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Items: 24


Inflammatory and immunometabolic consequences of gut dysfunction in HIV: Parallels with IBD and implications for reservoir persistence and non-AIDS comorbidities.

Alzahrani J, Hussain T, Simar D, Palchaudhuri R, Abdel-Mohsen M, Crowe SM, Mbogo GW, Palmer CS.

EBioMedicine. 2019 Aug;46:522-531. doi: 10.1016/j.ebiom.2019.07.027. Epub 2019 Jul 18. Review.


Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation.

Czechowicz A, Palchaudhuri R, Scheck A, Hu Y, Hoggatt J, Saez B, Pang WW, Mansour MK, Tate TA, Chan YY, Walck E, Wernig G, Shizuru JA, Winau F, Scadden DT, Rossi DJ.

Nat Commun. 2019 Feb 6;10(1):617. doi: 10.1038/s41467-018-08201-x.


Polymorphism rs1385129 Within Glut1 Gene SLC2A1 Is Linked to Poor CD4+ T Cell Recovery in Antiretroviral-Treated HIV+ Individuals.

Masson JJR, Cherry CL, Murphy NM, Sada-Ovalle I, Hussain T, Palchaudhuri R, Martinson J, Landay AL, Billah B, Crowe SM, Palmer CS.

Front Immunol. 2018 May 17;9:900. doi: 10.3389/fimmu.2018.00900. eCollection 2018.


Exploiting immune cell metabolic machinery for functional HIV cure and the prevention of inflammaging.

Palmer CS, Palchaudhuri R, Albargy H, Abdel-Mohsen M, Crowe SM.

F1000Res. 2018 Jan 30;7:125. doi: 10.12688/f1000research.11881.1. eCollection 2018. Review.


Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1.

Schiroli G, Ferrari S, Conway A, Jacob A, Capo V, Albano L, Plati T, Castiello MC, Sanvito F, Gennery AR, Bovolenta C, Palchaudhuri R, Scadden DT, Holmes MC, Villa A, Sitia G, Lombardo A, Genovese P, Naldini L.

Sci Transl Med. 2017 Oct 11;9(411). pii: eaan0820. doi: 10.1126/scitranslmed.aan0820.


Eliminating HIV & AIDS in India: A roadmap to zero new HIV infections, zero discrimination & zero AIDS-related deaths.

Palchaudhuri R, Niggl M, Palmer CS.

Indian J Med Res. 2016 Dec;144(6):789-792. doi: 10.4103/ijmr.IJMR_1902_16. No abstract available.


Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.

Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT.

Nat Biotechnol. 2016 Jul;34(7):738-45. doi: 10.1038/nbt.3584. Epub 2016 Jun 6.


Can HIV reverse transcriptase activity assay be a low-cost alternative for viral load monitoring in resource-limited settings?

Gupta S, Palchaudhuri R, Neogi U, Srinivasa H, Ashorn P, De Costa A, Källander C, Shet A.

BMJ Open. 2016 Jan 27;6(1):e008795. doi: 10.1136/bmjopen-2015-008795.


A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.

Palchaudhuri R, Lambrecht MJ, Botham RC, Partlow KC, van Ham TJ, Putt KS, Nguyen LT, Kim SH, Peterson RT, Fan TM, Hergenrother PJ.

Cell Rep. 2015 Dec 1;13(9):2027-36. doi: 10.1016/j.celrep.2015.10.042. Epub 2015 Nov 19.


Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.

Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT.

Blood. 2014 Nov 6;124(19):2937-47. doi: 10.1182/blood-2014-08-593426. Epub 2014 Sep 8.


Limited evolution but increasing trends of primary non-nucleoside reverse transcriptase inhibitor resistance mutations in therapy-naive HIV-1-infected individuals in India.

Neogi U, Gupta S, Palchaudhuri R, Rao SD, Shastri S, Diwan V, Laishram RS, De Costa A, Shet A.

Antivir Ther. 2014;19(8):813-8. doi: 10.3851/IMP2769. Epub 2014 Apr 4.


Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.

Calvaresi EC, Granchi C, Tuccinardi T, Di Bussolo V, Huigens RW 3rd, Lee HY, Palchaudhuri R, Macchia M, Martinelli A, Minutolo F, Hergenrother PJ.

Chembiochem. 2013 Nov 25;14(17):2263-7. doi: 10.1002/cbic.201300562. Epub 2013 Oct 31.


Genetic architecture of HIV type 1 Nef and Tat from HLA-B57-typed long-term survivors in an Indian cohort of perinatally HIV-infected children.

Neogi U, Palchaudhuri R, Bommana S, Shet A.

AIDS Res Hum Retroviruses. 2013 Dec;29(12):1613-6. doi: 10.1089/AID.2013.0195. Epub 2013 Oct 5.


High viremia in HIV-1 subtype C infection and spread of the epidemic.

Neogi U, Palchaudhuri R, Shet A.

J Infect Dis. 2013 Sep 1;208(5):866-7. doi: 10.1093/infdis/jit258. Epub 2013 Jun 10. No abstract available.


Differential effects of procaspase-3 activating compounds in the induction of cancer cell death.

West DC, Qin Y, Peterson QP, Thomas DL, Palchaudhuri R, Morrison KC, Lucas PW, Palmer AE, Fan TM, Hergenrother PJ.

Mol Pharm. 2012 May 7;9(5):1425-34. doi: 10.1021/mp200673n. Epub 2012 Apr 27.


Triphenylmethyl derivatives enhances the anticancer effect of immunotoxins.

Risberg K, Guldvik IJ, Palchaudhuri R, Xi Y, Ju J, Fodstad O, Hergenrother PJ, Andersson Y.

J Immunother. 2011 Jun;34(5):438-47. doi: 10.1097/CJI.0b013e31821e00ae.


Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

Granchi C, Roy S, Giacomelli C, Macchia M, Tuccinardi T, Martinelli A, Lanza M, Betti L, Giannaccini G, Lucacchini A, Funel N, León LG, Giovannetti E, Peters GJ, Palchaudhuri R, Calvaresi EC, Hergenrother PJ, Minutolo F.

J Med Chem. 2011 Mar 24;54(6):1599-612. doi: 10.1021/jm101007q. Epub 2011 Feb 18.


Transcript profiling and RNA interference as tools to identify small molecule mechanisms and therapeutic potential.

Palchaudhuri R, Hergenrother PJ.

ACS Chem Biol. 2011 Jan 21;6(1):21-33. doi: 10.1021/cb100310h. Epub 2010 Dec 23. Review.


Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death.

Bair JS, Palchaudhuri R, Hergenrother PJ.

J Am Chem Soc. 2010 Apr 21;132(15):5469-78. doi: 10.1021/ja100610m.


N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.

Stefely JA, Palchaudhuri R, Miller PA, Peterson RJ, Moraski GC, Hergenrother PJ, Miller MJ.

J Med Chem. 2010 Apr 22;53(8):3389-95. doi: 10.1021/jm1000979.


Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism.

Hoyt MT, Palchaudhuri R, Hergenrother PJ.

Invest New Drugs. 2011 Aug;29(4):562-73. doi: 10.1007/s10637-010-9390-x. Epub 2010 Feb 20.


Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells.

Palchaudhuri R, Hergenrother PJ.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5888-91. doi: 10.1016/j.bmcl.2008.07.128. Epub 2008 Aug 3.


The complex role of the triphenylmethyl motif in anticancer compounds.

Palchaudhuri R, Nesterenko V, Hergenrother PJ.

J Am Chem Soc. 2008 Aug 6;130(31):10274-81. doi: 10.1021/ja8020999. Epub 2008 Jul 9.


DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action.

Palchaudhuri R, Hergenrother PJ.

Curr Opin Biotechnol. 2007 Dec;18(6):497-503. Epub 2007 Nov 7. Review.


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