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Crystal structure of basal pilin SpaE reveals the molecular basis of its incorporation in the lactobacillar SpaFED pilus.

Megta AK, Mishra AK, Palva A, von Ossowski I, Krishnan V.

J Struct Biol. 2019 Jul 1;207(1):74-84. doi: 10.1016/j.jsb.2019.04.016. Epub 2019 Apr 23.


Silica-gentamicin nanohybrids: combating antibiotic resistance, bacterial biofilms, and in vivo toxicity.

Mosselhy DA, He W, Hynönen U, Meng Y, Mohammadi P, Palva A, Feng Q, Hannula SP, Nordström K, Linder MB.

Int J Nanomedicine. 2018 Nov 28;13:7939-7957. doi: 10.2147/IJN.S182611. eCollection 2018. Erratum in: Int J Nanomedicine. 2018 Dec 13;13:8577-8578.


Bent conformation of a backbone pilin N-terminal domain supports a three-stage pilus assembly mechanism.

Chaurasia P, Pratap S, Palva A, von Ossowski I, Krishnan V.

Commun Biol. 2018 Jul 17;1:94. doi: 10.1038/s42003-018-0100-0. eCollection 2018.


Molecular networks affected by neonatal microbial colonization in porcine jejunum, luminally perfused with enterotoxigenic Escherichia coli, F4ac fimbria or Lactobacillus amylovorus.

Trevisi P, Priori D, Jansman AJM, Luise D, Koopmans SJ, Hynönen U, Palva A, van der Meulen J, Bosi P.

PLoS One. 2018 Aug 30;13(8):e0202160. doi: 10.1371/journal.pone.0202160. eCollection 2018.


Comparative genome analysis of 24 bovine-associated Staphylococcus isolates with special focus on the putative virulence genes.

Åvall-Jääskeläinen S, Taponen S, Kant R, Paulin L, Blom J, Palva A, Koort J.

PeerJ. 2018 Mar 30;6:e4560. doi: 10.7717/peerj.4560. eCollection 2018.


Nanosilver-Silica Composite: Prolonged Antibacterial Effects and Bacterial Interaction Mechanisms for Wound Dressings.

Mosselhy DA, Granbohm H, Hynönen U, Ge Y, Palva A, Nordström K, Hannula SP.

Nanomaterials (Basel). 2017 Sep 6;7(9). pii: E261. doi: 10.3390/nano7090261.


Crystallization and X-ray diffraction analysis of SpaE, a basal pilus protein from the gut-adapted Lactobacillus rhamnosus GG.

Mishra AK, Megta AK, Palva A, von Ossowski I, Krishnan V.

Acta Crystallogr F Struct Biol Commun. 2017 Jun 1;73(Pt 6):321-327. doi: 10.1107/S2053230X17006963. Epub 2017 May 25.


A Comparative Characterization of Different Host-sourced Lactobacillus ruminis Strains and Their Adhesive, Inhibitory, and Immunomodulating Functions.

Yu X, Åvall-Jääskeläinen S, Koort J, Lindholm A, Rintahaka J, von Ossowski I, Palva A, Hynönen U.

Front Microbiol. 2017 Apr 13;8:657. doi: 10.3389/fmicb.2017.00657. eCollection 2017.


An in silico pan-genomic probe for the molecular traits behind Lactobacillus ruminis gut autochthony.

Kant R, Palva A, von Ossowski I.

PLoS One. 2017 Apr 17;12(4):e0175541. doi: 10.1371/journal.pone.0175541. eCollection 2017.


Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function.

Ottman N, Reunanen J, Meijerink M, Pietilä TE, Kainulainen V, Klievink J, Huuskonen L, Aalvink S, Skurnik M, Boeren S, Satokari R, Mercenier A, Palva A, Smidt H, de Vos WM, Belzer C.

PLoS One. 2017 Mar 1;12(3):e0173004. doi: 10.1371/journal.pone.0173004. eCollection 2017.


New insights about pilus formation in gut-adapted Lactobacillus rhamnosus GG from the crystal structure of the SpaA backbone-pilin subunit.

Chaurasia P, Pratap S, von Ossowski I, Palva A, Krishnan V.

Sci Rep. 2016 Jun 28;6:28664. doi: 10.1038/srep28664.


Polymorphisms, Chromosomal Rearrangements, and Mutator Phenotype Development during Experimental Evolution of Lactobacillus rhamnosus GG.

Douillard FP, Ribbera A, Xiao K, Ritari J, Rasinkangas P, Paulin L, Palva A, Hao Y, de Vos WM.

Appl Environ Microbiol. 2016 Jun 13;82(13):3783-92. doi: 10.1128/AEM.00255-16. Print 2016 Jul 1.


Faecal Metaproteomic Analysis Reveals a Personalized and Stable Functional Microbiome and Limited Effects of a Probiotic Intervention in Adults.

Kolmeder CA, Salojärvi J, Ritari J, de Been M, Raes J, Falony G, Vieira-Silva S, Kekkonen RA, Corthals GL, Palva A, Salonen A, de Vos WM.

PLoS One. 2016 Apr 12;11(4):e0153294. doi: 10.1371/journal.pone.0153294. eCollection 2016.


The N-Terminal GYPSY Motif Is Required for Pilin-Specific Sortase SrtC1 Functionality in Lactobacillus rhamnosus Strain GG.

Douillard FP, Rasinkangas P, Bhattacharjee A, Palva A, de Vos WM.

PLoS One. 2016 Apr 12;11(4):e0153373. doi: 10.1371/journal.pone.0153373. eCollection 2016.


Genome Sequence of Lactobacillus brevis Strain D6, Isolated from Smoked Fresh Cheese.

Kant R, Uroić K, Hynönen U, Kos B, Šušković J, Palva A.

Genome Announc. 2016 Apr 7;4(2). pii: e00264-16. doi: 10.1128/genomeA.00264-16.


Physiological Concentration of Exogenous Lactate Reduces Antimycin A Triggered Oxidative Stress in Intestinal Epithelial Cell Line IPEC-1 and IPEC-J2 In Vitro.

Kahlert S, Junnikkala S, Renner L, Hynönen U, Hartig R, Nossol C, Barta-Böszörményi A, Dänicke S, Souffrant WB, Palva A, Rothkötter HJ, Kluess J.

PLoS One. 2016 Apr 7;11(4):e0153135. doi: 10.1371/journal.pone.0153135. eCollection 2016.


Isolation and whole genome sequencing of a Ruminococcus-like bacterium, associated with irritable bowel syndrome.

Hynönen U, Rasinkangas P, Satokari R, Paulin L, de Vos WM, Pietilä TE, Kant R, Palva A.

Anaerobe. 2016 Jun;39:60-7. doi: 10.1016/j.anaerobe.2016.03.001. Epub 2016 Mar 2.


Human Gut-Commensalic Lactobacillus ruminis ATCC 25644 Displays Sortase-Assembled Surface Piliation: Phenotypic Characterization of Its Fimbrial Operon through In Silico Predictive Analysis and Recombinant Expression in Lactococcus lactis.

Yu X, Jaatinen A, Rintahaka J, Hynönen U, Lyytinen O, Kant R, Åvall-Jääskeläinen S, von Ossowski I, Palva A.

PLoS One. 2015 Dec 28;10(12):e0145718. doi: 10.1371/journal.pone.0145718. eCollection 2015.


Colonic metaproteomic signatures of active bacteria and the host in obesity.

Kolmeder CA, Ritari J, Verdam FJ, Muth T, Keskitalo S, Varjosalo M, Fuentes S, Greve JW, Buurman WA, Reichl U, Rapp E, Martens L, Palva A, Salonen A, Rensen SS, de Vos WM.

Proteomics. 2015 Oct;15(20):3544-52. doi: 10.1002/pmic.201500049. Epub 2015 Sep 11.


Genome Sequences of Four Staphylococcus aureus Strains Isolated from Bovine Mastitis.

Kant R, Taponen S, Koort J, Paulin L, Åvall-Jääskeläinen S, Palva A.

Genome Announc. 2015 Apr 23;3(2). pii: e00334-15. doi: 10.1128/genomeA.00334-15.


Genome Sequence of the Butyrate-Producing Anaerobic Bacterium Anaerostipes hadrus PEL 85.

Kant R, Rasinkangas P, Satokari R, Pietilä TE, Palva A.

Genome Announc. 2015 Apr 2;3(2). pii: e00224-15. doi: 10.1128/genomeA.00224-15.


Purification, crystallization and preliminary X-ray diffraction analysis of SpaD, a backbone-pilin subunit encoded by the fimbrial spaFED operon in Lactobacillus rhamnosus GG.

Chaurasia P, von Ossowski I, Palva A, Krishnan V.

Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):103-6. doi: 10.1107/S2053230X14027216. Epub 2015 Jan 1.


Lactobacillus rhamnosus GG and its SpaC pilus adhesin modulate inflammatory responsiveness and TLR-related gene expression in the fetal human gut.

Ganguli K, Collado MC, Rautava J, Lu L, Satokari R, von Ossowski I, Reunanen J, de Vos WM, Palva A, Isolauri E, Salminen S, Walker WA, Rautava S.

Pediatr Res. 2015 Apr;77(4):528-35. doi: 10.1038/pr.2015.5. Epub 2015 Jan 12.


Piliation of Lactobacillus rhamnosus GG promotes adhesion, phagocytosis, and cytokine modulation in macrophages.

Vargas García CE, Petrova M, Claes IJ, De Boeck I, Verhoeven TL, Dilissen E, von Ossowski I, Palva A, Bullens DM, Vanderleyden J, Lebeer S.

Appl Environ Microbiol. 2015 Mar;81(6):2050-62. doi: 10.1128/AEM.03949-14. Epub 2015 Jan 9.


Effects of bowel cleansing on the intestinal microbiota.

Jalanka J, Salonen A, Salojärvi J, Ritari J, Immonen O, Marciani L, Gowland P, Hoad C, Garsed K, Lam C, Palva A, Spiller RC, de Vos WM.

Gut. 2015 Oct;64(10):1562-8. doi: 10.1136/gutjnl-2014-307240. Epub 2014 Dec 19.


Phenotypical analysis of the Lactobacillus rhamnosus GG fimbrial spaFED operon: surface expression and functional characterization of recombinant SpaFED pili in Lactococcus lactis.

Rintahaka J, Yu X, Kant R, Palva A, von Ossowski I.

PLoS One. 2014 Nov 21;9(11):e113922. doi: 10.1371/journal.pone.0113922. eCollection 2014.


Genomic characterization of non-mucus-adherent derivatives of Lactobacillus rhamnosus GG reveals genes affecting pilus biogenesis.

Rasinkangas P, Reunanen J, Douillard FP, Ritari J, Uotinen V, Palva A, de Vos WM.

Appl Environ Microbiol. 2014 Nov;80(22):7001-9. doi: 10.1128/AEM.02006-14. Epub 2014 Sep 5.


Functional characterization of probiotic surface layer protein-carrying Lactobacillus amylovorus strains.

Hynönen U, Kant R, Lähteinen T, Pietilä TE, Beganović J, Smidt H, Uroić K, Avall-Jääskeläinen S, Palva A.

BMC Microbiol. 2014 Jul 28;14:199. doi: 10.1186/1471-2180-14-199.


A comparative pan-genome perspective of niche-adaptable cell-surface protein phenotypes in Lactobacillus rhamnosus.

Kant R, Rintahaka J, Yu X, Sigvart-Mattila P, Paulin L, Mecklin JP, Saarela M, Palva A, von Ossowski I.

PLoS One. 2014 Jul 17;9(7):e102762. doi: 10.1371/journal.pone.0102762. eCollection 2014.


The structure of Lactobacillus brevis surface layer reassembled on liposomes differs from native structure as revealed by SAXS.

Kontro I, Wiedmer SK, Hynönen U, Penttilä PA, Palva A, Serimaa R.

Biochim Biophys Acta. 2014 Aug;1838(8):2099-104. doi: 10.1016/j.bbamem.2014.04.022. Epub 2014 May 4.


Functional identification of conserved residues involved in Lactobacillus rhamnosus strain GG sortase specificity and pilus biogenesis.

Douillard FP, Rasinkangas P, von Ossowski I, Reunanen J, Palva A, de Vos WM.

J Biol Chem. 2014 May 30;289(22):15764-75. doi: 10.1074/jbc.M113.542332. Epub 2014 Apr 21.


Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome.

Jalanka-Tuovinen J, Salojärvi J, Salonen A, Immonen O, Garsed K, Kelly FM, Zaitoun A, Palva A, Spiller RC, de Vos WM.

Gut. 2014 Nov;63(11):1737-45. doi: 10.1136/gutjnl-2013-305994. Epub 2013 Dec 5.


Immunostimulatory CpG motifs in the genomes of gut bacteria and their role in human health and disease.

Kant R, de Vos WM, Palva A, Satokari R.

J Med Microbiol. 2014 Feb;63(Pt 2):293-308. doi: 10.1099/jmm.0.064220-0. Epub 2013 Nov 19.


Purification, crystallization and preliminary crystallographic analysis of the SpaA backbone-pilin subunit from probiotic Lactobacillus rhamnosus GG.

Singh D, von Ossowski I, Palva A, Krishnan V.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Oct;69(Pt 10):1182-5. doi: 10.1107/S1744309113024676. Epub 2013 Sep 30.


Effect of Lactobacillus brevis ATCC 8287 as a feeding supplement on the performance and immune function of piglets.

Lähteinen T, Lindholm A, Rinttilä T, Junnikkala S, Kant R, Pietilä TE, Levonen K, von Ossowski I, Solano-Aguilar G, Jakava-Viljanen M, Palva A.

Vet Immunol Immunopathol. 2014 Mar 15;158(1-2):14-25. doi: 10.1016/j.vetimm.2013.09.002. Epub 2013 Sep 7.


Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

Pemovska T, Kontro M, Yadav B, Edgren H, Eldfors S, Szwajda A, Almusa H, Bespalov MM, Ellonen P, Elonen E, Gjertsen BT, Karjalainen R, Kulesskiy E, Lagström S, Lehto A, Lepistö M, Lundán T, Majumder MM, Marti JM, Mattila P, Murumägi A, Mustjoki S, Palva A, Parsons A, Pirttinen T, Rämet ME, Suvela M, Turunen L, Västrik I, Wolf M, Knowles J, Aittokallio T, Heckman CA, Porkka K, Kallioniemi O, Wennerberg K.

Cancer Discov. 2013 Dec;3(12):1416-29. doi: 10.1158/2159-8290.CD-13-0350. Epub 2013 Sep 20.


BopA does not have a major role in the adhesion of Bifidobacterium bifidum to intestinal epithelial cells, extracellular matrix proteins, and mucus.

Kainulainen V, Reunanen J, Hiippala K, Guglielmetti S, Vesterlund S, Palva A, Satokari R.

Appl Environ Microbiol. 2013 Nov;79(22):6989-97. doi: 10.1128/AEM.01993-13. Epub 2013 Sep 6.


Comparative genomic and functional analysis of 100 Lactobacillus rhamnosus strains and their comparison with strain GG.

Douillard FP, Ribbera A, Kant R, Pietilä TE, Järvinen HM, Messing M, Randazzo CL, Paulin L, Laine P, Ritari J, Caggia C, Lähteinen T, Brouns SJ, Satokari R, von Ossowski I, Reunanen J, Palva A, de Vos WM.

PLoS Genet. 2013;9(8):e1003683. doi: 10.1371/journal.pgen.1003683. Epub 2013 Aug 15.


Duodenal microbiota composition and mucosal homeostasis in pediatric celiac disease.

Cheng J, Kalliomäki M, Heilig HG, Palva A, Lähteenoja H, de Vos WM, Salojärvi J, Satokari R.

BMC Gastroenterol. 2013 Jul 11;13:113. doi: 10.1186/1471-230X-13-113.


Comparative genome analysis of Lactobacillus casei strains isolated from Actimel and Yakult products reveals marked similarities and points to a common origin.

Douillard FP, Kant R, Ritari J, Paulin L, Palva A, de Vos WM.

Microb Biotechnol. 2013 Sep;6(5):576-87. doi: 10.1111/1751-7915.12062. Epub 2013 Jul 1. Erratum in: Microb Biotechnol. 2014 Jan;7(1):85.


Intestinal microbiota in healthy U.S. young children and adults--a high throughput microarray analysis.

Ringel-Kulka T, Cheng J, Ringel Y, Salojärvi J, Carroll I, Palva A, de Vos WM, Satokari R.

PLoS One. 2013 May 23;8(5):e64315. doi: 10.1371/journal.pone.0064315. Print 2013.


Using recombinant Lactococci as an approach to dissect the immunomodulating capacity of surface piliation in probiotic Lactobacillus rhamnosus GG.

von Ossowski I, Pietilä TE, Rintahaka J, Nummenmaa E, Mäkinen VM, Reunanen J, Satokari R, de Vos WM, Palva I, Palva A.

PLoS One. 2013 May 14;8(5):e64416. doi: 10.1371/journal.pone.0064416. Print 2013.


Lactobacillus surface layer proteins: structure, function and applications.

Hynönen U, Palva A.

Appl Microbiol Biotechnol. 2013 Jun;97(12):5225-43. doi: 10.1007/s00253-013-4962-2. Epub 2013 May 16. Review.


Associations between the human intestinal microbiota, Lactobacillus rhamnosus GG and serum lipids indicated by integrated analysis of high-throughput profiling data.

Lahti L, Salonen A, Kekkonen RA, Salojärvi J, Jalanka-Tuovinen J, Palva A, Orešič M, de Vos WM.

PeerJ. 2013 Feb 26;1:e32. doi: 10.7717/peerj.32. Print 2013.


Adhesion and nanomechanics of pili from the probiotic Lactobacillus rhamnosus GG.

Tripathi P, Beaussart A, Alsteens D, Dupres V, Claes I, von Ossowski I, de Vos WM, Palva A, Lebeer S, Vanderleyden J, Dufrêne YF.

ACS Nano. 2013 Apr 23;7(4):3685-97. doi: 10.1021/nn400705u. Epub 2013 Mar 26.


Comparative genomic and functional analysis of Lactobacillus casei and Lactobacillus rhamnosus strains marketed as probiotics.

Douillard FP, Ribbera A, Järvinen HM, Kant R, Pietilä TE, Randazzo C, Paulin L, Laine PK, Caggia C, von Ossowski I, Reunanen J, Satokari R, Salminen S, Palva A, de Vos WM.

Appl Environ Microbiol. 2013 Mar;79(6):1923-33. doi: 10.1128/AEM.03467-12. Epub 2013 Jan 11.


Epidemiology and host spectrum of Borna disease virus infections.

Kinnunen PM, Palva A, Vaheri A, Vapalahti O.

J Gen Virol. 2013 Feb;94(Pt 2):247-62. doi: 10.1099/vir.0.046961-0. Epub 2012 Dec 5. Review.


Genetic and biochemical characterization of the cell wall hydrolase activity of the major secreted protein of Lactobacillus rhamnosus GG.

Claes IJ, Schoofs G, Regulski K, Courtin P, Chapot-Chartier MP, Rolain T, Hols P, von Ossowski I, Reunanen J, de Vos WM, Palva A, Vanderleyden J, De Keersmaecker SC, Lebeer S.

PLoS One. 2012;7(2):e31588. doi: 10.1371/journal.pone.0031588. Epub 2012 Feb 16.

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