alvord WG, Choyke PL, Lifson JD, Brenchley JM, Apetrei C, Pandrea I, Estes JD.

Nat Commun. 2015 Aug 18;6:8020. doi: 10.1038/ncomms9020.


Critical Role for the Adenosine Pathway in Controlling Simian Immunodeficiency Virus-Related Immune Activation and Inflammation in Gut Mucosal Tissues.

He T, Brocca-Cofano E, Gillespie DG, Xu C, Stock JL, Ma D, Policicchio BB, Raehtz KD, Rinaldo CR, Apetrei C, Jackson EK, Macatangay BJ, Pandrea I.

J Virol. 2015 Sep;89(18):9616-30. doi: 10.1128/JVI.01196-15. Epub 2015 Jul 15.


Population Bottlenecks and Pathogen Extinction: "Make This Everyone's Mission to Mars, Including Yours".

Policicchio BB, Pandrea I, Apetrei C.

J Virol. 2015 Aug;89(16):8104-6. doi: 10.1128/JVI.00920-15. Epub 2015 May 27.


Simian Immunodeficiency Virus SIVsab Infection of Rhesus Macaques as a Model of Complete Immunological Suppression with Persistent Reservoirs of Replication-Competent Virus: Implications for Cure Research.

Ma D, Xu C, Cillo AR, Policicchio B, Kristoff J, Haret-Richter G, Mellors JW, Pandrea I, Apetrei C.

J Virol. 2015 Jun;89(11):6155-60. doi: 10.1128/JVI.00256-15. Epub 2015 Apr 1.


Using the pathogenic and nonpathogenic nonhuman primate model for studying non-AIDS comorbidities.

Pandrea I, Landay A, Wilson C, Stock J, Tracy R, Apetrei C.

Curr HIV/AIDS Rep. 2015 Mar;12(1):54-67. doi: 10.1007/s11904-014-0245-5. Review.


Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication.

Kristoff J, Haret-Richter G, Ma D, Ribeiro RM, Xu C, Cornell E, Stock JL, He T, Mobley AD, Ross S, Trichel A, Wilson C, Tracy R, Landay A, Apetrei C, Pandrea I.

J Clin Invest. 2014 Jun;124(6):2802-6. doi: 10.1172/JCI75090. Epub 2014 May 16.


Pathogenic features associated with increased virulence upon Simian immunodeficiency virus cross-species transmission from natural hosts.

Mandell DT, Kristoff J, Gaufin T, Gautam R, Ma D, Sandler N, Haret-Richter G, Xu C, Aamer H, Dufour J, Trichel A, Douek DC, Keele BF, Apetrei C, Pandrea I.

J Virol. 2014 Jun;88(12):6778-92. doi: 10.1128/JVI.03785-13. Epub 2014 Apr 2.


Factors associated with siman immunodeficiency virus transmission in a natural African nonhuman primate host in the wild.

Ma D, Jasinska AJ, Feyertag F, Wijewardana V, Kristoff J, He T, Raehtz K, Schmitt CA, Jung Y, Cramer JD, Dione M, Antonio M, Tracy R, Turner T, Robertson DL, Pandrea I, Freimer N, Apetrei C; International Vervet Research Consortium.

J Virol. 2014 May;88(10):5687-705. doi: 10.1128/JVI.03606-13. Epub 2014 Mar 12.


Kinetics of myeloid dendritic cell trafficking and activation: impact on progressive, nonprogressive and controlled SIV infections.

Wijewardana V, Kristoff J, Xu C, Ma D, Haret-Richter G, Stock JL, Policicchio BB, Mobley AD, Nusbaum R, Aamer H, Trichel A, Ribeiro RM, Apetrei C, Pandrea I.

PLoS Pathog. 2013;9(10):e1003600. doi: 10.1371/journal.ppat.1003600. Epub 2013 Oct 3.


SIVagm infection in wild African green monkeys from South Africa: epidemiology, natural history, and evolutionary considerations.

Ma D, Jasinska A, Kristoff J, Grobler JP, Turner T, Jung Y, Schmitt C, Raehtz K, Feyertag F, Martinez Sosa N, Wijewardana V, Burke DS, Robertson DL, Tracy R, Pandrea I, Freimer N, Apetrei C; International Vervet Research Consortium.

PLoS Pathog. 2013 Jan;9(1):e1003011. doi: 10.1371/journal.ppat.1003011. Epub 2013 Jan 17.


Distinct evolutionary pressures underlie diversity in simian immunodeficiency virus and human immunodeficiency virus lineages.

Fischer W, Apetrei C, Santiago ML, Li Y, Gautam R, Pandrea I, Shaw GM, Hahn BH, Letvin NL, Nabel GJ, Korber BT.

J Virol. 2012 Dec;86(24):13217-31. doi: 10.1128/JVI.01862-12. Epub 2012 Oct 10.


Nonhuman primate models for HIV cure research.

Apetrei C, Pandrea I, Mellors JW.

PLoS Pathog. 2012;8(8):e1002892. doi: 10.1371/journal.ppat.1002892. Epub 2012 Aug 30. No abstract available.


Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates.

Pandrea I, Cornell E, Wilson C, Ribeiro RM, Ma D, Kristoff J, Xu C, Haret-Richter GS, Trichel A, Apetrei C, Landay A, Tracy R.

Blood. 2012 Aug 16;120(7):1357-66. doi: 10.1182/blood-2012-03-414706. Epub 2012 May 31. Erratum in: Blood. 2014 Aug 7;124(6):981.


Mucosal simian immunodeficiency virus transmission in African green monkeys: susceptibility to infection is proportional to target cell availability at mucosal sites.

Pandrea I, Parrish NF, Raehtz K, Gaufin T, Barbian HJ, Ma D, Kristoff J, Gautam R, Zhong F, Haret-Richter GS, Trichel A, Shaw GM, Hahn BH, Apetrei C.

J Virol. 2012 Apr;86(8):4158-68. doi: 10.1128/JVI.07141-11. Epub 2012 Feb 8.


Reply to "Control of Simian Immunodeficiency Virus SIVmnd-1 RNA Plasma Viremia after Coinfection or Superinfection with SIVmnd-1 in SIVmnd-2-Infected Mandrills and Vice Versa".

Souquiere S, Apetrei C, Chahroudi A, Pandrea I, Silvestri G, Roques P.

J Virol. 2012 Feb;86(4):2387-8. doi: 10.1128/JVI.06953-11. No abstract available.


Immunovirological analyses of chronically simian immunodeficiency virus SIVmnd-1- and SIVmnd-2-infected mandrills (Mandrillus sphinx).

Apetrei C, Sumpter B, Souquiere S, Chahroudi A, Makuwa M, Reed P, Ribeiro RM, Pandrea I, Roques P, Silvestri G.

J Virol. 2011 Dec;85(24):13077-87. doi: 10.1128/JVI.05693-11. Epub 2011 Sep 28. Erratum in: J Virol. 2012 Feb;86(3):1900.


Functional cure of SIVagm infection in rhesus macaques results in complete recovery of CD4+ T cells and is reverted by CD8+ cell depletion.

Pandrea I, Gaufin T, Gautam R, Kristoff J, Mandell D, Montefiori D, Keele BF, Ribeiro RM, Veazey RS, Apetrei C.

PLoS Pathog. 2011 Aug;7(8):e1002170. doi: 10.1371/journal.ppat.1002170. Epub 2011 Aug 4.


CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus.

Vinton C, Klatt NR, Harris LD, Briant JA, Sanders-Beer BE, Herbert R, Woodward R, Silvestri G, Pandrea I, Apetrei C, Hirsch VM, Brenchley JM.

J Virol. 2011 Sep;85(17):8702-8. doi: 10.1128/JVI.00332-11. Epub 2011 Jun 29.


Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression.

Paiardini M, Cervasi B, Reyes-Aviles E, Micci L, Ortiz AM, Chahroudi A, Vinton C, Gordon SN, Bosinger SE, Francella N, Hallberg PL, Cramer E, Schlub T, Chan ML, Riddick NE, Collman RG, Apetrei C, Pandrea I, Else J, Munch J, Kirchhoff F, Davenport MP, Brenchley JM, Silvestri G.

Nat Med. 2011 Jun 26;17(7):830-6. doi: 10.1038/nm.2395.


Pattern of SIVagm infection in patas monkeys suggests that host adaptation to simian immunodeficiency virus infection may result in resistance to infection and virus extinction.

Apetrei C, Gaufin T, Gautam R, Vinton C, Hirsch V, Lewis M, Brenchley J, Pandrea I.

J Infect Dis. 2010 Nov 1;202 Suppl 3:S371-6. doi: 10.1086/655970.


Genetic identity and biological phenotype of a transmitted/founder virus representative of nonpathogenic simian immunodeficiency virus infection in African green monkeys.

Gnanadurai CW, Pandrea I, Parrish NF, Kraus MH, Learn GH, Salazar MG, Sauermann U, Töpfer K, Gautam R, Münch J, Stahl-Hennig C, Apetrei C, Hahn BH, Kirchhoff F.

J Virol. 2010 Dec;84(23):12245-54. doi: 10.1128/JVI.01603-10. Epub 2010 Sep 29.


Experimental depletion of CD8+ cells in acutely SIVagm-infected African Green Monkeys results in increased viral replication.

Gaufin T, Ribeiro RM, Gautam R, Dufour J, Mandell D, Apetrei C, Pandrea I.

Retrovirology. 2010 May 11;7:42. doi: 10.1186/1742-4690-7-42.


Where the wild things are: pathogenesis of SIV infection in African nonhuman primate hosts.

Pandrea I, Apetrei C.

Curr HIV/AIDS Rep. 2010 Feb;7(1):28-36. doi: 10.1007/s11904-009-0034-8. Review.


CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells.

Klatt NR, Shudo E, Ortiz AM, Engram JC, Paiardini M, Lawson B, Miller MD, Else J, Pandrea I, Estes JD, Apetrei C, Schmitz JE, Ribeiro RM, Perelson AS, Silvestri G.

PLoS Pathog. 2010 Jan 29;6(1):e1000747. doi: 10.1371/journal.ppat.1000747.


Alcohol's role in HIV transmission and disease progression.

Pandrea I, Happel KI, Amedee AM, Bagby GJ, Nelson S.

Alcohol Res Health. 2010;33(3):203-18. Review.


Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts.

Sodora DL, Allan JS, Apetrei C, Brenchley JM, Douek DC, Else JG, Estes JD, Hahn BH, Hirsch VM, Kaur A, Kirchhoff F, Muller-Trutwin M, Pandrea I, Schmitz JE, Silvestri G.

Nat Med. 2009 Aug;15(8):861-5. doi: 10.1038/nm.2013. Review.


Effect of B-cell depletion on viral replication and clinical outcome of simian immunodeficiency virus infection in a natural host.

Gaufin T, Pattison M, Gautam R, Stoulig C, Dufour J, MacFarland J, Mandell D, Tatum C, Marx MH, Ribeiro RM, Montefiori D, Apetrei C, Pandrea I.

J Virol. 2009 Oct;83(20):10347-57. doi: 10.1128/JVI.00880-09. Epub 2009 Aug 5.


Lessons learned from the natural hosts of HIV-related viruses.

Paiardini M, Pandrea I, Apetrei C, Silvestri G.

Annu Rev Med. 2009;60:485-95. doi: 10.1146/ Review.


CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection.

Beaumier CM, Harris LD, Goldstein S, Klatt NR, Whitted S, McGinty J, Apetrei C, Pandrea I, Hirsch VM, Brenchley JM.

Nat Med. 2009 Aug;15(8):879-85. doi: 10.1038/nm.1970. Epub 2009 Jun 14.


Simian immunodeficiency virus SIVrcm, a unique CCR2-tropic virus, selectively depletes memory CD4+ T cells in pigtailed macaques through expanded coreceptor usage in vivo.

Gautam R, Gaufin T, Butler I, Gautam A, Barnes M, Mandell D, Pattison M, Tatum C, Macfarland J, Monjure C, Marx PA, Pandrea I, Apetrei C.

J Virol. 2009 Aug;83(16):7894-908. doi: 10.1128/JVI.00444-09. Epub 2009 Jun 3.


Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.

Favre D, Lederer S, Kanwar B, Ma ZM, Proll S, Kasakow Z, Mold J, Swainson L, Barbour JD, Baskin CR, Palermo R, Pandrea I, Miller CJ, Katze MG, McCune JM.

PLoS Pathog. 2009 Feb;5(2):e1000295. doi: 10.1371/journal.ppat.1000295. Epub 2009 Feb 13.


Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain.

Gaufin T, Gautam R, Kasheta M, Ribeiro R, Ribka E, Barnes M, Pattison M, Tatum C, MacFarland J, Montefiori D, Kaur A, Pandrea I, Apetrei C.

Blood. 2009 Apr 30;113(18):4250-61. doi: 10.1182/blood-2008-09-177741. Epub 2009 Jan 23.


AIDS in african nonhuman primate hosts of SIVs: a new paradigm of SIV infection.

Pandrea I, Silvestri G, Apetrei C.

Curr HIV Res. 2009 Jan;7(1):57-72. Review.


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