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Items: 1 to 50 of 182

1.

Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy.

Ranea-Robles P, Launay N, Ruiz M, Calingasan NY, Dumont M, Naudí A, Portero-Otín M, Pamplona R, Ferrer I, Beal MF, Fourcade S, Pujol A.

EMBO Mol Med. 2018 Jul 11. pii: e8604. doi: 10.15252/emmm.201708604. [Epub ahead of print]

PMID:
29997171
2.

Essential physiological differences characterise short- and long-lived strains of Drosophila melanogaster.

Gubina N, Naudi A, Stefanatos R, Jove M, Scialo F, Fernandez-Ayala DJ, Rantapero T, Yurkevych I, Portero-Otin M, Nykter M, Lushchak O, Navas P, Pamplona R, Sanz A.

J Gerontol A Biol Sci Med Sci. 2018 Jun 26. doi: 10.1093/gerona/gly143. [Epub ahead of print]

PMID:
29945183
3.

CRYPTIC EXON SPLICING FUNCTION OF TARDBP INTERACTS WITH AUTOPHAGY IN NERVOUS TISSUE.

Torres P, Ramírez-Núñez O, Romero-Guevara R, Barés G, Granado-Serrano AB, Ayala V, Boada J, Fontdevila L, Povedano M, Sanchís D, Pamplona R, Ferrer I, Portero-Otín M.

Autophagy. 2018 Jun 18. doi: 10.1080/15548627.2018.1474311. [Epub ahead of print]

PMID:
29912613
4.

Subcutaneous advanced glycation end-products and lung function according to glucose abnormalities: The ILERVAS Project.

Sánchez E, Lecube A, Betriu À, Hernández C, López-Cano C, Gutiérrez-Carrasquilla L, Kerkeni M, Yeramian A, Purroy F, Pamplona R, Farràs C, Fernández E, Barbé F, Simó R; ILERVAS project, Hernández M, Rius F, Polanco D, de la Torre MS, Torres G, Godoy P, Portero-Otin M, Jové M, Colàs-Compàs L, Benabdelhak I, Miquel E, Ortega M, Valdivielso JM, Bermúdez M, Martínez-Alonso M.

Diabetes Metab. 2018 Apr 13. pii: S1262-3636(18)30079-X. doi: 10.1016/j.diabet.2018.04.002. [Epub ahead of print] No abstract available.

PMID:
29706471
5.

Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome.

Jové M, Pradas I, Naudí A, Rovira-Llopis S, Bañuls C, Rocha M, Portero-Otin M, Hernández-Mijares A, Victor VM, Pamplona R.

Oncotarget. 2017 Dec 17;9(4):4522-4536. doi: 10.18632/oncotarget.23393. eCollection 2018 Jan 12.

6.

Tumour-microenvironmental blood flow determines a metabolomic signature identifying lysophospholipids and resolvin D as biomarkers in endometrial cancer patients.

Eritja N, Jové M, Fasmer KE, Gatius S, Portero-Otin M, Trovik J, Krakstad C, Sol J, Pamplona R, Haldorsen IS, Matias-Guiu X.

Oncotarget. 2017 Nov 20;8(65):109018-109026. doi: 10.18632/oncotarget.22558. eCollection 2017 Dec 12.

7.

Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance.

Fourcade S, Morató L, Parameswaran J, Ruiz M, Ruiz-Cortés T, Jové M, Naudí A, Martínez-Redondo P, Dierssen M, Ferrer I, Villarroya F, Pamplona R, Vaquero A, Portero-Otín M, Pujol A.

Aging Cell. 2017 Dec;16(6):1404-1413. doi: 10.1111/acel.12682. Epub 2017 Oct 5.

8.

Lipid Profile in Human Frontal Cortex Is Sustained Throughout Healthy Adult Life Span to Decay at Advanced Ages.

Cabré R, Naudí A, Dominguez-Gonzalez M, Jové M, Ayala V, Mota-Martorell N, Pradas I, Nogueras L, Rué M, Portero-Otín M, Ferrer I, Pamplona R.

J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):703-710. doi: 10.1093/gerona/glx164.

PMID:
28958038
9.

Differential metabolic profiles associated to movement behaviour of stream-resident brown trout (Salmo trutta).

Oromi N, Jové M, Pascual-Pons M, Royo JL, Rocaspana R, Aparicio E, Pamplona R, Palau A, Sanuy D, Fibla J, Portero-Otin M.

PLoS One. 2017 Jul 27;12(7):e0181697. doi: 10.1371/journal.pone.0181697. eCollection 2017.

10.

Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system.

Naudí A, Cabré R, Dominguez-Gonzalez M, Ayala V, Jové M, Mota-Martorell N, Piñol-Ripoll G, Gil-Villar MP, Rué M, Portero-Otín M, Ferrer I, Pamplona R.

Biochim Biophys Acta. 2017 May;1862(5):485-495. doi: 10.1016/j.bbalip.2017.02.001. Epub 2017 Feb 7.

PMID:
28185952
11.

A plasma metabolomic signature discloses human breast cancer.

Jové M, Collado R, Quiles JL, Ramírez-Tortosa MC, Sol J, Ruiz-Sanjuan M, Fernandez M, de la Torre Cabrera C, Ramírez-Tortosa C, Granados-Principal S, Sánchez-Rovira P, Pamplona R.

Oncotarget. 2017 Mar 21;8(12):19522-19533. doi: 10.18632/oncotarget.14521.

12.

Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex.

Cabré R, Jové M, Naudí A, Ayala V, Piñol-Ripoll G, Gil-Villar MP, Dominguez-Gonzalez M, Obis È, Berdun R, Mota-Martorell N, Portero-Otin M, Ferrer I, Pamplona R.

Front Mol Neurosci. 2016 Dec 8;9:138. doi: 10.3389/fnmol.2016.00138. eCollection 2016.

13.

Adipocyte lipopolysaccharide binding protein (LBP) is linked to a specific lipidomic signature.

Moreno-Navarrete JM, Jové M, Padró T, Boada J, Ortega F, Ricart W, Pamplona R, Badimón L, Portero-Otín M, Fernández-Real JM.

Obesity (Silver Spring). 2017 Feb;25(2):391-400. doi: 10.1002/oby.21711. Epub 2016 Dec 21.

14.

Sixty years old is the breakpoint of human frontal cortex aging.

Cabré R, Naudí A, Dominguez-Gonzalez M, Ayala V, Jové M, Mota-Martorell N, Piñol-Ripoll G, Gil-Villar MP, Rué M, Portero-Otín M, Ferrer I, Pamplona R.

Free Radic Biol Med. 2017 Feb;103:14-22. doi: 10.1016/j.freeradbiomed.2016.12.010. Epub 2016 Dec 13.

PMID:
27979658
15.

Metabolomics Predicts Neuroimaging Characteristics of Transient Ischemic Attack Patients.

Purroy F, Cambray S, Mauri-Capdevila G, Jové M, Sanahuja J, Farré J, Benabdelhak I, Molina-Seguin J, Colàs-Campàs L, Begue R, Gil MI, Pamplona R, Portero-Otín M.

EBioMedicine. 2016 Dec;14:131-138. doi: 10.1016/j.ebiom.2016.11.010. Epub 2016 Nov 9.

16.

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice.

Martínez-Cisuelo V, Gómez J, García-Junceda I, Naudí A, Cabré R, Mota-Martorell N, López-Torres M, González-Sánchez M, Pamplona R, Barja G.

Exp Gerontol. 2016 Oct;83:130-8. doi: 10.1016/j.exger.2016.08.002. Epub 2016 Aug 4.

PMID:
27498120
17.

Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism.

Jové M, Gatius S, Yeramian A, Portero-Otin M, Eritja N, Santacana M, Colas E, Ruiz M, Pamplona R, Matias-Guiu X.

Oncotarget. 2016 Aug 9;7(32):52364-52374. doi: 10.18632/oncotarget.10564.

18.

A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans.

Jové M, Naudí A, Gambini J, Borras C, Cabré R, Portero-Otín M, Viña J, Pamplona R.

J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):30-37. Epub 2016 Mar 24.

PMID:
27013396
19.

Redox proteomic profiling of neuroketal-adducted proteins in human brain: Regional vulnerability at middle age increases in the elderly.

Domínguez M, de Oliveira E, Odena MA, Portero M, Pamplona R, Ferrer I.

Free Radic Biol Med. 2016 Jun;95:1-15. doi: 10.1016/j.freeradbiomed.2016.02.034. Epub 2016 Mar 8.

PMID:
26968793
20.

Erratum: Obesity changes the human gut mycobiome.

Mar Rodríguez M, Pérez D, Javier Chaves F, Esteve E, Marin-Garcia P, Xifra G, Vendrell J, Jové M, Pamplona R, Ricart W, Portero-Otin M, Chacón MR, Fernández Real JM.

Sci Rep. 2016 Feb 24;6:21679. doi: 10.1038/srep21679. No abstract available.

21.

Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity.

Moreno-Navarrete JM, Jove M, Ortega F, Xifra G, Ricart W, Obis È, Pamplona R, Portero-Otin M, Fernández-Real JM.

Diabetologia. 2016 Apr;59(4):822-32. doi: 10.1007/s00125-016-3863-1. Epub 2016 Feb 2.

PMID:
26831303
22.

Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice.

Eritja N, Arjó G, Santacana M, Gatius S, Ramírez-Núñez O, Arcal L, Serrano JCE, Pamplona R, Dolcet X, Piñol C, Christou P, Matias-Guiu X, Portero-Otin M.

Biochim Biophys Acta. 2016 Apr;1862(4):526-535. doi: 10.1016/j.bbadis.2016.01.018. Epub 2016 Jan 26.

23.

Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis.

Cacabelos D, Ayala V, Granado-Serrano AB, Jové M, Torres P, Boada J, Cabré R, Ramírez-Núñez O, Gonzalo H, Soler-Cantero A, Serrano JC, Bellmunt MJ, Romero MP, Motilva MJ, Nonaka T, Hasegawa M, Ferrer I, Pamplona R, Portero-Otín M.

Neurobiol Dis. 2016 Apr;88:148-60. doi: 10.1016/j.nbd.2016.01.007. Epub 2016 Jan 12.

PMID:
26805387
24.

Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS.

Cacabelos D, Ramírez-Núñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J.

Acta Neuropathol Commun. 2016 Jan 13;4:3. doi: 10.1186/s40478-015-0271-6.

25.

Obesity changes the human gut mycobiome.

Mar Rodríguez M, Pérez D, Javier Chaves F, Esteve E, Marin-Garcia P, Xifra G, Vendrell J, Jové M, Pamplona R, Ricart W, Portero-Otin M, Chacón MR, Fernández Real JM.

Sci Rep. 2015 Oct 12;5:14600. doi: 10.1038/srep14600. Erratum in: Sci Rep. 2016;6:21679.

26.

Voltage-gated calcium channel blockers deregulate macroautophagy in cardiomyocytes.

Pushparaj C, Das A, Purroy R, Nàger M, Herreros J, Pamplona R, Cantí C.

Int J Biochem Cell Biol. 2015 Nov;68:166-75. doi: 10.1016/j.biocel.2015.09.010. Epub 2015 Sep 30. Erratum in: Int J Biochem Cell Biol. 2016 Jan;70:173.

PMID:
26429067
27.

Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy.

Ruiz M, Jové M, Schlüter A, Casasnovas C, Villarroya F, Guilera C, Ortega FJ, Naudí A, Pamplona R, Gimeno R, Fourcade S, Portero-Otín M, Pujol A.

Hum Mol Genet. 2015 Dec 15;24(24):6861-76. doi: 10.1093/hmg/ddv375. Epub 2015 Sep 14.

PMID:
26370417
28.

Neuroinflammatory Gene Regulation, Mitochondrial Function, Oxidative Stress, and Brain Lipid Modifications With Disease Progression in Tau P301S Transgenic Mice as a Model of Frontotemporal Lobar Degeneration-Tau.

López-González I, Aso E, Carmona M, Armand-Ugon M, Blanco R, Naudí A, Cabré R, Portero-Otin M, Pamplona R, Ferrer I.

J Neuropathol Exp Neurol. 2015 Oct;74(10):975-99. doi: 10.1097/NEN.0000000000000241.

PMID:
26360374
29.

Lipidomics of human brain aging and Alzheimer's disease pathology.

Naudí A, Cabré R, Jové M, Ayala V, Gonzalo H, Portero-Otín M, Ferrer I, Pamplona R.

Int Rev Neurobiol. 2015;122:133-89. doi: 10.1016/bs.irn.2015.05.008. Epub 2015 Jun 19. Review.

PMID:
26358893
30.

Long lifespans have evolved with long and monounsaturated fatty acids in birds.

Galván I, Naudí A, Erritzøe J, Møller AP, Barja G, Pamplona R.

Evolution. 2015 Oct;69(10):2776-84. doi: 10.1111/evo.12754. Epub 2015 Sep 24.

PMID:
26294378
31.

Target of rapamycin activation predicts lifespan in fruit flies.

Scialò F, Sriram A, Naudí A, Ayala V, Jové M, Pamplona R, Sanz A.

Cell Cycle. 2015;14(18):2949-58. doi: 10.1080/15384101.2015.1071745.

32.

Nutridynamics: mechanism(s) of action of bioactive compounds and their effects.

Serrano JC, Jove M, Gonzalo H, Pamplona R, Portero-Otin M.

Int J Food Sci Nutr. 2015 Jul;66 Suppl 1:S22-30. Review.

PMID:
26241008
33.

Human Aging Is a Metabolome-related Matter of Gender.

Jové M, Maté I, Naudí A, Mota-Martorell N, Portero-Otín M, De la Fuente M, Pamplona R.

J Gerontol A Biol Sci Med Sci. 2016 May;71(5):578-85. doi: 10.1093/gerona/glv074. Epub 2015 May 26.

PMID:
26019184
34.

Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.

Morató L, Ruiz M, Boada J, Calingasan NY, Galino J, Guilera C, Jové M, Naudí A, Ferrer I, Pamplona R, Serrano M, Portero-Otín M, Beal MF, Fourcade S, Pujol A.

Cell Death Differ. 2015 Nov;22(11):1742-53. doi: 10.1038/cdd.2015.20. Epub 2015 Mar 27.

35.

Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction.

Gomez A, Gomez J, Lopez Torres M, Naudi A, Mota-Martorell N, Pamplona R, Barja G.

J Bioenerg Biomembr. 2015 Jun;47(3):199-208. doi: 10.1007/s10863-015-9608-x. Epub 2015 Mar 15.

PMID:
25773352
36.

Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species.

López-González I, Schlüter A, Aso E, Garcia-Esparcia P, Ansoleaga B, LLorens F, Carmona M, Moreno J, Fuso A, Portero-Otin M, Pamplona R, Pujol A, Ferrer I.

J Neuropathol Exp Neurol. 2015 Apr;74(4):319-44. doi: 10.1097/NEN.0000000000000176.

PMID:
25756590
37.

In vitro plant regeneration of Aster scaber via somatic embryogenesis.

Boo KH, Cao DV, Pamplona RS, Lee D, Riu KZ, Lee DS.

Biosci Biotechnol Biochem. 2015;79(5):725-31. doi: 10.1080/09168451.2014.996202. Epub 2015 Feb 2.

PMID:
25640866
38.

Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux.

Ost M, Keipert S, van Schothorst EM, Donner V, van der Stelt I, Kipp AP, Petzke KJ, Jove M, Pamplona R, Portero-Otin M, Keijer J, Klaus S.

FASEB J. 2015 Apr;29(4):1314-28. doi: 10.1096/fj.14-261503. Epub 2014 Dec 9.

PMID:
25491309
39.

Metabolomics predicts stroke recurrence after transient ischemic attack.

Jové M, Mauri-Capdevila G, Suárez I, Cambray S, Sanahuja J, Quílez A, Farré J, Benabdelhak I, Pamplona R, Portero-Otín M, Purroy F.

Neurology. 2015 Jan 6;84(1):36-45. doi: 10.1212/WNL.0000000000001093. Epub 2014 Dec 3.

40.

Deregulation of purine metabolism in Alzheimer's disease.

Ansoleaga B, Jové M, Schlüter A, Garcia-Esparcia P, Moreno J, Pujol A, Pamplona R, Portero-Otín M, Ferrer I.

Neurobiol Aging. 2015 Jan;36(1):68-80. doi: 10.1016/j.neurobiolaging.2014.08.004. Epub 2014 Aug 8.

PMID:
25311278
41.

Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype.

Jové M, Naudí A, Portero-Otin M, Cabré R, Rovira-Llopis S, Bañuls C, Rocha M, Hernández-Mijares A, Victor VM, Pamplona R.

FASEB J. 2014 Dec;28(12):5163-71. doi: 10.1096/fj.14-253187. Epub 2014 Aug 28.

PMID:
25169057
42.

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice.

Jové M, Naudí A, Ramírez-Núñez O, Portero-Otín M, Selman C, Withers DJ, Pamplona R.

Aging Cell. 2014 Oct;13(5):828-37. doi: 10.1111/acel.12241. Epub 2014 Jul 23.

43.

Plasma antioxidant capacity in critical polytraumatized patients?: methods, severity, and anatomic location.

Serviá L, Trujillano J, Serrano JC, Pamplona R, Badia M, Jové M, Justes M, Domingo J, Portero-Otin M.

Crit Care. 2014 Jun 12;18(3):434. doi: 10.1186/cc13917. No abstract available.

44.

Dietary lipid unsaturation influences survival and oxidative modifications of an amyotrophic lateral sclerosis model in a gender-specific manner.

Cacabelos D, Ayala V, Ramírez-Nunez O, Granado-Serrano AB, Boada J, Serrano JC, Cabré R, Nadal-Rey G, Bellmunt MJ, Ferrer I, Pamplona R, Portero-Otin M.

Neuromolecular Med. 2014 Dec;16(4):669-85. doi: 10.1007/s12017-014-8317-7. Epub 2014 Jul 1.

PMID:
24980941
45.

Metabolomics of human brain aging and age-related neurodegenerative diseases.

Jové M, Portero-Otín M, Naudí A, Ferrer I, Pamplona R.

J Neuropathol Exp Neurol. 2014 Jul;73(7):640-57. doi: 10.1097/NEN.0000000000000091. Review.

PMID:
24918636
46.

Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.

Granados-Principal S, El-Azem N, Pamplona R, Ramirez-Tortosa C, Pulido-Moran M, Vera-Ramirez L, Quiles JL, Sanchez-Rovira P, Naudí A, Portero-Otin M, Perez-Lopez P, Ramirez-Tortosa M.

Biochem Pharmacol. 2014 Jul 1;90(1):25-33. doi: 10.1016/j.bcp.2014.04.001. Epub 2014 Apr 12.

PMID:
24727461
47.

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity.

Gómez A, Sánchez-Roman I, Gomez J, Cruces J, Mate I, Lopez-Torres M, Naudi A, Portero-Otin M, Pamplona R, De la Fuente M, Barja G.

Aging Cell. 2014 Jun;13(3):551-60. doi: 10.1111/acel.12205. Epub 2014 Feb 26.

48.

Membrane lipid unsaturation as physiological adaptation to animal longevity.

Naudí A, Jové M, Ayala V, Portero-Otín M, Barja G, Pamplona R.

Front Physiol. 2013 Dec 17;4:372. doi: 10.3389/fphys.2013.00372. Review.

49.

Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress.

Sanchez-Roman I, Gomez A, Naudí A, Jove M, Gómez J, Lopez-Torres M, Pamplona R, Barja G.

J Bioenerg Biomembr. 2014 Jun;46(3):159-72. doi: 10.1007/s10863-013-9535-7. Epub 2013 Dec 8.

PMID:
24318105
50.

Plasma long-chain free fatty acids predict mammalian longevity.

Jové M, Naudí A, Aledo JC, Cabré R, Ayala V, Portero-Otin M, Barja G, Pamplona R.

Sci Rep. 2013 Nov 28;3:3346. doi: 10.1038/srep03346.

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