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Items: 1 to 50 of 167

1.

Prognostic role of a new inflammatory index with neutrophil-to-lymphocyte ratio and lactate dehydrogenase (CII: Colon Inflammatory Index) in patients with metastatic colorectal cancer: results from the randomized Italian Trial in Advanced Colorectal Cancer (ITACa) study.

Casadei-Gardini A, Scarpi E, Ulivi P, Palladino MA, Accettura C, Bernardini I, Spallanzani A, Gelsomino F, Corbelli J, Marisi G, Ruscelli S, Valgiusti M, Frassineti GL, Passardi A.

Cancer Manag Res. 2019 May 10;11:4357-4369. doi: 10.2147/CMAR.S198651. eCollection 2019.

2.

Effects of lipopolysaccharide-induced inflammation on hypoxia and inflammatory gene expression pathways of the rat testis.

Palladino MA, Fasano GA, Patel D, Dugan C, London M.

Basic Clin Androl. 2018 Nov 16;28:14. doi: 10.1186/s12610-018-0079-x. eCollection 2018.

3.

Impact of second-line cetuximab-containing therapy in patients with KRAS wild-type metastatic colorectal cancer: results from the ITACa randomized clinical trial.

Passardi A, Scarpi E, Gelsomino F, Palladino MA, Casadei Gardini A, Turci D, Chiuri VE, Mucciarini C, Tassinari D, Ragazzini A, Frassineti GL, Valgiusti M, Ulivi P, Amadori D.

Sci Rep. 2017 Sep 5;7(1):10426. doi: 10.1038/s41598-017-11048-9.

4.

MicroRNAs downregulated following immune activation of rat testis.

Parker MI, Palladino MA.

Am J Reprod Immunol. 2017 Jun;77(6). doi: 10.1111/aji.12673. Epub 2017 Mar 22.

PMID:
28328045
5.

Aprepitant versus metoclopramide, both combined with dexamethasone, for the prevention of cisplatin-induced delayed emesis: a randomized, double-blind study.

Roila F, Ruggeri B, Ballatori E, Fatigoni S, Caserta C, Licitra L, Mirabile A, Ionta MT, Massidda B, Cavanna L, Palladino MA, Tocci A, Fava S, Colantonio I, Angelelli L, Ciuffreda L, Fasola G, Zerilli F; Italian Group for Antiemetic Research.

Ann Oncol. 2015 Jun;26(6):1248-53. doi: 10.1093/annonc/mdv132. Epub 2015 Mar 5.

PMID:
25743855
6.

Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110γ/δ subunits and inhibition of NF-κB.

Través PG, Pimentel-Santillana M, Rico D, Rodriguez N, Miethke T, Castrillo A, Theodorakis EA, Martín-Sanz P, Palladino MA, Boscá L.

Chem Biol. 2014 Aug 14;21(8):955-66. doi: 10.1016/j.chembiol.2014.06.005. Epub 2014 Jul 24.

7.

Ultrasound guidance reduces pneumothorax rate and improves safety of thoracentesis in malignant pleural effusion: report on 445 consecutive patients with advanced cancer.

Cavanna L, Mordenti P, Bertè R, Palladino MA, Biasini C, Anselmi E, Seghini P, Vecchia S, Civardi G, Di Nunzio C.

World J Surg Oncol. 2014 May 2;12:139. doi: 10.1186/1477-7819-12-139.

8.

Effects of video-game play on information processing: a meta-analytic investigation.

Powers KL, Brooks PJ, Aldrich NJ, Palladino MA, Alfieri L.

Psychon Bull Rev. 2013 Dec;20(6):1055-79. doi: 10.3758/s13423-013-0418-z.

PMID:
23519430
9.

Myeloid cell leukemia-1 (Mc1-1) is a candidate target gene of hypoxia-inducible factor-1 (HIF-1) in the testis.

Palladino MA, Shah A, Tyson R, Horvath J, Dugan C, Karpodinis M.

Reprod Biol Endocrinol. 2012 Dec 5;10:104. doi: 10.1186/1477-7827-10-104.

10.

Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination.

Millward M, Price T, Townsend A, Sweeney C, Spencer A, Sukumaran S, Longenecker A, Lee L, Lay A, Sharma G, Gemmill RM, Drabkin HA, Lloyd GK, Neuteboom ST, McConkey DJ, Palladino MA, Spear MA.

Invest New Drugs. 2012 Dec;30(6):2303-17. doi: 10.1007/s10637-011-9766-6. Epub 2011 Nov 12.

PMID:
22080430
11.

Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors.

Steverding D, Wang X, Potts BC, Palladino MA.

Planta Med. 2012 Jan;78(2):131-4. doi: 10.1055/s-0031-1280315. Epub 2011 Oct 27.

PMID:
22034066
12.

Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs.

Miller CP, Manton CA, Hale R, Debose L, Macherla VR, Potts BC, Palladino MA, Chandra J.

Chem Biol Interact. 2011 Oct 15;194(1):58-68. doi: 10.1016/j.cbi.2011.08.005. Epub 2011 Aug 16.

13.

A novel vascular disrupting agent plinabulin triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells.

Singh AV, Bandi M, Raje N, Richardson P, Palladino MA, Chauhan D, Anderson KC.

Blood. 2011 May 26;117(21):5692-700. doi: 10.1182/blood-2010-12-323857. Epub 2011 Mar 31.

14.

Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs.

Obaidat A, Weiss J, Wahlgren B, Manam RR, Macherla VR, McArthur K, Chao TH, Palladino MA, Lloyd GK, Potts BC, Enna SJ, Neuteboom ST, Hagenbuch B.

J Pharmacol Exp Ther. 2011 May;337(2):479-86. doi: 10.1124/jpet.110.177824. Epub 2011 Feb 8.

15.

Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials.

Potts BC, Albitar MX, Anderson KC, Baritaki S, Berkers C, Bonavida B, Chandra J, Chauhan D, Cusack JC Jr, Fenical W, Ghobrial IM, Groll M, Jensen PR, Lam KS, Lloyd GK, McBride W, McConkey DJ, Miller CP, Neuteboom ST, Oki Y, Ovaa H, Pajonk F, Richardson PG, Roccaro AM, Sloss CM, Spear MA, Valashi E, Younes A, Palladino MA.

Curr Cancer Drug Targets. 2011 Mar;11(3):254-84. Review.

16.

Normoxic expression of hypoxia-inducible factor 1 in rat Leydig cells in vivo and in vitro.

Palladino MA, Pirlamarla PR, McNamara J, Sottas CM, Korah N, Hardy MP, Hales DB, Hermo L.

J Androl. 2011 May-Jun;32(3):307-23. doi: 10.2164/jandrol.110.011494. Epub 2010 Oct 21.

PMID:
20966422
17.

Ultrasound-guided central venous catheterization in cancer patients improves the success rate of cannulation and reduces mechanical complications: a prospective observational study of 1,978 consecutive catheterizations.

Cavanna L, Civardi G, Vallisa D, Di Nunzio C, Cappucciati L, Bertè R, Cordani MR, Lazzaro A, Cremona G, Biasini C, Muroni M, Mordenti P, Gorgni S, Zaffignani E, Ambroggi M, Bidin L, Palladino MA, Rodinò C, Tibaldi L.

World J Surg Oncol. 2010 Oct 19;8:91. doi: 10.1186/1477-7819-8-91.

18.

Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin.

Muehlbauer SM, Lima H Jr, Goldman DL, Jacobson LS, Rivera J, Goldberg MF, Palladino MA, Casadevall A, Brojatsch J.

Am J Pathol. 2010 Aug;177(2):735-43. doi: 10.2353/ajpath.2010.090828. Epub 2010 Jul 1. Erratum in: Am J Pathol. 2010 Oct;177(4):2145.

19.

Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI-0052 (marizomib) in a human plasmacytoma xenograft murine model.

Singh AV, Palladino MA, Lloyd GK, Potts BC, Chauhan D, Anderson KC.

Br J Haematol. 2010 May;149(4):550-9. doi: 10.1111/j.1365-2141.2010.08144.x. Epub 2010 Mar 12.

20.

Activation of EGFR by proteasome inhibition requires HB-EGF in pancreatic cancer cells.

Sloss CM, Wang F, Palladino MA, Cusack JC Jr.

Oncogene. 2010 May 27;29(21):3146-52. doi: 10.1038/onc.2010.52. Epub 2010 Mar 8.

21.

Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma.

Chauhan D, Singh AV, Ciccarelli B, Richardson PG, Palladino MA, Anderson KC.

Blood. 2010 Jan 28;115(4):834-45. doi: 10.1182/blood-2009-03-213009. Epub 2009 Nov 13.

22.

Localization of Toll-like receptors on epididymal epithelial cells and spermatozoa.

Palladino MA, Savarese MA, Chapman JL, Dughi MK, Plaska D.

Am J Reprod Immunol. 2008 Dec;60(6):541-55. doi: 10.1111/j.1600-0897.2008.00654.x.

PMID:
19032616
23.

Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

Fenical W, Jensen PR, Palladino MA, Lam KS, Lloyd GK, Potts BC.

Bioorg Med Chem. 2009 Mar 15;17(6):2175-80. doi: 10.1016/j.bmc.2008.10.075. Epub 2008 Nov 5.

24.

Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides.

Manam RR, McArthur KA, Chao TH, Weiss J, Ali JA, Palombella VJ, Groll M, Lloyd GK, Palladino MA, Neuteboom ST, Macherla VR, Potts BC.

J Med Chem. 2008 Nov 13;51(21):6711-24. doi: 10.1021/jm800548b. Epub 2008 Oct 22.

PMID:
18939815
25.

Proteasome inhibition activates epidermal growth factor receptor (EGFR) and EGFR-independent mitogenic kinase signaling pathways in pancreatic cancer cells.

Sloss CM, Wang F, Liu R, Xia L, Houston M, Ljungman D, Palladino MA, Cusack JC Jr.

Clin Cancer Res. 2008 Aug 15;14(16):5116-23. doi: 10.1158/1078-0432.CCR-07-4506.

26.

Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia.

Roccaro AM, Leleu X, Sacco A, Jia X, Melhem M, Moreau AS, Ngo HT, Runnels J, Azab A, Azab F, Burwick N, Farag M, Treon SP, Palladino MA, Hideshima T, Chauhan D, Anderson KC, Ghobrial IM.

Blood. 2008 May 1;111(9):4752-63. doi: 10.1182/blood-2007-11-120972. Epub 2008 Mar 3.

27.

Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma.

Chauhan D, Singh A, Brahmandam M, Podar K, Hideshima T, Richardson P, Munshi N, Palladino MA, Anderson KC.

Blood. 2008 Feb 1;111(3):1654-64. Epub 2007 Nov 15.

28.

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.

Ahn KS, Sethi G, Chao TH, Neuteboom ST, Chaturvedi MM, Palladino MA, Younes A, Aggarwal BB.

Blood. 2007 Oct 1;110(7):2286-95. Epub 2007 Jul 3.

29.

Selective activation of liver X receptors by acanthoic acid-related diterpenes.

Traves PG, Hortelano S, Zeini M, Chao TH, Lam T, Neuteboom ST, Theodorakis EA, Palladino MA, Castrillo A, Bosca L.

Mol Pharmacol. 2007 Jun;71(6):1545-53. Epub 2007 Feb 28.

PMID:
17329499
30.

Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract.

Palladino MA, Johnson TA, Gupta R, Chapman JL, Ojha P.

Biol Reprod. 2007 Jun;76(6):958-64. Epub 2007 Feb 21.

PMID:
17314314
31.

NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model.

Cusack JC Jr, Liu R, Xia L, Chao TH, Pien C, Niu W, Palombella VJ, Neuteboom ST, Palladino MA.

Clin Cancer Res. 2006 Nov 15;12(22):6758-64.

32.

NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent.

Nicholson B, Lloyd GK, Miller BR, Palladino MA, Kiso Y, Hayashi Y, Neuteboom ST.

Anticancer Drugs. 2006 Jan;17(1):25-31.

PMID:
16317287
33.

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib.

Chauhan D, Catley L, Li G, Podar K, Hideshima T, Velankar M, Mitsiades C, Mitsiades N, Yasui H, Letai A, Ovaa H, Berkers C, Nicholson B, Chao TH, Neuteboom ST, Richardson P, Palladino MA, Anderson KC.

Cancer Cell. 2005 Nov;8(5):407-19.

34.

Recovery of polymerase chain reaction products from frozen agarose gels.

Johnson T, Palladino MA.

Anal Biochem. 2005 Nov 15;346(2):339-41. Epub 2005 Sep 7. No abstract available.

PMID:
16185649
35.

Oncologic emergencies secondary to advanced colorectal cancer successfully treated with oxaliplatin/5-fluorouracil/leucovorin: report of three cases.

Cavanna L, Bertè R, Bidin L, Civardi G, Anselmi E, Lazzaro A, Moroni CF, Palladino MA, Rodinò C, Vallisa D.

J Chemother. 2005 Jun;17(3):334-8.

PMID:
16038529
36.

Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor.

Macherla VR, Mitchell SS, Manam RR, Reed KA, Chao TH, Nicholson B, Deyanat-Yazdi G, Mai B, Jensen PR, Fenical WF, Neuteboom ST, Lam KS, Palladino MA, Potts BC.

J Med Chem. 2005 Jun 2;48(11):3684-7.

PMID:
15916417
37.

A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation.

Chao TH, Lam T, Vong BG, Través PG, Hortelano S, Chowdhury C, Bahjat FR, Lloyd GK, Moldawer LL, Boscá L, Palladino MA, Theodorakis EA.

Chembiochem. 2005 Jan;6(1):133-44.

PMID:
15540220
38.

Expression and localization of hypoxia-inducible factor-1 subunits in the adult rat epididymis.

Palladino MA, Powell JD, Korah N, Hermo L.

Biol Reprod. 2004 Apr;70(4):1121-30. Epub 2003 Dec 10.

PMID:
14668208
39.

Anti-TNF-alpha therapies: the next generation.

Palladino MA, Bahjat FR, Theodorakis EA, Moldawer LL.

Nat Rev Drug Discov. 2003 Sep;2(9):736-46. Review.

PMID:
12951580
40.

Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents.

Lam T, Ling T, Chowdhury C, Chao TH, Bahjat FR, Lloyd GK, Moldawer LL, Palladino MA, Theodorakis EA.

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3217-21.

PMID:
12951096
43.

Enantioselective synthesis of the antiinflammatory agent (-)-acanthoic acid.

Ling T, Chowdhury C, Kramer BA, Vong BG, Palladino MA, Theodorakis EA.

J Org Chem. 2001 Dec 28;66(26):8843-53.

PMID:
11749614
44.

Stereoselective synthesis of (-)-acanthoic acid.

Ling T, Kramer BA, Palladino MA, Theodorakis EA.

Org Lett. 2000 Jul 13;2(14):2073-6.

PMID:
10891233
45.

Intravenous itasetron: establishing the effective dose range for the prophylactic control of acute emesis in cancer patients undergoing high-dose cisplatin chemotherapy.

Patoia L, Del Favero A, Giglietti A, Malacarne P, Donati D, Indelli M, Bensi G, Palladino MA, Cigarini P, Kempe R, Voigt T.

Clin Oncol (R Coll Radiol). 1999;11(2):99-104.

PMID:
10378635
46.

Chemotherapy with cisplatin and teniposide for cerebral metastases in non-small cell lung cancer.

Minotti V, Crinò L, Meacci ML, Corgna E, Darwish S, Palladino MA, Betti M, Tonato M.

Lung Cancer. 1998 May;20(2):93-8.

PMID:
9711527
47.

Prevention of radiotherapy-induced emesis.

Roila F, Ciccarese G, Palladino MA, De Angelis V.

Tumori. 1998 Mar-Apr;84(2):274-8. Review.

PMID:
9620257
48.

A better therapeutic profile for the combination of mitomycin-C, ifosfamide and cisplatin (MIC) in advanced non-small-cell lung cancer: a useful dose-schedule modification.

Crinò L, Corgna E, Porrozzi S, Palladino MA, Darwish S, Minotti V, Mosconi AM, Tonato M.

Ann Oncol. 1997 Jul;8(7):709-11.

PMID:
9296229
49.

Clinical and methodological issues in antiemetic therapy: a worldwide survey of experts' opinions. Multinational Association of Supportive Care in Cancer.

Ballatori E, Roila F, De Angelis V, Ciccarese G, Palladino MA, Tonato M, Del Favero A, Herrstedt J, Dicato M, du Bois A, Hesketh P, Kris M, Gralla RJ.

Support Care Cancer. 1997 Jul;5(4):269-73.

PMID:
9257422

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