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Items: 1 to 50 of 457

1.

The functions and regulation of the PTEN tumour suppressor: new modes and prospects.

Lee YR, Chen M, Pandolfi PP.

Nat Rev Mol Cell Biol. 2018 Jun 1. doi: 10.1038/s41580-018-0015-0. [Epub ahead of print] Review.

PMID:
29858604
2.

An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance.

Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP.

Cell. 2018 Apr 19;173(3):649-664.e20. doi: 10.1016/j.cell.2018.03.052.

PMID:
29677511
3.

The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth.

Zhang J, Guo J, Qin X, Wang B, Zhang L, Wang Y, Gan W, Pandolfi PP, Chen W, Wei W.

Sci Signal. 2018 Mar 27;11(523). pii: eaao1052. doi: 10.1126/scisignal.aao1052.

PMID:
29588411
4.

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.

Ding M, Van der Kwast TH, Vellanki RN, Foltz WD, McKee TD, Sonenberg N, Pandolfi PP, Koritzinsky M, Wouters BG.

Mol Cancer Res. 2018 Apr;16(4):682-695. doi: 10.1158/1541-7786.MCR-17-0696. Epub 2018 Feb 16.

PMID:
29453322
5.

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.

Chen M, Zhang J, Sampieri K, Clohessy JG, Mendez L, Gonzalez-Billalabeitia E, Liu XS, Lee YR, Fung J, Katon JM, Menon AV, Webster KA, Ng C, Palumbieri MD, Diolombi MS, Breitkopf SB, Teruya-Feldstein J, Signoretti S, Bronson RT, Asara JM, Castillo-Martin M, Cordon-Cardo C, Pandolfi PP.

Nat Genet. 2018 Feb;50(2):206-218. doi: 10.1038/s41588-017-0027-2. Epub 2018 Jan 15.

PMID:
29335545
6.

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.

Chen M, Wan L, Zhang J, Zhang J, Mendez L, Clohessy JG, Berry K, Victor J, Yin Q, Zhu Y, Wei W, Pandolfi PP.

Nat Commun. 2018 Jan 15;9(1):159. doi: 10.1038/s41467-017-02272-y.

7.

Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.

Bezzi M, Seitzer N, Ishikawa T, Reschke M, Chen M, Wang G, Mitchell C, Ng C, Katon J, Lunardi A, Signoretti S, Clohessy JG, Zhang J, Pandolfi PP.

Nat Med. 2018 Feb;24(2):165-175. doi: 10.1038/nm.4463. Epub 2018 Jan 8.

PMID:
29309058
8.

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.

Guarnerio J, Mendez LM, Asada N, Menon AV, Fung J, Berry K, Frenette PS, Ito K, Pandolfi PP.

Nat Commun. 2018 Jan 4;9(1):66. doi: 10.1038/s41467-017-02427-x.

9.

Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure.

de Thé H, Pandolfi PP, Chen Z.

Cancer Cell. 2017 Nov 13;32(5):552-560. doi: 10.1016/j.ccell.2017.10.002. Review.

PMID:
29136503
10.

A circular twist on microRNA regulation.

Bezzi M, Guarnerio J, Pandolfi PP.

Cell Res. 2017 Dec;27(12):1401-1402. doi: 10.1038/cr.2017.136. Epub 2017 Oct 31.

PMID:
29086764
11.

Preclinical and Coclinical Studies in Prostate Cancer.

Chen M, Pandolfi PP.

Cold Spring Harb Perspect Med. 2018 Apr 2;8(4). pii: a030544. doi: 10.1101/cshperspect.a030544. Review.

PMID:
29038335
12.

Identification of competing endogenous RNAs of the tumor suppressor gene PTEN: A probabilistic approach.

Zarringhalam K, Tay Y, Kulkarni P, Bester AC, Pandolfi PP, Kulkarni RV.

Sci Rep. 2017 Aug 10;7(1):7755. doi: 10.1038/s41598-017-08209-1.

13.

Persistent Immune Stimulation Exacerbates Genetically Driven Myeloproliferative Disorders via Stromal Remodeling.

Tripodo C, Burocchi A, Piccaluga PP, Chiodoni C, Portararo P, Cappetti B, Botti L, Gulino A, Isidori A, Liso A, Visani G, Martelli MP, Falini B, Pandolfi PP, Colombo MP, Sangaletti S.

Cancer Res. 2017 Jul 1;77(13):3685-3699. doi: 10.1158/0008-5472.CAN-17-1098. Epub 2017 May 23.

14.

Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation.

van de Ven AL, Tangutoori S, Baldwin P, Qiao J, Gharagouzloo C, Seitzer N, Clohessy JG, Makrigiorgos GM, Cormack R, Pandolfi PP, Sridhar S.

Mol Cancer Ther. 2017 Jul;16(7):1279-1289. doi: 10.1158/1535-7163.MCT-16-0740. Epub 2017 May 12.

15.

Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones.

Carrà G, Panuzzo C, Torti D, Parvis G, Crivellaro S, Familiari U, Volante M, Morena D, Lingua MF, Brancaccio M, Guerrasio A, Pandolfi PP, Saglio G, Taulli R, Morotti A.

Oncotarget. 2017 May 30;8(22):35508-35522. doi: 10.18632/oncotarget.16348.

16.

The Epitranscriptome of Noncoding RNAs in Cancer.

Esteller M, Pandolfi PP.

Cancer Discov. 2017 Apr;7(4):359-368. doi: 10.1158/2159-8290.CD-16-1292. Epub 2017 Mar 20. Review.

17.

SPAR, a lncRNA encoded mTORC1 inhibitor.

Matsumoto A, Clohessy JG, Pandolfi PP.

Cell Cycle. 2017 May 3;16(9):815-816. doi: 10.1080/15384101.2017.1304735. Epub 2017 Mar 20. No abstract available.

18.

Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity.

Patnaik A, Swanson KD, Csizmadia E, Solanki A, Landon-Brace N, Gehring MP, Helenius K, Olson BM, Pyzer AR, Wang LC, Elemento O, Novak J, Thornley TB, Asara JM, Montaser L, Timmons JJ, Morgan TM, Wang Y, Levantini E, Clohessy JG, Kelly K, Pandolfi PP, Rosenblatt JM, Avigan DE, Ye H, Karp JM, Signoretti S, Balk SP, Cantley LC.

Cancer Discov. 2017 Jul;7(7):750-765. doi: 10.1158/2159-8290.CD-16-0778. Epub 2017 Mar 8.

19.

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.

Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W.

Cancer Discov. 2017 Apr;7(4):424-441. doi: 10.1158/2159-8290.CD-16-0647. Epub 2017 Feb 7.

20.

MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia.

Pyzer AR, Stroopinsky D, Rajabi H, Washington A, Tagde A, Coll M, Fung J, Bryant MP, Cole L, Palmer K, Somaiya P, Karp Leaf R, Nahas M, Apel A, Jain S, McMasters M, Mendez L, Levine J, Joyce R, Arnason J, Pandolfi PP, Kufe D, Rosenblatt J, Avigan D.

Blood. 2017 Mar 30;129(13):1791-1801. doi: 10.1182/blood-2016-07-730614. Epub 2017 Jan 26.

21.

The RNA-binding protein ESRP1 promotes human colorectal cancer progression.

Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfò I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F.

Oncotarget. 2017 Feb 7;8(6):10007-10024. doi: 10.18632/oncotarget.14318.

22.

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto A, Pasut A, Matsumoto M, Yamashita R, Fung J, Monteleone E, Saghatelian A, Nakayama KI, Clohessy JG, Pandolfi PP.

Nature. 2017 Jan 12;541(7636):228-232. doi: 10.1038/nature21034. Epub 2016 Dec 26.

PMID:
28024296
23.

The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.

Davidson D, Zhong MC, Pandolfi PP, Bolland S, Xavier RJ, Seed B, Li X, Gu H, Veillette A.

Cell Rep. 2016 Dec 6;17(10):2776-2788. doi: 10.1016/j.celrep.2016.11.035.

24.

The pleiotropic role of non-coding genes in development and cancer.

Pasut A, Matsumoto A, Clohessy JG, Pandolfi PP.

Curr Opin Cell Biol. 2016 Dec;43:104-113. doi: 10.1016/j.ceb.2016.10.005. Epub 2016 Nov 16. Review.

25.

MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer.

Lo Sardo F, Forcato M, Sacconi A, Capaci V, Zanconato F, Di Agostino S, Del Sal G, Pandolfi PP, Strano S, Bicciato S, Blandino G.

Carcinogenesis. 2017 Jan;38(1):64-75. doi: 10.1093/carcin/bgw110. Epub 2016 Oct 17.

PMID:
27797825
26.

Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling.

Shukla-Dave A, Castillo-Martin M, Chen M, Lobo J, Gladoun N, Collazo-Lorduy A, Khan FM, Ponomarev V, Yi Z, Zhang W, Pandolfi PP, Hricak H, Cordon-Cardo C.

Am J Pathol. 2016 Dec;186(12):3131-3145. doi: 10.1016/j.ajpath.2016.08.021. Epub 2016 Oct 19.

27.

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.

German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG Jr, Haigis MC.

Mol Cell. 2016 Sep 15;63(6):1006-20. doi: 10.1016/j.molcel.2016.08.014.

28.

PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity.

Noguera NI, Piredda ML, Taulli R, Catalano G, Angelini G, Gaur G, Nervi C, Voso MT, Lunardi A, Pandolfi PP, Lo-Coco F.

Oncotarget. 2016 Oct 11;7(41):66386-66397. doi: 10.18632/oncotarget.11964.

29.

PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development.

Missiroli S, Bonora M, Patergnani S, Poletti F, Perrone M, Gafà R, Magri E, Raimondi A, Lanza G, Tacchetti C, Kroemer G, Pandolfi PP, Pinton P, Giorgi C.

Cell Rep. 2016 Aug 30;16(9):2415-27. doi: 10.1016/j.celrep.2016.07.082. Epub 2016 Aug 18.

30.

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations.

Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH, Pandolfi PP.

Cell. 2016 Aug 11;166(4):1055-1056. doi: 10.1016/j.cell.2016.07.035. No abstract available.

31.

Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells.

Coppin E, De Grandis M, Pandolfi PP, Arcangeli ML, Aurrand-Lions M, Nunès JA.

J Immunol. 2016 May 15;196(10):4110-21. doi: 10.4049/jimmunol.1501037. Epub 2016 Apr 18.

32.

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA, Zon LI.

Mol Cell. 2016 Apr 7;62(1):34-46. doi: 10.1016/j.molcel.2016.03.013.

33.

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations.

Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH, Pandolfi PP.

Cell. 2016 Apr 7;165(2):289-302. doi: 10.1016/j.cell.2016.03.020. Epub 2016 Mar 31. Erratum in: Cell. 2016 Aug 11;166(4):1055-1056.

34.

Modeling Cancer-Associated Mutations of PTEN in Mice.

Papa A, Pandolfi PP.

Methods Mol Biol. 2016;1388:289-306. doi: 10.1007/978-1-4939-3299-3_16.

PMID:
27033081
35.

Posttranscriptional Regulation of PTEN by Competing Endogenous RNAs.

Tay Y, Pandolfi PP.

Methods Mol Biol. 2016;1388:139-54. doi: 10.1007/978-1-4939-3299-3_10.

PMID:
27033075
36.

Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth.

Nemeth Z, Csizmadia E, Vikstrom L, Li M, Bisht K, Feizi A, Otterbein S, Zuckerbraun B, Costa DB, Pandolfi PP, Fillinger J, Döme B, Otterbein LE, Wegiel B.

Oncotarget. 2016 Apr 26;7(17):23919-32. doi: 10.18632/oncotarget.8081.

37.

Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice.

Niki M, Nayak MK, Jin H, Bhasin N, Plow EF, Pandolfi PP, Rothman PB, Chauhan AK, Lentz SR.

Thromb Haemost. 2016 May 2;115(5):969-78. doi: 10.1160/TH15-05-0373. Epub 2016 Jan 21.

38.

Endosome and INPP4B.

Chew CL, Chen M, Pandolfi PP.

Oncotarget. 2016 Jan 5;7(1):5-6. doi: 10.18632/oncotarget.6663. No abstract available.

39.

Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.

Duquette M, Sadow PM, Husain A, Sims JN, Antonello ZA, Fischer AH, Song C, Castellanos-Rizaldos E, Makrigiorgos GM, Kurebayashi J, Nose V, Van Hummelen P, Bronson RT, Vinco M, Giordano TJ, Dias-Santagata D, Pandolfi PP, Nucera C.

Oncotarget. 2015 Dec 15;6(40):42445-67. doi: 10.18632/oncotarget.6442.

40.

Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity.

Gaublomme JT, Yosef N, Lee Y, Gertner RS, Yang LV, Wu C, Pandolfi PP, Mak T, Satija R, Shalek AK, Kuchroo VK, Park H, Regev A.

Cell. 2015 Dec 3;163(6):1400-12. doi: 10.1016/j.cell.2015.11.009. Epub 2015 Nov 19.

41.

Causality and Chance in the Development of Cancer.

Luzzatto L, Pandolfi PP.

N Engl J Med. 2015 Oct 15;373(16):1579. doi: 10.1056/NEJMc1509651. No abstract available.

42.

Somatic human ZBTB7A zinc finger mutations promote cancer progression.

Liu XS, Liu Z, Gerarduzzi C, Choi DE, Ganapathy S, Pandolfi PP, Yuan ZM.

Oncogene. 2016 Jun 9;35(23):3071-8. doi: 10.1038/onc.2015.371. Epub 2015 Oct 12.

43.

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP.

Nat Commun. 2015 Oct 8;6:8325. doi: 10.1038/ncomms9325.

44.

Pseudogenes in Human Cancer.

Poliseno L, Marranci A, Pandolfi PP.

Front Med (Lausanne). 2015 Sep 25;2:68. doi: 10.3389/fmed.2015.00068. eCollection 2015. Review.

45.

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.

Gan W, Dai X, Lunardi A, Li Z, Inuzuka H, Liu P, Varmeh S, Zhang J, Cheng L, Sun Y, Asara JM, Beck AH, Huang J, Pandolfi PP, Wei W.

Mol Cell. 2015 Sep 17;59(6):917-30. doi: 10.1016/j.molcel.2015.07.026. Epub 2015 Sep 3.

46.

The PTEN Tumor Suppressor Forms Homodimers in Solution.

Heinrich F, Chakravarthy S, Nanda H, Papa A, Pandolfi PP, Ross AH, Harishchandra RK, Gericke A, Lösche M.

Structure. 2015 Oct 6;23(10):1952-1957. doi: 10.1016/j.str.2015.07.012. Epub 2015 Aug 20.

47.

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.

Serra H, Chivite I, Angulo-Urarte A, Soler A, Sutherland JD, Arruabarrena-Aristorena A, Ragab A, Lim R, Malumbres M, Fruttiger M, Potente M, Serrano M, Fabra À, Viñals F, Casanovas O, Pandolfi PP, Bigas A, Carracedo A, Gerhardt H, Graupera M.

Nat Commun. 2015 Jul 31;6:7935. doi: 10.1038/ncomms8935.

48.

Causality and Chance in the Development of Cancer.

Luzzatto L, Pandolfi PP.

N Engl J Med. 2015 Jul 2;373(1):84-8. doi: 10.1056/NEJMsb1502456. No abstract available.

PMID:
26132946
49.

The promyelocytic leukemia protein is upregulated in conditions of obesity and liver steatosis.

Carracedo A, Rousseau D, Douris N, Fernández-Ruiz S, Martín-Martín N, Weiss D, Webster K, Adams AC, Vazquez-Chantada M, Martinez-Chantar ML, Anty R, Tran A, Maratos-Flier E, Gual P, Pandolfi PP.

Int J Biol Sci. 2015 Apr 11;11(6):629-32. doi: 10.7150/ijbs.11615. eCollection 2015. No abstract available.

50.

ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM.

Liu XS, Genet MD, Haines JE, Mehanna EK, Wu S, Chen HI, Chen Y, Qureshi AA, Han J, Chen X, Fisher DE, Pandolfi PP, Yuan ZM.

Mol Cancer Res. 2015 Aug;13(8):1206-17. doi: 10.1158/1541-7786.MCR-15-0169. Epub 2015 May 20.

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