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Items: 1 to 50 of 495

1.

Protective effect of a locked retinal chromophore analogue against light-induced retinal degeneration.

Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B.

Mol Pharmacol. 2018 Jul 17. pii: mol.118.112581. doi: 10.1124/mol.118.112581. [Epub ahead of print]

2.

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.

Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K.

Nat Commun. 2018 May 18;9(1):1996. doi: 10.1038/s41467-018-04432-0.

3.

A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration.

Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, Harte WE, Tochtrop GP, Palczewski K.

Nat Commun. 2018 May 17;9(1):1976. doi: 10.1038/s41467-018-04261-1.

4.

Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.

Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD.

Hum Mol Genet. 2018 Jul 1;27(13):2225-2243. doi: 10.1093/hmg/ddy128.

PMID:
29659842
5.

An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2-(thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic acid, a Potent Apelin Receptor (APJ) Agonist.

Trifonov L, Afri M, Palczewski K, Korshin EE, Gruzman A.

Med Chem. 2018 Apr 12. doi: 10.2174/1573406414666180412154952. [Epub ahead of print]

PMID:
29651942
6.

Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function.

Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K.

J Gen Physiol. 2018 Apr 2;150(4):571-590. doi: 10.1085/jgp.201711815. Epub 2018 Mar 2.

PMID:
29500274
7.

Human aging and disease: Lessons from age-related macular degeneration.

Luu J, Palczewski K.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):2866-2872. doi: 10.1073/pnas.1721033115. Epub 2018 Feb 26.

PMID:
29483257
8.

Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs.

Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K.

Mol Pharmacol. 2018 May;93(5):438-452. doi: 10.1124/mol.117.111294. Epub 2018 Feb 16.

PMID:
29453250
9.

New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models.

Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR.

FASEB J. 2018 Jun;32(6):3289-3300. doi: 10.1096/fj.201701250R. Epub 2018 Jan 24.

PMID:
29401616
10.

Increasing the Stability of Recombinant Human Green Cone Pigment.

Owen TS, Salom D, Sun W, Palczewski K.

Biochemistry. 2018 Feb 13;57(6):1022-1030. doi: 10.1021/acs.biochem.7b01118. Epub 2018 Jan 29.

11.

Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser.

Murashova GA, Mancuso CA, Canfield JL, Sakami S, Palczewski K, Palczewska G, Dantus M.

Biomed Opt Express. 2017 Oct 26;8(11):5228-5242. doi: 10.1364/BOE.8.005228. eCollection 2017 Nov 1.

12.

A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration.

Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K.

J Pharmacol Exp Ther. 2018 Feb;364(2):207-220. doi: 10.1124/jpet.117.245167. Epub 2017 Nov 21.

PMID:
29162627
13.

Context-dependent compensation among phosphatidylserine-recognition receptors.

Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS.

Sci Rep. 2017 Nov 7;7(1):14623. doi: 10.1038/s41598-017-15191-1.

14.

Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors.

Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9675-E9684. doi: 10.1073/pnas.1712405114. Epub 2017 Oct 23.

15.

Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser.

Murashova GA, Mancuso CA, Sakami S, Palczewski K, Palczewska G, Dantus M.

Proc SPIE Int Soc Opt Eng. 2017 Mar;10069. pii: 100692K. doi: 10.1117/12.2252457.

16.

Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium.

Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D, Palczewski K.

J Biol Chem. 2017 Dec 1;292(48):19826-19839. doi: 10.1074/jbc.M117.812677. Epub 2017 Oct 4.

PMID:
28978645
17.

Designing Safer Analgesics via μ-Opioid Receptor Pathways.

Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S.

Trends Pharmacol Sci. 2017 Nov;38(11):1016-1037. doi: 10.1016/j.tips.2017.08.004. Epub 2017 Sep 19. Review.

18.

Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness.

Sears AE, Bernstein PS, Cideciyan AV, Hoyng C, Charbel Issa P, Palczewski K, Rosenfeld PJ, Sadda S, Schraermeyer U, Sparrow JR, Washington I, Scholl HPN.

Transl Vis Sci Technol. 2017 Sep 14;6(5):6. doi: 10.1167/tvst.6.5.6. eCollection 2017 Sep. Review.

19.

Crowd sourcing difficult problems in protein science.

Alexander NS, Palczewski K.

Protein Sci. 2017 Nov;26(11):2118-2125. doi: 10.1002/pro.3247. Epub 2017 Aug 29. Review.

PMID:
28762619
20.

Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes.

Tonade D, Liu H, Palczewski K, Kern TS.

Diabetologia. 2017 Oct;60(10):2111-2120. doi: 10.1007/s00125-017-4381-5. Epub 2017 Jul 28.

21.

Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis.

Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR.

Mol Ther Nucleic Acids. 2017 Jun 16;7:42-52. doi: 10.1016/j.omtn.2017.02.005. Epub 2017 Feb 28.

22.

The role of retinol dehydrogenase 10 in the cone visual cycle.

Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ.

Sci Rep. 2017 May 24;7(1):2390. doi: 10.1038/s41598-017-02549-8.

23.

Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center.

Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD.

Biochemistry. 2017 Jun 6;56(22):2836-2852. doi: 10.1021/acs.biochem.7b00251. Epub 2017 May 19.

24.

Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue.

Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska B.

J Biol Chem. 2017 Jun 30;292(26):10983-10997. doi: 10.1074/jbc.M117.780478. Epub 2017 May 9.

25.

Rational Tuning of Visual Cycle Modulator Pharmacodynamics.

Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K.

J Pharmacol Exp Ther. 2017 Jul;362(1):131-145. doi: 10.1124/jpet.117.240721. Epub 2017 May 5.

26.

Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors.

Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K.

Biochemistry. 2017 May 2;56(17):2338-2348. doi: 10.1021/acs.biochem.7b00165. Epub 2017 Apr 21.

27.

Skunkworks project for Big Pharma.

Palczewski K.

Pharmacol Res. 2017 Oct;124:167-168. doi: 10.1016/j.phrs.2017.03.022. Epub 2017 Mar 28. No abstract available.

28.

Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.

Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2608-E2615. doi: 10.1073/pnas.1617446114. Epub 2017 Mar 13.

29.

Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas.

Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K.

Hum Mol Genet. 2016 Oct 15;25(20):4376-4388. doi: 10.1093/hmg/ddw268.

30.

Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy.

Sharma R, Schwarz C, Hunter JJ, Palczewska G, Palczewski K, Williams DR.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):604-613. doi: 10.1167/iovs.16-20061.

31.

MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice.

Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K.

J Biol Chem. 2017 Feb 24;292(8):3366-3378. doi: 10.1074/jbc.M116.770024. Epub 2017 Jan 19.

32.

Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration.

Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME.

Hum Mol Genet. 2017 Jan 15;26(2):305-319. doi: 10.1093/hmg/ddw387.

33.

A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins.

Jastrzebska B, Comar WD, Kaliszewski MJ, Skinner KC, Torcasio MH, Esway AS, Jin H, Palczewski K, Smith AW.

Biochemistry. 2017 Jan 10;56(1):61-72. doi: 10.1021/acs.biochem.6b00877. Epub 2016 Nov 29.

34.

Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans.

Schwarz C, Sharma R, Fischer WS, Chung M, Palczewska G, Palczewski K, Williams DR, Hunter JJ.

Biomed Opt Express. 2016 Nov 16;7(12):5148-5169. doi: 10.1364/BOE.7.005148. eCollection 2016 Dec 1.

35.

Retinoids and Retinal Diseases.

Kiser PD, Palczewski K.

Annu Rev Vis Sci. 2016 Oct;2:197-234. Epub 2016 Jul 18. Review.

36.

Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium.

Palczewska G, Maeda A, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K.

J Biol Chem. 2016 Dec 23;291(52):26937-26949. doi: 10.1074/jbc.M116.764563. Epub 2016 Nov 14.

37.

Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa.

Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K.

Pharmacol Res. 2017 Jan;115:1-13. doi: 10.1016/j.phrs.2016.10.031. Epub 2016 Nov 9.

38.

Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family.

Hofmann L, Tsybovsky Y, Alexander NS, Babino D, Leung NY, Montell C, Banerjee S, von Lintig J, Palczewski K.

Biochemistry. 2016 Nov 29;55(47):6545-6557. Epub 2016 Nov 16.

39.

Eyes on systems pharmacology.

Chen Y, Kern TS, Kiser PD, Palczewski K.

Pharmacol Res. 2016 Dec;114:39-41. doi: 10.1016/j.phrs.2016.09.026. Epub 2016 Oct 5. No abstract available.

40.

Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance.

Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ.

Nucleic Acids Res. 2016 Dec 1;44(21):10467-10479. Epub 2016 Sep 20.

41.

Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes.

Liu H, Tang J, Du Y, Saadane A, Tonade D, Samuels I, Veenstra A, Palczewski K, Kern TS.

Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4272-81. doi: 10.1167/iovs.16-19415.

42.

Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration.

Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K.

Sci Signal. 2016 Jul 26;9(438):ra74. doi: 10.1126/scisignal.aag0245.

43.

The Molecular Mechanism of P2Y1 Receptor Activation.

Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K.

Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10331-5. doi: 10.1002/anie.201605147. Epub 2016 Jul 27.

44.

Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase.

Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD.

J Biol Chem. 2016 Sep 9;291(37):19401-12. doi: 10.1074/jbc.M116.744912. Epub 2016 Jul 24.

45.

Image registration and averaging of low laser power two-photon fluorescence images of mouse retina.

Alexander NS, Palczewska G, Stremplewski P, Wojtkowski M, Kern TS, Palczewski K.

Biomed Opt Express. 2016 Jun 20;7(7):2671-91. doi: 10.1364/BOE.7.002671. eCollection 2016 Jul 1.

46.

Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor.

Yuan S, Peng Q, Palczewski K, Vogel H, Filipek S.

Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8661-5. doi: 10.1002/anie.201603766. Epub 2016 May 31.

47.

Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle.

Sears AE, Palczewski K.

Biochemistry. 2016 Jun 7;55(22):3082-91. doi: 10.1021/acs.biochem.6b00319. Epub 2016 May 23. Review.

48.

Dominant and recessive mutations in rhodopsin activate different cell death pathways.

Comitato A, Di Salvo MT, Turchiano G, Montanari M, Sakami S, Palczewski K, Marigo V.

Hum Mol Genet. 2016 Jul 1;25(13):2801-2812. Epub 2016 May 5.

PMID:
27149983
49.

Rural Practices: Founded in Family and Community.

Palczewski K.

Mich Med. 2016 Mar-Apr;115(2):18-23. No abstract available.

PMID:
27149754
50.

Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage.

Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y.

J Biol Chem. 2016 Jun 17;291(25):12951-9. doi: 10.1074/jbc.M115.713248. Epub 2016 Apr 18.

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