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Items: 36

1.

High Molecular Weight Polymer Promotes Bone Health and Prevents Bone Loss Under Salmonella Challenge in Broiler Chickens.

Raehtz S, Hargis BM, Kuttappan VA, Pamukcu R, Bielke LR, McCabe LR.

Front Physiol. 2018 Apr 13;9:384. doi: 10.3389/fphys.2018.00384. eCollection 2018.

2.

Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells.

Lim JT, Piazza GA, Pamukcu R, Thompson WJ, Weinstein IB.

Clin Cancer Res. 2003 Oct 15;9(13):4972-82.

3.

Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival.

Whitehead CM, Earle KA, Fetter J, Xu S, Hartman T, Chan DC, Zhao TL, Piazza G, Klein-Szanto AJ, Pamukcu R, Alila H, Bunn PA Jr, Thompson WJ.

Mol Cancer Ther. 2003 May;2(5):479-88.

4.

beta-Catenin signaling: therapeutic strategies in oncology.

Li H, Pamukcu R, Thompson WJ.

Cancer Biol Ther. 2002 Nov-Dec;1(6):621-5. Review.

PMID:
12642683
5.
6.

CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells.

Yoon JT, Palazzo AF, Xiao D, Delohery TM, Warburton PE, Bruce JN, Thompson WJ, Sperl G, Whitehead C, Fetter J, Pamukcu R, Gundersen GG, Weinstein IB.

Mol Cancer Ther. 2002 Apr;1(6):393-404.

7.

Rapid development of colitis in NSAID-treated IL-10-deficient mice.

Berg DJ, Zhang J, Weinstock JV, Ismail HF, Earle KA, Alila H, Pamukcu R, Moore S, Lynch RG.

Gastroenterology. 2002 Nov;123(5):1527-42.

PMID:
12404228
8.

Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation.

Li H, Liu L, David ML, Whitehead CM, Chen M, Fetter JR, Sperl GJ, Pamukcu R, Thompson WJ.

Biochem Pharmacol. 2002 Nov 1;64(9):1325-36.

PMID:
12392815
9.

Exisulind in combination with docetaxel inhibits growth and metastasis of human lung cancer and prolongs survival in athymic nude rats with orthotopic lung tumors.

Chan DC, Earle KA, Zhao TL, Helfrich B, Zeng C, Baron A, Whitehead CM, Piazza G, Pamukcu R, Thompson WJ, Alila H, Nelson P, Bunn PA Jr.

Clin Cancer Res. 2002 Mar;8(3):904-12.

10.

Preclinical and clinical studies of docetaxel and exisulind in the treatment of human lung cancer.

Bunn PA Jr, Chan DC, Earle K, Zhao TL, Helfrich B, Kelly K, Piazza G, Whitehead CM, Pamukcu R, Thompson W, Alila H.

Semin Oncol. 2002 Feb;29(1 Suppl 4):87-94. Review.

PMID:
11894018
11.

Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase.

Liu L, Underwood T, Li H, Pamukcu R, Thompson WJ.

Cell Signal. 2002 Jan;14(1):45-51.

PMID:
11747988
12.

Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells.

Liu L, Li H, Underwood T, Lloyd M, David M, Sperl G, Pamukcu R, Thompson WJ.

J Pharmacol Exp Ther. 2001 Nov;299(2):583-92.

PMID:
11602670
13.

Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis.

Piazza GA, Thompson WJ, Pamukcu R, Alila HW, Whitehead CM, Liu L, Fetter JR, Gresh WE Jr, Klein-Szanto AJ, Farnell DR, Eto I, Grubbs CJ.

Cancer Res. 2001 May 15;61(10):3961-8.

14.

Proapoptotic anti-inflammatory drugs.

Myers C, Koki A, Pamukcu R, Wechter W, Padley RJ.

Urology. 2001 Apr;57(4 Suppl 1):73-6.

PMID:
11295599
15.

Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1.

Soh JW, Mao Y, Liu L, Thompson WJ, Pamukcu R, Weinstein IB.

J Biol Chem. 2001 May 11;276(19):16406-10. Epub 2001 Mar 14.

16.

Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1.

Soh JW, Mao Y, Kim MG, Pamukcu R, Li H, Piazza GA, Thompson WJ, Weinstein IB.

Clin Cancer Res. 2000 Oct;6(10):4136-41. Erratum in: Clin Cancer Res 2000 Dec;6(12):4967.

17.

Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.

Thompson WJ, Piazza GA, Li H, Liu L, Fetter J, Zhu B, Sperl G, Ahnen D, Pamukcu R.

Cancer Res. 2000 Jul 1;60(13):3338-42.

18.

Sulindac sulfone induced regression of rectal polyps in patients with familial adenomatous polyposis.

Stoner GD, Budd GT, Ganapathi R, DeYoung B, Kresty LA, Nitert M, Fryer B, Church JM, Provencher K, Pamukcu R, Piazza G, Hawk E, Kelloff G, Elson P, van Stolk RU.

Adv Exp Med Biol. 1999;470:45-53.

PMID:
10709673
19.

Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines.

Lim JT, Piazza GA, Han EK, Delohery TM, Li H, Finn TS, Buttyan R, Yamamoto H, Sperl GJ, Brendel K, Gross PH, Pamukcu R, Weinstein IB.

Biochem Pharmacol. 1999 Oct 1;58(7):1097-107.

PMID:
10484067
20.

Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis.

Goluboff ET, Shabsigh A, Saidi JA, Weinstein IB, Mitra N, Heitjan D, Piazza GA, Pamukcu R, Buttyan R, Olsson CA.

Urology. 1999 Feb;53(2):440-5.

PMID:
9933075
21.

Inhibition of angiogenesis by sulindac and its sulfone metabolite (FGN-1): a potential mechanism for their antineoplastic properties.

Skopińska-Rózewska E, Piazza GA, Sommer E, Pamukcu R, Barcz E, Filewska M, Kupis W, Caban R, Rudziński P, Bogdan J, Mlekodaj S, Sikorska E.

Int J Tissue React. 1998;20(3):85-9.

PMID:
9894180
22.

Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone).

Malkinson AM, Koski KM, Dwyer-Nield LD, Rice PL, Rioux N, Castonguay A, Ahnen DJ, Thompson H, Pamukcu R, Piazza GA.

Carcinogenesis. 1998 Aug;19(8):1353-6.

PMID:
9744528
23.

Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines.

Han EK, Arber N, Yamamoto H, Lim JT, Delohery T, Pamukcu R, Piazza GA, Xing WQ, Weinstein IB.

Breast Cancer Res Treat. 1998 Apr;48(3):195-203.

PMID:
9598866
24.

A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes.

Arber N, Han EK, Sgambato A, Piazza GA, Delohery TM, Begemann M, Weghorst CM, Kim NH, Pamukcu R, Ahnen DJ, Reed JC, Weinstein IB, Holt PR.

Gastroenterology. 1997 Dec;113(6):1892-900.

PMID:
9394728
25.

Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.

Piazza GA, Alberts DS, Hixson LJ, Paranka NS, Li H, Finn T, Bogert C, Guillen JM, Brendel K, Gross PH, Sperl G, Ritchie J, Burt RW, Ellsworth L, Ahnen DJ, Pamukcu R.

Cancer Res. 1997 Jul 15;57(14):2909-15.

27.

Sulfone metabolite of sulindac inhibits mammary carcinogenesis.

Thompson HJ, Jiang C, Lu J, Mehta RG, Piazza GA, Paranka NS, Pamukcu R, Ahnen DJ.

Cancer Res. 1997 Jan 15;57(2):267-71.

28.

Determination of FGN-1 (an active metabolite of sulindac) in human plasma, urine, and feces by HPLC.

Ray GF, Lanman RC, Fu CJ, Paranka NS, Pamukcu R, Wheeler SC.

J Pharm Biomed Anal. 1995 Dec;14(1-2):213-20. No abstract available.

PMID:
8833984
29.

Inhibition of mammary carcinogenesis in rats by sulfone metabolite of sulindac.

Thompson HJ, Briggs S, Paranka NS, Piazza GA, Brendel K, Gross PH, Sperl GJ, Pamukcu R, Ahnen DJ.

J Natl Cancer Inst. 1995 Aug 16;87(16):1259-60. No abstract available.

PMID:
7563174
30.

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.

Piazza GA, Rahm AL, Krutzsch M, Sperl G, Paranka NS, Gross PH, Brendel K, Burt RW, Alberts DS, Pamukcu R, et al.

Cancer Res. 1995 Jul 15;55(14):3110-6.

31.

Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?

Alberts DS, Hixson L, Ahnen D, Bogert C, Einspahr J, Paranka N, Brendel K, Gross PH, Pamukcu R, Burt RW.

J Cell Biochem Suppl. 1995;22:18-23.

PMID:
8538196
32.

Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells.

Hixson LJ, Alberts DS, Krutzsch M, Einsphar J, Brendel K, Gross PH, Paranka NS, Baier M, Emerson S, Pamukcu R, et al.

Cancer Epidemiol Biomarkers Prev. 1994 Jul-Aug;3(5):433-8.

33.

Biochemical and immunochemical localization of GTP-binding proteins in the rat ileal enterocyte.

Pamukcu R, Spiegel AM, Chang EB.

J Lab Clin Med. 1993 May;121(5):689-96.

PMID:
8478596
36.

Idiopathic acute interstitial nephritis: characterization of the infiltrating cells in the renal interstitium as T helper lymphocytes.

Pamukcu R, Moorthy V, Singer JR, Hong R, Simpson DP.

Am J Kidney Dis. 1984 Jul;4(1):24-9.

PMID:
6234796

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