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Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase.

Horikoshi N, Sharma D, Leonard F, Pandita RK, Charaka VK, Hambarde S, Horikoshi NT, Gaur Khaitan P, Chakraborty S, Cote J, Godin B, Hunt CR, Pandita TK.

Commun Biol. 2019 Jul 5;2:253. doi: 10.1038/s42003-019-0498-z. eCollection 2019.

Free PMC Article

The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development.

Ge C, Vilfranc CL, Che L, Pandita RK, Hambarde S, Andreassen PR, Niu L, Olowokure O, Shah S, Waltz SE, Zou L, Wang J, Pandita TK, Du C.

Hepatology. 2019 Jun;69(6):2608-2622. doi: 10.1002/hep.30529. Epub 2019 Mar 13.


Genetic and Pharmacological Targeting of Heat Shock Protein 70 in the Mouse Amygdala-Kindling Model.

von Rüden EL, Wolf F, Gualtieri F, Keck M, Hunt CR, Pandita TK, Potschka H.

ACS Chem Neurosci. 2019 Mar 20;10(3):1434-1444. doi: 10.1021/acschemneuro.8b00475. Epub 2018 Nov 16.


Correction: A homozygous FANCM frameshift pathogenic variant causes male infertility.

Yin H, Ma H, Hussain S, Zhang H, Xie X, Jiang L, Jiang X, Iqbal F, Bukhari I, Jiang H, Ali A, Zhong L, Li T, Fan S, Zhang B, Gao J, Li Y, Nazish J, Khan T, Khan M, Zubair M, Hao Q, Fang H, Huang J, Huleihel M, Sha J, Pandita TK, Zhang Y, Shi Q.

Genet Med. 2019 Jan;21(1):266. doi: 10.1038/s41436-018-0127-0.


The small heat shock protein HSPB1 protects mice from sepsis.

Breed ER, Hilliard CA, Yoseph B, Mittal R, Liang Z, Chen CW, Burd EM, Brewster LP, Hansen LM, Gleason RL Jr, Pandita TK, Ford ML, Hunt CR, Coopersmith CM.

Sci Rep. 2018 Aug 21;8(1):12493. doi: 10.1038/s41598-018-30752-8.


Complete Local and Abscopal Responses from a Combination of Radiation and Nivolumab in Refractory Hodgkin's Lymphoma.

Qin Q, Nan X, Miller T, Fisher R, Teh B, Pandita S, Farach AM, Pingali SR, Pandita RK, Butler EB, Pandita TK, Iyer SP.

Radiat Res. 2018 Sep;190(3):322-329. doi: 10.1667/RR15048.1. Epub 2018 Jun 27.


A homozygous FANCM frameshift pathogenic variant causes male infertility.

Yin H, Ma H, Hussain S, Zhang H, Xie X, Jiang L, Jiang X, Iqbal F, Bukhari I, Jiang H, Ali A, Zhong L, Li T, Fan S, Zhang B, Gao J, Li Y, Nazish J, Khan T, Khan M, Zubair M, Hao Q, Fang H, Huang J, Huleihel M, Sha J, Pandita TK, Zhang Y, Shi Q.

Genet Med. 2019 Jan;21(1):62-70. doi: 10.1038/s41436-018-0015-7. Epub 2018 Jun 12. Erratum in: Genet Med. 2018 Aug 29;:.


SMARCAD1 Phosphorylation and Ubiquitination Are Required for Resection during DNA Double-Strand Break Repair.

Chakraborty S, Pandita RK, Hambarde S, Mattoo AR, Charaka V, Ahmed KM, Iyer SP, Hunt CR, Pandita TK.

iScience. 2018 Apr 27;2:123-135. doi: 10.1016/j.isci.2018.03.016.


MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice.

Jiang H, Gao Q, Zheng W, Yin S, Wang L, Zhong L, Ali A, Khan T, Hao Q, Fang H, Sun X, Xu P, Pandita TK, Jiang X, Shi Q.

PLoS Genet. 2018 May 24;14(5):e1007300. doi: 10.1371/journal.pgen.1007300. eCollection 2018 May.


Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes.

Mujoo K, Hunt CR, Pandita RK, Ferrari M, Krishnan S, Cooke JP, Hahn S, Pandita TK.

Mol Cancer Res. 2018 Aug;16(8):1209-1214. doi: 10.1158/1541-7786.MCR-17-0743. Epub 2018 Mar 28. Review.


β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination.

Ahmed KM, Pandita RK, Singh DK, Hunt CR, Pandita TK.

Mol Cell Biol. 2018 Apr 16;38(9). pii: e00672-17. doi: 10.1128/MCB.00672-17. Print 2018 May 1.


MOF Suppresses Replication Stress and Contributes to Resolution of Stalled Replication Forks.

Singh DK, Pandita RK, Singh M, Chakraborty S, Hambarde S, Ramnarain D, Charaka V, Ahmed KM, Hunt CR, Pandita TK.

Mol Cell Biol. 2018 Feb 27;38(6). pii: e00484-17. doi: 10.1128/MCB.00484-17. Print 2018 Mar 15.


Cross Talk between Radiation and Immunotherapy: The Twain Shall Meet.

Iyer SP, Hunt CR, Pandita TK.

Radiat Res. 2018 Mar;189(3):219-224. doi: 10.1667/RR14941.1. Epub 2017 Dec 20. Review.


CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition.

Gadhikar MA, Zhang J, Shen L, Rao X, Wang J, Zhao M, Kalu NN, Johnson FM, Byers LA, Heymach J, Hittelman WN, Udayakumar D, Pandita RK, Pandita TK, Pickering CR, Redwood AB, Piwnica-Worms H, Schlacher K, Frederick MJ, Myers JN.

Cancer Res. 2018 Feb 1;78(3):781-797. doi: 10.1158/0008-5472.CAN-17-2802. Epub 2017 Dec 11.


HER2 Confers Resistance to Foretinib Inhibition of MET-Amplified Esophageal Adenocarcinoma Cells.

Goltsov AA, Fang B, Pandita TK, Maru DM, Swisher SG, Hofstetter WL.

Ann Thorac Surg. 2018 Feb;105(2):363-370. doi: 10.1016/j.athoracsur.2017.09.003. Epub 2017 Dec 7.


Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination.

Mujoo K, Pandita RK, Tiwari A, Charaka V, Chakraborty S, Singh DK, Hambarde S, Hittelman WN, Horikoshi N, Hunt CR, Khanna KK, Kots AY, Butler EB, Murad F, Pandita TK.

Stem Cell Reports. 2017 Nov 14;9(5):1660-1674. doi: 10.1016/j.stemcr.2017.10.002. Epub 2017 Nov 2.


Erratum: miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin.

Patel N, Garikapati KR, Pandita RK, Singh DK, Pandita TK, Bhadra U, Bhadra MP.

Sci Rep. 2017 Oct 10;7(1):12932. doi: 10.1038/s41598-017-12314-6.


Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex.

Hussain T, Saha D, Purohit G, Kar A, Kishore Mukherjee A, Sharma S, Sengupta S, Dhapola P, Maji B, Vedagopuram S, Horikoshi NT, Horikoshi N, Pandita RK, Bhattacharya S, Bajaj A, Riou JF, Pandita TK, Chowdhury S.

Sci Rep. 2017 Sep 14;7(1):11541. doi: 10.1038/s41598-017-11177-1.


miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin.

Patel N, Garikapati KR, Pandita RK, Singh DK, Pandita TK, Bhadra U, Bhadra MP.

Sci Rep. 2017 Jun 27;7(1):4263. doi: 10.1038/s41598-017-02800-2. Erratum in: Sci Rep. 2017 Oct 10;7(1):12932.


Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels.

Yin S, Jiang X, Jiang H, Gao Q, Wang F, Fan S, Khan T, Jabeen N, Khan M, Ali A, Xu P, Pandita TK, Fan HY, Zhang Y, Shi Q.

Development. 2017 Jun 15;144(12):2165-2174. doi: 10.1242/dev.149518. Epub 2017 May 15.


Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis.

Wang H, Peng B, Pandita RK, Engler DA, Matsunami RK, Xu X, Hegde PM, Butler BE, Pandita TK, Mitra S, Xu B, Hegde ML.

Oncotarget. 2017 Jul 25;8(30):48671-48687. doi: 10.18632/oncotarget.16225.


Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.

Shi W, Vu T, Boucher D, Biernacka A, Nde J, Pandita RK, Straube J, Boyle GM, Al-Ejeh F, Nag P, Jeffery J, Harris JL, Bain AL, Grzelak M, Skrzypczak M, Mitra A, Dojer N, Crosetto N, Cloonan N, Becherel OJ, Finnie J, Skaar JR, Walkley CR, Pandita TK, Rowicka M, Ginalski K, Lane SW, Khanna KK.

Blood. 2017 May 4;129(18):2479-2492. doi: 10.1182/blood-2016-06-725093. Epub 2017 Mar 7.


Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.

Valerio DG, Xu H, Chen CW, Hoshii T, Eisold ME, Delaney C, Cusan M, Deshpande AJ, Huang CH, Lujambio A, Zheng YG, Zuber J, Pandita TK, Lowe SW, Armstrong SA.

Cancer Res. 2017 Apr 1;77(7):1753-1762. doi: 10.1158/0008-5472.CAN-16-2374. Epub 2017 Feb 15.


Nuclear functions of β2-Spectrin in genomic stability.

Mujoo K, Hunt CR, Pandita TK.

Aging (Albany NY). 2016 Dec 14;8(12):3151-3152. doi: 10.18632/aging.101147. No abstract available.


Critical role of the POT1 OB domain in maintaining genomic stability.

Pandita TK.

Oncogene. 2017 Apr 6;36(14):1908-1910. doi: 10.1038/onc.2016.365. Epub 2016 Nov 21.


Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice.

Valerio DG, Xu H, Eisold ME, Woolthuis CM, Pandita TK, Armstrong SA.

Blood. 2017 Jan 5;129(1):48-59. doi: 10.1182/blood-2016-05-714568. Epub 2016 Nov 8.


MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks.

Mattoo AR, Pandita RK, Chakraborty S, Charaka V, Mujoo K, Hunt CR, Pandita TK.

Mol Cell Biol. 2017 Jan 19;37(3). pii: e00535-16. doi: 10.1128/MCB.00535-16. Print 2017 Feb 1.


Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes.

Chakraborty A, Tapryal N, Venkova T, Horikoshi N, Pandita RK, Sarker AH, Sarkar PS, Pandita TK, Hazra TK.

Nat Commun. 2016 Oct 5;7:13049. doi: 10.1038/ncomms13049.


Pluripotent Stem Cells and DNA Damage Response to Ionizing Radiations.

Mujoo K, Butler EB, Pandita RK, Hunt CR, Pandita TK.

Radiat Res. 2016 Jul;186(1):17-26. doi: 10.1667/RR14417.1. Epub 2016 Jun 22. Review.


HOXC10 Expression Supports the Development of Chemotherapy Resistance by Fine Tuning DNA Repair in Breast Cancer Cells.

Sadik H, Korangath P, Nguyen NK, Gyorffy B, Kumar R, Hedayati M, Teo WW, Park S, Panday H, Munoz TG, Menyhart O, Shah N, Pandita RK, Chang JC, DeWeese T, Chang HY, Pandita TK, Sukumar S.

Cancer Res. 2016 Aug 1;76(15):4443-56. doi: 10.1158/0008-5472.CAN-16-0774. Epub 2016 Jun 14.


β2-spectrin depletion impairs DNA damage repair.

Horikoshi N, Pandita RK, Mujoo K, Hambarde S, Sharma D, Mattoo AR, Chakraborty S, Charaka V, Hunt CR, Pandita TK.

Oncotarget. 2016 Jun 7;7(23):33557-70. doi: 10.18632/oncotarget.9677.


The many faces of histone H3K79 methylation.

Farooq Z, Banday S, Pandita TK, Altaf M.

Mutat Res Rev Mutat Res. 2016 Apr-Jun;768:46-52. doi: 10.1016/j.mrrev.2016.03.005. Epub 2016 Mar 31. Review.


Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo.

Deb P, Bhan A, Hussain I, Ansari KI, Bobzean SA, Pandita TK, Perrotti LI, Mandal SS.

Gene. 2016 Sep 30;590(2):234-43. doi: 10.1016/j.gene.2016.05.009. Epub 2016 May 13.


The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.

Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Côté J.

Mol Cell. 2016 May 5;62(3):409-421. doi: 10.1016/j.molcel.2016.03.031.


Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair.

Udayakumar D, Pandita RK, Horikoshi N, Liu Y, Liu Q, Wong KK, Hunt CR, Gray NS, Minna JD, Pandita TK, Westover KD.

Radiat Res. 2016 May;185(5):527-38. doi: 10.1667/RR14373.1. Epub 2016 May 2.


Emerging therapeutic targets in esophageal adenocarcinoma.

Gaur P, Hunt CR, Pandita TK.

Oncotarget. 2016 Jul 26;7(30):48644-48655. doi: 10.18632/oncotarget.8777. Review.


A multifaceted role for MOF histone modifying factor in genome maintenance.

Mujoo K, Hunt CR, Horikoshi N, Pandita TK.

Mech Ageing Dev. 2017 Jan;161(Pt A):177-180. doi: 10.1016/j.mad.2016.03.012. Epub 2016 Mar 30. Review.


More complex transcriptional regulation and stress response by MOF.

Horikoshi N, Hunt CR, Pandita TK.

Oncogene. 2016 May;35(21):2681-3. doi: 10.1038/onc.2015.373. Epub 2015 Oct 5.


ATM functions at the peroxisome to induce pexophagy in response to ROS.

Zhang J, Tripathi DN, Jing J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL.

Nat Cell Biol. 2015 Oct;17(10):1259-1269. doi: 10.1038/ncb3230. Epub 2015 Sep 7.


Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.

Torres MJ, Pandita RK, Kulak O, Kumar R, Formstecher E, Horikoshi N, Mujoo K, Hunt CR, Zhao Y, Lum L, Zaman A, Yeaman C, White MA, Pandita TK.

Mol Cell Biol. 2015 Nov;35(21):3633-45. doi: 10.1128/MCB.00768-15. Epub 2015 Aug 17.


Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.

Chakraborty A, Wakamiya M, Venkova-Canova T, Pandita RK, Aguilera-Aguirre L, Sarker AH, Singh DK, Hosoki K, Wood TG, Sharma G, Cardenas V, Sarkar PS, Sur S, Pandita TK, Boldogh I, Hazra TK.

J Biol Chem. 2015 Oct 9;290(41):24636-48. doi: 10.1074/jbc.M115.658146. Epub 2015 Aug 5.


Targeted inhibition of histone deacetylases and hedgehog signaling suppress tumor growth and homologous recombination in aerodigestive cancers.

Chun SG, Park H, Pandita RK, Horikoshi N, Pandita TK, Schwartz DL, Yordy JS.

Am J Cancer Res. 2015 Mar 15;5(4):1337-52. eCollection 2015.


USP7 saves RIDDLE for the end.

Pandita TK.

Cell Cycle. 2015;14(13):1999. doi: 10.1080/15384101.2015.1049087. Epub 2015 May 27. No abstract available.


Detecting ATM-dependent chromatin modification in DNA damage response.

Udayakumar D, Horikoshi N, Mishra L, Hunt C, Pandita TK.

Methods Mol Biol. 2015;1288:317-36. doi: 10.1007/978-1-4939-2474-5_18.


BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.

Ge C, Che L, Ren J, Pandita RK, Lu J, Li K, Pandita TK, Du C.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1210-9. doi: 10.1073/pnas.1418335112. Epub 2015 Mar 2.


The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.

Chatterjee A, Saha S, Chakraborty A, Silva-Fernandes A, Mandal SM, Neves-Carvalho A, Liu Y, Pandita RK, Hegde ML, Hegde PM, Boldogh I, Ashizawa T, Koeppen AH, Pandita TK, Maciel P, Sarkar PS, Hazra TK.

PLoS Genet. 2015 Jan 29;11(1):e1004749. doi: 10.1371/journal.pgen.1004749. eCollection 2015 Jan.


A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells.

Wang H, Adhikari S, Butler BE, Pandita TK, Mitra S, Hegde ML.

Jacobs J Radiat Oncol. 2014;1(1). pii: 003. No abstract available.


Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs.

Pandita RK, Chow TT, Udayakumar D, Bain AL, Cubeddu L, Hunt CR, Shi W, Horikoshi N, Zhao Y, Wright WE, Khanna KK, Shay JW, Pandita TK.

Cancer Res. 2015 Mar 1;75(5):858-69. doi: 10.1158/0008-5472.CAN-14-2289. Epub 2015 Jan 14.


Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks.

Chakraborty S, Li L, Puliyappadamba VT, Guo G, Hatanpaa KJ, Mickey B, Souza RF, Vo P, Herz J, Chen MR, Boothman DA, Pandita TK, Wang DH, Sen GC, Habib AA.

Nat Commun. 2014 Dec 15;5:5811. doi: 10.1038/ncomms6811.


Promoter-proximal transcription factor binding is transcriptionally active when coupled with nucleosome repositioning in immediate vicinity.

Yadav VK, Thakur RK, Eckloff B, Baral A, Singh A, Halder R, Kumar A, Alam MP, Kundu TK, Pandita R, Pandita TK, Wieben ED, Chowdhury S.

Nucleic Acids Res. 2014 Sep;42(15):9602-11. doi: 10.1093/nar/gku596. Epub 2014 Jul 31.

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