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Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis.

Kahremany S, Sander CL, Tochtrop GP, Kubas A, Palczewski K.

Org Biomol Chem. 2019 Sep 21;17(35):8125-8139. doi: 10.1039/c9ob01645g. Epub 2019 Aug 28.


Sensitivity of Mammalian Cone Photoreceptors to Infrared Light.

Vinberg F, Palczewska G, Zhang J, Komar K, Wojtkowski M, Kefalov VJ, Palczewski K.

Neuroscience. 2019 Aug 7;416:100-108. doi: 10.1016/j.neuroscience.2019.07.047. [Epub ahead of print]


Cryo-EM structure of the native rhodopsin dimer in nanodiscs.

Zhao DY, Poege M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K.

J Biol Chem. 2019 Aug 9. pii: jbc.RA119.010089. doi: 10.1074/jbc.RA119.010089. [Epub ahead of print]


Catalytic synthesis of 9-cis-retinoids: mechanistic insights.

Kahremany S, Kubas A, Tochtrop GP, Palczewski K.

Dalton Trans. 2019 Jul 16;48(28):10581-10595. doi: 10.1039/c9dt02189b.


Stereospecific modulation of dimeric rhodopsin.

Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K.

FASEB J. 2019 Aug;33(8):9526-9539. doi: 10.1096/fj.201900443RR. Epub 2019 May 23.


Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention.

Mustafi D, Arbabi A, Ameri H, Palczewski K.

Pharmaceuticals (Basel). 2019 May 17;12(2). pii: E74. doi: 10.3390/ph12020074.


The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration.

Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K.

J Biol Chem. 2019 Jun 14;294(24):9461-9475. doi: 10.1074/jbc.RA119.008697. Epub 2019 May 9.


Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy.

Liu H, Tang J, Du Y, Saadane A, Samuels I, Veenstra A, Kiser JZ, Palczewski K, Kern TS.

Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1538-1546. doi: 10.1167/iovs.18-26433.


Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates.

Salom D, Jin H, Gerken TA, Yu C, Huang L, Palczewski K.

J Biol Chem. 2019 May 17;294(20):8123-8133. doi: 10.1074/jbc.RA118.006835. Epub 2019 Apr 4.


A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness.

Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K.

Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1442-1453. doi: 10.1167/iovs.19-26560.


Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases.

Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L.

Sci Adv. 2019 Feb 27;5(2):eaav4322. doi: 10.1126/sciadv.aav4322. eCollection 2019 Feb.


Specificity of the chromophore-binding site in human cone opsins.

Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B.

J Biol Chem. 2019 Apr 12;294(15):6082-6093. doi: 10.1074/jbc.RA119.007587. Epub 2019 Feb 15.


Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones.

Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K.

FASEB J. 2019 Apr;33(4):5782-5792. doi: 10.1096/fj.201802493R. Epub 2019 Jan 15.


Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease.

Sakami S, Imanishi Y, Palczewski K.

FASEB J. 2019 Mar;33(3):3680-3692. doi: 10.1096/fj.201801662R. Epub 2018 Nov 21.


Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State.

Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ.

J Neurosci. 2019 Jan 9;39(2):212-223. doi: 10.1523/JNEUROSCI.1980-18.2018. Epub 2018 Nov 20.


Structural biology of 11-cis-retinaldehyde production in the classical visual cycle.

Daruwalla A, Choi EH, Palczewski K, Kiser PD.

Biochem J. 2018 Oct 22;475(20):3171-3188. doi: 10.1042/BCJ20180193. Review.


Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium.

Palczewska G, Kern TS, Palczewski K.

Methods Mol Biol. 2019;1834:333-343. doi: 10.1007/978-1-4939-8669-9_21.


Immuno-TEM/STEM in Retinal Research.

Sakami S, Palczewski K.

Methods Mol Biol. 2019;1834:311-332. doi: 10.1007/978-1-4939-8669-9_20.


Exploring a new ligand binding site of G protein-coupled receptors.

Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S.

Chem Sci. 2018 Jul 13;9(31):6480-6489. doi: 10.1039/c8sc01680a. eCollection 2018 Aug 21.


A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness.

Behnen P, Felline A, Comitato A, Di Salvo MT, Raimondi F, Gulati S, Kahremany S, Palczewski K, Marigo V, Fanelli F.

iScience. 2018 Jun 29;4:1-19. doi: 10.1016/j.isci.2018.05.001. Epub 2018 May 5.


Two-photon imaging of the mammalian retina with ultrafast pulsing laser.

Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K.

JCI Insight. 2018 Sep 6;3(17). pii: 121555. doi: 10.1172/jci.insight.121555. eCollection 2018 Sep 6.


Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration.

Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B.

Mol Pharmacol. 2018 Oct;94(4):1132-1144. doi: 10.1124/mol.118.112581. Epub 2018 Jul 17.


Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.

Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K.

Nat Commun. 2018 May 18;9(1):1996. doi: 10.1038/s41467-018-04432-0.


A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration.

Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, Harte WE, Tochtrop GP, Palczewski K.

Nat Commun. 2018 May 17;9(1):1976. doi: 10.1038/s41467-018-04261-1.


Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.

Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD.

Hum Mol Genet. 2018 Jul 1;27(13):2225-2243. doi: 10.1093/hmg/ddy128.


An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist.

Trifonov L, Afri M, Palczewski K, Korshin EE, Gruzman A.

Med Chem. 2018;14(7):688-694. doi: 10.2174/1573406414666180412154952.


Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function.

Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K.

J Gen Physiol. 2018 Apr 2;150(4):571-590. doi: 10.1085/jgp.201711815. Epub 2018 Mar 2.


Human aging and disease: Lessons from age-related macular degeneration.

Luu J, Palczewski K.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):2866-2872. doi: 10.1073/pnas.1721033115. Epub 2018 Feb 26.


Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs.

Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K.

Mol Pharmacol. 2018 May;93(5):438-452. doi: 10.1124/mol.117.111294. Epub 2018 Feb 16.


New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models.

Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR.

FASEB J. 2018 Jun;32(6):3289-3300. doi: 10.1096/fj.201701250R. Epub 2018 Jan 24.


Increasing the Stability of Recombinant Human Green Cone Pigment.

Owen TS, Salom D, Sun W, Palczewski K.

Biochemistry. 2018 Feb 13;57(6):1022-1030. doi: 10.1021/acs.biochem.7b01118. Epub 2018 Jan 29.


Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser.

Murashova GA, Mancuso CA, Canfield JL, Sakami S, Palczewski K, Palczewska G, Dantus M.

Biomed Opt Express. 2017 Oct 26;8(11):5228-5242. doi: 10.1364/BOE.8.005228. eCollection 2017 Nov 1.


A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration.

Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K.

J Pharmacol Exp Ther. 2018 Feb;364(2):207-220. doi: 10.1124/jpet.117.245167. Epub 2017 Nov 21.


Context-dependent compensation among phosphatidylserine-recognition receptors.

Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS.

Sci Rep. 2017 Nov 7;7(1):14623. doi: 10.1038/s41598-017-15191-1.


Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors.

Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9675-E9684. doi: 10.1073/pnas.1712405114. Epub 2017 Oct 23.


Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser.

Murashova GA, Mancuso CA, Sakami S, Palczewski K, Palczewska G, Dantus M.

Proc SPIE Int Soc Opt Eng. 2017 Mar;10069. pii: 100692K. doi: 10.1117/12.2252457.


Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium.

Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D, Palczewski K.

J Biol Chem. 2017 Dec 1;292(48):19826-19839. doi: 10.1074/jbc.M117.812677. Epub 2017 Oct 4.


Designing Safer Analgesics via μ-Opioid Receptor Pathways.

Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S.

Trends Pharmacol Sci. 2017 Nov;38(11):1016-1037. doi: 10.1016/ Epub 2017 Sep 19. Review.


Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness.

Sears AE, Bernstein PS, Cideciyan AV, Hoyng C, Charbel Issa P, Palczewski K, Rosenfeld PJ, Sadda S, Schraermeyer U, Sparrow JR, Washington I, Scholl HPN.

Transl Vis Sci Technol. 2017 Sep 14;6(5):6. doi: 10.1167/tvst.6.5.6. eCollection 2017 Sep. Review.


Crowd sourcing difficult problems in protein science.

Alexander NS, Palczewski K.

Protein Sci. 2017 Nov;26(11):2118-2125. doi: 10.1002/pro.3247. Epub 2017 Aug 29. Review.


Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes.

Tonade D, Liu H, Palczewski K, Kern TS.

Diabetologia. 2017 Oct;60(10):2111-2120. doi: 10.1007/s00125-017-4381-5. Epub 2017 Jul 28.


Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis.

Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR.

Mol Ther Nucleic Acids. 2017 Jun 16;7:42-52. doi: 10.1016/j.omtn.2017.02.005. Epub 2017 Feb 28.


The role of retinol dehydrogenase 10 in the cone visual cycle.

Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ.

Sci Rep. 2017 May 24;7(1):2390. doi: 10.1038/s41598-017-02549-8.


Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center.

Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD.

Biochemistry. 2017 Jun 6;56(22):2836-2852. doi: 10.1021/acs.biochem.7b00251. Epub 2017 May 19.


Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue.

Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska B.

J Biol Chem. 2017 Jun 30;292(26):10983-10997. doi: 10.1074/jbc.M117.780478. Epub 2017 May 9.


Rational Tuning of Visual Cycle Modulator Pharmacodynamics.

Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K.

J Pharmacol Exp Ther. 2017 Jul;362(1):131-145. doi: 10.1124/jpet.117.240721. Epub 2017 May 5.


Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors.

Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K.

Biochemistry. 2017 May 2;56(17):2338-2348. doi: 10.1021/acs.biochem.7b00165. Epub 2017 Apr 21.


Skunkworks project for Big Pharma.

Palczewski K.

Pharmacol Res. 2017 Oct;124:167-168. doi: 10.1016/j.phrs.2017.03.022. Epub 2017 Mar 28. No abstract available.


Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.

Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2608-E2615. doi: 10.1073/pnas.1617446114. Epub 2017 Mar 13.


Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas.

Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K.

Hum Mol Genet. 2016 Oct 15;25(20):4376-4388. doi: 10.1093/hmg/ddw268.

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