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Development and Evaluation of a Novel Protein-Based Assay for Specific Detection of KPC β-Lactamases from Klebsiella pneumoniae Clinical Isolates.

Lu S, Soeung V, Nguyen HAT, Long SW, Musser JM, Palzkill T.

mSphere. 2020 Jan 8;5(1). pii: e00918-19. doi: 10.1128/mSphere.00918-19.


DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters.

Sutton MN, Lu Z, Li YC, Zhou Y, Huang T, Reger AS, Hurwitz AM, Palzkill T, Logsdon C, Liang X, Gray JW, Nan X, Hancock J, Wahl GM, Bast RC Jr.

Cell Rep. 2019 Dec 10;29(11):3448-3459.e6. doi: 10.1016/j.celrep.2019.11.045.


A standard numbering scheme for class C β-lactamases.

Mack AR, Barnes MD, Taracila MA, Hujer AM, Hujer KM, Cabot G, Feldgarden M, Haft DH, Klimke W, van den Akker F, Vila AJ, Smania A, Haider S, Papp-Wallace KM, Bradford PA, Rossolini GM, Docquier JD, Frère JM, Galleni M, Hanson ND, Oliver A, Plésiat P, Poirel L, Nordmann P, Palzkill TG, Jacoby GA, Bush K, Bonomo RA.

Antimicrob Agents Chemother. 2019 Nov 11. pii: AAC.01841-19. doi: 10.1128/AAC.01841-19. [Epub ahead of print]


Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae.

Beggs GA, Zalucki YM, Brown NG, Rastegari S, Phillips RK, Palzkill T, Shafer WM, Kumaraswami M, Brennan RG.

J Bacteriol. 2019 Sep 20;201(20). pii: e00401-19. doi: 10.1128/JB.00401-19. Print 2019 Oct 15.


Extensively Drug-Resistant Pseudomonas aeruginosa ST309 Harboring Tandem Guiana Extended Spectrum β-Lactamase Enzymes: A Newly Emerging Threat in the United States.

Khan A, Tran TT, Rios R, Hanson B, Shropshire WC, Sun Z, Diaz L, Dinh AQ, Wanger A, Ostrosky-Zeichner L, Palzkill T, Arias CA, Miller WR.

Open Forum Infect Dis. 2019 Jun 6;6(7):ofz273. doi: 10.1093/ofid/ofz273. eCollection 2019 Jul.


DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1.

Sutton MN, Huang GY, Liang X, Sharma R, Reger AS, Mao W, Pang L, Rask PJ, Lee K, Gray JP, Hurwitz AM, Palzkill T, Millward SW, Kim C, Lu Z, Bast RC Jr.

Cancers (Basel). 2019 Apr 18;11(4). pii: E557. doi: 10.3390/cancers11040557.


GII.4 Norovirus Protease Shows pH-Sensitive Proteolysis with a Unique Arg-His Pairing in the Catalytic Site.

Viskovska MA, Zhao B, Shanker S, Choi JM, Deng L, Song Y, Palzkill T, Hu L, Estes MK, Venkataram Prasad BV.

J Virol. 2019 Mar 5;93(6). pii: e01479-18. doi: 10.1128/JVI.01479-18. Print 2019 Mar 15.


An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function.

Wang L, Pang K, Han K, Adamski CJ, Wang W, He L, Lai JK, Bondar VV, Duman JG, Richman R, Tolias KF, Barth P, Palzkill T, Liu Z, Holder JL Jr, Zoghbi HY.

Mol Psychiatry. 2019 Jan 4. doi: 10.1038/s41380-018-0324-x. [Epub ahead of print]


Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics.

Sun Z, Hu L, Sankaran B, Prasad BVV, Palzkill T.

Nat Commun. 2018 Oct 30;9(1):4524. doi: 10.1038/s41467-018-06839-1.


Quantitative Real-Time Imaging of Glutathione with Subcellular Resolution.

Jiang X, Zhang C, Chen J, Choi S, Zhou Y, Zhao M, Song X, Chen X, Maletić-Savatić M, Palzkill T, Moore D, Wang MC, Wang J.

Antioxid Redox Signal. 2019 Jun 1;30(16):1900-1910. doi: 10.1089/ars.2018.7605. Epub 2018 Dec 20.


Synergistic effects of functionally distinct substitutions in β-lactamase variants shed light on the evolution of bacterial drug resistance.

Patel MP, Hu L, Brown CA, Sun Z, Adamski CJ, Stojanoski V, Sankaran B, Prasad BVV, Palzkill T.

J Biol Chem. 2018 Nov 16;293(46):17971-17984. doi: 10.1074/jbc.RA118.003792. Epub 2018 Oct 1.


Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases.

Palzkill T.

Front Mol Biosci. 2018 Feb 23;5:16. doi: 10.3389/fmolb.2018.00016. eCollection 2018. Review.


Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria.

Chen J, Jiang X, Zhang C, MacKenzie KR, Stossi F, Palzkill T, Wang MC, Wang J.

ACS Sens. 2017 Sep 22;2(9):1257-1261. doi: 10.1021/acssensors.7b00425. Epub 2017 Aug 18.


The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation.

Patel MP, Hu L, Stojanoski V, Sankaran B, Prasad BVV, Palzkill T.

Biochemistry. 2017 Jul 11;56(27):3443-3453. doi: 10.1021/acs.biochem.7b00176. Epub 2017 Jun 27.


Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A β-lactamases.

Adamski CJ, Palzkill T.

BMC Biochem. 2017 Mar 6;18(1):2. doi: 10.1186/s12858-017-0077-1.


BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A β-Lactamases.

Adamski CJ, Palzkill T.

Biochemistry. 2017 Feb 28;56(8):1075-1084. doi: 10.1021/acs.biochem.6b00978. Epub 2017 Feb 16.


Identification and Characterization of Single-Chain Antibodies that Specifically Bind GI Noroviruses.

Hurwitz AM, Huang W, Kou B, Estes MK, Atmar RL, Palzkill T.

PLoS One. 2017 Jan 17;12(1):e0170162. doi: 10.1371/journal.pone.0170162. eCollection 2017.


Deep sequencing of phage-displayed peptide libraries reveals sequence motif that detects norovirus.

Hurwitz AM, Huang W, Estes MK, Atmar RL, Palzkill T.

Protein Eng Des Sel. 2017 Feb;30(2):129-139. doi: 10.1093/protein/gzw074. Epub 2016 Dec 28.


Structure of the catalytic domain of the colistin resistance enzyme MCR-1.

Stojanoski V, Sankaran B, Prasad BV, Poirel L, Nordmann P, Palzkill T.

BMC Biol. 2016 Sep 21;14(1):81.


Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-β-Lactamase is Fragile to Mutations.

Sun Z, Mehta SC, Adamski CJ, Gibbs RA, Palzkill T.

Sci Rep. 2016 Sep 12;6:33195. doi: 10.1038/srep33195.


Antiviral targets of human noroviruses.

Prasad BV, Shanker S, Muhaxhiri Z, Deng L, Choi JM, Estes MK, Song Y, Palzkill T, Atmar RL.

Curr Opin Virol. 2016 Jun;18:117-25. doi: 10.1016/j.coviro.2016.06.002. Epub 2016 Jun 17. Review.


Comment on: Resistance gene naming and numbering: is it a new gene or not?

Jacoby GA, Bonomo RA, Bradford PA, Bush K, Doi Y, Feldgarden M, Haft D, Klimke W, Nordmann P, Palzkill T, Poirel L, Prasad A, Rossolini GM, Walsh T.

J Antimicrob Chemother. 2016 Sep;71(9):2677-8. doi: 10.1093/jac/dkw204. Epub 2016 Jun 3. No abstract available.


Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3.

Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O'Malley BW, Wang J.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5. doi: 10.1073/pnas.1604274113. Epub 2016 Apr 15.


Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine β-Lactamases by Relieving Steric Strain.

Stojanoski V, Adamski CJ, Hu L, Mehta SC, Sankaran B, Zwart P, Prasad BV, Palzkill T.

Biochemistry. 2016 May 3;55(17):2479-90. doi: 10.1021/acs.biochem.6b00056. Epub 2016 Apr 22.


Norovirus Antigen Detection with a Combination of Monoclonal and Single-Chain Antibodies.

Kou B, Huang W, Neill FH, Palzkill T, Estes MK, Atmar RL.

J Clin Microbiol. 2015 Dec;53(12):3916-8. doi: 10.1128/JCM.02371-15. Epub 2015 Oct 7.


Characterization of the global stabilizing substitution A77V and its role in the evolution of CTX-M β-lactamases.

Patel MP, Fryszczyn BG, Palzkill T.

Antimicrob Agents Chemother. 2015 Nov;59(11):6741-8. doi: 10.1128/AAC.00618-15. Epub 2015 Aug 17.


Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.

Wang L, Yu Y, Chow DC, Yan F, Hsu CC, Stossi F, Mancini MA, Palzkill T, Liao L, Zhou S, Xu J, Lonard DM, O'Malley BW.

Cancer Cell. 2015 Aug 10;28(2):240-52. doi: 10.1016/j.ccell.2015.07.005.


Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability.

Mehta SC, Rice K, Palzkill T.

PLoS Pathog. 2015 Jun 1;11(6):e1004949. doi: 10.1371/journal.ppat.1004949. eCollection 2015 Jun.


Structural Basis for Different Substrate Profiles of Two Closely Related Class D β-Lactamases and Their Inhibition by Halogens.

Stojanoski V, Chow DC, Fryszczyn B, Hu L, Nordmann P, Poirel L, Sankaran B, Prasad BV, Palzkill T.

Biochemistry. 2015 Jun 2;54(21):3370-80. doi: 10.1021/acs.biochem.5b00298. Epub 2015 May 14.


A triple mutant in the Ω-loop of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis.

Stojanoski V, Chow DC, Hu L, Sankaran B, Gilbert HF, Prasad BV, Palzkill T.

J Biol Chem. 2015 Apr 17;290(16):10382-94. doi: 10.1074/jbc.M114.633438. Epub 2015 Feb 20.


How structural and physicochemical determinants shape sequence constraints in a functional enzyme.

Abriata LA, Palzkill T, Dal Peraro M.

PLoS One. 2015 Feb 23;10(2):e0118684. doi: 10.1371/journal.pone.0118684. eCollection 2015.


Generation and characterization of antibodies against Asian elephant (Elephas maximus) IgG, IgM, and IgA.

Humphreys AF, Tan J, Peng R, Benton SM, Qin X, Worley KC, Mikulski RL, Chow DC, Palzkill TG, Ling PD.

PLoS One. 2015 Feb 6;10(2):e0116318. doi: 10.1371/journal.pone.0116318. eCollection 2015.


Molecular basis for the catalytic specificity of the CTX-M extended-spectrum β-lactamases.

Adamski CJ, Cardenas AM, Brown NG, Horton LB, Sankaran B, Prasad BV, Gilbert HF, Palzkill T.

Biochemistry. 2015 Jan 20;54(2):447-57. doi: 10.1021/bi501195g. Epub 2014 Dec 24.


GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex.

He B, Lanz RB, Fiskus W, Geng C, Yi P, Hartig SM, Rajapakshe K, Shou J, Wei L, Shah SS, Foley C, Chew SA, Eedunuri VK, Bedoya DJ, Feng Q, Minami T, Mitsiades CS, Frolov A, Weigel NL, Hilsenbeck SG, Rosen DG, Palzkill T, Ittmann MM, Song Y, Coarfa C, O'Malley BW, Mitsiades N.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18261-6. doi: 10.1073/pnas.1421415111. Epub 2014 Dec 8.


Characterization of cross-reactive norovirus-specific monoclonal antibodies.

Kou B, Crawford SE, Ajami NJ, Czakó R, Neill FH, Tanaka TN, Kitamoto N, Palzkill TG, Estes MK, Atmar RL.

Clin Vaccine Immunol. 2015 Feb;22(2):160-7. doi: 10.1128/CVI.00519-14. Epub 2014 Nov 26.


Probing the sites of interactions of rotaviral proteins involved in replication.

Viskovska M, Anish R, Hu L, Chow DC, Hurwitz AM, Brown NG, Palzkill T, Estes MK, Prasad BV.

J Virol. 2014 Nov;88(21):12866-81. doi: 10.1128/JVI.02251-14. Epub 2014 Aug 27.


PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates.

Long SW, Olsen RJ, Mehta SC, Palzkill T, Cernoch PL, Perez KK, Musick WL, Rosato AE, Musser JM.

Antimicrob Agents Chemother. 2014 Nov;58(11):6668-74. doi: 10.1128/AAC.03622-14. Epub 2014 Aug 25.


Role of β-lactamase residues in a common interface for binding the structurally unrelated inhibitory proteins BLIP and BLIP-II.

Fryszczyn BG, Adamski CJ, Brown NG, Rice K, Huang W, Palzkill T.

Protein Sci. 2014 Sep;23(9):1235-46. doi: 10.1002/pro.2505. Epub 2014 Jul 1.


Identification of human single-chain antibodies with broad reactivity for noroviruses.

Huang W, Samanta M, Crawford SE, Estes MK, Neill FH, Atmar RL, Palzkill T.

Protein Eng Des Sel. 2014 Oct;27(10):339-49. doi: 10.1093/protein/gzu023. Epub 2014 Jun 19.


Neutral β-Lactams Inactivate High Molecular Mass Penicillin-Binding Proteins of Class B1, Including PBP2a of MRSA.

Dave K, Palzkill T, Pratt RF.

ACS Med Chem Lett. 2013 Dec 16;5(2):154-7. doi: 10.1021/ml400408c. eCollection 2014 Feb 13.


Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor.

Yan F, Yu Y, Chow DC, Palzkill T, Madoux F, Hodder P, Chase P, Griffin PR, O'Malley BW, Lonard DM.

PLoS One. 2014 Apr 17;9(4):e95243. doi: 10.1371/journal.pone.0095243. eCollection 2014.


Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1.

Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, Wang J, Qi R, Matzuk AJ, Song X, Madoux F, Hodder P, Chase P, Griffin PR, Zhou S, Liao L, Xu J, O'Malley BW.

Cancer Res. 2014 Mar 1;74(5):1506-1517. doi: 10.1158/0008-5472.CAN-13-2939. Epub 2014 Jan 3.


Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors.

Deng L, Muhaxhiri Z, Estes MK, Palzkill T, Prasad BV, Song Y.

Medchemcomm. 2013 Oct;4(10). doi: 10.1039/C3MD00219E.


Identification of the β-lactamase inhibitor protein-II (BLIP-II) interface residues essential for binding affinity and specificity for class A β-lactamases.

Brown NG, Chow DC, Ruprecht KE, Palzkill T.

J Biol Chem. 2013 Jun 14;288(24):17156-66. doi: 10.1074/jbc.M113.463521. Epub 2013 Apr 27.


BLIP-II is a highly potent inhibitor of Klebsiella pneumoniae carbapenemase (KPC-2).

Brown NG, Chow DC, Palzkill T.

Antimicrob Agents Chemother. 2013 Jul;57(7):3398-401. doi: 10.1128/AAC.00215-13. Epub 2013 Apr 15.


Identification and characterization of a peptide affinity reagent for detection of noroviruses in clinical samples.

Rogers JD, Ajami NJ, Fryszczyn BG, Estes MK, Atmar RL, Palzkill T.

J Clin Microbiol. 2013 Jun;51(6):1803-8. doi: 10.1128/JCM.00295-13. Epub 2013 Apr 3.


Structural basis of substrate specificity and protease inhibition in Norwalk virus.

Muhaxhiri Z, Deng L, Shanker S, Sankaran B, Estes MK, Palzkill T, Song Y, Prasad BV.

J Virol. 2013 Apr;87(8):4281-92. doi: 10.1128/JVI.02869-12. Epub 2013 Jan 30.


Metallo-β-lactamase structure and function.

Palzkill T.

Ann N Y Acad Sci. 2013 Jan;1277:91-104. doi: 10.1111/j.1749-6632.2012.06796.x. Epub 2012 Nov 16. Review.


Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase.

Cai G, Deng L, Fryszczyn BG, Brown NG, Liu Z, Jiang H, Palzkill T, Song Y.

ACS Med Chem Lett. 2012 Jun 14;3(6):496-500. Epub 2012 May 7.

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