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Items: 40


Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo.

Taverner AM, Yang L, Barile ZJ, Lin B, Peng J, Pinharanda AP, Rao AS, Roland BP, Talsma AD, Wei D, Petschenka G, Palladino MJ, Andolfatto P.

Elife. 2019 Aug 27;8. pii: e48224. doi: 10.7554/eLife.48224.


Missense variant in TPI1 (Arg189Gln) causes neurologic deficits through structural changes in the triosephosphate isomerase catalytic site and reduced enzyme levels in vivo.

Roland BP, Richards KR, Hrizo SL, Eicher S, Barile ZJ, Chang TC, Savon G, Bianchi P, Fermo E, Ricerca BM, Tortorolo L, Vockley J, VanDemark AP, Palladino MJ.

Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2257-2266. doi: 10.1016/j.bbadis.2019.05.002. Epub 2019 May 7.


Sleep and circadian defects in a Drosophila model of mitochondrial encephalomyopathy.

Fogle KJ, Mobini CL, Paseos AS, Palladino MJ.

Neurobiol Sleep Circadian Rhythms. 2019 Jan;6:44-52. doi: 10.1016/j.nbscr.2019.01.003. Epub 2019 Feb 4.


Ketogenic and anaplerotic dietary modifications ameliorate seizure activity in Drosophila models of mitochondrial encephalomyopathy and glycolytic enzymopathy.

Fogle KJ, Smith AR, Satterfield SL, Gutierrez AC, Hertzler JI, McCardell CS, Shon JH, Barile ZJ, Novak MO, Palladino MJ.

Mol Genet Metab. 2019 Apr;126(4):439-447. doi: 10.1016/j.ymgme.2019.01.008. Epub 2019 Jan 17.


Molecular Neuroprotection Induced by Zinc-Dependent Expression of Hepatitis C-Derived Protein NS5A Targeting Kv2.1 Potassium Channels.

Justice JA, Manjooran DT, Yeh CY, Hartnett-Scott KA, Schulien AJ, Kosobucki GJ, Mammen S, Palladino MJ, Aizenman E.

J Pharmacol Exp Ther. 2018 Nov;367(2):348-355. doi: 10.1124/jpet.118.252338. Epub 2018 Sep 6.


Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington's disease.

Drombosky KW, Rode S, Kodali R, Jacob TC, Palladino MJ, Wetzel R.

Neurobiol Dis. 2018 Dec;120:126-138. doi: 10.1016/j.nbd.2018.08.019. Epub 2018 Aug 30.


Protein coding mitochondrial-targeted RNAs rescue mitochondrial disease in vivo.

Markantone DM, Towheed A, Crain AT, Collins JM, Celotto AM, Palladino MJ.

Neurobiol Dis. 2018 Sep;117:203-210. doi: 10.1016/j.nbd.2018.06.009. Epub 2018 Jun 13.


The ATP-sensitive K channel is seizure protective and required for effective dietary therapy in a model of mitochondrial encephalomyopathy.

Fogle KJ, Hertzler JI, Shon JH, Palladino MJ.

J Neurogenet. 2016 Sep - Dec;30(3-4):247-258. Epub 2016 Nov 21.


Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics.

Roland BP, Zeccola AM, Larsen SB, Amrich CG, Talsma AD, Stuchul KA, Heroux A, Levitan ES, VanDemark AP, Palladino MJ.

PLoS Genet. 2016 Mar 31;12(3):e1005941. doi: 10.1371/journal.pgen.1005941. eCollection 2016 Mar.


Cost of surviving sepsis: a novel model of recovery from sepsis in Drosophila melanogaster.

Kaynar AM, Bakalov V, Laverde SM, Cambriel AI, Lee BH, Towheed A, Gregory AD, Webb SA, Palladino MJ, Bozza FA, Shapiro SD, Angus DC.

Intensive Care Med Exp. 2016 Dec;4(1):4. doi: 10.1186/s40635-016-0075-4. Epub 2016 Jan 21.


A conserved polybasic domain mediates plasma membrane targeting of Lgl and its regulation by hypoxia.

Dong W, Zhang X, Liu W, Chen YJ, Huang J, Austin E, Celotto AM, Jiang WZ, Palladino MJ, Jiang Y, Hammond GR, Hong Y.

J Cell Biol. 2015 Oct 26;211(2):273-86. doi: 10.1083/jcb.201503067. Epub 2015 Oct 19.


Genome-wide screen for modifiers of Na (+) /K (+) ATPase alleles identifies critical genetic loci.

Talsma AD, Chaves JF, LaMonaca A, Wieczorek ED, Palladino MJ.

Mol Brain. 2014 Dec 5;7:89. doi: 10.1186/s13041-014-0089-3.


Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency.

Roland BP, Amrich CG, Kammerer CJ, Stuchul KA, Larsen SB, Rode S, Aslam AA, Heroux A, Wetzel R, VanDemark AP, Palladino MJ.

Biochim Biophys Acta. 2015 Jan;1852(1):61-9. doi: 10.1016/j.bbadis.2014.10.010. Epub 2014 Oct 16.


Genetically encoded redox sensors.

Chiu WK, Towheed A, Palladino MJ.

Methods Enzymol. 2014;542:263-87. doi: 10.1016/B978-0-12-416618-9.00014-5. Review.


Small mitochondrial-targeted RNAs modulate endogenous mitochondrial protein expression in vivo.

Towheed A, Markantone DM, Crain AT, Celotto AM, Palladino MJ.

Neurobiol Dis. 2014 Sep;69:15-22. doi: 10.1016/j.nbd.2014.04.017. Epub 2014 May 5.


Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity.

Roland BP, Stuchul KA, Larsen SB, Amrich CG, Vandemark AP, Celotto AM, Palladino MJ.

J Cell Sci. 2013 Jul 15;126(Pt 14):3151-8. doi: 10.1242/jcs.124586. Epub 2013 May 2.


Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency.

Hrizo SL, Fisher IJ, Long DR, Hutton JA, Liu Z, Palladino MJ.

Neurobiol Dis. 2013 Jun;54:289-96. doi: 10.1016/j.nbd.2012.12.020. Epub 2013 Jan 12.


A novel Drosophila SOD2 mutant demonstrates a role for mitochondrial ROS in neurodevelopment and disease.

Celotto AM, Liu Z, Vandemark AP, Palladino MJ.

Brain Behav. 2012 Jul;2(4):424-34. doi: 10.1002/brb3.73. Epub 2012 Jun 25.


Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction.

Celotto AM, Chiu WK, Van Voorhies W, Palladino MJ.

PLoS One. 2011;6(10):e25823. doi: 10.1371/journal.pone.0025823. Epub 2011 Oct 3.


Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis.

Liu Z, Celotto AM, Romero G, Wipf P, Palladino MJ.

Neurobiol Dis. 2012 Jan;45(1):362-8. doi: 10.1016/j.nbd.2011.08.022. Epub 2011 Aug 25.


Hsp70- and Hsp90-mediated proteasomal degradation underlies TPI sugarkill pathogenesis in Drosophila.

Hrizo SL, Palladino MJ.

Neurobiol Dis. 2010 Dec;40(3):676-83. doi: 10.1016/j.nbd.2010.08.011. Epub 2010 Aug 19.


Of fish, flies, worms and men: powerful approaches to neuropsychiatric disease using genetic models.

Burton EA, Palladino MJ.

Neurobiol Dis. 2010 Oct;40(1):1-3. doi: 10.1016/j.nbd.2010.07.009. Epub 2010 Jul 21. No abstract available.


Modeling mitochondrial encephalomyopathy in Drosophila.

Palladino MJ.

Neurobiol Dis. 2010 Oct;40(1):40-5. doi: 10.1016/j.nbd.2010.05.009. Epub 2010 May 21. Review.


Novel mutations affecting the Na, K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevity.

Ashmore LJ, Hrizo SL, Paul SM, Van Voorhies WA, Beitel GJ, Palladino MJ.

Hum Genet. 2009 Sep;126(3):431-47. doi: 10.1007/s00439-009-0673-2. Epub 2009 May 12.


Cleavage of mispaired heteroduplex DNA substrates by numerous restriction enzymes.

Langhans MT, Palladino MJ.

Curr Issues Mol Biol. 2009;11(1):1-12. Epub 2008 May 19.


Degradation of functional triose phosphate isomerase protein underlies sugarkill pathology.

Seigle JL, Celotto AM, Palladino MJ.

Genetics. 2008 Jun;179(2):855-62. doi: 10.1534/genetics.108.087551. Epub 2008 May 5.


Neuropathology in Drosophila mutants with increased seizure susceptibility.

Fergestad T, Olson L, Patel KP, Miller R, Palladino MJ, Ganetzky B.

Genetics. 2008 Feb;178(2):947-56. doi: 10.1534/genetics.107.082115. Epub 2008 Feb 1.


Drosophila model of human inherited triosephosphate isomerase deficiency glycolytic enzymopathy.

Celotto AM, Frank AC, Seigle JL, Palladino MJ.

Genetics. 2006 Nov;174(3):1237-46. Epub 2006 Sep 15.


Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria.

Bayir H, Fadeel B, Palladino MJ, Witasp E, Kurnikov IV, Tyurina YY, Tyurin VA, Amoscato AA, Jiang J, Kochanek PM, DeKosky ST, Greenberger JS, Shvedova AA, Kagan VE.

Biochim Biophys Acta. 2006 May-Jun;1757(5-6):648-59. Epub 2006 Mar 31. Review.


Mitochondrial encephalomyopathy in Drosophila.

Celotto AM, Frank AC, McGrath SW, Fergestad T, Van Voorhies WA, Buttle KF, Mannella CA, Palladino MJ.

J Neurosci. 2006 Jan 18;26(3):810-20.


Neuropathology in Drosophila membrane excitability mutants.

Fergestad T, Ganetzky B, Palladino MJ.

Genetics. 2006 Feb;172(2):1031-42. Epub 2005 Nov 4.


Drosophila: a "model" model system to study neurodegeneration.

Celotto AM, Palladino MJ.

Mol Interv. 2005 Oct;5(5):292-303. Review.


A deficiency screen of the major autosomes identifies a gene (matrimony) that is haplo-insufficient for achiasmate segregation in Drosophila oocytes.

Harris D, Orme C, Kramer J, Namba L, Champion M, Palladino MJ, Natzle J, Hawley RS.

Genetics. 2003 Oct;165(2):637-52.


Neural dysfunction and neurodegeneration in Drosophila Na+/K+ ATPase alpha subunit mutants.

Palladino MJ, Bower JE, Kreber R, Ganetzky B.

J Neurosci. 2003 Feb 15;23(4):1276-86.


A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity.

Palladino MJ, Keegan LP, O'Connell MA, Reenan RA.

Cell. 2000 Aug 18;102(4):437-49.


RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation.

Hanrahan CJ, Palladino MJ, Ganetzky B, Reenan RA.

Genetics. 2000 Jul;155(3):1149-60.


RNA editing of a Drosophila sodium channel gene.

Hanrahan CJ, Palladino MJ, Bonneau LJ, Reenan RA.

Ann N Y Acad Sci. 1999 Apr 30;868:51-66. Review.


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