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Items: 15


T cell metabolism in chronic viral infection.

Pallett LJ, Schmidt N, Schurich A.

Clin Exp Immunol. 2019 Apr 30. doi: 10.1111/cei.13308. [Epub ahead of print] Review.


Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response.

Schwenzer H, Jühling F, Chu A, Pallett LJ, Baumert TF, Maini M, Fassati A.

Cell Rep. 2019 Mar 19;26(12):3416-3428.e5. doi: 10.1016/j.celrep.2019.02.077.


Fine needle aspirates comprehensively sample intrahepatic immunity.

Gill US, Pallett LJ, Thomas N, Burton AR, Patel AA, Yona S, Kennedy PTF, Maini MK.

Gut. 2018 Nov 28. pii: gutjnl-2018-317071. doi: 10.1136/gutjnl-2018-317071. [Epub ahead of print]


Circulating and intrahepatic antiviral B cells are defective in hepatitis B.

Burton AR, Pallett LJ, McCoy LE, Suveizdyte K, Amin OE, Swadling L, Alberts E, Davidson BR, Kennedy PT, Gill US, Mauri C, Blair PA, Pelletier N, Maini MK.

J Clin Invest. 2018 Oct 1;128(10):4588-4603. doi: 10.1172/JCI121960. Epub 2018 Aug 9.


Defective T-cell immunity in hepatitis B virus infection: why therapeutic vaccination needs a helping hand.

Maini MK, Pallett LJ.

Lancet Gastroenterol Hepatol. 2018 Mar;3(3):192-202. doi: 10.1016/S2468-1253(18)30007-4. Review.


IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction.

Easom NJW, Stegmann KA, Swadling L, Pallett LJ, Burton AR, Odera D, Schmidt N, Huang WC, Fusai G, Davidson B, Maini MK.

Front Immunol. 2018 May 9;9:1009. doi: 10.3389/fimmu.2018.01009. eCollection 2018.


Liver sampling: a vital window into HBV pathogenesis on the path to functional cure.

Gill US, Pallett LJ, Kennedy PTF, Maini MK.

Gut. 2018 Apr;67(4):767-775. doi: 10.1136/gutjnl-2017-314873. Epub 2018 Jan 13. Review.


IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection.

Pallett LJ, Davies J, Colbeck EJ, Robertson F, Hansi N, Easom NJW, Burton AR, Stegmann KA, Schurich A, Swadling L, Gill US, Male V, Luong T, Gander A, Davidson BR, Kennedy PTF, Maini MK.

J Exp Med. 2017 Jun 5;214(6):1567-1580. doi: 10.1084/jem.20162115. Epub 2017 May 19.


Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.

Cuff AO, Robertson FP, Stegmann KA, Pallett LJ, Maini MK, Davidson BR, Male V.

J Immunol. 2016 Dec 1;197(11):4283-4291. Epub 2016 Oct 21.


Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host.

Schurich A, Pallett LJ, Jajbhay D, Wijngaarden J, Otano I, Gill US, Hansi N, Kennedy PT, Nastouli E, Gilson R, Frezza C, Henson SM, Maini MK.

Cell Rep. 2016 Aug 2;16(5):1243-1252. doi: 10.1016/j.celrep.2016.06.078. Epub 2016 Jul 21.


CXCR6 marks a novel subset of T-bet(lo)Eomes(hi) natural killer cells residing in human liver.

Stegmann KA, Robertson F, Hansi N, Gill U, Pallant C, Christophides T, Pallett LJ, Peppa D, Dunn C, Fusai G, Male V, Davidson BR, Kennedy P, Maini MK.

Sci Rep. 2016 May 23;6:26157. doi: 10.1038/srep26157.


Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells.

Pallett LJ, Gill US, Quaglia A, Sinclair LV, Jover-Cobos M, Schurich A, Singh KP, Thomas N, Das A, Chen A, Fusai G, Bertoletti A, Cantrell DA, Kennedy PT, Davies NA, Haniffa M, Maini MK.

Nat Med. 2015 Jun;21(6):591-600. doi: 10.1038/nm.3856. Epub 2015 May 11.


Defective natural killer cell anti-viral capacity in paediatric HBV infection.

Heiberg IL, Pallett LJ, Winther TN, Høgh B, Maini MK, Peppa D.

Clin Exp Immunol. 2015 Mar;179(3):466-76. doi: 10.1111/cei.12470.


The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells.

Schurich A, Pallett LJ, Lubowiecki M, Singh HD, Gill US, Kennedy PT, Nastouli E, Tanwar S, Rosenberg W, Maini MK.

PLoS Pathog. 2013 Mar;9(3):e1003208. doi: 10.1371/journal.ppat.1003208. Epub 2013 Mar 14.


Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion.

Peppa D, Gill US, Reynolds G, Easom NJ, Pallett LJ, Schurich A, Micco L, Nebbia G, Singh HD, Adams DH, Kennedy PT, Maini MK.

J Exp Med. 2013 Jan 14;210(1):99-114. doi: 10.1084/jem.20121172. Epub 2012 Dec 17.

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