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Items: 32


Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.

Friedman CE, Nguyen Q, Lukowski SW, Helfer A, Chiu HS, Miklas J, Levy S, Suo S, Han JJ, Osteil P, Peng G, Jing N, Baillie GJ, Senabouth A, Christ AN, Bruxner TJ, Murry CE, Wong ES, Ding J, Wang Y, Hudson J, Ruohola-Baker H, Bar-Joseph Z, Tam PPL, Powell JE, Palpant NJ.

Cell Stem Cell. 2018 Oct 4;23(4):586-598.e8. doi: 10.1016/j.stem.2018.09.009.


Genetic Lineage Tracing of Sca-1+ Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart.

Vagnozzi RJ, Sargent MA, Lin SJ, Palpant NJ, Murry CE, Molkentin JD.

Circulation. 2018 Jul 10. pii: CIRCULATIONAHA.118.035210. doi: 10.1161/CIRCULATIONAHA.118.035210. [Epub ahead of print]


Single-cell RNA-seq of human induced pluripotent stem cells reveals cellular heterogeneity and cell state transitions between subpopulations.

Nguyen QH, Lukowski SW, Chiu HS, Senabouth A, Bruxner TJC, Christ AN, Palpant NJ, Powell JE.

Genome Res. 2018 Jul;28(7):1053-1066. doi: 10.1101/gr.223925.117. Epub 2018 May 11.


Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal.

Ferreccio A, Mathieu J, Detraux D, Somasundaram L, Cavanaugh C, Sopher B, Fischer K, Bello T, M Hussein A, Levy S, Cook S, Sidhu SB, Artoni F, Palpant NJ, Reinecke H, Wang Y, Paddison P, Murry C, Jayadev S, Ware C, Ruohola-Baker H.

Cell Cycle. 2018;17(5):535-549. doi: 10.1080/15384101.2018.1442621. Epub 2018 Apr 5.


Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species.

Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF.

Sci Signal. 2017 Dec 5;10(508). pii: eaan3398. doi: 10.1126/scisignal.aan3398.


A transcribed enhancer dictates mesendoderm specification in pluripotency.

Alexanian M, Maric D, Jenkinson SP, Mina M, Friedman CE, Ting CC, Micheletti R, Plaisance I, Nemir M, Maison D, Kernen J, Pezzuto I, Villeneuve D, Burdet F, Ibberson M, Leib SL, Palpant NJ, Hernandez N, Ounzain S, Pedrazzini T.

Nat Commun. 2017 Nov 27;8(1):1806. doi: 10.1038/s41467-017-01804-w.


Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis.

Palpant NJ, Wang Y, Hadland B, Zaunbrecher RJ, Redd M, Jones D, Pabon L, Jain R, Epstein J, Ruzzo WL, Zheng Y, Bernstein I, Margolin A, Murry CE.

Cell Rep. 2017 Aug 15;20(7):1597-1608. doi: 10.1016/j.celrep.2017.07.067.


Erratum to: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development.

Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J.

Genome Biol. 2016 Dec 19;17(1):263. No abstract available.


Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells.

Palpant NJ, Pabon L, Friedman CE, Roberts M, Hadland B, Zaunbrecher RJ, Bernstein I, Zheng Y, Murry CE.

Nat Protoc. 2017 Jan;12(1):15-31. doi: 10.1038/nprot.2016.153. Epub 2016 Dec 1.


The developmental origins and lineage contributions of endocardial endothelium.

Nakano A, Nakano H, Smith KA, Palpant NJ.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1937-47. doi: 10.1016/j.bbamcr.2016.01.022. Epub 2016 Jan 29. Review.


Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes.

Palpant NJ, Pabon L, Roberts M, Hadland B, Jones D, Jones C, Moon RT, Ruzzo WL, Bernstein I, Zheng Y, Murry CE.

Development. 2015 Sep 15;142(18):3198-209. doi: 10.1242/dev.117010. Epub 2015 Jul 7.


Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development.

Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J.

Genome Biol. 2015 Jun 16;16:126. doi: 10.1186/s13059-015-0690-5. Erratum in: Genome Biol. 2016 Dec 19;17 (1):263.


Cardiac development in zebrafish and human embryonic stem cells is inhibited by exposure to tobacco cigarettes and e-cigarettes.

Palpant NJ, Hofsteen P, Pabon L, Reinecke H, Murry CE.

PLoS One. 2015 May 15;10(5):e0126259. doi: 10.1371/journal.pone.0126259. eCollection 2015.


Methods for assessing the electromechanical integration of human pluripotent stem cell-derived cardiomyocyte grafts.

Zhu WZ, Filice D, Palpant NJ, Laflamme MA.

Methods Mol Biol. 2014;1181:229-47. doi: 10.1007/978-1-4939-1047-2_20.


Proliferation at the heart of preadolescence.

Palpant NJ, Murry CE.

Cell. 2014 May 8;157(4):765-7. doi: 10.1016/j.cell.2014.04.025.


Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.

Chong JJ, Yang X, Don CW, Minami E, Liu YW, Weyers JJ, Mahoney WM, Van Biber B, Cook SM, Palpant NJ, Gantz JA, Fugate JA, Muskheli V, Gough GM, Vogel KW, Astley CA, Hotchkiss CE, Baldessari A, Pabon L, Reinecke H, Gill EA, Nelson V, Kiem HP, Laflamme MA, Murry CE.

Nature. 2014 Jun 12;510(7504):273-7. doi: 10.1038/nature13233. Epub 2014 Apr 30.


Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development.

Palpant NJ, Pabon L, Rabinowitz JS, Hadland BK, Stoick-Cooper CL, Paige SL, Bernstein ID, Moon RT, Murry CE.

Development. 2013 Sep;140(18):3799-808. doi: 10.1242/dev.094789. Epub 2013 Aug 7.


Cardiopoietry in motion: primed mesenchymal stem cells for ischemic cardiomyopathy.

Murry CE, Palpant NJ, MacLellan WR.

J Am Coll Cardiol. 2013 Jun 11;61(23):2339-40. doi: 10.1016/j.jacc.2013.03.028. Epub 2013 Apr 10. No abstract available.


Targeted genomic integration of a selectable floxed dual fluorescence reporter in human embryonic stem cells.

Gantz JA, Palpant NJ, Welikson RE, Hauschka SD, Murry CE, Laflamme MA.

PLoS One. 2012;7(10):e46971. doi: 10.1371/journal.pone.0046971. Epub 2012 Oct 10.


Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts.

Shiba Y, Fernandes S, Zhu WZ, Filice D, Muskheli V, Kim J, Palpant NJ, Gantz J, Moyes KW, Reinecke H, Van Biber B, Dardas T, Mignone JL, Izawa A, Hanna R, Viswanathan M, Gold JD, Kotlikoff MI, Sarvazyan N, Kay MW, Murry CE, Laflamme MA.

Nature. 2012 Sep 13;489(7415):322-5. doi: 10.1038/nature11317.


Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy.

Davis J, Yasuda S, Palpant NJ, Martindale J, Stevenson T, Converso K, Metzger JM.

J Mol Cell Cardiol. 2012 Sep;53(3):446-57. doi: 10.1016/j.yjmcc.2012.05.018. Epub 2012 Jun 6.


Regenerative medicine: Reprogramming the injured heart.

Palpant NJ, Murry CE.

Nature. 2012 May 31;485(7400):585-6. doi: 10.1038/485585a. No abstract available.


pH-responsive titratable inotropic performance of histidine-modified cardiac troponin I.

Palpant NJ, Houang EM, Sham YY, Metzger JM.

Biophys J. 2012 Apr 4;102(7):1570-9. doi: 10.1016/j.bpj.2012.01.024. Epub 2012 Apr 3.


Zinc finger nucleases: looking toward translation.

Palpant NJ, Dudzinski D.

Gene Ther. 2013 Feb;20(2):121-7. doi: 10.1038/gt.2012.2. Epub 2012 Feb 9. Review.


Cardiac disease in mucopolysaccharidosis type I attributed to catecholaminergic and hemodynamic deficiencies.

Palpant NJ, Bedada FB, Peacock B, Blazar BR, Metzger JM, Tolar J.

Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H356-65. doi: 10.1152/ajpheart.00774.2010. Epub 2010 Nov 12.


Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains.

Barnabei MS, Palpant NJ, Metzger JM.

Physiol Genomics. 2010 Oct;42A(2):103-13. doi: 10.1152/physiolgenomics.00071.2010. Epub 2010 Jul 13.


Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.

Palpant NJ, Houang EM, Delport W, Hastings KE, Onufriev AV, Sham YY, Metzger JM.

Physiol Genomics. 2010 Jul 7;42(2):287-99. doi: 10.1152/physiolgenomics.00033.2010. Epub 2010 Apr 27.


Aesthetic cardiology: adipose-derived stem cells for myocardial repair.

Palpant NJ, Metzger JM.

Curr Stem Cell Res Ther. 2010 Jun;5(2):145-52. Review.


Artificial selection for whole animal low intrinsic aerobic capacity co-segregates with hypoxia-induced cardiac pump failure.

Palpant NJ, Szatkowski ML, Wang W, Townsend D, Bedada FB, Koch LG, Britton SL, Metzger JM.

PLoS One. 2009 Jul 1;4(7):e6117. doi: 10.1371/journal.pone.0006117.


Single histidine button in cardiac troponin I sustains heart performance in response to severe hypercapnic respiratory acidosis in vivo.

Palpant NJ, D'Alecy LG, Metzger JM.

FASEB J. 2009 May;23(5):1529-40. doi: 10.1096/fj.08-121996. Epub 2009 Jan 13.


Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction.

Palpant NJ, Day SM, Herron TJ, Converso KL, Metzger JM.

Cardiovasc Res. 2008 Nov 1;80(2):209-18. doi: 10.1093/cvr/cvn198. Epub 2008 Jul 16.


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