Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 76


PTPα is required for laminin-2-induced Fyn-Akt signaling to drive oligodendrocyte differentiation.

Ly PTT, Stewart C, Pallen CJ.

J Cell Sci. 2018 Aug 6;131(15). pii: jcs212076. doi: 10.1242/jcs.212076.


Glial and Neuronal Protein Tyrosine Phosphatase Alpha (PTPα) Regulate Oligodendrocyte Differentiation and Myelination.

Shih Y, Ly PTT, Wang J, Pallen CJ.

J Mol Neurosci. 2017 Aug;62(3-4):329-343. doi: 10.1007/s12031-017-0941-x. Epub 2017 Jun 24.


Protein tyrosine phosphatases in mast cell signaling.

Geldman A, Pallen CJ.

Methods Mol Biol. 2015;1220:269-86. doi: 10.1007/978-1-4939-1568-2_17. Review.


Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.

Cheng SY, Sun G, Schlaepfer DD, Pallen CJ.

Mol Cell Biol. 2014 Feb;34(3):348-61. doi: 10.1128/MCB.00825-13. Epub 2013 Nov 18.


TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells.

Fam HK, Walton C, Mitra SA, Chowdhury M, Osborne N, Choi K, Sun G, Wong PC, O'Sullivan MJ, Turashvili G, Aparicio S, Triche TJ, Bond M, Pallen CJ, Boerkoel CF.

Mol Cancer Res. 2013 Oct;11(10):1179-92. doi: 10.1158/1541-7786.MCR-12-0575. Epub 2013 Aug 2.


Tyrosine phosphatase PTPα contributes to HER2-evoked breast tumor initiation and maintenance.

Meyer DS, Aceto N, Sausgruber N, Brinkhaus H, Müller U, Pallen CJ, Bentires-Alj M.

Oncogene. 2014 Jan 16;33(3):398-402. doi: 10.1038/onc.2012.585. Epub 2013 Jan 14.


Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.

Sun G, Cheng SY, Chen M, Lim CJ, Pallen CJ.

Mol Cell Biol. 2012 Sep;32(18):3776-89. doi: 10.1128/MCB.00214-12. Epub 2012 Jul 16.


Loss of protein-tyrosine phosphatase α (PTPα) increases proliferation and delays maturation of oligodendrocyte progenitor cells.

Wang PS, Wang J, Zheng Y, Pallen CJ.

J Biol Chem. 2012 Apr 6;287(15):12529-40. doi: 10.1074/jbc.M111.312769. Epub 2012 Feb 21.


YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth.

Fotovati A, Abu-Ali S, Wang PS, Deleyrolle LP, Lee C, Triscott J, Chen JY, Franciosi S, Nakamura Y, Sugita Y, Uchiumi T, Kuwano M, Leavitt BR, Singh SK, Jury A, Jones C, Wakimoto H, Reynolds BA, Pallen CJ, Dunn SE.

Cancer Res. 2011 Aug 15;71(16):5569-78. doi: 10.1158/0008-5472.CAN-10-2805. Epub 2011 Jul 5.


Receptor-like protein-tyrosine phosphatase α enhances cell surface expression of neural adhesion molecule NB-3.

Ye H, Zhao T, Tan YL, Liu J, Pallen CJ, Xiao ZC.

J Biol Chem. 2011 Jul 22;286(29):26071-80. doi: 10.1074/jbc.M110.214080. Epub 2011 May 27.


PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses.

Samayawardhena LA, Pallen CJ.

J Immunol. 2010 Nov 15;185(10):5993-6002. doi: 10.4049/jimmunol.1001261. Epub 2010 Oct 13.


Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas.

Hu K, Lee C, Qiu D, Fotovati A, Davies A, Abu-Ali S, Wai D, Lawlor ER, Triche TJ, Pallen CJ, Dunn SE.

Mol Cancer Ther. 2009 Nov;8(11):3024-35. doi: 10.1158/1535-7163.MCT-09-0365. Epub 2009 Nov 3.


Protein-tyrosine phosphatase alpha acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelination.

Wang PS, Wang J, Xiao ZC, Pallen CJ.

J Biol Chem. 2009 Nov 27;284(48):33692-702. doi: 10.1074/jbc.M109.061770. Epub 2009 Oct 6.


Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration.

Chen SC, Khanna RS, Bessette DC, Samayawardhena LA, Pallen CJ.

Am J Physiol Cell Physiol. 2009 Jul;297(1):C133-9. doi: 10.1152/ajpcell.00110.2009. Epub 2009 May 6.


Breaking the pain connection.

Pallen CJ.

Nat Med. 2008 Dec;14(12):1313-5. doi: 10.1038/nm1208-1313. No abstract available.


Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells.

Samayawardhena LA, Pallen CJ.

J Biol Chem. 2008 Oct 24;283(43):29175-85. doi: 10.1074/jbc.M804077200. Epub 2008 Aug 25.


PRL PTPs: mediators and markers of cancer progression.

Bessette DC, Qiu D, Pallen CJ.

Cancer Metastasis Rev. 2008 Jun;27(2):231-52. doi: 10.1007/s10555-008-9121-3. Review.


Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha.

Ye H, Tan YL, Ponniah S, Takeda Y, Wang SQ, Schachner M, Watanabe K, Pallen CJ, Xiao ZC.

EMBO J. 2008 Jan 9;27(1):188-200. Epub 2007 Nov 29.


Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility.

Wu L, Bernard-Trifilo JA, Lim Y, Lim ST, Mitra SK, Uryu S, Chen M, Pallen CJ, Cheung NK, Mikolon D, Mielgo A, Stupack DG, Schlaepfer DD.

Oncogene. 2008 Feb 28;27(10):1439-48. Epub 2007 Sep 10.


Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.

Ng TL, O'Sullivan MJ, Pallen CJ, Hayes M, Clarkson PW, Winstanley M, Sorensen PH, Nielsen TO, Horsman DE.

J Mol Diagn. 2007 Sep;9(4):459-63. Epub 2007 Jul 9.


PRL-3: a metastasis-associated phosphatase in search of a function.

Bessette DC, Wong PC, Pallen CJ.

Cells Tissues Organs. 2007;185(1-3):232-6. Review.


Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45.

Maksumova L, Wang Y, Wong NK, Le HT, Pallen CJ, Johnson P.

J Biol Chem. 2007 Jul 20;282(29):20925-32. Epub 2007 May 16.


Protein tyrosine phosphatase alpha regulates Fyn activity and Cbp/PAG phosphorylation in thymocyte lipid rafts.

Maksumova L, Le HT, Muratkhodjaev F, Davidson D, Veillette A, Pallen CJ.

J Immunol. 2005 Dec 15;175(12):7947-56.


Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells.

Sutherland BW, Kucab J, Wu J, Lee C, Cheang MC, Yorida E, Turbin D, Dedhar S, Nelson C, Pollak M, Leighton Grimes H, Miller K, Badve S, Huntsman D, Blake-Gilks C, Chen M, Pallen CJ, Dunn SE.

Oncogene. 2005 Jun 16;24(26):4281-92.


Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alpha.

Le HT, Ponniah S, Pallen CJ.

Biochem Biophys Res Commun. 2004 Feb 6;314(2):321-9.


Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization.

Nie DY, Zhou ZH, Ang BT, Teng FY, Xu G, Xiang T, Wang CY, Zeng L, Takeda Y, Xu TL, Ng YK, Faivre-Sarrailh C, Popko B, Ling EA, Schachner M, Watanabe K, Pallen CJ, Tang BL, Xiao ZC.

EMBO J. 2003 Nov 3;22(21):5666-78.


F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.

Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Sankar N, Ng YK, Ling EA, Maciag T, Small D, Trifonova R, Kopan R, Okano H, Nakafuku M, Chiba S, Hirai H, Aster JC, Schachner M, Pallen CJ, Watanabe K, Xiao ZC.

Cell. 2003 Oct 17;115(2):163-75.


Protein tyrosine phosphatase alpha (PTP alpha) knockout mice show deficits in Morris water maze learning, decreased locomotor activity, and decreases in anxiety.

Skelton MR, Ponniah S, Wang DZ, Doetschman T, Vorhees CV, Pallen CJ.

Brain Res. 2003 Sep 12;984(1-2):1-10.


PRL-3 and PRL-1 promote cell migration, invasion, and metastasis.

Zeng Q, Dong JM, Guo K, Li J, Tan HX, Koh V, Pallen CJ, Manser E, Hong W.

Cancer Res. 2003 Jun 1;63(11):2716-22.


PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration.

Zeng L, Si X, Yu WP, Le HT, Ng KP, Teng RM, Ryan K, Wang DZ, Ponniah S, Pallen CJ.

J Cell Biol. 2003 Jan 6;160(1):137-46. Epub 2003 Jan 6.


Conserved synteny between the Fugu and human PTEN locus and the evolutionary conservation of vertebrate PTEN function.

Yu WP, Pallen CJ, Tay A, Jirik FR, Brenner S, Tan YH, Venkatesh B.

Oncogene. 2001 Sep 6;20(39):5554-61.


Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II.

Si X, Zeng Q, Ng CH, Hong W, Pallen CJ.

J Biol Chem. 2001 Aug 31;276(35):32875-82. Epub 2001 Jul 10.


Isolation of a novel protein tyrosine phosphatase inhibitor, 2-methyl-fervenulone, and its precursors from Streptomyces.

Wang H, Lim KL, Yeo SL, Xu X, Sim MM, Ting AE, Wang Y, Yee S, Tan YH, Pallen CJ.

J Nat Prod. 2000 Dec;63(12):1641-6.


Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome.

Zeng Q, Si X, Horstmann H, Xu Y, Hong W, Pallen CJ.

J Biol Chem. 2000 Jul 14;275(28):21444-52.


Solid-phase synthesis of potential protein tyrosine phosphatase inhibitors via the Ugi four-component condensation.

Li Z, Yeo SL, Pallen CJ, Ganesan A.

Bioorg Med Chem Lett. 1998 Sep 22;8(18):2443-6.


Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM.

Schmidli RS, Colman PG, Cui L, Yu WP, Kewming K, Jankulovski C, Harrison LC, Pallen CJ, DeAizpurua HJ.

Autoimmunity. 1998;28(1):15-23.


Localization of the genes encoding the type I diabetes autoantigens, protein-tyrosine phosphatases IA2 and IAR.

Morahan G, Huang D, Yu WP, Cui L, DeAizpurua H, Pallen CJ.

Mamm Genome. 1998 Jul;9(7):593-4. No abstract available.


Kinetic analysis of two closely related receptor-like protein-tyrosine-phosphatases, PTP alpha and PTP epsilon.

Lim KL, Lai DS, Kalousek MB, Wang Y, Pallen CJ.

Eur J Biochem. 1997 May 1;245(3):693-700.

Supplemental Content

Loading ...
Support Center