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Correction to: An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons.

Canfield SG, Stebbins MJ, Faubion MG, Gastfriend BD, Palecek SP, Shusta EV.

Fluids Barriers CNS. 2019 Sep 10;16(1):31. doi: 10.1186/s12987-019-0151-8.


An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons.

Canfield SG, Stebbins MJ, Faubion MG, Gastfriend BD, Palecek SP, Shusta EV.

Fluids Barriers CNS. 2019 Aug 7;16(1):25. doi: 10.1186/s12987-019-0145-6. Erratum in: Fluids Barriers CNS. 2019 Sep 10;16(1):31.


Small-Molecule Morphogenesis Modulators Enhance the Ability of 14-Helical β-Peptides To Prevent Candida albicans Biofilm Formation.

Rodríguez López AL, Lee MR, Wang NB, Dunn KK, Sanchez H, Raman N, Andes DR, Lynn DM, Palecek SP.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e02653-18. doi: 10.1128/AAC.02653-18. Print 2019 Sep.


Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies.

Park TE, Mustafaoglu N, Herland A, Hasselkus R, Mannix R, FitzGerald EA, Prantil-Baun R, Watters A, Henry O, Benz M, Sanchez H, McCrea HJ, Goumnerova LC, Song HW, Palecek SP, Shusta E, Ingber DE.

Nat Commun. 2019 Jun 13;10(1):2621. doi: 10.1038/s41467-019-10588-0.


Regionally specified human pluripotent stem cell-derived astrocytes exhibit different molecular signatures and functional properties.

Bradley RA, Shireman J, McFalls C, Choi J, Canfield SG, Dong Y, Liu K, Lisota B, Jones JR, Petersen A, Bhattacharyya A, Palecek SP, Shusta EV, Kendziorski C, Zhang SC.

Development. 2019 Jul 8;146(13). pii: dev170910. doi: 10.1242/dev.170910.


Coculture of Endothelial Cells with Human Pluripotent Stem Cell-Derived Cardiac Progenitors Reveals a Differentiation Stage-Specific Enhancement of Cardiomyocyte Maturation.

Dunn KK, Reichardt IM, Simmons AD, Jin G, Floy ME, Hoon KM, Palecek SP.

Biotechnol J. 2019 Aug;14(8):e1800725. doi: 10.1002/biot.201800725. Epub 2019 May 14.


Human pluripotent stem cell-derived brain pericyte-like cells induce blood-brain barrier properties.

Stebbins MJ, Gastfriend BD, Canfield SG, Lee MS, Richards D, Faubion MG, Li WJ, Daneman R, Palecek SP, Shusta EV.

Sci Adv. 2019 Mar 13;5(3):eaau7375. doi: 10.1126/sciadv.aau7375. eCollection 2019 Mar.


Preventing S. aureus biofilm formation on titanium surfaces by the release of antimicrobial β-peptides from polyelectrolyte multilayers.

Rodríguez López AL, Lee MR, Ortiz BJ, Gastfriend BD, Whitehead R, Lynn DM, Palecek SP.

Acta Biomater. 2019 Jul 15;93:50-62. doi: 10.1016/j.actbio.2019.02.047. Epub 2019 Mar 1.


Directed Differentiation of Human Pluripotent Stem Cells to Podocytes under Defined Conditions.

Qian T, Hernday SE, Bao X, Olson WR, Panzer SE, Shusta EV, Palecek SP.

Sci Rep. 2019 Feb 26;9(1):2765. doi: 10.1038/s41598-019-39504-8.


Local and systemic metabolic alterations in brain, plasma, and liver of rats in response to aging and ischemic stroke, as detected by nuclear magnetic resonance (NMR) spectroscopy.

Wesley UV, Bhute VJ, Hatcher JF, Palecek SP, Dempsey RJ.

Neurochem Int. 2019 Jul;127:113-124. doi: 10.1016/j.neuint.2019.01.025. Epub 2019 Jan 30.


14-Helical β-Peptides Elicit Toxicity against C. albicans by Forming Pores in the Cell Membrane and Subsequently Disrupting Intracellular Organelles.

Lee MR, Raman N, Ortiz-Bermúdez P, Lynn DM, Palecek SP.

Cell Chem Biol. 2019 Feb 21;26(2):289-299.e4. doi: 10.1016/j.chembiol.2018.11.002. Epub 2018 Dec 20.


Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations.

Ayuso JM, Gillette A, Lugo-Cintrón K, Acevedo-Acevedo S, Gomez I, Morgan M, Heaster T, Wisinski KB, Palecek SP, Skala MC, Beebe DJ.

EBioMedicine. 2018 Nov;37:144-157. doi: 10.1016/j.ebiom.2018.10.046. Epub 2018 Oct 26.


Software to improve transfer and reproducibility of cell culture methods.

Canfield SG, Jin G, Palecek SP, Sampsell T.

Biotechniques. 2018 Nov;65(5):289-292. doi: 10.2144/btn-2018-0062.


Modeling the blood-brain barrier: Beyond the endothelial cells.

Gastfriend BD, Palecek SP, Shusta EV.

Curr Opin Biomed Eng. 2018 Mar;5:6-12. doi: 10.1016/j.cobme.2017.11.002.


Engineering Scalable Manufacturing of High-Quality Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Repair.

Dunn KK, Palecek SP.

Front Med (Lausanne). 2018 Apr 24;5:110. doi: 10.3389/fmed.2018.00110. eCollection 2018. Review.


Hyaluronan impairs the barrier integrity of brain microvascular endothelial cells through a CD44-dependent pathway.

Al-Ahmad AJ, Patel R, Palecek SP, Shusta EV.

J Cereb Blood Flow Metab. 2019 Sep;39(9):1759-1775. doi: 10.1177/0271678X18767748. Epub 2018 Mar 28.


Regenerative Medicine Manufacturing.

Cabral JMS, Palecek SP.

Biotechnol J. 2018 Feb;13(2). doi: 10.1002/biot.201800026. No abstract available.


Human pluripotent stem cell-derived epicardial progenitors can differentiate to endocardial-like endothelial cells.

Bao X, Bhute VJ, Han T, Qian T, Lian X, Palecek SP.

Bioeng Transl Med. 2017 Jun;2(2):191-201. doi: 10.1002/btm2.10062. Epub 2017 May 22.


Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells.

Qian T, Maguire SE, Canfield SG, Bao X, Olson WR, Shusta EV, Palecek SP.

Sci Adv. 2017 Nov 8;3(11):e1701679. doi: 10.1126/sciadv.1701679. eCollection 2017 Nov.


Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.

Kim BJ, Bee OB, McDonagh MA, Stebbins MJ, Palecek SP, Doran KS, Shusta EV.

mSphere. 2017 Nov 1;2(6). pii: e00398-17. doi: 10.1128/mSphere.00398-17. eCollection 2017 Nov-Dec.


Incorporation of β-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2.

Lee MR, Raman N, Gellman SH, Lynn DM, Palecek SP.

ACS Chem Biol. 2017 Dec 15;12(12):2975-2980. doi: 10.1021/acschembio.7b00843. Epub 2017 Nov 30.


Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.

Stebbins MJ, Lippmann ES, Faubion MG, Daneman R, Palecek SP, Shusta EV.

Biotechnol J. 2018 Feb;13(2). doi: 10.1002/biot.201700093. Epub 2017 Sep 28.


Bioengineering Solutions for Manufacturing Challenges in CAR T Cells.

Piscopo NJ, Mueller KP, Das A, Hematti P, Murphy WL, Palecek SP, Capitini CM, Saha K.

Biotechnol J. 2018 Feb;13(2). doi: 10.1002/biot.201700095. Epub 2017 Sep 18. Review.


Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions.

Bao X, Lian X, Qian T, Bhute VJ, Han T, Palecek SP.

Nat Protoc. 2017 Sep;12(9):1890-1900. doi: 10.1038/nprot.2017.080. Epub 2017 Aug 17.


Advances in Applications of Metabolomics in Pluripotent Stem Cell Research.

Bhute VJ, Bao X, Palecek SP.

Curr Opin Chem Eng. 2017 Feb;15:36-43. doi: 10.1016/j.coche.2016.11.007. Epub 2016 Dec 15.


Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach.

Manna U, Raman N, Welsh MA, Zayas-Gonzalez YM, Blackwell HE, Palecek SP, Lynn DM.

Adv Funct Mater. 2016 Jun 7;26(21):3599-3611. doi: 10.1002/adfm.201505522. Epub 2016 Apr 27.


Metabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes.

Bhute VJ, Bao X, Dunn KK, Knutson KR, McCurry EC, Jin G, Lee WH, Lewis S, Ikeda A, Palecek SP.

Theranostics. 2017 May 26;7(7):2078-2091. doi: 10.7150/thno.19390. eCollection 2017.


Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier.

Vatine GD, Al-Ahmad A, Barriga BK, Svendsen S, Salim A, Garcia L, Garcia VJ, Ho R, Yucer N, Qian T, Lim RG, Wu J, Thompson LM, Spivia WR, Chen Z, Van Eyk J, Palecek SP, Refetoff S, Shusta EV, Svendsen CN.

Cell Stem Cell. 2017 Jun 1;20(6):831-843.e5. doi: 10.1016/j.stem.2017.04.002. Epub 2017 May 16.


Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.

Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654. doi: 10.1073/pnas.1621346114. Epub 2017 Jan 31.


An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells.

Canfield SG, Stebbins MJ, Morales BS, Asai SW, Vatine GD, Svendsen CN, Palecek SP, Shusta EV.

J Neurochem. 2017 Mar;140(6):874-888. doi: 10.1111/jnc.13923. Epub 2017 Feb 14.


Sucrose Nonfermenting-Related Kinase Enzyme-Mediated Rho-Associated Kinase Signaling is Responsible for Cardiac Function.

Cossette SM, Bhute VJ, Bao X, Harmann LM, Horswill MA, Sinha I, Gastonguay A, Pooya S, Bordas M, Kumar SN, Mirza SP, Palecek SP, Strande JL, Ramchandran R.

Circ Cardiovasc Genet. 2016 Dec;9(6):474-486. doi: 10.1161/CIRCGENETICS.116.001515. Epub 2016 Oct 25.


Directed Endothelial Progenitor Differentiation from Human Pluripotent Stem Cells Via Wnt Activation Under Defined Conditions.

Bao X, Lian X, Palecek SP.

Methods Mol Biol. 2016;1481:183-96. doi: 10.1007/978-1-4939-6393-5_17.


Antifungal activity of a β-peptide in synthetic urine media: Toward materials-based approaches to reducing catheter-associated urinary tract fungal infections.

Raman N, Lee MR, Rodríguez López AL, Palecek SP, Lynn DM.

Acta Biomater. 2016 Oct 1;43:240-250. doi: 10.1016/j.actbio.2016.07.016. Epub 2016 Jul 12.


Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model.

Clark PA, Al-Ahmad AJ, Qian T, Zhang RR, Wilson HK, Weichert JP, Palecek SP, Kuo JS, Shusta EV.

Mol Pharm. 2016 Sep 6;13(9):3341-9. doi: 10.1021/acs.molpharmaceut.6b00441. Epub 2016 Aug 4.


Inhibition of Focal Adhesion Kinase Signaling by Integrin α6β1 Supports Human Pluripotent Stem Cell Self-Renewal.

Villa-Diaz LG, Kim JK, Laperle A, Palecek SP, Krebsbach PH.

Stem Cells. 2016 Jul;34(7):1753-64. doi: 10.1002/stem.2349. Epub 2016 Mar 27.


Intraluminal Release of an Antifungal β-Peptide Enhances the Antifungal and Anti-Biofilm Activities of Multilayer-Coated Catheters in a Rat Model of Venous Catheter Infection.

Raman N, Marchillo K, Lee MR, Rodríguez López AL, Andes DR, Palecek SP, Lynn DM.

ACS Biomater Sci Eng. 2016 Jan 11;2(1):112-121. Epub 2015 Dec 8.


Human pluripotent stem cell culture density modulates YAP signaling.

Hsiao C, Lampe M, Nillasithanukroh S, Han W, Lian X, Palecek SP.

Biotechnol J. 2016 May;11(5):662-75. doi: 10.1002/biot.201500374. Epub 2016 Feb 16.


Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions.

Bao X, Lian X, Hacker TA, Schmuck EG, Qian T, Bhute VJ, Han T, Shi M, Drowley L, Plowright A, Wang QD, Goumans MJ, Palecek SP.

Nat Biomed Eng. 2016;1. pii: 0003. doi: 10.1038/s41551-016-0003. Epub 2016 Dec 5.


Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells.

Stebbins MJ, Wilson HK, Canfield SG, Qian T, Palecek SP, Shusta EV.

Methods. 2016 May 15;101:93-102. doi: 10.1016/j.ymeth.2015.10.016. Epub 2015 Oct 27.


Metabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells.

Bhute VJ, Palecek SP.

Metabolomics. 2015 Dec;11(6):1779-1791. Epub 2015 Jul 30.


Editorial: Stem Cell Engineering.

Cabral JM, Palecek SP.

Biotechnol J. 2015 Oct;10(10):1509-10. doi: 10.1002/biot.201500531.


Advances in microfluidic platforms for analyzing and regulating human pluripotent stem cells.

Qian T, Shusta EV, Palecek SP.

Curr Opin Genet Dev. 2015 Oct;34:54-60. doi: 10.1016/j.gde.2015.07.007. Epub 2015 Aug 24. Review.


Antifungal Activity of 14-Helical β-Peptides against Planktonic Cells and Biofilms of Candida Species.

Raman N, Lee MR, Lynn DM, Palecek SP.

Pharmaceuticals (Basel). 2015 Aug 13;8(3):483-503. doi: 10.3390/ph8030483.


α-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal.

Laperle A, Hsiao C, Lampe M, Mortier J, Saha K, Palecek SP, Masters KS.

Stem Cell Reports. 2015 Aug 11;5(2):195-206. doi: 10.1016/j.stemcr.2015.06.009. Epub 2015 Jul 30.


Chemically defined, albumin-free human cardiomyocyte generation.

Lian X, Bao X, Zilberter M, Westman M, Fisahn A, Hsiao C, Hazeltine LB, Dunn KK, Kamp TJ, Palecek SP.

Nat Methods. 2015 Jul;12(7):595-6. doi: 10.1038/nmeth.3448. No abstract available.


Chemically-defined albumin-free differentiation of human pluripotent stem cells to endothelial progenitor cells.

Bao X, Lian X, Dunn KK, Shi M, Han T, Qian T, Bhute VJ, Canfield SG, Palecek SP.

Stem Cell Res. 2015 Jul;15(1):122-129. doi: 10.1016/j.scr.2015.05.004. Epub 2015 May 14.


Exploring the effects of cell seeding density on the differentiation of human pluripotent stem cells to brain microvascular endothelial cells.

Wilson HK, Canfield SG, Hjortness MK, Palecek SP, Shusta EV.

Fluids Barriers CNS. 2015 May 21;12:13. doi: 10.1186/s12987-015-0007-9.


Epidermal growth factor mediated healing in stem cell-derived vocal fold mucosa.

Palencia L, Das A, Palecek SP, Thibeault SL, Leydon C.

J Surg Res. 2015 Jul;197(1):32-8. doi: 10.1016/j.jss.2015.02.066. Epub 2015 Mar 5.

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