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Items: 1 to 50 of 214

1.

MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance.

Joosten SPJ, Mizutani T, Spaargaren M, Clevers H, Pals ST.

Gastroenterology. 2019 Jun 27. pii: S0016-5085(19)41038-X. doi: 10.1053/j.gastro.2019.06.029. [Epub ahead of print] No abstract available.

PMID:
31255653
2.

MYD88 mutations identify a molecular subgroup of diffuse large B-cell lymphoma with an unfavourable prognosis.

Vermaat JS, Somers SF, de Wreede LC, Kraan W, de Groen RAL, Schrader AMR, Kerver ED, Scheepstra CG, Beerenschot H, Deenik W, Wegman J, Broers R, de Boer JD, Nijland M, van Wezel T, Veelken H, Spaargaren M, Cleven AH, Kersten MJ, Pals ST.

Haematologica. 2019 May 23. pii: haematol.2018.214122. doi: 10.3324/haematol.2018.214122. [Epub ahead of print]

3.

Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options.

van Andel H, Kocemba KA, Spaargaren M, Pals ST.

Leukemia. 2019 May;33(5):1063-1075. doi: 10.1038/s41375-019-0404-1. Epub 2019 Feb 15. Review.

PMID:
30770859
4.

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life.

Schreurs RRCE, Baumdick ME, Sagebiel AF, Kaufmann M, Mokry M, Klarenbeek PL, Schaltenberg N, Steinert FL, van Rijn JM, Drewniak A, The SML, Bakx R, Derikx JPM, de Vries N, Corpeleijn WE, Pals ST, Gagliani N, Friese MA, Middendorp S, Nieuwenhuis EES, Reinshagen K, Geijtenbeek TBH, van Goudoever JB, Bunders MJ.

Immunity. 2019 Feb 19;50(2):462-476.e8. doi: 10.1016/j.immuni.2018.12.010. Epub 2019 Feb 12.

PMID:
30770246
5.

High prevalence of MYD88 and CD79B mutations in intravascular large B-cell lymphoma.

Schrader AMR, Jansen PM, Willemze R, Vermeer MH, Cleton-Jansen AM, Somers SF, Veelken H, van Eijk R, Kraan W, Kersten MJ, van den Brand M, Stevens WBC, de Jong D, Abdul Hamid M, Tanis BC, Posthuma EFM, Nijland M, Diepstra A, Pals ST, Cleven AHG, Vermaat JSP.

Blood. 2018 May 3;131(18):2086-2089. doi: 10.1182/blood-2017-12-822817. Epub 2018 Mar 7. No abstract available.

6.

Clinicopathological characteristics of T-cell non-Hodgkin lymphoma arising in patients with immunodeficiencies: a single-center case series of 25 patients and a review of the literature.

Nijland ML, Koens L, Pals ST, Berge IJMT, Bemelman FJ, Kersten MJ.

Haematologica. 2018 Mar;103(3):486-496. doi: 10.3324/haematol.2017.169987. Epub 2017 Dec 21.

7.

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins.

Ren Z, van Andel H, de Lau W, Hartholt RB, Maurice MM, Clevers H, Kersten MJ, Spaargaren M, Pals ST.

Blood. 2018 Mar 1;131(9):982-994. doi: 10.1182/blood-2017-07-797050. Epub 2017 Dec 6.

8.

High prevalence of the MYD88 L265P mutation in IgM anti-MAG paraprotein-associated peripheral neuropathy.

Vos JM, Notermans NC, D'Sa S, Lunn MP, van der Pol WL, Kraan W, Reilly MM, Chalker J, Gupta R, Kersten MJ, Pals ST, Minnema MC.

J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):1007-1009. doi: 10.1136/jnnp-2017-316689. Epub 2017 Oct 10. No abstract available.

PMID:
29018161
9.

Acute lymphoblastic leukemia during the third trimester of pregnancy.

Vlijm-Kievit A, Jorna NGE, Moll E, Pajkrt E, Pals ST, Middeldorp S, Biemond BJ, Zeerleder SS, Tio MA, Kemper EM, Hazenberg MD.

Leuk Lymphoma. 2018 May;59(5):1274-1276. doi: 10.1080/10428194.2017.1375104. Epub 2017 Sep 15. No abstract available.

PMID:
28914556
10.

CXCL13 levels are elevated in patients with Waldenström macroglobulinemia, and are predictive of major response to ibrutinib.

Vos JM, Tsakmaklis N, Patterson CJ, Meid K, Castillo JJ, Brodsky P, Ganz T, Pals ST, Kersten MJ, Xu L, Yang G, Treon SP, Hunter ZR.

Haematologica. 2017 Nov;102(11):e452-e455. doi: 10.3324/haematol.2017.172627. Epub 2017 Aug 10. No abstract available.

11.

MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.

Joosten SPJ, Zeilstra J, van Andel H, Mijnals RC, Zaunbrecher J, Duivenvoorden AAM, van de Wetering M, Clevers H, Spaargaren M, Pals ST.

Gastroenterology. 2017 Oct;153(4):1040-1053.e4. doi: 10.1053/j.gastro.2017.07.008. Epub 2017 Jul 14.

PMID:
28716720
12.

Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome.

Oud MM, Tuijnenburg P, Hempel M, van Vlies N, Ren Z, Ferdinandusse S, Jansen MH, Santer R, Johannsen J, Bacchelli C, Alders M, Li R, Davies R, Dupuis L, Cale CM, Wanders RJA, Pals ST, Ocaka L, James C, Müller I, Lehmberg K, Strom T, Engels H, Williams HJ, Beales P, Roepman R, Dias P, Brunner HG, Cobben JM, Hall C, Hartley T, Le Quesne Stabej P, Mendoza-Londono R, Davies EG, de Sousa SB, Lessel D, Arts HH, Kuijpers TW.

Am J Hum Genet. 2017 Feb 2;100(2):281-296. doi: 10.1016/j.ajhg.2017.01.013. Epub 2017 Jan 26.

13.

Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins.

van Andel H, Ren Z, Koopmans I, Joosten SP, Kocemba KA, de Lau W, Kersten MJ, de Bruin AM, Guikema JE, Clevers H, Spaargaren M, Pals ST.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):376-381. doi: 10.1073/pnas.1618650114. Epub 2016 Dec 27.

14.

Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency.

Kuijpers TW, Tool ATJ, van der Bijl I, de Boer M, van Houdt M, de Cuyper IM, Roos D, van Alphen F, van Leeuwen K, Cambridge EL, Arends MJ, Dougan G, Clare S, Ramirez-Solis R, Pals ST, Adams DJ, Meijer AB, van den Berg TK.

J Allergy Clin Immunol. 2017 Jul;140(1):273-277.e10. doi: 10.1016/j.jaci.2016.09.061. Epub 2016 Dec 10. No abstract available.

PMID:
27965109
15.

The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells.

van Keimpema M, Grüneberg LJ, Schilder-Tol EJ, Oud ME, Beuling EA, Hensbergen PJ, de Jong J, Pals ST, Spaargaren M.

Haematologica. 2017 Mar;102(3):573-583. doi: 10.3324/haematol.2016.156455. Epub 2016 Dec 1.

16.

Targeting cell adhesion and homing as strategy to cure Waldenström's macroglobulinemia.

Pals ST, Kersten MJ, Spaargaren M.

Best Pract Res Clin Haematol. 2016 Jun;29(2):161-168. doi: 10.1016/j.beha.2016.08.019. Epub 2016 Sep 7. Review.

PMID:
27825462
17.

Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease.

van Andel H, Kocemba KA, de Haan-Kramer A, Mellink CH, Piwowar M, Broijl A, van Duin M, Sonneveld P, Maurice MM, Kersten MJ, Spaargaren M, Pals ST.

Oncogene. 2017 Apr;36(15):2105-2115. doi: 10.1038/onc.2016.368. Epub 2016 Oct 24.

PMID:
27775078
18.

Epstein-Barr Virus-Positive Posttransplant Lymphoproliferative Disease After Solid Organ Transplantation: Pathogenesis, Clinical Manifestations, Diagnosis, and Management.

Nijland ML, Kersten MJ, Pals ST, Bemelman FJ, Ten Berge IJ.

Transplant Direct. 2015 Dec 15;2(1):e48. doi: 10.1097/TXD.0000000000000557. eCollection 2016 Jan.

19.

Hepatosplenic T-Cell Lymphoma: A Population-Based Study Assessing Incidence and Association With Immune-Mediated Disease.

Montgomery M, van Santen MM, Biemond BJ, Diamond RH, Pals ST.

Gastroenterol Hepatol (N Y). 2015 Mar;11(3):160-3.

20.

AML relapse after rituximab treatment for GvHD: crucial role for B cells in GvL responses.

Gillissen MA, de Jong G, Levie SE, Yasuda E, Bakker AQ, Evers LM, Pals ST, Huisman C, van Helden PM, Spits H, Hazenberg MD.

Bone Marrow Transplant. 2016 Sep;51(9):1245-8. doi: 10.1038/bmt.2016.90. Epub 2016 Apr 18. No abstract available.

PMID:
27088384
21.

Ibrutinib and idelalisib target B cell receptor- but not CXCL12/CXCR4-controlled integrin-mediated adhesion in Waldenström macroglobulinemia.

de Rooij MF, Kuil A, Kraan W, Kersten MJ, Treon SP, Pals ST, Spaargaren M.

Haematologica. 2016 Mar;101(3):e111-5. doi: 10.3324/haematol.2015.137265. Epub 2015 Dec 3. No abstract available.

22.

Precision medicine in diffuse large B-cell lymphoma: hitting the target.

Vermaat JS, Pals ST, Younes A, Dreyling M, Federico M, Aurer I, Radford J, Kersten MJ; EHA Lymphoma Group, a Scientific Working Group of the European Hematology Association.

Haematologica. 2015 Aug;100(8):989-93. doi: 10.3324/haematol.2015.128371. No abstract available.

23.

The forkhead transcription factor FOXP1 represses human plasma cell differentiation.

van Keimpema M, Grüneberg LJ, Mokry M, van Boxtel R, van Zelm MC, Coffer P, Pals ST, Spaargaren M.

Blood. 2015 Oct 29;126(18):2098-109. doi: 10.1182/blood-2015-02-626176. Epub 2015 Aug 19.

24.

A 43-Year-Old Female with Multifocal Cerebral Lesions. Histiocytic Sarcoma.

Nieuwenhuis MB, van der Salm SM, Verhoeff JJ, van der Kooi AJ, Slavujecvic-Letic I, Pals ST, Vos JM.

Brain Pathol. 2015 May;25(3):371-2. No abstract available.

PMID:
26086057
25.

Effective treatment of Bing-Neel Syndrome with oral fludarabine: a case series of four consecutive patients.

Vos JM, Kersten MJ, Kraan W, Groeneveld ON, Linn C, Pals ST, Minnema MC.

Br J Haematol. 2016 Feb;172(3):461-4. doi: 10.1111/bjh.13483. Epub 2015 May 5. No abstract available.

PMID:
25944724
26.

Ibrutinib and idelalisib synergistically target BCR-controlled adhesion in MCL and CLL: a rationale for combination therapy.

de Rooij MF, Kuil A, Kater AP, Kersten MJ, Pals ST, Spaargaren M.

Blood. 2015 Apr 2;125(14):2306-9. doi: 10.1182/blood-2014-12-619163. No abstract available.

27.

Diffuse large B cell lymphomas relapsing in the CNS lack oncogenic MYD88 and CD79B mutations.

Kersten MJ, Kraan W, Doorduijn J, Bromberg J, Lam K, Kluin PM, van der Holt BJ, Spaargaren M, Pals ST.

Blood Cancer J. 2014 Dec 12;4:e266. doi: 10.1038/bcj.2014.87. No abstract available.

28.

FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells.

van Keimpema M, Grüneberg LJ, Mokry M, van Boxtel R, Koster J, Coffer PJ, Pals ST, Spaargaren M.

Blood. 2014 Nov 27;124(23):3431-40. doi: 10.1182/blood-2014-01-553412. Epub 2014 Sep 29.

29.

Opposite role of CD44-standard and CD44-variant-3 in tubular injury and development of renal fibrosis during chronic obstructive nephropathy.

Rampanelli E, Rouschop KM, Claessen N, Teske GJ, Pals ST, Leemans JC, Florquin S.

Kidney Int. 2014 Sep;86(3):558-69. doi: 10.1038/ki.2014.87. Epub 2014 Apr 9.

30.

CD44-deficiency attenuates the immunologic responses to LPS and delays the onset of endotoxic shock-induced renal inflammation and dysfunction.

Rampanelli E, Dessing MC, Claessen N, Teske GJ, Joosten SP, Pals ST, Leemans JC, Florquin S.

PLoS One. 2013 Dec 23;8(12):e84479. doi: 10.1371/journal.pone.0084479. eCollection 2013.

31.

High prevalence of oncogenic MYD88 and CD79B mutations in primary testicular diffuse large B-cell lymphoma.

Kraan W, van Keimpema M, Horlings HM, Schilder-Tol EJ, Oud ME, Noorduyn LA, Kluin PM, Kersten MJ, Spaargaren M, Pals ST.

Leukemia. 2014 Mar;28(3):719-20. doi: 10.1038/leu.2013.348. Epub 2013 Nov 20. No abstract available.

PMID:
24253023
32.

IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells.

Pascutti MF, Jak M, Tromp JM, Derks IA, Remmerswaal EB, Thijssen R, van Attekum MH, van Bochove GG, Luijks DM, Pals ST, van Lier RA, Kater AP, van Oers MH, Eldering E.

Blood. 2013 Oct 24;122(17):3010-9. doi: 10.1182/blood-2012-11-467670. Epub 2013 Sep 6.

33.

High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites.

Kraan W, Horlings HM, van Keimpema M, Schilder-Tol EJ, Oud ME, Scheepstra C, Kluin PM, Kersten MJ, Spaargaren M, Pals ST.

Blood Cancer J. 2013 Sep 6;3:e139. doi: 10.1038/bcj.2013.28.

34.

CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status.

Zeilstra J, Joosten SP, Vermeulen L, Koster J, Medema JP, Versteeg R, Spaargaren M, Pals ST.

PLoS One. 2013 Aug 29;8(8):e72849. doi: 10.1371/journal.pone.0072849. eCollection 2013.

35.

A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe.

Hovius JW, de Wever B, Sohne M, Brouwer MC, Coumou J, Wagemakers A, Oei A, Knol H, Narasimhan S, Hodiamont CJ, Jahfari S, Pals ST, Horlings HM, Fikrig E, Sprong H, van Oers MH.

Lancet. 2013 Aug 17;382(9892):658. doi: 10.1016/S0140-6736(13)61644-X. No abstract available.

36.

Egress of CD19(+)CD5(+) cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients.

Chang BY, Francesco M, De Rooij MF, Magadala P, Steggerda SM, Huang MM, Kuil A, Herman SE, Chang S, Pals ST, Wilson W, Wiestner A, Spaargaren M, Buggy JJ, Elias L.

Blood. 2013 Oct 3;122(14):2412-24. doi: 10.1182/blood-2013-02-482125. Epub 2013 Aug 12.

37.

Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis.

aan de Kerk DJ, van Leeuwen EM, Jansen MH, van den Berg JM, Alders M, Vermont CL, van Lier RA, Pals ST, Kuijpers TW.

Clin Immunol. 2013 Oct;149(1):25-31. doi: 10.1016/j.clim.2013.06.002. Epub 2013 Jun 19.

PMID:
23891736
38.

The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis.

Kocemba KA, van Andel H, de Haan-Kramer A, Mahtouk K, Versteeg R, Kersten MJ, Spaargaren M, Pals ST.

Leukemia. 2013 Aug;27(8):1729-37. doi: 10.1038/leu.2013.76. Epub 2013 Mar 12.

PMID:
23478664
39.

Guideline for diagnosis and treatment of Waldenström's macroglobulinaemia.

Vos JM, Minnema MC, Wijermans PW, Croockewit S, Chamuleau ME, Pals ST, Klein SK, Delforge M, van Imhoff GW, Kersten MJ; HOVON Multiple Myeloma Working Party; HOVON Lymphoma Working Party.

Neth J Med. 2013 Mar;71(2):54-62.

40.

Heparan sulfate proteoglycans in the control of B cell development and the pathogenesis of multiple myeloma.

Reijmers RM, Spaargaren M, Pals ST.

FEBS J. 2013 May;280(10):2180-93. doi: 10.1111/febs.12180. Epub 2013 Mar 4. Review.

41.

Distinct CD44 splice variants differentially affect collateral artery growth.

Bot PT, Grundmann S, van Royen N, Joosten SP, Schirmer SH, de Kleijn DP, Pals ST, Pasterkamp G, Piek JJ, Hoefer IE.

Curr Vasc Pharmacol. 2013 Jan;11(1):13-20.

PMID:
23391418
42.

Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling.

Zeilstra J, Joosten SP, van Andel H, Tolg C, Berns A, Snoek M, van de Wetering M, Spaargaren M, Clevers H, Pals ST.

Oncogene. 2014 Jan 30;33(5):665-70. doi: 10.1038/onc.2012.611. Epub 2013 Jan 14.

PMID:
23318432
43.

Memory CD4(+)CCR5(+) T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1.

Bunders MJ, van der Loos CM, Klarenbeek PL, van Hamme JL, Boer K, Wilde JC, de Vries N, van Lier RA, Kootstra N, Pals ST, Kuijpers TW.

Blood. 2012 Nov 22;120(22):4383-90. doi: 10.1182/blood-2012-06-437566. Epub 2012 Oct 1.

44.

Chlamydia psittaci-negative ocular adnexal marginal zone B-cell lymphomas have biased VH4-34 immunoglobulin gene expression and proliferate in a distinct inflammatory environment.

van Maldegem F, Wormhoudt TA, Mulder MM, Oud ME, Schilder-Tol E, Musler AR, Aten J, Saeed P, Kersten MJ, Pals ST, van Noesel CJ, Bende RJ.

Leukemia. 2012 Jul;26(7):1647-53. doi: 10.1038/leu.2012.28. Epub 2012 Feb 3.

PMID:
22382892
45.

Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma.

Kocemba KA, Groen RW, van Andel H, Kersten MJ, Mahtouk K, Spaargaren M, Pals ST.

PLoS One. 2012;7(2):e30359. doi: 10.1371/journal.pone.0030359. Epub 2012 Feb 17.

46.

The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia.

de Rooij MF, Kuil A, Geest CR, Eldering E, Chang BY, Buggy JJ, Pals ST, Spaargaren M.

Blood. 2012 Mar 15;119(11):2590-4. doi: 10.1182/blood-2011-11-390989. Epub 2012 Jan 25.

47.

Clinical pathological conference: a non-Hodgkin's lymphoma patient with persistent anaemia after chemotherapy.

Hazenberg MD, Biemond BJ, Pals ST, Zumpolle CM, Schinkel CJ, Linthorst GE, Hoekstra JB, Vos JM.

Neth J Med. 2011 Oct;69(10):469-73. No abstract available.

48.

Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients.

de Sousa E Melo F, Colak S, Buikhuisen J, Koster J, Cameron K, de Jong JH, Tuynman JB, Prasetyanti PR, Fessler E, van den Bergh SP, Rodermond H, Dekker E, van der Loos CM, Pals ST, van de Vijver MJ, Versteeg R, Richel DJ, Vermeulen L, Medema JP.

Cell Stem Cell. 2011 Nov 4;9(5):476-85. doi: 10.1016/j.stem.2011.10.008.

49.

Intracerebral infiltration as the unique cause of the clinical presentation of chronic lymphocytic leukemia/small lymphocytic leukemia.

Tonino SH, Rijssenbeek AL, Oud ME, Pals ST, van Oers MH, Kater AP.

J Clin Oncol. 2011 Dec 1;29(34):e837-9. doi: 10.1200/JCO.2011.37.5055. Epub 2011 Oct 24. No abstract available.

PMID:
22025138
50.

N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation.

Groen RW, de Rooij MF, Kocemba KA, Reijmers RM, de Haan-Kramer A, Overdijk MB, Aalders L, Rozemuller H, Martens AC, Bergsagel PL, Kersten MJ, Pals ST, Spaargaren M.

Haematologica. 2011 Nov;96(11):1653-61. doi: 10.3324/haematol.2010.038133. Epub 2011 Aug 9.

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