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Items: 33


Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila.

Andreazza S, Samstag CL, Sanchez-Martinez A, Fernandez-Vizarra E, Gomez-Duran A, Lee JJ, Tufi R, Hipp MJ, Schmidt EK, Nicholls TJ, Gammage PA, Chinnery PF, Minczuk M, Pallanck LJ, Kennedy SR, Whitworth AJ.

Nat Commun. 2019 Jul 23;10(1):3280. doi: 10.1038/s41467-019-10857-y.


Autophagy accounts for approximately one-third of mitochondrial protein turnover and is protein selective.

Vincow ES, Thomas RE, Merrihew GE, Shulman NJ, Bammler TK, MacDonald JW, MacCoss MJ, Pallanck LJ.

Autophagy. 2019 Sep;15(9):1592-1605. doi: 10.1080/15548627.2019.1586258. Epub 2019 Mar 21.


Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ.

Samstag CL, Hoekstra JG, Huang CH, Chaisson MJ, Youle RJ, Kennedy SR, Pallanck LJ.

PLoS Genet. 2018 Nov 19;14(11):e1007805. doi: 10.1371/journal.pgen.1007805. eCollection 2018 Nov.


Lon protease inactivation in Drosophila causes unfolded protein stress and inhibition of mitochondrial translation.

Pareek G, Thomas RE, Vincow ES, Morris DR, Pallanck LJ.

Cell Death Discov. 2018 Oct 22;4:51. doi: 10.1038/s41420-018-0110-1. eCollection 2018. Erratum in: Cell Death Discov. 2019 Jul 10;5:116.


Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles.

Thomas RE, Vincow ES, Merrihew GE, MacCoss MJ, Davis MY, Pallanck LJ.

PLoS Genet. 2018 Sep 26;14(9):e1007694. doi: 10.1371/journal.pgen.1007694. eCollection 2018 Sep.


PINK1/Parkin mitophagy and neurodegeneration-what do we really know in vivo?

Whitworth AJ, Pallanck LJ.

Curr Opin Genet Dev. 2017 Jun;44:47-53. doi: 10.1016/j.gde.2017.01.016. Epub 2017 Feb 16. Review.


A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster.

Patel MR, Miriyala GK, Littleton AJ, Yang H, Trinh K, Young JM, Kennedy SR, Yamashita YM, Pallanck LJ, Malik HS.

Elife. 2016 Aug 2;5. pii: e16923. doi: 10.7554/eLife.16923.


Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.

Davis MY, Trinh K, Thomas RE, Yu S, Germanos AA, Whitley BN, Sardi SP, Montine TJ, Pallanck LJ.

PLoS Genet. 2016 Mar 28;12(3):e1005944. doi: 10.1371/journal.pgen.1005944. eCollection 2016 Mar.


A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer.

Burman JL, Itsara LS, Kayser EB, Suthammarak W, Wang AM, Kaeberlein M, Sedensky MM, Morgan PG, Pallanck LJ.

Dis Model Mech. 2014 Oct;7(10):1165-74. doi: 10.1242/dmm.015321. Epub 2014 Aug 1.


PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix.

Thomas RE, Andrews LA, Burman JL, Lin WY, Pallanck LJ.

PLoS Genet. 2014 May 29;10(5):e1004279. doi: 10.1371/journal.pgen.1004279. eCollection 2014.


Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations.

Itsara LS, Kennedy SR, Fox EJ, Yu S, Hewitt JJ, Sanchez-Contreras M, Cardozo-Pelaez F, Pallanck LJ.

PLoS Genet. 2014 Feb 6;10(2):e1003974. doi: 10.1371/journal.pgen.1003974. eCollection 2014 Feb.


The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo.

Vincow ES, Merrihew G, Thomas RE, Shulman NJ, Beyer RP, MacCoss MJ, Pallanck LJ.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6400-5. doi: 10.1073/pnas.1221132110. Epub 2013 Mar 18.


Culling sick mitochondria from the herd.

Pallanck LJ.

J Cell Biol. 2010 Dec 27;191(7):1225-7. doi: 10.1083/jcb.201011068.


Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration mice reveals a role for Nna proteins in neuronal bioenergetics.

Chakrabarti L, Zahra R, Jackson SM, Kazemi-Esfarjani P, Sopher BL, Mason AG, Toneff T, Ryu S, Shaffer S, Kansy JW, Eng J, Merrihew G, MacCoss MJ, Murphy A, Goodlett DR, Hook V, Bennett CL, Pallanck LJ, La Spada AR.

Neuron. 2010 Jun 24;66(6):835-47. doi: 10.1016/j.neuron.2010.05.024.


The PINK1/Parkin pathway: a mitochondrial quality control system?

Whitworth AJ, Pallanck LJ.

J Bioenerg Biomembr. 2009 Dec;41(6):499-503. doi: 10.1007/s10863-009-9253-3. Review.


Genetic models of Parkinson's disease: mechanisms and therapies.

Whitworth AJ, Pallanck LJ.

SEB Exp Biol Ser. 2008;60:93-113. Review. No abstract available.


The PINK1/Parkin pathway regulates mitochondrial morphology.

Poole AC, Thomas RE, Andrews LA, McBride HM, Whitworth AJ, Pallanck LJ.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1638-43. doi: 10.1073/pnas.0709336105. Epub 2008 Jan 29.


Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.

Trinh K, Moore K, Wes PD, Muchowski PJ, Dey J, Andrews L, Pallanck LJ.

J Neurosci. 2008 Jan 9;28(2):465-72. doi: 10.1523/JNEUROSCI.4778-07.2008.


Drosophila NPC1b promotes an early step in sterol absorption from the midgut epithelium.

Voght SP, Fluegel ML, Andrews LA, Pallanck LJ.

Cell Metab. 2007 Mar;5(3):195-205.


Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes.

Satterfield TF, Pallanck LJ.

Hum Mol Genet. 2006 Aug 15;15(16):2523-32. Epub 2006 Jul 11.


Drosophila models pioneer a new approach to drug discovery for Parkinson's disease.

Whitworth AJ, Wes PD, Pallanck LJ.

Drug Discov Today. 2006 Feb;11(3-4):119-26. Review.


Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.

Meulener M, Whitworth AJ, Armstrong-Gold CE, Rizzu P, Heutink P, Wes PD, Pallanck LJ, Bonini NM.

Curr Biol. 2005 Sep 6;15(17):1572-7.


Mutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defects.

Fluegel ML, Parker TJ, Pallanck LJ.

Genetics. 2006 Jan;172(1):185-96. Epub 2005 Aug 3.


Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease.

Whitworth AJ, Theodore DA, Greene JC, Benes H, Wes PD, Pallanck LJ.

Proc Natl Acad Sci U S A. 2005 May 31;102(22):8024-9. Epub 2005 May 23.


A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage.

Jackson SM, Whitworth AJ, Greene JC, Libby RT, Baccam SL, Pallanck LJ, La Spada AR.

Gene. 2005 Feb 28;347(1):35-41.


Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.

Greene JC, Whitworth AJ, Andrews LA, Parker TJ, Pallanck LJ.

Hum Mol Genet. 2005 Mar 15;14(6):799-811. Epub 2005 Feb 2.


A genetic screen for synaptic transmission mutants mapping to the right arm of chromosome 3 in Drosophila.

Babcock MC, Stowers RS, Leither J, Goodman CS, Pallanck LJ.

Genetics. 2003 Sep;165(1):171-83.


Parkin: a multipurpose neuroprotective agent?

Feany MB, Pallanck LJ.

Neuron. 2003 Apr 10;38(1):13-6.


Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants.

Greene JC, Whitworth AJ, Kuo I, Andrews LA, Feany MB, Pallanck LJ.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4078-83. Epub 2003 Mar 17.


The 21-kDa protein is a transformation-sensitive metalloproteinase inhibitor of chicken fibroblasts.

Staskus PW, Masiarz FR, Pallanck LJ, Hawkes SP.

J Biol Chem. 1991 Jan 5;266(1):449-54.

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