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Items: 45

1.

Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors.

Palmer JT, Axford LC, Barker S, Bennett JM, Blair M, Collins I, Davies DT, Ford L, Gannon CT, Lancett P, Logan A, Lunniss CJ, Morton CJ, Offermann DA, Pitt GR, Rao BN, Singh AK, Shukla T, Srivastava A, Stokes NR, Thomaides-Brears HB, Yadav A, Haydon DJ.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4215-22. doi: 10.1016/j.bmcl.2014.07.037. Epub 2014 Jul 19.

PMID:
25086682
2.

Family history, not lack of medication use, is associated with the development of postpartum depression in a high-risk sample.

Kimmel M, Hess E, Roy PS, Palmer JT, Meltzer-Brody S, Meuchel JM, Bost-Baxter E, Payne JL.

Arch Womens Ment Health. 2015 Feb;18(1):113-21. doi: 10.1007/s00737-014-0432-9. Epub 2014 Jul 1.

3.

Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.

Axford LC, Agarwal PK, Anderson KH, Andrau LN, Atherall J, Barker S, Bennett JM, Blair M, Collins I, Czaplewski LG, Davies DT, Gannon CT, Kumar D, Lancett P, Logan A, Lunniss CJ, Mitchell DR, Offermann DA, Palmer JT, Palmer N, Pitt GR, Pommier S, Price D, Narasinga Rao B, Saxena R, Shukla T, Singh AK, Singh M, Srivastava A, Steele C, Stokes NR, Thomaides-Brears HB, Tyndall EM, Watson D, Haydon DJ.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6598-603. doi: 10.1016/j.bmcl.2013.10.058. Epub 2013 Nov 4.

PMID:
24239017
4.

Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).

Burns CJ, Bourke DG, Andrau L, Bu X, Charman SA, Donohue AC, Fantino E, Farrugia M, Feutrill JT, Joffe M, Kling MR, Kurek M, Nero TL, Nguyen T, Palmer JT, Phillips I, Shackleford DM, Sikanyika H, Styles M, Su S, Treutlein H, Zeng J, Wilks AF.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92. doi: 10.1016/j.bmcl.2009.08.071. Epub 2009 Aug 23.

PMID:
19762238
5.

A reproductive subtype of depression: conceptualizing models and moving toward etiology.

Payne JL, Palmer JT, Joffe H.

Harv Rev Psychiatry. 2009;17(2):72-86. doi: 10.1080/10673220902899706. Review.

6.

Stabilization of hypomania following initiation of tamoxifen.

Palmer JT, Payne JL.

Am J Psychiatry. 2008 May;165(5):650-1. doi: 10.1176/appi.ajp.2007.07071165. No abstract available.

PMID:
18450946
7.

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

Gauthier JY, Chauret N, Cromlish W, Desmarais S, Duong LT, Falgueyret JP, Kimmel DB, Lamontagne S, Léger S, LeRiche T, Li CS, Massé F, McKay DJ, Nicoll-Griffith DA, Oballa RM, Palmer JT, Percival MD, Riendeau D, Robichaud J, Rodan GA, Rodan SB, Seto C, Thérien M, Truong VL, Venuti MC, Wesolowski G, Young RN, Zamboni R, Black WC.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):923-8. doi: 10.1016/j.bmcl.2007.12.047. Epub 2008 Jan 15.

PMID:
18226527
8.

Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase.

Pan Z, Scheerens H, Li SJ, Schultz BE, Sprengeler PA, Burrill LC, Mendonca RV, Sweeney MD, Scott KC, Grothaus PG, Jeffery DA, Spoerke JM, Honigberg LA, Young PR, Dalrymple SA, Palmer JT.

ChemMedChem. 2007 Jan;2(1):58-61. No abstract available.

PMID:
17154430
9.

Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K.

Setti EL, Venkatraman S, Palmer JT, Xie X, Cheung H, Yu W, Wesolowski G, Robichaud J.

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4296-9. Epub 2006 Jun 5.

PMID:
16750630
10.

Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors.

Rydzewski RM, Burrill L, Mendonca R, Palmer JT, Rice M, Tahilramani R, Bass KE, Leung L, Gjerstad E, Janc JW, Pan L.

J Med Chem. 2006 May 18;49(10):2953-68.

PMID:
16686537
11.

Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors.

Palmer JT, Rydzewski RM, Mendonca RV, Sperandio D, Spencer JR, Hirschbein BL, Lohman J, Beltman J, Nguyen M, Liu L.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3434-9. Epub 2006 Apr 27.

PMID:
16644215
12.

Keto-1,3,4-oxadiazoles as cathepsin K inhibitors.

Palmer JT, Hirschbein BL, Cheung H, McCarter J, Janc JW, Yu ZW, Wesolowski G.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2909-14. Epub 2006 Mar 20.

PMID:
16546382
13.

Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K.

Crane SN, Black WC, Palmer JT, Davis DE, Setti E, Robichaud J, Paquet J, Oballa RM, Bayly CI, McKay DJ, Somoza JR, Chauret N, Seto C, Scheigetz J, Wesolowski G, Massé F, Desmarais S, Ouellet M.

J Med Chem. 2006 Feb 9;49(3):1066-79.

PMID:
16451072
14.

Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.

Palmer JT, Bryant C, Wang DX, Davis DE, Setti EL, Rydzewski RM, Venkatraman S, Tian ZQ, Burrill LC, Mendonca RV, Springman E, McCarter J, Chung T, Cheung H, Janc JW, McGrath M, Somoza JR, Enriquez P, Yu ZW, Strickley RM, Liu L, Venuti MC, Percival MD, Falgueyret JP, Prasit P, Oballa R, Riendeau D, Young RN, Wesolowski G, Rodan SB, Johnson C, Kimmel DB, Rodan G.

J Med Chem. 2005 Dec 1;48(24):7520-34.

PMID:
16302794
15.

Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.

Black WC, Bayly CI, Davis DE, Desmarais S, Falgueyret JP, Léger S, Li CS, Massé F, McKay DJ, Palmer JT, Percival MD, Robichaud J, Tsou N, Zamboni R.

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4741-4.

PMID:
16154747
16.

Peptide ketobenzoxazole inhibitors bound to cathepsin K.

McGrath ME, Sprengeler PA, Hill CM, Martichonok V, Cheung H, Somoza JR, Palmer JT, Janc JW.

Biochemistry. 2003 Dec 30;42(51):15018-28.

PMID:
14690410
17.

A novel class of nonpeptidic biaryl inhibitors of human cathepsin K.

Robichaud J, Oballa R, Prasit P, Falgueyret JP, Percival MD, Wesolowski G, Rodan SB, Kimmel D, Johnson C, Bryant C, Venkatraman S, Setti E, Mendonca R, Palmer JT.

J Med Chem. 2003 Aug 14;46(17):3709-27.

PMID:
12904076
18.

Expression, purification, crystallization and preliminary X-ray diffraction studies of human cathepsin F complexed with an irreversible vinyl sulfone inhibitor.

Ho JD, Meltser Y, Buggy JJ, Palmer JT, Elrod KC, Chan H, Mortara KD, Somoza JR.

Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):2187-90. Epub 2002 Nov 23.

PMID:
12454497
19.

pH Dependence of inhibitors targeting the occluding loop of cathepsin B.

Cathers BE, Barrett C, Palmer JT, Rydzewski RM.

Bioorg Chem. 2002 Aug;30(4):264-75.

PMID:
12392705
20.

Novel route to the synthesis of peptides containing 2-amino-1'-hydroxymethyl ketones and their application as cathepsin K inhibitors.

Mendonca RV, Venkatraman S, Palmer JT.

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2887-91.

PMID:
12270170
21.
22.

Cysteine protease activity is up-regulated in inflamed ankle joints of rats with adjuvant-induced arthritis and decreases with in vivo administration of a vinyl sulfone cysteine protease inhibitor.

Biroc SL, Gay S, Hummel K, Magill C, Palmer JT, Spencer DR, Sa S, Klaus JL, Michel BA, Rasnick D, Gay RE.

Arthritis Rheum. 2001 Mar;44(3):703-11.

23.

Crystal structure of human cathepsin V.

Somoza JR, Zhan H, Bowman KK, Yu L, Mortara KD, Palmer JT, Clark JM, McGrath ME.

Biochemistry. 2000 Oct 17;39(41):12543-51. Erratum in: Biochemistry 2001 Apr 3;40(13):4200.

PMID:
11027133
24.

Transient focal cerebral ischemia induces sensorimotor deficits in mice.

Gerlai R, Thibodeaux H, Palmer JT, van Lookeren Campagne M, Van Bruggen N.

Behav Brain Res. 2000 Feb;108(1):63-71.

PMID:
10680758
25.

Secondary reduction in the apparent diffusion coefficient of water, increase in cerebral blood volume, and delayed neuronal death after middle cerebral artery occlusion and early reperfusion in the rat.

van Lookeren Campagne M, Thomas GR, Thibodeaux H, Palmer JT, Williams SP, Lowe DG, van Bruggen N.

J Cereb Blood Flow Metab. 1999 Dec;19(12):1354-64.

PMID:
10598940
26.

VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain.

van Bruggen N, Thibodeaux H, Palmer JT, Lee WP, Fu L, Cairns B, Tumas D, Gerlai R, Williams SP, van Lookeren Campagne M, Ferrara N.

J Clin Invest. 1999 Dec;104(11):1613-20.

27.

Evidence for a protective role of metallothionein-1 in focal cerebral ischemia.

van Lookeren Campagne M, Thibodeaux H, van Bruggen N, Cairns B, Gerlai R, Palmer JT, Williams SP, Lowe DG.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12870-5.

28.

Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones.

Xia L, Kilb J, Wex H, Li Z, Lipyansky A, Breuil V, Stein L, Palmer JT, Dempster DW, Brömme D.

Biol Chem. 1999 Jun;380(6):679-87.

PMID:
10430032
29.

High-resolution mapping of discrete representational areas in rat somatosensory cortex using blood volume-dependent functional MRI.

Palmer JT, de Crespigny AJ, Williams S, Busch E, van Bruggen N.

Neuroimage. 1999 Apr;9(4):383-92.

PMID:
10191167
30.

Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei.

Troeberg L, Morty RE, Pike RN, Lonsdale-Eccles JD, Palmer JT, McKerrow JH, Coetzer TH.

Exp Parasitol. 1999 Apr;91(4):349-55.

PMID:
10092479
31.

High-resolution functional magnetic resonance imaging of the rat brain: mapping changes in cerebral blood volume using iron oxide contrast media.

van Bruggen N, Busch E, Palmer JT, Williams SP, de Crespigny AJ.

J Cereb Blood Flow Metab. 1998 Nov;18(11):1178-83.

PMID:
9809506
32.

Crystal structure of human cathepsin S.

McGrath ME, Palmer JT, Brömme D, Somoza JR.

Protein Sci. 1998 Jun;7(6):1294-302.

33.

Cathepsin S activity regulates antigen presentation and immunity.

Riese RJ, Mitchell RN, Villadangos JA, Shi GP, Palmer JT, Karp ER, De Sanctis GT, Ploegh HL, Chapman HA.

J Clin Invest. 1998 Jun 1;101(11):2351-63.

34.

Improved perfusion with rt-PA and hirulog in a rabbit model of embolic stroke.

Yenari MA, de Crespigny A, Palmer JT, Roberts S, Schrier SL, Albers GW, Moseley ME, Steinberg GK.

J Cereb Blood Flow Metab. 1997 Apr;17(4):401-11.

PMID:
9143222
35.

Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex.

Linnevers CJ, McGrath ME, Armstrong R, Mistry FR, Barnes MG, Klaus JL, Palmer JT, Katz BA, Brömme D.

Protein Sci. 1997 Apr;6(4):919-21.

36.

Time-course and treatment response with SNX-111, an N-type calcium channel blocker, in a rodent model of focal cerebral ischemia using diffusion-weighted MRI.

Yenari MA, Palmer JT, Sun GH, de Crespigny A, Mosely ME, Steinberg GK.

Brain Res. 1996 Nov 11;739(1-2):36-45.

PMID:
8955922
37.

Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors.

Rosenthal PJ, Olson JE, Lee GK, Palmer JT, Klaus JL, Rasnick D.

Antimicrob Agents Chemother. 1996 Jul;40(7):1600-3.

39.

Vinyl sulfones as mechanism-based cysteine protease inhibitors.

Palmer JT, Rasnick D, Klaus JL, Brömme D.

J Med Chem. 1995 Aug 18;38(17):3193-6. No abstract available.

PMID:
7650671
40.

Thrombolysis with tissue plasminogen activator (tPA) is temperature dependent.

Yenari MA, Palmer JT, Bracci PM, Steinberg GK.

Thromb Res. 1995 Mar 1;77(5):475-81.

PMID:
7778062
41.

Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis.

Esser RE, Angelo RA, Murphey MD, Watts LM, Thornburg LP, Palmer JT, Talhouk JW, Smith RE.

Arthritis Rheum. 1994 Feb;37(2):236-47.

PMID:
8129779
42.

The effects of fluoromethyl ketone inhibitors of cathepsin B on adjuvant induced arthritis.

Esser RE, Watts LM, Angelo RA, Thornburg LP, Prior JJ, Palmer JT.

J Rheumatol. 1993 Jul;20(7):1176-83.

PMID:
8371213
43.

Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase.

Rosenthal PJ, Wollish WS, Palmer JT, Rasnick D.

J Clin Invest. 1991 Nov;88(5):1467-72.

44.

Career development of physically disabled youth.

Victor J, McCarthy H, Palmer JT.

Annu Rev Rehabil. 1986;5:97-150. No abstract available.

PMID:
2952060
45.

AN ANALYSIS OF THE SERVICE RELATIONSHIPS BETWEEN STATE MENTAL HOSPITALS AND ONE LOCAL MENTAL HEALTH PROGRAM.

MCINNES RS, PALMER JT, DOWNING JJ.

Am J Public Health Nations Health. 1964 Jan;54:60-8. No abstract available.

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