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Items: 17

1.

Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition.

Abdel-Aziz AK, Pallavicini I, Ceccacci E, Meroni G, Saadeldin MK, Varasi M, Minucci S.

Haematologica. 2019 Sep 19. pii: haematol.2019.224501. doi: 10.3324/haematol.2019.224501. [Epub ahead of print]

2.

Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells.

Roberti M, Schipani F, Bagnolini G, Milano D, Giacomini E, Falchi F, Balboni A, Manerba M, Farabegoli F, De Franco F, Robertson J, Minucci S, Pallavicini I, Di Stefano G, Girotto S, Pellicciari R, Cavalli A.

Eur J Med Chem. 2019 Mar 1;165:80-92. doi: 10.1016/j.ejmech.2019.01.008. Epub 2019 Jan 10.

PMID:
30660828
3.

miR-194-5p/BCLAF1 deregulation in AML tumorigenesis.

Dell'Aversana C, Giorgio C, D'Amato L, Lania G, Matarese F, Saeed S, Di Costanzo A, Belsito Petrizzi V, Ingenito C, Martens JHA, Pallavicini I, Minucci S, Carissimo A, Stunnenberg HG, Altucci L.

Leukemia. 2018 Feb;32(2):573. doi: 10.1038/leu.2017.310. Epub 2017 Dec 22.

PMID:
29271969
4.

Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors.

Falchi F, Giacomini E, Masini T, Boutard N, Di Ianni L, Manerba M, Farabegoli F, Rossini L, Robertson J, Minucci S, Pallavicini I, Di Stefano G, Roberti M, Pellicciari R, Cavalli A.

ACS Chem Biol. 2017 Oct 20;12(10):2491-2497. doi: 10.1021/acschembio.7b00707. Epub 2017 Sep 1.

PMID:
28841282
5.

Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.

Gerboth S, Frittoli E, Palamidessi A, Baltanas FC, Salek M, Rappsilber J, Giuliani C, Troglio F, Rolland Y, Pruneri G, Kreutmair S, Pallavicini I, Zobel M, Cinquanta M, Minucci S, Gomez C, Santos E, Illert AL, Scita G.

Leukemia. 2018 Mar;32(3):820-827. doi: 10.1038/leu.2017.267. Epub 2017 Aug 18.

6.

miR-194-5p/BCLAF1 deregulation in AML tumorigenesis.

Dell'Aversana C, Giorgio C, D'Amato L, Lania G, Matarese F, Saeed S, Di Costanzo A, Belsito Petrizzi V, Ingenito C, Martens JHA, Pallavicini I, Minucci S, Carissimo A, Stunnenberg HG, Altucci L.

Leukemia. 2017 Nov;31(11):2315-2325. doi: 10.1038/leu.2017.64. Epub 2017 Feb 20. Erratum in: Leukemia. 2017 Dec 22;:.

7.

Dual modulation of MCL-1 and mTOR determines the response to sunitinib.

Elgendy M, Abdel-Aziz AK, Renne SL, Bornaghi V, Procopio G, Colecchia M, Kanesvaran R, Toh CK, Bossi D, Pallavicini I, Perez-Gracia JL, Lozano MD, Giandomenico V, Mercurio C, Lanfrancone L, Fazio N, Nole F, Teh BT, Renne G, Minucci S.

J Clin Invest. 2017 Jan 3;127(1):153-168. doi: 10.1172/JCI84386. Epub 2016 Nov 28.

8.

PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL.

di Masi A, Cilli D, Berardinelli F, Talarico A, Pallavicini I, Pennisi R, Leone S, Antoccia A, Noguera NI, Lo-Coco F, Ascenzi P, Minucci S, Nervi C.

Cell Death Dis. 2016 Jul 28;7:e2308. doi: 10.1038/cddis.2016.115.

9.

c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer.

Nebbioso A, Carafa V, Conte M, Tambaro FP, Abbondanza C, Martens J, Nees M, Benedetti R, Pallavicini I, Minucci S, Garcia-Manero G, Iovino F, Lania G, Ingenito C, Belsito Petrizzi V, Stunnenberg HG, Altucci L.

Clin Cancer Res. 2017 May 15;23(10):2542-2555. doi: 10.1158/1078-0432.CCR-15-2388. Epub 2016 Jun 29.

10.

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

Bossi D, Cicalese A, Dellino GI, Luzi L, Riva L, D'Alesio C, Diaferia GR, Carugo A, Cavallaro E, Piccioni R, Barberis M, Mazzarol G, Testori A, Punzi S, Pallavicini I, Tosti G, Giacó L, Melloni G, Heffernan TP, Natoli G, Draetta GF, Minucci S, Pelicci P, Lanfrancone L.

Cancer Discov. 2016 Jun;6(6):650-63. doi: 10.1158/2159-8290.CD-15-1200. Epub 2016 May 13.

11.

Functional characterization of a novel FGFR1OP-RET rearrangement in hematopoietic malignancies.

Bossi D, Carlomagno F, Pallavicini I, Pruneri G, Trubia M, Raviele PR, Marinelli A, Anaganti S, Cox MC, Viale G, Santoro M, Di Fiore PP, Minucci S.

Mol Oncol. 2014 Mar;8(2):221-31. doi: 10.1016/j.molonc.2013.11.004. Epub 2013 Nov 19.

12.

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

Santoro F, Botrugno OA, Dal Zuffo R, Pallavicini I, Matthews GM, Cluse L, Barozzi I, Senese S, Fornasari L, Moretti S, Altucci L, Pelicci PG, Chiocca S, Johnstone RW, Minucci S.

Blood. 2013 Apr 25;121(17):3459-68. doi: 10.1182/blood-2012-10-461988. Epub 2013 Feb 25.

13.

The DNA demethylating agent decitabine activates the TRAIL pathway and induces apoptosis in acute myeloid leukemia.

Soncini M, Santoro F, Gutierrez A, Frigè G, Romanenghi M, Botrugno OA, Pallavicini I, Pelicci P, Di Croce L, Minucci S.

Biochim Biophys Acta. 2013 Jan;1832(1):114-20. doi: 10.1016/j.bbadis.2012.10.001. Epub 2012 Oct 6.

14.

Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL.

Leiva M, Moretti S, Soilihi H, Pallavicini I, Peres L, Mercurio C, Dal Zuffo R, Minucci S, de Thé H.

Leukemia. 2012 Jul;26(7):1630-7. doi: 10.1038/leu.2012.39. Epub 2012 Feb 15.

PMID:
22333881
15.

The self-association coiled-coil domain of PML is sufficient for the oncogenic conversion of the retinoic acid receptor (RAR) alpha.

Occhionorelli M, Santoro F, Pallavicini I, Gruszka A, Moretti S, Bossi D, Viale A, Shing D, Ronzoni S, Muradore I, Soncini M, Pruneri G, Rafaniello P, Viale G, Pelicci PG, Minucci S.

Leukemia. 2011 May;25(5):814-20. doi: 10.1038/leu.2011.18. Epub 2011 Feb 18.

PMID:
21331069
16.

Specific immunofluorimetric assay detecting the chemotactic epitope of the urokinase receptor (uPAR).

Resnati M, Pallavicini I, Daverio R, Sidenius N, Bonini P, Blasi F.

J Immunol Methods. 2006 Jan 20;308(1-2):192-202. Epub 2005 Dec 19.

PMID:
16386755
17.

The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.

Resnati M, Pallavicini I, Wang JM, Oppenheim J, Serhan CN, Romano M, Blasi F.

Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1359-64. Epub 2002 Jan 29.

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