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Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention?

Jaiswal PK, Koul S, Palanisamy N, Koul HK.

Cancer Cell Int. 2019 Aug 31;19:224. doi: 10.1186/s12935-019-0947-2. eCollection 2019.


CDK7 inhibition suppresses Castration-Resistant Prostate Cancer through MED1 inactivation.

Rasool RU, Natesan R, Deng Q, Aras S, Lal P, Sander Effron S, Mitchell-Velasquez E, Posimo JM, Carskadon S, Baca SC, Pomerantz MM, Siddiqui J, Schwartz LE, Lee DJ, Palanisamy N, Narla G, Den RB, Freedman ML, Brady DC, Asangani IA.

Cancer Discov. 2019 Aug 29. pii: CD-19-0189. doi: 10.1158/2159-8290.CD-19-0189. [Epub ahead of print]


Pseudogene Associated Recurrent Gene Fusion in Prostate Cancer.

Chakravarthi BV, Dedigama-Arachchige P, Carskadon S, Sundaram SK, Li J, Wu KH, Chandrashekar DS, Peabody JO, Stricker H, Hwang C, Chitale DA, Williamson SR, Gupta NS, Navone NM, Rogers C, Menon M, Varambally S, Palanisamy N.

Neoplasia. 2019 Aug 22;21(10):989-1002. doi: 10.1016/j.neo.2019.07.010. [Epub ahead of print]


A pediatric case of pigmented epithelioid melanocytoma with chromosomal copy number alterations in 15q and 17q and a novel NTRK3-SCAPER gene fusion.

Friedman BJ, Hernandez S, Fidai C, Jiang A, Shwayder TA, Carskadon S, Andea AA, Harms PW, Chitale D, Palanisamy N.

J Cutan Pathol. 2019 Aug 22. doi: 10.1111/cup.13566. [Epub ahead of print]


Effect of the baseline Y93H resistance-associated substitution in HCV genotype 3 for direct-acting antiviral treatment: real-life experience from a multicenter study in Sweden and Norway.

Kjellin M, Kileng H, Akaberi D, Palanisamy N, Duberg AS, Danielsson A, Kristiansen MG, Nöjd J, Aleman S, Gutteberg T, Goll R, Lannergård A, Lennerstrand J.

Scand J Gastroenterol. 2019 Aug 19:1-9. doi: 10.1080/00365521.2019.1652846. [Epub ahead of print]


Combined loss of TFF3 and PTEN is associated with lethal outcome and overall survival in men with prostate cancer.

Abou-Ouf H, Ghosh S, Box A, Palanisamy N, Bismar TA.

J Cancer Res Clin Oncol. 2019 Jul;145(7):1751-1759. doi: 10.1007/s00432-019-02933-z. Epub 2019 May 25.


Prostate cancer with comedonecrosis is frequently, but not exclusively, intraductal carcinoma: a need for reappraisal of grading criteria.

Madan R, Deebajah M, Alanee S, Gupta NS, Carskadon S, Palanisamy N, Williamson SR.

Histopathology. 2019 Jun;74(7):1081-1087. doi: 10.1111/his.13833. Epub 2019 Apr 29.


Epigenetic Silencing of miRNA-338-5p and miRNA-421 Drives SPINK1-Positive Prostate Cancer.

Bhatia V, Yadav A, Tiwari R, Nigam S, Goel S, Carskadon S, Gupta N, Goel A, Palanisamy N, Ateeq B.

Clin Cancer Res. 2019 May 1;25(9):2755-2768. doi: 10.1158/1078-0432.CCR-18-3230. Epub 2018 Dec 26.


A Multicolor Large Stokes Shift Fluorogen-Activating RNA Aptamer with Cationic Chromophores.

Steinmetzger C, Palanisamy N, Gore KR, Höbartner C.

Chemistry. 2019 Feb 6;25(8):1931-1935. doi: 10.1002/chem.201805882. Epub 2019 Jan 11.


Low frequency ultrasound inactivation of thermophilic bacilli (Geobacillus spp. and Anoxybacillus flavithermus) in the presence of sodium hydroxide and hydrogen peroxide.

Palanisamy N, Seale B, Turner A, Hemar Y.

Ultrason Sonochem. 2019 Mar;51:325-331. doi: 10.1016/j.ultsonch.2018.09.025. Epub 2018 Sep 19.


Baseline dasabuvir resistance in Hepatitis C virus from the genotypes 1, 2 and 3 and modeling of the NS5B-dasabuvir complex by the in silico approach.

Akaberi D, Bergfors A, Kjellin M, Kameli N, Lidemalm L, Kolli B, Shafer RW, Palanisamy N, Lennerstrand J.

Infect Ecol Epidemiol. 2018 Oct 5;8(1):1528117. doi: 10.1080/20008686.2018.1528117. eCollection 2018.


Association of ERG/PTEN status with biochemical recurrence after radical prostatectomy for clinically localized prostate cancer.

Mehra R, Salami SS, Lonigro R, Bhalla R, Siddiqui J, Cao X, Spratt DE, Palapattu GS, Palanisamy N, Wei JT, Chinnaiyan AM, Tomlins SA.

Med Oncol. 2018 Oct 5;35(12):152. doi: 10.1007/s12032-018-1212-6.


Neurofilament is superior to cytokeratin 20 in supporting cutaneous origin for neuroendocrine carcinoma.

Stanoszek LM, Chan MP, Palanisamy N, Carskadon S, Siddiqui J, Patel RM, Harms KL, Lowe L, Fullen DR, Harms PW.

Histopathology. 2019 Feb;74(3):504-513. doi: 10.1111/his.13758. Epub 2018 Dec 5.


Clinical utility of assessing PTEN and ERG protein expression in prostate cancer patients: a proposed method for risk stratification.

Bismar TA, Hegazy S, Feng Z, Yu D, Donnelly B, Palanisamy N, Trock BJ.

J Cancer Res Clin Oncol. 2018 Nov;144(11):2117-2125. doi: 10.1007/s00432-018-2730-5. Epub 2018 Aug 12.


Wnt receptor Frizzled 8 is a target of ERG in prostate cancer.

Chakravarthi BVSK, Chandrashekar DS, Hodigere Balasubramanya SA, Robinson AD, Carskadon S, Rao U, Gordetsky J, Manne U, Netto GJ, Sudarshan S, Palanisamy N, Varambally S.

Prostate. 2018 Dec;78(16):1311-1320. doi: 10.1002/pros.23704. Epub 2018 Jul 26.


Identification of putative drug targets and annotation of unknown proteins in Tropheryma whipplei.

Palanisamy N.

Comput Biol Chem. 2018 Oct;76:130-138. doi: 10.1016/j.compbiolchem.2018.05.024. Epub 2018 Jun 9.


Deleterious single nucleotide polymorphisms of protein kinase R identified by the computational approach.

Melzer AM, Palanisamy N.

Mol Immunol. 2018 Sep;101:65-73. doi: 10.1016/j.molimm.2018.05.026. Epub 2018 Jun 4.


Worldwide prevalence of baseline resistance-associated polymorphisms and resistance mutations in HCV against current direct-acting antivirals.

Palanisamy N, Kalaghatgi P, Akaberi D, Lundkvist Å, Chen ZW, Hu P, Lennerstrand J.

Antivir Ther. 2018;23(6):485-493. doi: 10.3851/IMP3237.


Comparative genome analysis of Alkhumra hemorrhagic fever virus with Kyasanur forest disease and tick-borne encephalitis viruses by the in silico approach.

Palanisamy N, Akaberi D, Lennerstrand J, Lundkvist Å.

Pathog Glob Health. 2018 Jun;112(4):210-226. doi: 10.1080/20477724.2018.1471187. Epub 2018 May 10.


Expression and role of PAICS, a de novo purine biosynthetic gene in prostate cancer.

Chakravarthi BVSK, Goswami MT, Pathi SS, Dodson M, Chandrashekar DS, Agarwal S, Nepal S, Hodigere Balasubramanya SA, Siddiqui J, Lonigro RJ, Chinnaiyan AM, Kunju LP, Palanisamy N, Varambally S.

Prostate. 2018 Jun;78(9):693-694. doi: 10.1002/pros.23533. Epub 2018 Apr 10. No abstract available.


Enrichment and mutation detection of circulating tumor cells from blood samples.

Kou R, Zhao J, Gogoi P, Carskadon S, Chow W, Hwang C, Palanisamy N, Leung C, Wang Y.

Oncol Rep. 2018 Jun;39(6):2537-2544. doi: 10.3892/or.2018.6342. Epub 2018 Mar 30.


Pseudosarcomatous myofibroblastic proliferations of the genitourinary tract are genetically different from nodular fasciitis and lack USP6, ROS1 and ETV6 gene rearrangements.

Jebastin JAS, Smith SC, Perry KD, Gupta NS, Alanee S, Carskadon S, Chitale DA, Palanisamy N, Williamson SR.

Histopathology. 2018 Aug;73(2):321-326. doi: 10.1111/his.13526. Epub 2018 May 30.


Pediatric High-flow Pial Arteriovenous Fistula (AVF) for Glue Embolization: An Anesthetic Challenge.

Venkatesulu K, Nandhakumar A, Cherian M, Mehta P, Palanisamy N.

J Neurosurg Anesthesiol. 2019 Apr;31(2):262-263. doi: 10.1097/ANA.0000000000000480. No abstract available.


Protein backbone flexibility pattern is evolutionarily conserved in the Flaviviridae family: A case of NS3 protease in Flavivirus and Hepacivirus.

Palanisamy N, Akaberi D, Lennerstrand J.

Mol Phylogenet Evol. 2018 Jan;118:58-63. doi: 10.1016/j.ympev.2017.09.015. Epub 2017 Sep 22.


Solitary Fibrous Tumors of the Head and Neck: A Multi-Institutional Clinicopathologic Study.

Smith SC, Gooding WE, Elkins M, Patel RM, Harms PW, McDaniel AS, Palanisamy N, Uram-Tuculescu C, Balzer BB, Lucas DR, Seethala RR, McHugh JB.

Am J Surg Pathol. 2017 Dec;41(12):1642-1656. doi: 10.1097/PAS.0000000000000940.


Evaluation of Sofosbuvir (β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine) as an inhibitor of Dengue virus replication<sup/>.

Xu HT, Colby-Germinario SP, Hassounah SA, Fogarty C, Osman N, Palanisamy N, Han Y, Oliveira M, Quan Y, Wainberg MA.

Sci Rep. 2017 Jul 24;7(1):6345. doi: 10.1038/s41598-017-06612-2.


Increased expression of EZH2 in Merkel cell carcinoma is associated with disease progression and poorer prognosis.

Harms KL, Chubb H, Zhao L, Fullen DR, Bichakjian CK, Johnson TM, Carskadon S, Palanisamy N, Harms PW.

Hum Pathol. 2017 Sep;67:78-84. doi: 10.1016/j.humpath.2017.07.009. Epub 2017 Jul 21.


Renal cell tumors with clear cell histology and intact VHL and chromosome 3p: a histological review of tumors from the Cancer Genome Atlas database.

Favazza L, Chitale DA, Barod R, Rogers CG, Kalyana-Sundaram S, Palanisamy N, Gupta NS, Williamson SR.

Mod Pathol. 2017 Nov;30(11):1603-1612. doi: 10.1038/modpathol.2017.72. Epub 2017 Jul 21.


Poor Prognosis Indicated by Venous Circulating Tumor Cell Clusters in Early-Stage Lung Cancers.

Murlidhar V, Reddy RM, Fouladdel S, Zhao L, Ishikawa MK, Grabauskiene S, Zhang Z, Lin J, Chang AC, Carrott P, Lynch WR, Orringer MB, Kumar-Sinha C, Palanisamy N, Beer DG, Wicha MS, Ramnath N, Azizi E, Nagrath S.

Cancer Res. 2017 Sep 15;77(18):5194-5206. doi: 10.1158/0008-5472.CAN-16-2072. Epub 2017 Jul 17.


Age and Gender Associations of Virus Positivity in Merkel Cell Carcinoma Characterized Using a Novel RNA In Situ Hybridization Assay.

Wang L, Harms PW, Palanisamy N, Carskadon S, Cao X, Siddiqui J, Patel RM, Zelenka-Wang S, Durham AB, Fullen DR, Harms KL, Su F, Shukla S, Mehra R, Chinnaiyan AM.

Clin Cancer Res. 2017 Sep 15;23(18):5622-5630. doi: 10.1158/1078-0432.CCR-17-0299. Epub 2017 Jun 12.


Computational Prediction of Usutu Virus E Protein B Cell and T Cell Epitopes for Potential Vaccine Development.

Palanisamy N, Lennerstrand J.

Scand J Immunol. 2017 May;85(5):350-364. doi: 10.1111/sji.12544.


Does antiretroviral treatment change HIV-1 codon usage patterns in its genes: a preliminary bioinformatics study.

Palanisamy N, Osman N, Ohnona F, Xu HT, Brenner B, Mesplède T, Wainberg MA.

AIDS Res Ther. 2017 Jan 7;14(1):2. doi: 10.1186/s12981-016-0130-y.


Renal Cell Carcinoma With Chromosome 6p Amplification Including the TFEB Gene: A Novel Mechanism of Tumor Pathogenesis?

Williamson SR, Grignon DJ, Cheng L, Favazza L, Gondim DD, Carskadon S, Gupta NS, Chitale DA, Kalyana-Sundaram S, Palanisamy N.

Am J Surg Pathol. 2017 Mar;41(3):287-298. doi: 10.1097/PAS.0000000000000776.


Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer.

Mani RS, Amin MA, Li X, Kalyana-Sundaram S, Veeneman BA, Wang L, Ghosh A, Aslam A, Ramanand SG, Rabquer BJ, Kimura W, Tran M, Cao X, Roychowdhury S, Dhanasekaran SM, Palanisamy N, Sadek HA, Kapur P, Koch AE, Chinnaiyan AM.

Cell Rep. 2016 Dec 6;17(10):2620-2631. doi: 10.1016/j.celrep.2016.11.019.


Sclerosing TFEB-rearrangement renal cell carcinoma: a recurring histologic pattern.

Williamson SR, Eble JN, Palanisamy N.

Hum Pathol. 2017 Apr;62:175-179. doi: 10.1016/j.humpath.2016.10.024. Epub 2016 Nov 15.


HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone.

Day KC, Lorenzatti Hiles G, Kozminsky M, Dawsey SJ, Paul A, Broses LJ, Shah R, Kunja LP, Hall C, Palanisamy N, Daignault-Newton S, El-Sawy L, Wilson SJ, Chou A, Ignatoski KW, Keller E, Thomas D, Nagrath S, Morgan T, Day ML.

Cancer Res. 2017 Jan 1;77(1):74-85. doi: 10.1158/0008-5472.CAN-16-1656. Epub 2016 Oct 28.


The utility of ETV1, ETV4 and ETV5 RNA in-situ hybridization in the diagnosis of CIC-DUX sarcomas.

Smith SC, Palanisamy N, Martin E, Almenara J, McHugh JB, Choi EK, Lucas DR, Betz BL, Thomas D, Patel RM.

Histopathology. 2017 Mar;70(4):657-663. doi: 10.1111/his.13112. Epub 2016 Dec 16.


Correction: RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC.

Majumder M, House R, Palanisamy N, Qie S, Day TA, Neskey D, Diehl JA, Palanisamy V.

PLoS Genet. 2016 Oct 26;12(10):e1006411. doi: 10.1371/journal.pgen.1006411. eCollection 2016 Oct.


Cultured circulating tumor cells and their derived xenografts for personalized oncology.

Wang R, Chu GCY, Mrdenovic S, Annamalai AA, Hendifar AE, Nissen NN, Tomlinson JS, Lewis M, Palanisamy N, Tseng HR, Posadas EM, Freeman MR, Pandol SJ, Zhau HE, Chung LWK.

Asian J Urol. 2016 Oct;3(4):240-253. doi: 10.1016/j.ajur.2016.08.005. Epub 2016 Aug 25. Review.


RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC.

Majumder M, House R, Palanisamy N, Qie S, Day TA, Neskey D, Diehl JA, Palanisamy V.

PLoS Genet. 2016 Sep 8;12(9):e1006306. doi: 10.1371/journal.pgen.1006306. eCollection 2016 Sep. Erratum in: PLoS Genet. 2016 Oct 26;12 (10 ):e1006411.


Loss of p16 expression and copy number changes of CDKN2A in a spectrum of spitzoid melanocytic lesions.

Harms PW, Hocker TL, Zhao L, Chan MP, Andea AA, Wang M, Harms KL, Wang ML, Carskadon S, Palanisamy N, Fullen DR.

Hum Pathol. 2016 Dec;58:152-160. doi: 10.1016/j.humpath.2016.07.029. Epub 2016 Aug 26.


Expression and Role of PAICS, a De Novo Purine Biosynthetic Gene in Prostate Cancer.

Chakravarthi BV, Goswami MT, Pathi SS, Dodson M, Chandrashekar DS, Agarwal S, Nepal S, Hodigere Balasubramanya SA, Siddiqui J, Lonigro RJ, Chinnaiyan AM, Kunju LP, Palanisamy N, Varambally S.

Prostate. 2017 Jan;77(1):10-21. doi: 10.1002/pros.23243. Epub 2016 Aug 22. Erratum in: Prostate. 2018 Jun;78(9):693-694.


Expanded Circulating Tumor Cells from a Patient with ALK-Positive Lung Cancer Present with EML4-ALK Rearrangement Along with Resistance Mutation and Enable Drug Sensitivity Testing: A Case Study.

Zhang Z, Shiratsuchi H, Palanisamy N, Nagrath S, Ramnath N.

J Thorac Oncol. 2017 Feb;12(2):397-402. doi: 10.1016/j.jtho.2016.07.027. Epub 2016 Aug 6.


SYBR Green II Dye-Based Real-Time Assay for Measuring Inhibitor Activity Against HIV-1 Reverse Transcriptase.

Kokkula C, Palanisamy N, Ericstam M, Lennerstrand J.

Mol Biotechnol. 2016 Oct;58(10):619-625. doi: 10.1007/s12033-016-9961-y.


Biophysical Studies on HCV 1a NS3/4A Protease and Its Catalytic Triad in Wild Type and Mutants by the In Silico Approach.

Palanisamy N, Lennerstrand J.

Interdiscip Sci. 2018 Mar;10(1):143-156. doi: 10.1007/s12539-016-0177-4. Epub 2016 Jun 16.


MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer.

Chakravarthi BV, Goswami MT, Pathi SS, Robinson AD, Cieślik M, Chandrashekar DS, Agarwal S, Siddiqui J, Daignault S, Carskadon SL, Jing X, Chinnaiyan AM, Kunju LP, Palanisamy N, Varambally S.

Oncogene. 2016 Dec 8;35(49):6330-6340. doi: 10.1038/onc.2016.164. Epub 2016 Jun 6.


Hepatic artery reconstruction following iatrogenic injury during laparoscopic distal pancreatectomy: Minimal access surgery is new horizon.

Palanisamy S, Deuri B, Naidu SB, Palanisamy NV, Natesan VA, Chinnusamy P.

J Minim Access Surg. 2016 Oct-Dec;12(4):382-4. doi: 10.4103/0972-9941.181330.


Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells.

Yoon HJ, Shanker A, Wang Y, Kozminsky M, Jin Q, Palanisamy N, Burness ML, Azizi E, Simeone DM, Wicha MS, Kim J, Nagrath S.

Adv Mater. 2016 Jun;28(24):4891-7. doi: 10.1002/adma.201600658. Epub 2016 Apr 26.


Morpheaform Basal Cell Carcinomas With Areas of Predominantly Single-Cell Pattern of Infiltration: Diagnostic Utility of p63 and Cytokeratin.

East E, Fullen DR, Arps D, Patel RM, Palanisamy N, Carskadon S, Harms PW.

Am J Dermatopathol. 2016 Oct;38(10):744-50. doi: 10.1097/DAD.0000000000000541.


Corrigendum: TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer.

Banerjee R, Russo N, Liu M, Basrur V, Bellile E, Palanisamy N, Scanlon CS, van Tubergen E, Inglehart RC, Metwally T, Mani RS, Yocum A, Nyati MK, Castilho RM, Varambally S, Chinnaiyan AM, D'Silva NJ.

Nat Commun. 2016 Feb 24;7:10726. doi: 10.1038/ncomms10726. No abstract available.

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