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Items: 1 to 50 of 236

1.

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring.

Izquierdo V, Palomera-Ávalos V, López-Ruiz S, Canudas AM, Pallàs M, Griñán-Ferré C.

Int J Mol Sci. 2019 Mar 6;20(5). pii: E1134. doi: 10.3390/ijms20051134.

2.

Long-term exercise training improves memory in middle-aged men and modulates peripheral levels of BDNF and Cathepsin B.

De la Rosa A, Solana E, Corpas R, Bartrés-Faz D, Pallàs M, Vina J, Sanfeliu C, Gomez-Cabrera MC.

Sci Rep. 2019 Mar 4;9(1):3337. doi: 10.1038/s41598-019-40040-8.

3.

Temporal Integrative Analysis of mRNA and microRNAs Expression Profiles and Epigenetic Alterations in Female SAMP8, a Model of Age-Related Cognitive Decline.

Cosín-Tomás M, Álvarez-López MJ, Companys-Alemany J, Kaliman P, González-Castillo C, Ortuño-Sahagún D, Pallàs M, Griñán-Ferré C.

Front Genet. 2018 Dec 11;9:596. doi: 10.3389/fgene.2018.00596. eCollection 2018.

4.

Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice.

Griñán-Ferré C, Vasilopoulou F, Abás S, Rodríguez-Arévalo S, Bagán A, Sureda FX, Pérez B, Callado LF, García-Sevilla JA, García-Fuster MJ, Escolano C, Pallàs M.

Neurotherapeutics. 2018 Nov 20. doi: 10.1007/s13311-018-00681-5. [Epub ahead of print]

PMID:
30460457
5.

Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.

Bahous RH, Cosín-Tomás M, Deng L, Leclerc D, Malysheva O, Ho MK, Pallàs M, Kaliman P, Bedell BJ, Caudill MA, Rozen R.

Mol Neurobiol. 2018 Oct 4. doi: 10.1007/s12035-018-1375-3. [Epub ahead of print]

PMID:
30288696
6.

Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model.

Griñán-Ferré C, Izquierdo V, Otero E, Puigoriol-Illamola D, Corpas R, Sanfeliu C, Ortuño-Sahagún D, Pallàs M.

Front Cell Neurosci. 2018 Aug 15;12:224. doi: 10.3389/fncel.2018.00224. eCollection 2018.

7.

Resveratrol Modulates and Reverses the Age-Related Effect on Adenosine-Mediated Signalling in SAMP8 Mice.

Sánchez-Melgar A, Albasanz JL, Palomera-Ávalos V, Pallàs M, Martín M.

Mol Neurobiol. 2018 Aug 1. doi: 10.1007/s12035-018-1281-8. [Epub ahead of print]

PMID:
30069829
8.

Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement.

Corpas R, Griñán-Ferré C, Rodríguez-Farré E, Pallàs M, Sanfeliu C.

Mol Neurobiol. 2019 Feb;56(2):1502-1516. doi: 10.1007/s12035-018-1157-y. Epub 2018 Jun 13.

PMID:
29948950
9.

Melatonin induces mechanisms of brain resilience against neurodegeneration.

Corpas R, Griñán-Ferré C, Palomera-Ávalos V, Porquet D, García de Frutos P, Franciscato Cozzolino SM, Rodríguez-Farré E, Pallàs M, Sanfeliu C, Cardoso BR.

J Pineal Res. 2018 Nov;65(4):e12515. doi: 10.1111/jpi.12515. Epub 2018 Jul 4.

PMID:
29907977
10.

11β-HSD1 Inhibition by RL-118 Promotes Autophagy and Correlates with Reduced Oxidative Stress and Inflammation, Enhancing Cognitive Performance in SAMP8 Mouse Model.

Puigoriol-Illamola D, Griñán-Ferré C, Vasilopoulou F, Leiva R, Vázquez S, Pallàs M.

Mol Neurobiol. 2018 Dec;55(12):8904-8915. doi: 10.1007/s12035-018-1026-8. Epub 2018 Apr 2.

PMID:
29611102
11.

Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model.

Griñán-Ferré C, Corpas R, Puigoriol-Illamola D, Palomera-Ávalos V, Sanfeliu C, Pallàs M.

J Alzheimers Dis. 2018;62(3):943-963. doi: 10.3233/JAD-170664.

12.

Impairment of Novel Object Recognition Memory and Brain Insulin Signaling in Fructose- but Not Glucose-Drinking Female Rats.

Sangüesa G, Cascales M, Griñán C, Sánchez RM, Roglans N, Pallàs M, Laguna JC, Alegret M.

Mol Neurobiol. 2018 Aug;55(8):6984-6999. doi: 10.1007/s12035-017-0863-1. Epub 2018 Jan 26.

PMID:
29372547
13.

Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain.

Palomera-Ávalos V, Griñán-Ferré C, Izquierdo V, Camins A, Sanfeliu C, Canudas AM, Pallàs M.

Exp Gerontol. 2018 Feb;102:3-11. doi: 10.1016/j.exger.2017.11.014. Epub 2017 Nov 24.

PMID:
29174969
14.

Poisson Plus Quantification for Digital PCR Systems.

Majumdar N, Banerjee S, Pallas M, Wessel T, Hegerich P.

Sci Rep. 2017 Aug 29;7(1):9617. doi: 10.1038/s41598-017-09183-4.

15.

Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive dysfunction.

Leiva R, Griñan-Ferré C, Seira C, Valverde E, McBride A, Binnie M, Pérez B, Luque FJ, Pallàs M, Bidon-Chanal A, Webster SP, Vázquez S.

Eur J Med Chem. 2017 Oct 20;139:412-428. doi: 10.1016/j.ejmech.2017.08.003. Epub 2017 Aug 4.

PMID:
28818766
16.

Early Preclinical Changes in Hippocampal CREB-Binding Protein Expression in a Mouse Model of Familial Alzheimer's Disease.

Ettcheto M, Abad S, Petrov D, Pedrós I, Busquets O, Sánchez-López E, Casadesús G, Beas-Zarate C, Carro E, Auladell C, Olloquequi J, Pallàs M, Folch J, Camins A.

Mol Neurobiol. 2018 Jun;55(6):4885-4895. doi: 10.1007/s12035-017-0690-4. Epub 2017 Jul 27.

PMID:
28752224
17.

Experimental Models for Aging and their Potential for Novel Drug Discovery.

Folch J, Busquets O, Ettcheto M, Sánchez-López E, Pallàs M, Beas-Zarate C, Marin M, Casadesus G, Olloquequi J, Auladell C, Camins A.

Curr Neuropharmacol. 2018;16(10):1466-1483. doi: 10.2174/1570159X15666170707155345. Review.

PMID:
28685671
18.

Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways.

Ettcheto M, Sánchez-López E, Pons L, Busquets O, Olloquequi J, Beas-Zarate C, Pallas M, García ML, Auladell C, Folch J, Camins A.

Redox Biol. 2017 Oct;13:345-352. doi: 10.1016/j.redox.2017.06.003. Epub 2017 Jun 15.

19.

SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions.

Akiguchi I, Pallàs M, Budka H, Akiyama H, Ueno M, Han J, Yagi H, Nishikawa T, Chiba Y, Sugiyama H, Takahashi R, Unno K, Higuchi K, Hosokawa M.

Neuropathology. 2017 Aug;37(4):293-305. doi: 10.1111/neup.12373. Epub 2017 Mar 6. Review.

PMID:
28261874
20.

High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.

Bahous RH, Jadavji NM, Deng L, Cosín-Tomás M, Lu J, Malysheva O, Leung KY, Ho MK, Pallàs M, Kaliman P, Greene NDE, Bedell BJ, Caudill MA, Rozen R.

Hum Mol Genet. 2017 Mar 1;26(5):888-900. doi: 10.1093/hmg/ddx004.

21.

Metabolic Stress Induces Cognitive Disturbances and Inflammation in Aged Mice: Protective Role of Resveratrol.

Palomera-Ávalos V, Griñán-Ferré C, Izquierdo V, Camins A, Sanfeliu C, Pallàs M.

Rejuvenation Res. 2017 Jun;20(3):202-217. doi: 10.1089/rej.2016.1885. Epub 2017 Jan 25.

22.

The therapeutic potential of metabolic hormones in the treatment of age-related cognitive decline and Alzheimer's disease.

Grizzanti J, Lee HG, Camins A, Pallas M, Casadesus G.

Nutr Res. 2016 Dec;36(12):1305-1315. doi: 10.1016/j.nutres.2016.11.002. Epub 2016 Nov 8. Review.

23.

Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer's disease.

Busquets O, Ettcheto M, Pallàs M, Beas-Zarate C, Verdaguer E, Auladell C, Folch J, Camins A.

Mech Ageing Dev. 2017 Mar;162:38-45. doi: 10.1016/j.mad.2016.11.002. Epub 2016 Nov 15.

PMID:
27863851
24.

Environmental Enrichment Modified Epigenetic Mechanisms in SAMP8 Mouse Hippocampus by Reducing Oxidative Stress and Inflammaging and Achieving Neuroprotection.

Griñan-Ferré C, Puigoriol-Illamola D, Palomera-Ávalos V, Pérez-Cáceres D, Companys-Alemany J, Camins A, Ortuño-Sahagún D, Rodrigo MT, Pallàs M.

Front Aging Neurosci. 2016 Oct 18;8:241. eCollection 2016.

25.

Evaluation of the Role of JNK1 in the Hippocampus in an Experimental Model of Familial Alzheimer's Disease.

Petrov D, Luque M, Pedrós I, Ettcheto M, Abad S, Pallàs M, Verdaguer E, Auladell C, Folch J, Camins A.

Mol Neurobiol. 2016 Nov;53(9):6183-6193. doi: 10.1007/s12035-015-9522-6. Epub 2015 Nov 12.

PMID:
26558630
26.

Plasma miR-34a-5p and miR-545-3p as Early Biomarkers of Alzheimer's Disease: Potential and Limitations.

Cosín-Tomás M, Antonell A, Lladó A, Alcolea D, Fortea J, Ezquerra M, Lleó A, Martí MJ, Pallàs M, Sanchez-Valle R, Molinuevo JL, Sanfeliu C, Kaliman P.

Mol Neurobiol. 2017 Sep;54(7):5550-5562. doi: 10.1007/s12035-016-0088-8. Epub 2016 Sep 8.

PMID:
27631879
27.

SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms.

Corpas R, Revilla S, Ursulet S, Castro-Freire M, Kaliman P, Petegnief V, Giménez-Llort L, Sarkis C, Pallàs M, Sanfeliu C.

Mol Neurobiol. 2017 Sep;54(7):5604-5619. doi: 10.1007/s12035-016-0087-9. Epub 2016 Sep 10.

PMID:
27614878
28.

Evaluation of Neuropathological Effects of a High-Fat Diet in a Presymptomatic Alzheimer's Disease Stage in APP/PS1 Mice.

Ettcheto M, Petrov D, Pedrós I, Alva N, Carbonell T, Beas-Zarate C, Pallas M, Auladell C, Folch J, Camins A.

J Alzheimers Dis. 2016 Jul 14;54(1):233-51. doi: 10.3233/JAD-160150.

PMID:
27567882
29.

The absence of pleiotrophin modulates gene expression in the hippocampus in vivo and in cerebellar granule cells in vitro.

González-Castillo C, Ortuño-Sahagún D, Guzmán-Brambila C, Márquez-Aguirre AL, Raisman-Vozari R, Pallás M, Rojas-Mayorquín AE.

Mol Cell Neurosci. 2016 Sep;75:113-21. doi: 10.1016/j.mcn.2016.07.004. Epub 2016 Jul 26.

PMID:
27468976
30.

Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence.

Griñan-Ferré C, Palomera-Ávalos V, Puigoriol-Illamola D, Camins A, Porquet D, Plá V, Aguado F, Pallàs M.

Exp Gerontol. 2016 Jul;80:57-69. doi: 10.1016/j.exger.2016.03.014. Epub 2016 Apr 17.

31.

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice.

Griñán-Ferré C, Sarroca S, Ivanova A, Puigoriol-Illamola D, Aguado F, Camins A, Sanfeliu C, Pallàs M.

Aging (Albany NY). 2016 Apr;8(4):664-84. doi: 10.18632/aging.100906.

32.

Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway.

Palomera-Avalos V, Griñán-Ferré C, Puigoriol-Ilamola D, Camins A, Sanfeliu C, Canudas AM, Pallàs M.

Mol Neurobiol. 2017 Apr;54(3):1661-1676. doi: 10.1007/s12035-016-9770-0. Epub 2016 Feb 12.

PMID:
26873850
33.

Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies.

Manich G, Augé E, Cabezón I, Pallàs M, Vilaplana J, Pelegrí C.

Immun Ageing. 2015 Nov 24;12:23. doi: 10.1186/s12979-015-0050-z. eCollection 2015.

34.

Environmental Enrichment Improves Behavior, Cognition, and Brain Functional Markers in Young Senescence-Accelerated Prone Mice (SAMP8).

Griñan-Ferré C, Pérez-Cáceres D, Gutiérrez-Zetina SM, Camins A, Palomera-Avalos V, Ortuño-Sahagún D, Rodrigo MT, Pallàs M.

Mol Neurobiol. 2016 May;53(4):2435-50. doi: 10.1007/s12035-015-9210-6. Epub 2015 May 27.

PMID:
26014386
35.

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents.

Petrov D, Pedrós I, Artiach G, Sureda FX, Barroso E, Pallàs M, Casadesús G, Beas-Zarate C, Carro E, Ferrer I, Vazquez-Carrera M, Folch J, Camins A.

Biochim Biophys Acta. 2015 Sep;1852(9):1687-99. doi: 10.1016/j.bbadis.2015.05.004. Epub 2015 May 21.

36.

Adipokine pathways are altered in hippocampus of an experimental mouse model of Alzheimer's disease.

Pedrós I, Petrov D, Artiach G, Abad S, Ramon-Duaso C, Sureda F, Pallàs M, Beas-Zarate C, Folch J, Camins A.

J Nutr Health Aging. 2015 Apr;19(4):403-12. doi: 10.1007/s12603-014-0574-5.

PMID:
25809804
37.

Hypercholesterolemia and neurodegeneration. Comparison of hippocampal phenotypes in LDLr knockout and APPswe/PS1dE9 mice.

Ettcheto M, Petrov D, Pedrós I, de Lemos L, Pallàs M, Alegret M, Laguna JC, Folch J, Camins A.

Exp Gerontol. 2015 May;65:69-78. doi: 10.1016/j.exger.2015.03.010. Epub 2015 Mar 20.

PMID:
25797218
38.

Regulation of the p19(Arf)/p53 pathway by histone acetylation underlies neural stem cell behavior in senescence-prone SAMP8 mice.

Soriano-Cantón R, Perez-Villalba A, Morante-Redolat JM, Marqués-Torrejón MÁ, Pallás M, Pérez-Sánchez F, Fariñas I.

Aging Cell. 2015 Jun;14(3):453-62. doi: 10.1111/acel.12328. Epub 2015 Feb 26.

39.

In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes.

García-Matas S, Paul RK, Molina-Martínez P, Palacios H, Gutierrez VM, Corpas R, Pallas M, Cristòfol R, de Cabo R, Sanfeliu C.

Aging Cell. 2015 Jun;14(3):334-44. doi: 10.1111/acel.12259. Epub 2015 Feb 25.

40.

Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8).

Porquet D, Andrés-Benito P, Griñán-Ferré C, Camins A, Ferrer I, Canudas AM, Del Valle J, Pallàs M.

Age (Dordr). 2015 Feb;37(1):9747. doi: 10.1007/s11357-015-9747-3. Epub 2015 Feb 8.

41.

Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus.

González-Castillo C, Ortuño-Sahagún D, Guzmán-Brambila C, Pallàs M, Rojas-Mayorquín AE.

Front Cell Neurosci. 2015 Jan 8;8:443. doi: 10.3389/fncel.2014.00443. eCollection 2014. Review.

42.

Downregulation of canonical Wnt signaling in hippocampus of SAMP8 mice.

Bayod S, Felice P, Andrés P, Rosa P, Camins A, Pallàs M, Canudas AM.

Neurobiol Aging. 2015 Feb;36(2):720-9. doi: 10.1016/j.neurobiolaging.2014.09.017. Epub 2014 Sep 28.

PMID:
25443287
43.

Long-term wheel running changes on sensorimotor activity and skeletal muscle in male and female mice of accelerated senescence.

Sanchez-Roige S, Lalanza JF, Alvarez-López MJ, Cosín-Tomás M, Griñan-Ferré C, Pallàs M, Kaliman P, Escorihuela RM.

Age (Dordr). 2014;36(5):9697. doi: 10.1007/s11357-014-9697-1. Epub 2014 Aug 17.

44.

Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus.

Ettcheto M, Junyent F, de Lemos L, Pallas M, Folch J, Beas-Zarate C, Verdaguer E, Gómez-Sintes R, Lucas JJ, Auladell C, Camins A.

Mol Neurobiol. 2015 Aug;52(1):120-9. doi: 10.1007/s12035-014-8836-0. Epub 2014 Aug 15.

PMID:
25119776
45.

Clustered granules present in the hippocampus of aged mice result from a degenerative process affecting astrocytes and their surrounding neuropil.

Manich G, Cabezón I, Camins A, Pallàs M, Liberski PP, Vilaplana J, Pelegrí C.

Age (Dordr). 2014;36(4):9690. doi: 10.1007/s11357-014-9690-8. Epub 2014 Jul 30.

46.

Rcor2 underexpression in senescent mice: a target for inflammaging?

Alvarez-López MJ, Molina-Martínez P, Castro-Freire M, Cosín-Tomás M, Cristòfol R, Párrizas M, Escorihuela RM, Pallàs M, Sanfeliu C, Kaliman P.

J Neuroinflammation. 2014 Jul 23;11:126. doi: 10.1186/1742-2094-11-126.

47.

Voluntary exercise promotes beneficial anti-aging mechanisms in SAMP8 female brain.

Bayod S, Guzmán-Brambila C, Sanchez-Roige S, Lalanza JF, Kaliman P, Ortuño-Sahagun D, Escorihuela RM, Pallàs M.

J Mol Neurosci. 2015 Feb;55(2):525-32. doi: 10.1007/s12031-014-0376-6. Epub 2014 Jul 16.

PMID:
25027560
48.

Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease.

Porquet D, Griñán-Ferré C, Ferrer I, Camins A, Sanfeliu C, Del Valle J, Pallàs M.

J Alzheimers Dis. 2014;42(4):1209-20. doi: 10.3233/JAD-140444.

PMID:
25024312
49.

3,4-Methylenedioxymethamphetamine enhances kainic acid convulsive susceptibility.

Abad S, Junyent F, Auladell C, Pubill D, Pallàs M, Camarasa J, Escubedo E, Camins A.

Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:231-42. doi: 10.1016/j.pnpbp.2014.06.007. Epub 2014 Jun 28.

50.

Mavoglurant as a treatment for Parkinson's disease.

Petrov D, Pedros I, de Lemos ML, Pallàs M, Canudas AM, Lazarowski A, Beas-Zarate C, Auladell C, Folch J, Camins A.

Expert Opin Investig Drugs. 2014 Aug;23(8):1165-79. doi: 10.1517/13543784.2014.931370. Epub 2014 Jun 24. Review.

PMID:
24960254

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