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Development of high-throughput ATR-FTIR technology for rapid triage of brain cancer.

Butler HJ, Brennan PM, Cameron JM, Finlayson D, Hegarty MG, Jenkinson MD, Palmer DS, Smith BR, Baker MJ.

Nat Commun. 2019 Oct 8;10(1):4501. doi: 10.1038/s41467-019-12527-5.


First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant Fibroblast Growth Factor 19 Signaling as a Driver Event in Hepatocellular Carcinoma.

Kim RD, Sarker D, Meyer T, Yau T, Macarulla T, Park JW, Choo SP, Hollebecque A, Sung MW, Lim HY, Mazzaferro V, Trojan J, Zhu AX, Yoon JH, Sharma S, Lin ZZ, Chan SL, Faivre S, Feun LG, Yen CJ, Dufour JF, Palmer DH, Llovet JM, Manoogian M, Tugnait M, Stransky N, Hagel M, Kohl NE, Lengauer C, Sherwin CA, Schmidt-Kittler O, Hoeflich KP, Shi H, Wolf BB, Kang YK.

Cancer Discov. 2019 Oct 1. pii: CD-19-0555. doi: 10.1158/2159-8290.CD-19-0555. [Epub ahead of print]


A human tissue-specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence.

Chatsirisupachai K, Palmer D, Ferreira S, de Magalhães JP.

Aging Cell. 2019 Sep 27:e13041. doi: 10.1111/acel.13041. [Epub ahead of print]


How to identify sex chromosomes and their turnover.

Palmer DH, Rogers TF, Dean R, Wright AE.

Mol Ecol. 2019 Sep 20. doi: 10.1111/mec.15245. [Epub ahead of print]


Verbal memory predicts treatment outcome in syndromal anxious depression: An iSPOT-D report.

Braund TA, Tillman G, Palmer DM, Harris AWF.

J Affect Disord. 2019 Sep 4;260:245-253. doi: 10.1016/j.jad.2019.09.028. [Epub ahead of print]


Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Secondary Analysis of the ESPAC-4 Randomized Adjuvant Chemotherapy Trial.

Jones RP, Psarelli EE, Jackson R, Ghaneh P, Halloran CM, Palmer DH, Campbell F, Valle JW, Faluyi O, O'Reilly DA, Cunningham D, Wadsley J, Darby S, Meyer T, Gillmore R, Anthoney A, Lind P, Glimelius B, Falk S, Izbicki JR, Middleton GW, Cummins S, Ross PJ, Wasan H, McDonald A, Crosby T, Ting Y, Patel K, Sherriff D, Soomal R, Borg D, Sothi S, Hammel P, Lerch MM, Mayerle J, Tjaden C, Strobel O, Hackert T, Büchler MW, Neoptolemos JP; European Study Group for Pancreatic Cancer.

JAMA Surg. 2019 Sep 4. doi: 10.1001/jamasurg.2019.3337. [Epub ahead of print]


Prebiotics: Mechanisms and Preventive Effects in Allergy.

Brosseau C, Selle A, Palmer DJ, Prescott SL, Barbarot S, Bodinier M.

Nutrients. 2019 Aug 8;11(8). pii: E1841. doi: 10.3390/nu11081841. Review.


Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease.

Pretorius RA, Bodinier M, Prescott SL, Palmer DJ.

Nutrients. 2019 Aug 1;11(8). pii: E1767. doi: 10.3390/nu11081767.


The challenges of developing and optimising an assay to measure 25-hydroxyvitamin D in saliva.

Clarke MW, Black LJ, Hart PH, Jones AP, Palmer DJ, Siafarikas A, Lucas RM, Gorman S.

J Steroid Biochem Mol Biol. 2019 Jul 25;194:105437. doi: 10.1016/j.jsbmb.2019.105437. [Epub ahead of print]


Probing the "Default Network Interference Hypothesis" With EEG: An RDoC Approach Focused on Attention.

Gerrits B, Vollebregt MA, Olbrich S, van Dijk H, Palmer D, Gordon E, Pascual-Marqui R, Kessels RPC, Arns M.

Clin EEG Neurosci. 2019 Nov;50(6):404-412. doi: 10.1177/1550059419864461. Epub 2019 Jul 19.


Mapping the drivers of within-host pathogen evolution using massive data sets.

Palmer DS, Turner I, Fidler S, Frater J, Goedhals D, Goulder P, Huang KG, Oxenius A, Phillips R, Shapiro R, Vuuren CV, McLean AR, McVean G.

Nat Commun. 2019 Jul 9;10(1):3017. doi: 10.1038/s41467-019-10724-w.


A High-Fidelity Surgical Model and Perfusion Simulator Used to Demonstrate ECMO Cannulation, Initiation, and Stabilization.

Palmer D, Aspenleiter M, da Silva J, Castro-Medina M, Morell V, Sharma M, Viegas M.

J Extra Corpor Technol. 2019 Jun;51(2):94-99.


Sports injury and illness incidence in the PyeongChang 2018 Olympic Winter Games: a prospective study of 2914 athletes from 92 countries.

Soligard T, Palmer D, Steffen K, Lopes AD, Grant ME, Kim D, Lee SY, Salmina N, Toresdahl BG, Chang JY, Budgett R, Engebretsen L.

Br J Sports Med. 2019 Sep;53(17):1085-1092. doi: 10.1136/bjsports-2018-100236. Epub 2019 Jun 23.


Production of CRISPR/Cas9-Mediated Self-Cleaving Helper-Dependent Adenoviruses.

Palmer DJ, Turner DL, Ng P.

Mol Ther Methods Clin Dev. 2019 Apr 16;13:432-439. doi: 10.1016/j.omtm.2019.04.003. eCollection 2019 Jun 14.


Evaluation of the utility of prognostic models for patients with resected hilar cholangiocarcinoma.

Bird NTE, Manu N, Quinn L, Needham A, Jones R, Fenwick S, Poston G, Palmer D, Malik H.

HPB (Oxford). 2019 May 8. pii: S1365-182X(19)30099-1. doi: 10.1016/j.hpb.2019.02.014. [Epub ahead of print]


Advanced intrahepatic cholangiocarcinoma: post-hoc analysis of the ABC-01, -02 and -03 clinical trials.

Lamarca A, Ross P, Wasan HS, Hubner RA, McNamara MG, Lopes A, Manoharan P, Palmer D, Bridgewater J, Valle JW.

J Natl Cancer Inst. 2019 May 11. pii: djz071. doi: 10.1093/jnci/djz071. [Epub ahead of print]


Comparing Surgical Site Infection for Open and Endoscopic Component Separation.

Palmer DS, McDaniel CC, Samra NS, Griffen FD.

Am Surg. 2019 Apr 1;85(4):350-352.


Dimensions of anxiety in Major depressive disorder and their use in predicting antidepressant treatment outcome: an iSPOT-D report.

Braund TA, Palmer DM, Williams LM, Harris AWF.

Psychol Med. 2019 Apr 26:1-11. doi: 10.1017/S0033291719000941. [Epub ahead of print]


Increased multimodality treatment options has improved survival for Hepatocellular carcinoma but poor survival for biliary tract cancers remains unchanged.

Alabraba E, Joshi H, Bird N, Griffin R, Sturgess R, Stern N, Sieberhagen C, Cross T, Camenzuli A, Davis R, Evans J, O'Grady E, Palmer D, Diaz-Nieto R, Fenwick S, Poston G, Malik H.

Eur J Surg Oncol. 2019 Sep;45(9):1660-1667. doi: 10.1016/j.ejso.2019.04.002. Epub 2019 Apr 9.


Clinical risk for substance-affected patients attending an emergency department in the Northern Territory with police: A quality improvement initiative.

Brownlea SJ, Miller J, Meagher J, Barzi F, Palmer D.

Emerg Med Australas. 2019 Mar 28. doi: 10.1111/1742-6723.13273. [Epub ahead of print]


T cell stemness and dysfunction in tumors are triggered by a common mechanism.

Vodnala SK, Eil R, Kishton RJ, Sukumar M, Yamamoto TN, Ha NH, Lee PH, Shin M, Patel SJ, Yu Z, Palmer DC, Kruhlak MJ, Liu X, Locasale JW, Huang J, Roychoudhuri R, Finkel T, Klebanoff CA, Restifo NP.

Science. 2019 Mar 29;363(6434). pii: eaau0135. doi: 10.1126/science.aau0135.


Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study.

Primrose JN, Fox RP, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, Wasan H, Ross P, Wall L, Wadsley J, Evans JTR, Stocken D, Praseedom R, Ma YT, Davidson B, Neoptolemos JP, Iveson T, Raftery J, Zhu S, Cunningham D, Garden OJ, Stubbs C, Valle JW, Bridgewater J; BILCAP study group.

Lancet Oncol. 2019 May;20(5):663-673. doi: 10.1016/S1470-2045(18)30915-X. Epub 2019 Mar 25. Erratum in: Lancet Oncol. 2019 Apr 2;:.


Increased chronic stress predicts greater emotional negativity bias and poorer social skills but not cognitive functioning in healthy adults.

Braund TA, Palmer DM, Tillman G, Hanna H, Gordon E.

Anxiety Stress Coping. 2019 Jul;32(4):399-411. doi: 10.1080/10615806.2019.1598555. Epub 2019 Mar 26.


Comparing enrichment analysis and machine learning for identifying gene properties that discriminate between gene classes.

Fabris F, Palmer D, de Magalhães JP, Freitas AA.

Brief Bioinform. 2019 Mar 20. pii: bbz028. doi: 10.1093/bib/bbz028. [Epub ahead of print]


Characterising anxiety in major depressive disorder and its use in predicting antidepressant treatment outcome: An iSPOT-D report.

Braund TA, Palmer DM, Williams LM, Harris AW.

Aust N Z J Psychiatry. 2019 Aug;53(8):782-793. doi: 10.1177/0004867419835933. Epub 2019 Mar 18.


Assessing the risk of residues of the toxin indospicine in bovine muscle and liver from north-west Australia.

Netzel G, Palmer DG, Masters AM, Tai SY, Allen JG, Fletcher MT.

Toxicon. 2019 May;163:48-58. doi: 10.1016/j.toxicon.2019.03.007. Epub 2019 Mar 14.


Chemotherapy for pancreatic cancer.

Springfeld C, Jäger D, Büchler MW, Strobel O, Hackert T, Palmer DH, Neoptolemos JP.

Presse Med. 2019 Mar;48(3 Pt 2):e159-e174. doi: 10.1016/j.lpm.2019.02.025. Epub 2019 Mar 15. Review.


Extreme background-rejection techniques for the ELROI optical satellite license plate.

Holmes RM, Palmer DM.

Appl Opt. 2019 Feb 1;58(4):814-825. doi: 10.1364/AO.58.000814.


Identification of a novel scaffold for a small molecule GPR139 receptor agonist.

Nøhr AC, Shehata MA, Palmer D, Pokhrel R, Vallianou M, Foster SR, Gentry PR, Gloriam DE, Bräuner-Osborne H.

Sci Rep. 2019 Mar 7;9(1):3802. doi: 10.1038/s41598-019-40085-9.


Identification of common genetic risk variants for autism spectrum disorder.

Grove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, Pallesen J, Agerbo E, Andreassen OA, Anney R, Awashti S, Belliveau R, Bettella F, Buxbaum JD, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Christensen JH, Churchhouse C, Dellenvall K, Demontis D, De Rubeis S, Devlin B, Djurovic S, Dumont AL, Goldstein JI, Hansen CS, Hauberg ME, Hollegaard MV, Hope S, Howrigan DP, Huang H, Hultman CM, Klei L, Maller J, Martin J, Martin AR, Moran JL, Nyegaard M, Nærland T, Palmer DS, Palotie A, Pedersen CB, Pedersen MG, dPoterba T, Poulsen JB, Pourcain BS, Qvist P, Rehnström K, Reichenberg A, Reichert J, Robinson EB, Roeder K, Roussos P, Saemundsen E, Sandin S, Satterstrom FK, Davey Smith G, Stefansson H, Steinberg S, Stevens CR, Sullivan PF, Turley P, Walters GB, Xu X; Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium; BUPGEN; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; 23andMe Research Team, Stefansson K, Geschwind DH, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Neale BM, Daly MJ, Børglum AD.

Nat Genet. 2019 Mar;51(3):431-444. doi: 10.1038/s41588-019-0344-8. Epub 2019 Feb 25.


Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.

Evans JP, Winiarski BK, Sutton PA, Jones RP, Ressel L, Duckworth CA, Pritchard DM, Lin ZX, Fretwell VL, Tweedle EM, Costello E, Goldring CE, Copple IM, Park BK, Palmer DH, Kitteringham NR.

Oncotarget. 2019 Jan 18;10(6):685. doi: 10.18632/oncotarget.26625. eCollection 2019 Jan 18.


Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research.

Evans JP, Winiarski BK, Sutton PA, Ressel L, Duckworth CA, Pritchard DM, Palmer DH, Goldring CE, Kitteringham NR.

Lab Anim. 2019 Feb 13:23677219826165. doi: 10.1177/0023677219826165. [Epub ahead of print]


Hepatic glutamine synthetase augmentation enhances ammonia detoxification.

Soria LR, Nitzahn M, De Angelis A, Khoja S, Attanasio S, Annunziata P, Palmer DJ, Ng P, Lipshutz GS, Brunetti-Pierri N.

J Inherit Metab Dis. 2019 Feb 6. doi: 10.1002/jimd.12070. [Epub ahead of print]


Fibrillar force generation by fibroblasts depends on formin.

Eftekharjoo M, Palmer D, McCoy B, Maruthamuthu V.

Biochem Biophys Res Commun. 2019 Feb 26;510(1):72-77. doi: 10.1016/j.bbrc.2019.01.035. Epub 2019 Jan 17.


Dissociable cognitive impairments in two strains of transgenic Alzheimer's disease mice revealed by a battery of object-based tests.

Creighton SD, Mendell AL, Palmer D, Kalisch BE, MacLusky NJ, Prado VF, Prado MAM, Winters BD.

Sci Rep. 2019 Jan 11;9(1):57. doi: 10.1038/s41598-018-37312-0.


Left Atrial Electromechanical Remodeling Following 2 Years of High-Intensity Exercise Training in Sedentary Middle-Aged Adults.

McNamara DA, Aiad N, Howden E, Hieda M, Link MS, Palmer D, Samels M, Everding B, Ng J, Adams-Huet B, Opondo M, Sarma S, Levine BD.

Circulation. 2019 Mar 19;139(12):1507-1516. doi: 10.1161/CIRCULATIONAHA.118.037615.


Impact of intensified chemotherapy in metastatic pancreatic ductal adenocarcinoma (PDAC) in clinical routine in Europe.

Javed MA, Beyer G, Le N, Vinci A, Wong H, Palmer D, Morgan RD, Lamarca A, Hubner RA, Valle JW, Alam S, Chowdhury S, Ma YT, Archibugi L, Capurso G, Maisonneuve P, Neesse A, Sund M, Schober M, Krug S.

Pancreatology. 2019 Jan;19(1):97-104. doi: 10.1016/j.pan.2018.10.003. Epub 2018 Oct 15.


Optimised spectral pre-processing for discrimination of biofluids via ATR-FTIR spectroscopy.

Butler HJ, Smith BR, Fritzsch R, Radhakrishnan P, Palmer DS, Baker MJ.

Analyst. 2018 Dec 3;143(24):6121-6134. doi: 10.1039/c8an01384e.


Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.

Demontis D, Walters RK, Martin J, Mattheisen M, Als TD, Agerbo E, Baldursson G, Belliveau R, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Churchhouse C, Dumont A, Eriksson N, Gandal M, Goldstein JI, Grasby KL, Grove J, Gudmundsson OO, Hansen CS, Hauberg ME, Hollegaard MV, Howrigan DP, Huang H, Maller JB, Martin AR, Martin NG, Moran J, Pallesen J, Palmer DS, Pedersen CB, Pedersen MG, Poterba T, Poulsen JB, Ripke S, Robinson EB, Satterstrom FK, Stefansson H, Stevens C, Turley P, Walters GB, Won H, Wright MJ; ADHD Working Group of the Psychiatric Genomics Consortium (PGC); Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium; 23andMe Research Team, Andreassen OA, Asherson P, Burton CL, Boomsma DI, Cormand B, Dalsgaard S, Franke B, Gelernter J, Geschwind D, Hakonarson H, Haavik J, Kranzler HR, Kuntsi J, Langley K, Lesch KP, Middeldorp C, Reif A, Rohde LA, Roussos P, Schachar R, Sklar P, Sonuga-Barke EJS, Sullivan PF, Thapar A, Tung JY, Waldman ID, Medland SE, Stefansson K, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Daly MJ, Faraone SV, Børglum AD, Neale BM.

Nat Genet. 2019 Jan;51(1):63-75. doi: 10.1038/s41588-018-0269-7. Epub 2018 Nov 26.


Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of osteoinhibition.

McNeill EP, Reese RW, Tondon A, Clough BH, Pan S, Froese J, Palmer D, Krause U, Loeb DM, Kaunas R, Gregory CA.

Cell Death Dis. 2018 Nov 26;9(12):1161. doi: 10.1038/s41419-018-1203-8.


The impact of 2 years of high-intensity exercise training on a model of integrated cardiovascular regulation.

Hieda M, Howden EJ, Sarma S, Cornwell W, Lawley JS, Tarumi T, Palmer D, Samels M, Everding B, Livingston S, Fu Q, Zhang R, Levine BD.

J Physiol. 2019 Jan;597(2):419-429. doi: 10.1113/JP276676. Epub 2018 Nov 22.


Direct infant UV light exposure is associated with eczema and immune development.

Rueter K, Jones AP, Siafarikas A, Lim EM, Bear N, Noakes PS, Prescott SL, Palmer DJ.

J Allergy Clin Immunol. 2019 Mar;143(3):1012-1020.e2. doi: 10.1016/j.jaci.2018.08.037. Epub 2018 Oct 23.


Use of respiratory rates and heart rate variability in the assessment and treatment of children and adolescents with functional somatic symptoms.

Chudleigh C, Savage B, Cruz C, Lim M, McClure G, Palmer DM, Spooner CJ, Kozlowska K.

Clin Child Psychol Psychiatry. 2019 Jan;24(1):29-39. doi: 10.1177/1359104518807742. Epub 2018 Oct 25.


myo-Inositol dehydrogenase and scyllo-inositol dehydrogenase from Lactobacillus casei BL23 bind their substrates in very different orientations.

Aamudalapalli HB, Bertwistle D, Palmer DRJ, Sanders DAR.

Biochim Biophys Acta Proteins Proteom. 2018 Nov;1866(11):1115-1124. doi: 10.1016/j.bbapap.2018.08.011. Epub 2018 Aug 30.


A naturally protective epitope of limited variability as an influenza vaccine target.

Thompson CP, Lourenço J, Walters AA, Obolski U, Edmans M, Palmer DS, Kooblall K, Carnell GW, O'Connor D, Bowden TA, Pybus OG, Pollard AJ, Temperton NJ, Lambe T, Gilbert SC, Gupta S.

Nat Commun. 2018 Sep 21;9(1):3859. doi: 10.1038/s41467-018-06228-8.


Biotechnological Advances in Bacterial Microcompartment Technology.

Lee MJ, Palmer DJ, Warren MJ.

Trends Biotechnol. 2019 Mar;37(3):325-336. doi: 10.1016/j.tibtech.2018.08.006. Epub 2018 Sep 17. Review.


Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length.

Laisk T, Kukuškina V, Palmer D, Laber S, Chen CY, Ferreira T, Rahmioglu N, Zondervan K, Becker C, Smoller JW, Lippincott M, Salumets A, Granne I, Seminara S, Neale B, Mägi R, Lindgren CM.

Hum Mol Genet. 2018 Dec 15;27(24):4323-4332. doi: 10.1093/hmg/ddy317.


Fate and dynamics of metal precipitates arising from acid drainage discharges to a river system.

Mosley LM, Biswas TK, Dang T, Palmer D, Cummings C, Daly R, Simpson S, Kirby J.

Chemosphere. 2018 Dec;212:811-820. doi: 10.1016/j.chemosphere.2018.08.146. Epub 2018 Aug 30.


Experimental field tests of Batesian mimicry in the swallowtail butterfly Papilio polytes.

Palmer DH, Tan YQ, Finkbeiner SD, Briscoe AD, Monteiro A, Kronforst MR.

Ecol Evol. 2018 Jul 12;8(15):7657-7666. doi: 10.1002/ece3.4207. eCollection 2018 Aug.


Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses.

Russell KN, Mitchell NL, Anderson NG, Bunt CR, Wellby MP, Melzer TR, Barrell GK, Palmer DN.

Brain Behav. 2018 Sep;8(9):e01096. doi: 10.1002/brb3.1096. Epub 2018 Aug 23.

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