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p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity.

Valle-Casuso JC, Allouch A, David A, Lenzi GM, Studdard L, Barré-Sinoussi F, Müller-Trutwin M, Kim B, Pancino G, Sáez-Cirión A.

J Virol. 2017 Nov 14;91(23). pii: e01324-17. doi: 10.1128/JVI.01324-17. Print 2017 Dec 1.


Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.

Angin M, Wong G, Papagno L, Versmisse P, David A, Bayard C, Charmeteau-De Muylder B, Besseghir A, Thiébaut R, Boufassa F, Pancino G, Sauce D, Lambotte O, Brun-Vézinet F, Matheron S, Rowland-Jones SL, Cheynier R, Sáez-Cirión A, Appay V; ANRS CO5 IMMUNOVIR-2 Study Group.

J Immunol. 2016 Oct 1;197(7):2787-95. doi: 10.4049/jimmunol.1600693. Epub 2016 Aug 26.


Dendritic Cells from HIV Controllers Have Low Susceptibility to HIV-1 Infection In Vitro but High Capacity to Capture HIV-1 Particles.

Hamimi C, David A, Versmisse P, Weiss L, Bruel T, Zucman D, Appay V, Moris A, Ungeheuer MN, Lascoux-Combe C, Barré-Sinoussi F, Muller-Trutwin M, Boufassa F, Lambotte O, Pancino G, Sáez-Cirión A; ANRS CO21 CODEX cohort.

PLoS One. 2016 Aug 9;11(8):e0160251. doi: 10.1371/journal.pone.0160251. eCollection 2016.


Long-Term Spontaneous Control of HIV-1 Is Related to Low Frequency of Infected Cells and Inefficient Viral Reactivation.

Noel N, Peña R, David A, Avettand-Fenoel V, Erkizia I, Jimenez E, Lecuroux C, Rouzioux C, Boufassa F, Pancino G, Venet A, Van Lint C, Martinez-Picado J, Lambotte O, Sáez-Cirión A, Prado JG.

J Virol. 2016 Jun 10;90(13):6148-6158. doi: 10.1128/JVI.00419-16. Print 2016 Jul 1.


Long-term control of simian immunodeficiency virus (SIV) in cynomolgus macaques not associated with efficient SIV-specific CD8+ T-cell responses.

Bruel T, Hamimi C, Dereuddre-Bosquet N, Cosma A, Shin SY, Corneau A, Versmisse P, Karlsson I, Malleret B, Targat B, Barré-Sinoussi F, Le Grand R, Pancino G, Sáez-Cirión A, Vaslin B.

J Virol. 2015 Apr;89(7):3542-56. doi: 10.1128/JVI.03723-14. Epub 2015 Jan 14.


Immediate T-Helper 17 Polarization Upon Triggering CD11b/c on HIV-Exposed Dendritic Cells.

Wilflingseder D, Schroll A, Hackl H, Gallasch R, Frampton D, Lass-Flörl C, Pancino G, Saez-Cirion A, Lambotte O, Weiss L, Kellam P, Trajanoski Z, Geijtenbeek T, Weiss G, Posch W.

J Infect Dis. 2015 Jul 1;212(1):44-56. doi: 10.1093/infdis/jiv014. Epub 2015 Jan 12.


High eomesodermin expression among CD57+ CD8+ T cells identifies a CD8+ T cell subset associated with viral control during chronic human immunodeficiency virus infection.

Simonetta F, Hua S, Lécuroux C, Gérard S, Boufassa F, Sáez-Cirión A, Pancino G, Goujard C, Lambotte O, Venet A, Bourgeois C.

J Virol. 2014 Oct;88(20):11861-71. doi: 10.1128/JVI.02013-14. Epub 2014 Aug 6.


Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers.

Hua S, Lécuroux C, Sáez-Cirión A, Pancino G, Girault I, Versmisse P, Boufassa F, Taulera O, Sinet M, Lambotte O, Venet A.

PLoS One. 2014 Jul 7;9(7):e101920. doi: 10.1371/journal.pone.0101920. eCollection 2014.


Reply to Pauls et al.: p21 is a master regulator of HIV replication in macrophages through dNTP synthesis block.

Allouch A, David A, Amie SM, Lahouassa H, Chartier L, Margottin-Goguet F, Barré-Sinoussi F, Kim B, Sáez-Cirión A, Pancino G.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1325-6. No abstract available.


Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration.

Boufassa F, Lechenadec J, Meyer L, Costagliola D, Hunt PW, Pereyra F, Deeks S, Pancino G, Taulera O, Lichterfeld M, Delobel P, Saez-Cirion A, Lambotte O; ANRS CO18 HIV Controllers Cohort; Cascade Collaboration in Eurocoord; SCOPE Cohort; International HIV Controllers Study.

PLoS One. 2014 Jan 17;9(1):e85516. doi: 10.1371/journal.pone.0085516. eCollection 2014.


Elevated IP10 levels are associated with immune activation and low CD4⁺ T-cell counts in HIV controller patients.

Noel N, Boufassa F, Lécuroux C, Saez-Cirion A, Bourgeois C, Dunyach-Remy C, Goujard C, Rouzioux C, Meyer L, Pancino G, Venet A, Lambotte O; ANRS C021 CODEX Study Group.

AIDS. 2014 Feb 20;28(4):467-76. doi: 10.1097/QAD.0000000000000174.


Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers.

Lécuroux C, Sáez-Cirión A, Girault I, Versmisse P, Boufassa F, Avettand-Fenoël V, Rouzioux C, Meyer L, Pancino G, Lambotte O, Sinet M, Venet A.

J Virol. 2014 Jan;88(1):176-87. doi: 10.1128/JVI.02098-13. Epub 2013 Oct 16.


p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway.

Allouch A, David A, Amie SM, Lahouassa H, Chartier L, Margottin-Goguet F, Barré-Sinoussi F, Kim B, Sáez-Cirión A, Pancino G.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E3997-4006. doi: 10.1073/pnas.1306719110. Epub 2013 Sep 30.


HIV controllers: a genetically determined or inducible phenotype?

Sáez-Cirión A, Pancino G.

Immunol Rev. 2013 Jul;254(1):281-94. doi: 10.1111/imr.12076. Review.


CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection.

Lécuroux C, Girault I, Chéret A, Versmisse P, Nembot G, Meyer L, Rouzioux C, Pancino G, Venet A, Sáez-Cirión A; ANRS 147 OPTIPRIM clinical trial.

PLoS One. 2013;8(3):e59767. doi: 10.1371/journal.pone.0059767. Epub 2013 Mar 29.


Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study.

Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C; ANRS VISCONTI Study Group.

PLoS Pathog. 2013 Mar;9(3):e1003211. doi: 10.1371/journal.ppat.1003211. Epub 2013 Mar 14.


Will it be possible to live without antiretroviral therapy?

Hamimi C, Pancino G, Barré-Sinoussi F, Sáez-Cirión A.

Curr Opin HIV AIDS. 2013 May;8(3):196-203. doi: 10.1097/COH.0b013e32835f94d5. Review.


Antibodies attenuate the capacity of dendritic cells to stimulate HIV-specific cytotoxic T lymphocytes.

Posch W, Cardinaud S, Hamimi C, Fletcher A, Mühlbacher A, Loacker K, Eichberger P, Dierich MP, Pancino G, Lass-Flörl C, Moris A, Saez-Cirion A, Wilflingseder D.

J Allergy Clin Immunol. 2012 Dec;130(6):1368-74.e2. doi: 10.1016/j.jaci.2012.08.025. Epub 2012 Oct 11.


Natural killer cell degranulation capacity predicts early onset of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with tuberculosis.

Pean P, Nerrienet E, Madec Y, Borand L, Laureillard D, Fernandez M, Marcy O, Sarin C, Phon K, Taylor S, Pancino G, Barré-Sinoussi F, Scott-Algara D; Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study team.

Blood. 2012 Apr 5;119(14):3315-20. doi: 10.1182/blood-2011-09-377523. Epub 2012 Feb 17.


SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.

Lahouassa H, Daddacha W, Hofmann H, Ayinde D, Logue EC, Dragin L, Bloch N, Maudet C, Bertrand M, Gramberg T, Pancino G, Priet S, Canard B, Laguette N, Benkirane M, Transy C, Landau NR, Kim B, Margottin-Goguet F.

Nat Immunol. 2012 Feb 12;13(3):223-228. doi: 10.1038/ni.2236. Erratum in: Nat Immunol. 2013 Aug;14(8):877.


Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers.

Sáez-Cirión A, Hamimi C, Bergamaschi A, David A, Versmisse P, Mélard A, Boufassa F, Barré-Sinoussi F, Lambotte O, Rouzioux C, Pancino G; ANRS CO18 Cohort.

Blood. 2011 Jul 28;118(4):955-64. doi: 10.1182/blood-2010-12-327106. Epub 2011 Jun 3.


The AP-1 binding sites located in the pol gene intragenic regulatory region of HIV-1 are important for viral replication.

Colin L, Vandenhoudt N, de Walque S, Van Driessche B, Bergamaschi A, Martinelli V, Cherrier T, Vanhulle C, Guiguen A, David A, Burny A, Herbein G, Pancino G, Rohr O, Van Lint C.

PLoS One. 2011 Apr 19;6(4):e19084. doi: 10.1371/journal.pone.0019084.


Natural resistance to HIV infection: lessons learned from HIV‐exposed uninfected individuals.

Pancino G, Saez-Cirion A, Scott-Algara D, Paul P.

J Infect Dis. 2010 Nov 1;202 Suppl 3:S345-50. doi: 10.1086/655973.


Ex vivo T cell-based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses.

Sáez-Cirión A, Shin SY, Versmisse P, Barré-Sinoussi F, Pancino G.

Nat Protoc. 2010 Jun;5(6):1033-41. doi: 10.1038/nprot.2010.73. Epub 2010 May 13.


Host hindrance to HIV-1 replication in monocytes and macrophages.

Bergamaschi A, Pancino G.

Retrovirology. 2010 Apr 7;7:31. doi: 10.1186/1742-4690-7-31. Review.


Setting of methods for analysis of mucosal antibodies in seminal and vaginal fluids of HIV seropositive subjects from Cambodian and Italian cohorts.

Donadoni C, Bisighini C, Scotti L, Diomede L, Ngyen M, Nouhin J, DeSantis L, Zambon A, Ferrari D, Gallotta G, Corrao G, Pancino G, Lopalco L.

PLoS One. 2010 Mar 29;5(3):e9920. doi: 10.1371/journal.pone.0009920.


The CDK inhibitor p21Cip1/WAF1 is induced by FcgammaR activation and restricts the replication of human immunodeficiency virus type 1 and related primate lentiviruses in human macrophages.

Bergamaschi A, David A, Le Rouzic E, Nisole S, Barré-Sinoussi F, Pancino G.

J Virol. 2009 Dec;83(23):12253-65. doi: 10.1128/JVI.01395-09. Epub 2009 Sep 16.


Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses.

Sáez-Cirión A, Sinet M, Shin SY, Urrutia A, Versmisse P, Lacabaratz C, Boufassa F, Avettand-Fènoël V, Rouzioux C, Delfraissy JF, Barré-Sinoussi F, Lambotte O, Venet A, Pancino G; ANRS EP36 HIV Controllers Study Group.

J Immunol. 2009 Jun 15;182(12):7828-37. doi: 10.4049/jimmunol.0803928.


Biological and physical characterization of the X4 HIV-1 suppressive factor secreted by LPS-stimulated human macrophages.

Mikulak J, Gianolini M, Versmisse P, Pancino G, Lusso P, Verani A.

Virology. 2009 Jul 20;390(1):37-44. doi: 10.1016/j.virol.2009.04.005. Epub 2009 May 17.


Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity.

Almeida JR, Sauce D, Price DA, Papagno L, Shin SY, Moris A, Larsen M, Pancino G, Douek DC, Autran B, Sáez-Cirión A, Appay V.

Blood. 2009 Jun 18;113(25):6351-60. doi: 10.1182/blood-2009-02-206557. Epub 2009 Apr 23.


Human TRIM gene expression in response to interferons.

Carthagena L, Bergamaschi A, Luna JM, David A, Uchil PD, Margottin-Goguet F, Mothes W, Hazan U, Transy C, Pancino G, Nisole S.

PLoS One. 2009;4(3):e4894. doi: 10.1371/journal.pone.0004894. Epub 2009 Mar 17.


The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection.

Bergamaschi A, Ayinde D, David A, Le Rouzic E, Morel M, Collin G, Descamps D, Damond F, Brun-Vezinet F, Nisole S, Margottin-Goguet F, Pancino G, Transy C.

J Virol. 2009 May;83(10):4854-60. doi: 10.1128/JVI.00187-09. Epub 2009 Mar 4.


The CD85j+ NK cell subset potently controls HIV-1 replication in autologous dendritic cells.

Scott-Algara D, Arnold V, Didier C, Kattan T, Pirozzi G, Barré-Sinoussi F, Pancino G.

PLoS One. 2008 Apr 9;3(4):e1975. doi: 10.1371/journal.pone.0001975.


Localization of HIV-1 Vpr to the nuclear envelope: impact on Vpr functions and virus replication in macrophages.

Jacquot G, Le Rouzic E, David A, Mazzolini J, Bouchet J, Bouaziz S, Niedergang F, Pancino G, Benichou S.

Retrovirology. 2007 Nov 26;4:84.


HIV controllers: how do they tame the virus?

Sáez-Cirión A, Pancino G, Sinet M, Venet A, Lambotte O; ANRS EP36 HIV CONTROLLERS study group.

Trends Immunol. 2007 Dec;28(12):532-40. Epub 2007 Nov 5. Review.


Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study).

Lamine A, Caumont-Sarcos A, Chaix ML, Saez-Cirion A, Rouzioux C, Delfraissy JF, Pancino G, Lambotte O.

AIDS. 2007 May 11;21(8):1043-5.


HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype.

Sáez-Cirión A, Lacabaratz C, Lambotte O, Versmisse P, Urrutia A, Boufassa F, Barré-Sinoussi F, Delfraissy JF, Sinet M, Pancino G, Venet A; Agence Nationale de Recherches sur le Sida EP36 HIV Controllers Study Group.

Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6776-81. Epub 2007 Apr 11.


Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals.

Ravet S, Scott-Algara D, Bonnet E, Tran HK, Tran T, Nguyen N, Truong LX, Theodorou I, Barré-Sinoussi F, Pancino G, Paul P.

Blood. 2007 May 15;109(10):4296-305. Epub 2007 Feb 1.


Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks.

Sáez-Cirión A, Versmisse P, Truong LX, Chakrabarti LA, Carpentier W, Barré-Sinoussi F, Scott-Algara D, Pancino G.

Retrovirology. 2006 Nov 8;3:81.


The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages.

David A, Sáez-Cirión A, Versmisse P, Malbec O, Iannascoli B, Herschke F, Lucas M, Barré-Sinoussi F, Mouscadet JF, Daëron M, Pancino G.

J Immunol. 2006 Nov 1;177(9):6291-300. Erratum in: J Immunol. 2007 Mar 1;178(5):3333.


Efavirenz in plasma from HIV-infected patients does not directly block reverse transcriptase activity in cell-free assays but inhibits HIV replication in cellular assays.

Burrer R, Spiridon G, Einius-Haessig S, Richert S, Salmon-Ceron D, Pancino G, Aubertin AM, Moog C.

AIDS Res Hum Retroviruses. 2006 Sep;22(9):865-9.


Quantitative real-time analysis of HIV-1 gene expression dynamics in single living primary cells.

Sáez-Cirión A, Nicola MA, Pancino G, Shorte SL.

Biotechnol J. 2006 Jun;1(6):682-9.


HIV-specific antibodies but not t-cell responses are associated with protection in seronegative partners of HIV-1-infected individuals in Cambodia.

Nguyen M, Pean P, Lopalco L, Nouhin J, Phoung V, Ly N, Vermisse P, Henin Y, Barré-Sinoussi F, Burastero SE, Reynes JM, Carcelain G, Pancino G.

J Acquir Immune Defic Syndr. 2006 Aug 1;42(4):412-9.


Reduced CD4 T cell activation and in vitro susceptibility to HIV-1 infection in exposed uninfected Central Africans.

Bégaud E, Chartier L, Marechal V, Ipero J, Léal J, Versmisse P, Breton G, Fontanet A, Capoulade-Metay C, Fleury H, Barré-Sinoussi F, Scott-Algara D, Pancino G.

Retrovirology. 2006 Jun 22;3:35.


Systemic immune activation in HIV-1-exposed uninfected Vietnamese intravascular drug users.

Tran HK, Chartier L, Troung LX, Nguyen NN, Fontanet A, Barré-Sinoussi FE, Pancino G, Scott-Algara D.

AIDS Res Hum Retroviruses. 2006 Mar;22(3):255-61.


Differential susceptibility of human thymic dendritic cell subsets to X4 and R5 HIV-1 infection.

Schmitt N, Nugeyre MT, Scott-Algara D, Cumont MC, Barré-Sinoussi F, Pancino G, Israël N.

AIDS. 2006 Feb 28;20(4):533-42.


The MHC-haplotype influences primary, but not memory, immune responses to an immunodominant peptide containing T- and B-cell epitopes of the caprine arthritis encephalitis virus Gag protein.

Fluri A, Nenci C, Zahno ML, Vogt HR, Charan S, Busato A, Pancino G, Peterhans E, Obexer-Ruff G, Bertoni G.

Vaccine. 2006 Jan 30;24(5):597-606. Epub 2005 Aug 19.


Biochemical and HIV-1 coreceptor properties of K26R, a new CCR5 Variant in China's Sichuan population.

Ma L, Dudoit Y, Tran T, Xing H, Chen J, Pancino G, Bismuth G, Debré P, Shao Y, Theodorou I, Capoulade-Métay C.

J Acquir Immune Defic Syndr. 2005 May 1;39(1):38-43.


First Dominique Dormont International Conference on "Host-pathogen interactions in chronic infections - viral and host determinants of HCV, HCMV, and HIV infections".

Menu E, Müller-Trutwin MC, Pancino G, Saez-Cirion A, Bain C, Inchauspé G, Gras GS, Mabondzo AM, Samri A, Boutboul F, Le Grand R.

Retrovirology. 2005 Apr 6;2:24.


Predictive value of anti-cell and anti-human immunodeficiency virus (HIV) humoral responses in HIV-1-exposed seronegative cohorts of European and Asian origin.

Lopalco L, Barassi C, Paolucci C, Breda D, Brunelli D, Nguyen M, Nouhin J, Luong TT, Truong LX, Clerici M, Calori G, Lazzarin A, Pancino G, Burastero SE.

J Gen Virol. 2005 Feb;86(Pt 2):339-48.


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