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Items: 19


Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2.

Early JO, Menon D, Wyse CA, Cervantes-Silva MP, Zaslona Z, Carroll RG, Palsson-McDermott EM, Angiari S, Ryan DG, Corcoran SE, Timmons G, Geiger SS, Fitzpatrick DJ, O'Connell D, Xavier RJ, Hokamp K, O'Neill LAJ, Curtis AM.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8460-E8468. doi: 10.1073/pnas.1800431115. Epub 2018 Aug 20.


Metabolic Modulation in Macrophage Effector Function.

Diskin C, Pålsson-McDermott EM.

Front Immunol. 2018 Feb 19;9:270. doi: 10.3389/fimmu.2018.00270. eCollection 2018. Review.


Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.

Palsson-McDermott EM, Dyck L, Zasłona Z, Menon D, McGettrick AF, Mills KHG, O'Neill LA.

Front Immunol. 2017 Oct 13;8:1300. doi: 10.3389/fimmu.2017.01300. eCollection 2017.


The Induction of Pro-IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production.

Zasłona Z, Pålsson-McDermott EM, Menon D, Haneklaus M, Flis E, Prendeville H, Corcoran SE, Peters-Golden M, O'Neill LAJ.

J Immunol. 2017 May 1;198(9):3558-3564. doi: 10.4049/jimmunol.1602072. Epub 2017 Mar 15.


Pyruvate Kinase M2: A Potential Target for Regulating Inflammation.

Alves-Filho JC, Pålsson-McDermott EM.

Front Immunol. 2016 Apr 21;7:145. doi: 10.3389/fimmu.2016.00145. eCollection 2016. Review.


Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication.

Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J.

J Immunol. 2016 Mar 15;196(6):2444-9. doi: 10.4049/jimmunol.1501612. Epub 2016 Feb 12.


Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.

Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7231-6. doi: 10.1073/pnas.1501327112. Epub 2015 May 20.


Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.

Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MAR, Sheedy FJ, Gleeson LE, van den Bosch MWM, Quinn SR, Domingo-Fernandez R, Johnston DGW, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Xavier RJ, O'Neill LAJ.

Cell Metab. 2015 Feb 3;21(2):347. doi: 10.1016/j.cmet.2015.01.017. Epub 2015 Feb 3. No abstract available.


Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.

Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Xavier RJ, O'Neill LA.

Cell Metab. 2015 Jan 6;21(1):65-80. doi: 10.1016/j.cmet.2014.12.005. Erratum in: Cell Metab. 2015 Feb 3;21(2):347. Cell Metab. 2015 Feb 3;21(2):347. Jiang, Jain-Kang [corrected to Jiang, Jian-Kang]; Vanden Heiden, Matthew [corrected to Vander Heiden, Matthew].


The Warburg effect then and now: from cancer to inflammatory diseases.

Palsson-McDermott EM, O'Neill LA.

Bioessays. 2013 Nov;35(11):965-73. doi: 10.1002/bies.201300084. Epub 2013 Sep 20. Review.


MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C.

Corr SC, Palsson-McDermott EM, Grishina I, Barry SP, Aviello G, Bernard NJ, Casey PG, Ward JB, Keely SJ, Dandekar S, Fallon PG, O'Neill LA.

Mucosal Immunol. 2014 Jan;7(1):57-67. doi: 10.1038/mi.2013.24. Epub 2013 Apr 24.


Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA.

Nature. 2013 Apr 11;496(7444):238-42. doi: 10.1038/nature11986. Epub 2013 Mar 24.


TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.

Palsson-McDermott EM, Doyle SL, McGettrick AF, Hardy M, Husebye H, Banahan K, Gong M, Golenbock D, Espevik T, O'Neill LA.

Nat Immunol. 2009 Jun;10(6):579-86. doi: 10.1038/ni.1727. Epub 2009 May 3.


Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation.

McCoy CE, Carpenter S, Pålsson-McDermott EM, Gearing LJ, O'Neill LA.

J Biol Chem. 2008 May 23;283(21):14277-85. doi: 10.1074/jbc.M709731200. Epub 2008 Mar 20.


Building an immune system from nine domains.

Pålsson-McDermott EM, O'Neill LA.

Biochem Soc Trans. 2007 Dec;35(Pt 6):1437-44. Review.


The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases.

Pålsson-McDermott EM, O'Neill LA.

Ir J Med Sci. 2007 Dec;176(4):253-60. Epub 2007 Nov 15. Review.


Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.

McGettrick AF, Brint EK, Palsson-McDermott EM, Rowe DC, Golenbock DT, Gay NJ, Fitzgerald KA, O'Neill LA.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9196-201. Epub 2006 Jun 6.


Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4.

Pålsson-McDermott EM, O'Neill LA.

Immunology. 2004 Oct;113(2):153-62. Review.


Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.

Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA.

Nature. 2001 Sep 6;413(6851):78-83.


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