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Items: 1 to 50 of 143


Mechanisms of Persistent Neurobiological Changes Following Adolescent Alcohol Exposure: NADIA Consortium Findings.

Crews FT, Robinson DL, Chandler LJ, Ehlers CL, Mulholland PJ, Pandey SC, Rodd ZA, Spear LP, Swartzwelder HS, Vetreno RP.

Alcohol Clin Exp Res. 2019 Sep;43(9):1806-1822. doi: 10.1111/acer.14154. Epub 2019 Aug 14. Review.


Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1).

Gatta E, Grayson DR, Auta J, Saudagar V, Dong E, Chen Y, Krishnan HR, Drnevich J, Pandey SC, Guidotti A.

Mol Psychiatry. 2019 Jun 25. doi: 10.1038/s41380-019-0449-6. [Epub ahead of print]


Altered amygdala DNA methylation mechanisms after adolescent alcohol exposure contribute to adult anxiety and alcohol drinking.

Sakharkar AJ, Kyzar EJ, Gavin DP, Zhang H, Chen Y, Krishnan HR, Grayson DR, Pandey SC.

Neuropharmacology. 2019 Oct;157:107679. doi: 10.1016/j.neuropharm.2019.107679. Epub 2019 Jun 20.


Effect of Histone Deacetylase Inhibitor on Ethanol Withdrawal-Induced Hyperalgesia in Rats.

Pradhan AA, Tipton AF, Zhang H, Akbari A, Pandey SC.

Int J Neuropsychopharmacol. 2019 Aug 1;22(8):523-527. doi: 10.1093/ijnp/pyz031.


Acute Ethanol Produces Ataxia and Induces Fmr1 Expression via Histone Modifications in the Rat Cerebellum.

Dulman RS, Auta J, Teppen T, Pandey SC.

Alcohol Clin Exp Res. 2019 Jun;43(6):1191-1198. doi: 10.1111/acer.14044. Epub 2019 May 14.


The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) alleviates depression-like behavior and normalizes epigenetic changes in the hippocampus during ethanol withdrawal.

Chen WY, Zhang H, Gatta E, Glover EJ, Pandey SC, Lasek AW.

Alcohol. 2019 Aug;78:79-87. doi: 10.1016/j.alcohol.2019.02.005. Epub 2019 Mar 6.


Adolescent Alcohol Exposure Epigenetically Suppresses Amygdala Arc Enhancer RNA Expression to Confer Adult Anxiety Susceptibility.

Kyzar EJ, Zhang H, Pandey SC.

Biol Psychiatry. 2019 Jun 1;85(11):904-914. doi: 10.1016/j.biopsych.2018.12.021. Epub 2019 Jan 14.


Neuroimmune and epigenetic involvement in adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons: Restoration with voluntary exercise.

Vetreno RP, Bohnsack JP, Kusumo H, Liu W, Pandey SC, Crews FT.

Addict Biol. 2019 Feb 18. doi: 10.1111/adb.12731. [Epub ahead of print]


The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders.

Bohnsack JP, Teppen T, Kyzar EJ, Dzitoyeva S, Pandey SC.

Transl Psychiatry. 2019 Feb 6;9(1):34. doi: 10.1038/s41398-019-0367-z.


Essential Role of Histone Methyltransferase G9a in Rapid Tolerance to the Anxiolytic Effects of Ethanol.

Berkel TDM, Zhang H, Teppen T, Sakharkar AJ, Pandey SC.

Int J Neuropsychopharmacol. 2019 Apr 1;22(4):292-302. doi: 10.1093/ijnp/pyy102.


Ethanol acts on KCNK13 potassium channels in the ventral tegmental area to increase firing rate and modulate binge-like drinking.

You C, Savarese A, Vandegrift BJ, He D, Pandey SC, Lasek AW, Brodie MS.

Neuropharmacology. 2019 Jan;144:29-36. doi: 10.1016/j.neuropharm.2018.10.008. Epub 2018 Oct 14.


Evaluation of antileishmanial potential of computationally screened compounds targeting DEAD-box RNA helicase of Leishmania donovani.

Pandey SC, Jha A, Kumar A, Samant M.

Int J Biol Macromol. 2019 Jan;121:480-487. doi: 10.1016/j.ijbiomac.2018.10.053. Epub 2018 Oct 13.


Histone Deacetylase Inhibitor Suberanilohydroxamic Acid Treatment Reverses Hyposensitivity to γ-Aminobutyric Acid in the Ventral Tegmental Area During Ethanol Withdrawal.

You C, Vandegrift BJ, Zhang H, Lasek AW, Pandey SC, Brodie MS.

Alcohol Clin Exp Res. 2018 Nov;42(11):2160-2171. doi: 10.1111/acer.13870. Epub 2018 Sep 7.


Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring.

Dong E, Guidotti A, Zhang H, Pandey SC.

Neuropharmacology. 2018 Sep 15;140:76-85. doi: 10.1016/j.neuropharm.2018.07.010. Epub 2018 Aug 4.


Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala.

Zhang H, Kyzar EJ, Bohnsack JP, Kokare DM, Teppen T, Pandey SC.

Sci Rep. 2018 Jul 10;8(1):10376. doi: 10.1038/s41598-018-28415-9.


Potential role for histone deacetylation in chronic diazepam-induced downregulation of α1-GABAA receptor subunit expression.

Auta J, Gatta E, Davis JM, Pandey SC, Guidotti A.

Pharmacol Res Perspect. 2018 Jun 26;6(4):e00416. doi: 10.1002/prp2.416. eCollection 2018 Jul.


The development of a mouse model of mTBI-induced post-traumatic migraine, and identification of the delta opioid receptor as a novel therapeutic target.

Moye LS, Novack ML, Tipton AF, Krishnan H, Pandey SC, Pradhan AA.

Cephalalgia. 2019 Jan;39(1):77-90. doi: 10.1177/0333102418777507. Epub 2018 May 17.


Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis.

Kalinin S, González-Prieto M, Scheiblich H, Lisi L, Kusumo H, Heneka MT, Madrigal JLM, Pandey SC, Feinstein DL.

J Neuroinflammation. 2018 May 14;15(1):141. doi: 10.1186/s12974-018-1184-7.


Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure.

Mulholland PJ, Teppen TL, Miller KM, Sexton HG, Pandey SC, Swartzwelder HS.

Alcohol Clin Exp Res. 2018 Apr;42(4):706-717. doi: 10.1111/acer.13599. Epub 2018 Feb 15.


Epigenetic modulation of intestinal Na+/H+ exchanger-3 expression.

Kumar A, Malhotra P, Coffing H, Priyamvada S, Anbazhagan AN, Krishnan HR, Gill RK, Alrefai WA, Gavin DP, Pandey SC, Dudeja PK, Saksena S.

Am J Physiol Gastrointest Liver Physiol. 2018 Mar 1;314(3):G309-G318. doi: 10.1152/ajpgi.00293.2017. Epub 2017 Nov 22.


Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting.

Boule LA, Ju C, Agudelo M, Parira T, Cannon A, Davis B, Eby J, Cresci G, Samuelson DR, Shukla P, Alrefai WA, Sureshchandra S, Pandey SC, Schnabl B, Curtis BJ, Wyatt TA, Choudhry MA, Kovacs EJ.

Alcohol. 2018 Feb;66:35-43. doi: 10.1016/j.alcohol.2017.07.005. Epub 2017 Sep 23.


Cannabinoid-1 receptor neutral antagonist reduces binge-like alcohol consumption and alcohol-induced accumbal dopaminergic signaling.

Balla A, Dong B, Shilpa BM, Vemuri K, Makriyannis A, Pandey SC, Sershen H, Suckow RF, Vinod KY.

Neuropharmacology. 2018 Mar 15;131:200-208. doi: 10.1016/j.neuropharm.2017.10.040. Epub 2017 Nov 3.


Emerging Role of One-Carbon Metabolism and DNA Methylation Enrichment on δ-Containing GABAA Receptor Expression in the Cerebellum of Subjects with Alcohol Use Disorders (AUD).

Gatta E, Auta J, Gavin DP, Bhaumik DK, Grayson DR, Pandey SC, Guidotti A.

Int J Neuropsychopharmacol. 2017 Dec 1;20(12):1013-1026. doi: 10.1093/ijnp/pyx075.


Adolescent Alcohol Exposure-Induced Changes in Alpha-Melanocyte Stimulating Hormone and Neuropeptide Y Pathways via Histone Acetylation in the Brain During Adulthood.

Kokare DM, Kyzar EJ, Zhang H, Sakharkar AJ, Pandey SC.

Int J Neuropsychopharmacol. 2017 Sep 1;20(9):758-768. doi: 10.1093/ijnp/pyx041.


Epigenetic mechanisms of alcoholism and stress-related disorders.

Palmisano M, Pandey SC.

Alcohol. 2017 May;60:7-18. doi: 10.1016/j.alcohol.2017.01.001. Epub 2017 Mar 3. Review.


Chronic Alcohol Exposure Differentially Alters One-Carbon Metabolism in Rat Liver and Brain.

Auta J, Zhang H, Pandey SC, Guidotti A.

Alcohol Clin Exp Res. 2017 Jun;41(6):1105-1111. doi: 10.1111/acer.13382. Epub 2017 Apr 25.


Epigenetic basis of the dark side of alcohol addiction.

Pandey SC, Kyzar EJ, Zhang H.

Neuropharmacology. 2017 Aug 1;122:74-84. doi: 10.1016/j.neuropharm.2017.02.002. Epub 2017 Feb 4. Review.


Emerging Role of Epigenetic Mechanisms in Alcohol Addiction.

Berkel TD, Pandey SC.

Alcohol Clin Exp Res. 2017 Apr;41(4):666-680. doi: 10.1111/acer.13338. Epub 2017 Feb 18. Review.


Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex.

Trantham-Davidson H, Centanni SW, Garr SC, New NN, Mulholland PJ, Gass JT, Glover EJ, Floresco SB, Crews FT, Krishnan HR, Pandey SC, Chandler LJ.

Neuropsychopharmacology. 2017 Apr;42(5):1024-1036. doi: 10.1038/npp.2016.190. Epub 2016 Sep 13.


Adolescent Alcohol Exposure: Burden of Epigenetic Reprogramming, Synaptic Remodeling, and Adult Psychopathology.

Kyzar EJ, Floreani C, Teppen TL, Pandey SC.

Front Neurosci. 2016 May 31;10:222. doi: 10.3389/fnins.2016.00222. eCollection 2016. Review.


Adolescent alcohol exposure alters lysine demethylase 1 (LSD1) expression and histone methylation in the amygdala during adulthood.

Kyzar EJ, Zhang H, Sakharkar AJ, Pandey SC.

Addict Biol. 2017 Sep;22(5):1191-1204. doi: 10.1111/adb.12404. Epub 2016 May 15.


A Critical Role of Brain-Derived Neurotrophic Factor in Alcohol Consumption.

Pandey SC.

Biol Psychiatry. 2016 Mar 15;79(6):427-9. doi: 10.1016/j.biopsych.2015.12.020. No abstract available.


Role of Growth Arrest and DNA Damage-Inducible, Beta in Alcohol-Drinking Behaviors.

Gavin DP, Kusumo H, Zhang H, Guidotti A, Pandey SC.

Alcohol Clin Exp Res. 2016 Feb;40(2):263-72. doi: 10.1111/acer.12965.


The Potential Role of Amygdaloid MicroRNA-494 in Alcohol-Induced Anxiolysis.

Teppen TL, Krishnan HR, Zhang H, Sakharkar AJ, Pandey SC.

Biol Psychiatry. 2016 Nov 1;80(9):711-719. doi: 10.1016/j.biopsych.2015.10.028. Epub 2015 Nov 26.


Gadd45b and N-methyl-D-aspartate induced DNA demethylation in postmitotic neurons.

Gavin DP, Kusumo H, Sharma RP, Guizzetti M, Guidotti A, Pandey SC.

Epigenomics. 2015;7(4):567-79. doi: 10.2217/epi.15.12.


Neurogenetic and epigenetic correlates of adolescent predisposition to and risk for addictive behaviors as a function of prefrontal cortex dysregulation.

Blum K, Febo M, Smith DE, Roy AK 3rd, Demetrovics Z, Cronjé FJ, Femino J, Agan G, Fratantonio JL, Pandey SC, Badgaiyan RD, Gold MS.

J Child Adolesc Psychopharmacol. 2015 May;25(4):286-92. doi: 10.1089/cap.2014.0146. Epub 2015 Apr 28. Review.


Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood.

Pandey SC, Sakharkar AJ, Tang L, Zhang H.

Neurobiol Dis. 2015 Oct;82:607-619. doi: 10.1016/j.nbd.2015.03.019. Epub 2015 Mar 24.


Molecular mechanisms of synaptic remodeling in alcoholism.

Kyzar EJ, Pandey SC.

Neurosci Lett. 2015 Aug 5;601:11-9. doi: 10.1016/j.neulet.2015.01.051. Epub 2015 Jan 23. Review.


Adolescent alcohol exposure alters GABAA receptor subunit expression in adult hippocampus.

Centanni SW, Teppen T, Risher ML, Fleming RL, Moss JL, Acheson SK, Mulholland PJ, Pandey SC, Chandler LJ, Swartzwelder HS.

Alcohol Clin Exp Res. 2014 Nov;38(11):2800-8. doi: 10.1111/acer.12562.


Preface. Epigenetics.

Pandey SC.

Int Rev Neurobiol. 2014;115:xi-xiii. doi: 10.1016/B978-0-12-801311-3.10000-9. No abstract available.


The epigenetic landscape of alcoholism.

Krishnan HR, Sakharkar AJ, Teppen TL, Berkel TD, Pandey SC.

Int Rev Neurobiol. 2014;115:75-116. doi: 10.1016/B978-0-12-801311-3.00003-2. Review.


Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats.

Sakharkar AJ, Tang L, Zhang H, Chen Y, Grayson DR, Pandey SC.

Int J Neuropsychopharmacol. 2014 Dec;17(12):2057-67. doi: 10.1017/S1461145714001047. Epub 2014 Jun 26.


Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours.

Sakharkar AJ, Zhang H, Tang L, Baxstrom K, Shi G, Moonat S, Pandey SC.

Int J Neuropsychopharmacol. 2014 Aug;17(8):1207-20. doi: 10.1017/S1461145714000054. Epub 2014 Feb 17.


Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes.

Zhang X, Kusumo H, Sakharkar AJ, Pandey SC, Guizzetti M.

J Neurochem. 2014 Feb;128(3):344-9. doi: 10.1111/jnc.12465. Epub 2013 Oct 28.


Reversal of deficits in dendritic spines, BDNF and Arc expression in the amygdala during alcohol dependence by HDAC inhibitor treatment.

You C, Zhang H, Sakharkar AJ, Teppen T, Pandey SC.

Int J Neuropsychopharmacol. 2014 Feb;17(2):313-22. doi: 10.1017/S1461145713001144. Epub 2013 Oct 9.


Aberrant histone deacetylase2-mediated histone modifications and synaptic plasticity in the amygdala predisposes to anxiety and alcoholism.

Moonat S, Sakharkar AJ, Zhang H, Tang L, Pandey SC.

Biol Psychiatry. 2013 Apr 15;73(8):763-73. doi: 10.1016/j.biopsych.2013.01.012. Epub 2013 Feb 26.


Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors.

Arora DS, Nimitvilai S, Teppen TL, McElvain MA, Sakharkar AJ, You C, Pandey SC, Brodie MS.

Neuropsychopharmacology. 2013 Aug;38(9):1674-84. doi: 10.1038/npp.2013.65. Epub 2013 Mar 8.


Epigenetics-beyond the genome in alcoholism.

Starkman BG, Sakharkar AJ, Pandey SC.

Alcohol Res. 2012;34(3):293-305.


DNA methylation/demethylation network expression in psychotic patients with a history of alcohol abuse.

Guidotti A, Dong E, Gavin DP, Veldic M, Zhao W, Bhaumik DK, Pandey SC, Grayson DR.

Alcohol Clin Exp Res. 2013 Mar;37(3):417-24. doi: 10.1111/j.1530-0277.2012.01947.x. Epub 2012 Sep 7.


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