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Items: 1 to 50 of 72

1.

Design, synthesis, in silico pharmacokinetics prediction and biological evaluation of 1,4-dihydroindeno[1,2-c]pyrazole chalcone as EGFR /Akt pathway inhibitors.

Khan I, Garikapati KR, Setti A, Shaik AB, Kanth Makani VK, Shareef MA, Rajpurohit H, Vangara N, Pal-Bhadra M, Kamal A, Kumar CG.

Eur J Med Chem. 2019 Feb 1;163:636-648. doi: 10.1016/j.ejmech.2018.12.011. Epub 2018 Dec 8.

PMID:
30562699
2.

Synthesis and biological evaluation of chalcone-linked pyrazolo[1,5-a]pyrimidines as potential anticancer agents.

Bagul C, Rao GK, Makani VKK, Tamboli JR, Pal-Bhadra M, Kamal A.

Medchemcomm. 2017 Jul 13;8(9):1810-1816. doi: 10.1039/c7md00193b. eCollection 2017 Sep 1.

3.

Regulating BMI1 expression via miRNAs promote Mesenchymal to Epithelial Transition (MET) and sensitizes breast cancer cell to chemotherapeutic drug.

Patel N, Garikapati KR, Makani VKK, Nair AD, Vangara N, Bhadra U, Pal Bhadra M.

PLoS One. 2018 Feb 2;13(2):e0190245. doi: 10.1371/journal.pone.0190245. eCollection 2018.

4.

Two way controls of apoptotic regulators consign DmArgonaute-1 a better clasp on it.

Mondal T, Bag I, Sncvl P, Garikapati KR, Bhadra U, Pal Bhadra M.

PLoS One. 2018 Jan 31;13(1):e0190548. doi: 10.1371/journal.pone.0190548. eCollection 2018.

5.

Design, synthesis and biological evaluation of 1, 4-dihydro indeno[1,2-c] pyrazole linked oxindole analogues as potential anticancer agents targeting tubulin and inducing p53 dependent apoptosis.

Khan I, Garikapati KR, Shaik AB, Makani VKK, Rahim A, Shareef MA, Reddy VG, Pal-Bhadra M, Kamal A, Kumar CG.

Eur J Med Chem. 2018 Jan 20;144:104-115. doi: 10.1016/j.ejmech.2017.12.010. Epub 2017 Dec 5.

PMID:
29268127
6.

Epigenetic regulation of miR-200 as the potential strategy for the therapy against triple-negative breast cancer.

Mekala JR, Naushad SM, Ponnusamy L, Arivazhagan G, Sakthiprasad V, Pal-Bhadra M.

Gene. 2018 Jan 30;641:248-258. doi: 10.1016/j.gene.2017.10.018. Epub 2017 Oct 14. Review.

PMID:
29038000
7.

Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells.

Shaik AB, Rao GK, Kumar GB, Patel N, Reddy VS, Khan I, Routhu SR, Kumar CG, Veena I, Chandra Shekar K, Barkume M, Jadhav S, Juvekar A, Kode J, Pal-Bhadra M, Kamal A.

Eur J Med Chem. 2017 Oct 20;139:305-324. doi: 10.1016/j.ejmech.2017.07.056. Epub 2017 Jul 25.

PMID:
28803046
8.

Evolution of circadian rhythms: from bacteria to human.

Bhadra U, Thakkar N, Das P, Pal Bhadra M.

Sleep Med. 2017 Jul;35:49-61. doi: 10.1016/j.sleep.2017.04.008. Epub 2017 May 8. Review.

PMID:
28619182
9.

Cardinal Epigenetic Role of non-coding Regulatory RNAs in Circadian Rhythm.

Bhadra U, Patra P, Pal-Bhadra M.

Mol Neurobiol. 2018 Apr;55(4):3564-3576. doi: 10.1007/s12035-017-0573-8. Epub 2017 May 17. Review.

PMID:
28516429
10.

Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species.

Mathew R, Pal Bhadra M, Bhadra U.

Biogerontology. 2017 Feb;18(1):35-53. doi: 10.1007/s10522-016-9670-8. Epub 2017 Jan 18. Review.

PMID:
28101820
11.

Pigmy MicroRNA: surveillance cops in Therapies kingdom.

Bhadra U, Patra P, Chhatai J, Pal-Bhadra M.

Mol Med. 2016 Dec;22:759-775. doi: 10.2119/molmed.2016.00136. Epub 2016 Sep 28.

12.

Drosophila maleless gene counteracts X global aneuploid effects in males.

Bhadra U, Gandhi SG, Palaparthi R, Balyan MK, Pal-Bhadra M.

FEBS J. 2016 Sep;283(18):3457-70. doi: 10.1111/febs.13818. Epub 2016 Sep 9.

13.

Long non-coding RNA: Functional agent for disease traits.

Jain S, Thakkar N, Chhatai J, Pal Bhadra M, Bhadra U.

RNA Biol. 2017 May 4;14(5):522-535. doi: 10.1080/15476286.2016.1172756. Epub 2016 May 26. Review.

14.

A novel bisindole-PBD conjugate inhibits angiogenesis by regulating STAT3 and VEGF in breast cancer cells.

Sarma P, Ramaiah MJ, Pal D, Bhadra U, Pal Bhadra M.

Life Sci. 2016 Apr 15;151:264-276. doi: 10.1016/j.lfs.2016.03.024. Epub 2016 Mar 12.

PMID:
26979778
15.

Synthesis and mechanistic aspects of 2-anilinonicotinyl-pyrazolo[1,5-a]pyrimidine conjugates that regulate cell proliferation in MCF-7 cells via estrogen signaling.

Kamal A, Faazil S, Hussaini SM, Ramaiah MJ, Balakrishna M, Patel N, Pushpavalli SN, Pal-Bhadra M.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):2077-83. doi: 10.1016/j.bmcl.2016.02.072. Epub 2016 Feb 26.

PMID:
26948540
16.

Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway.

Pushpavalli SN, Sarkar A, Ramaiah MJ, Koteswara Rao G, Bag I, Bhadra U, Pal-Bhadra M.

Apoptosis. 2016 Mar;21(3):269-82. doi: 10.1007/s10495-015-1206-1.

PMID:
26711898
17.

Bisindole-PBD regulates breast cancer cell proliferation via SIRT-p53 axis.

Sarma P, Bag I, Ramaiah MJ, Kamal A, Bhadra U, Pal Bhadra M.

Cancer Biol Ther. 2015;16(10):1486-501. doi: 10.1080/15384047.2015.1071731. Epub 2015 Jul 20. Erratum in: Cancer Biol Ther. 2016 Aug 2;17(8):881.

18.

Computational approach for elucidating interactions of cross-species miRNAs and their targets in Flaviviruses.

Shinde SP, Banerjee AK, Arora N, Murty US, Sripathi VR, Pal-Bhadra M, Bhadra U.

J Vector Borne Dis. 2015 Mar;52(1):11-22.

19.

A spatio-temporal cardiomyocyte targeted vector system for efficient delivery of therapeutic payloads to regress cardiac hypertrophy abating bystander effect.

Rana S, Datta K, Reddy TL, Chatterjee E, Sen P, Pal-Bhadra M, Bhadra U, Pramanik A, Pramanik P, Chawla-Sarkar M, Sarkar S.

J Control Release. 2015 Feb 28;200:167-78. doi: 10.1016/j.jconrel.2015.01.008. Epub 2015 Jan 7.

PMID:
25575863
20.

Drosophila oncogene Gas41 is an RNA interference modulator that intersects heterochromatin and the small interfering RNA pathway.

Gandhi SG, Bag I, Sengupta S, Pal-Bhadra M, Bhadra U.

FEBS J. 2015 Jan;282(1):153-73. doi: 10.1111/febs.13115. Epub 2014 Nov 17.

21.

Tandem Prins/pinacol reaction for the synthesis of oxaspiro[4.5]decan-1-one scaffolds.

Reddy BV, Gopal Reddy S, Ramana Reddy M, Pal Bhadra M, Sarma AV.

Org Biomol Chem. 2014 Oct 7;12(37):7257-60. doi: 10.1039/c4ob01188k.

PMID:
25103114
22.

Cancer cell-selective promoter recognition accompanies antitumor effect by glucocorticoid receptor-targeted gold nanoparticle.

Sau S, Agarwalla P, Mukherjee S, Bag I, Sreedhar B, Pal-Bhadra M, Patra CR, Banerjee R.

Nanoscale. 2014 Jun 21;6(12):6745-54. doi: 10.1039/c4nr00974f.

PMID:
24824564
23.

Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat.

Padiya R, Chowdhury D, Borkar R, Srinivas R, Pal Bhadra M, Banerjee SK.

PLoS One. 2014 May 5;9(5):e94228. doi: 10.1371/journal.pone.0094228. eCollection 2014.

24.

Argonaute-1 functions as a mitotic regulator by controlling Cyclin B during Drosophila early embryogenesis.

Pushpavalli SN, Sarkar A, Bag I, Hunt CR, Ramaiah MJ, Pandita TK, Bhadra U, Pal-Bhadra M.

FASEB J. 2014 Feb;28(2):655-66. doi: 10.1096/fj.13-231167. Epub 2013 Oct 28.

25.

Quinazolino linked 4β-amidopodophyllotoxin conjugates regulate angiogenic pathway and control breast cancer cell proliferation.

Kamal A, Tamboli JR, Ramaiah MJ, Adil SF, Pushpavalli SN, Ganesh R, Sarma P, Bhadra U, Pal-Bhadra M.

Bioorg Med Chem. 2013 Nov 1;21(21):6414-26. doi: 10.1016/j.bmc.2013.08.051. Epub 2013 Sep 3.

PMID:
24055291
26.

Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells.

Kamal A, Faazil S, Ramaiah MJ, Ashraf M, Balakrishna M, Pushpavalli SN, Patel N, Pal-Bhadra M.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5733-9. doi: 10.1016/j.bmcl.2013.07.068. Epub 2013 Aug 8.

PMID:
23999041
27.

Novel anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates modulate the expression of p53-MYCN associated micro RNAs in neuroblastoma cells and cause cell cycle arrest and apoptosis.

Ramaiah MJ, Pushpavalli SN, Lavanya A, Bhadra K, Haritha V, Patel N, Tamboli JR, Kamal A, Bhadra U, Pal-Bhadra M.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5699-706. doi: 10.1016/j.bmcl.2013.08.018. Epub 2013 Aug 12.

PMID:
23992861
28.

4β-[4'-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents.

Kamal A, Suresh P, Ramaiah MJ, Srinivasa Reddy T, Kapavarapu RK, Rao BN, Imthiajali S, Lakshminarayan Reddy T, Pushpavalli SN, Shankaraiah N, Pal-Bhadra M.

Bioorg Med Chem. 2013 Sep 1;21(17):5198-208. doi: 10.1016/j.bmc.2013.06.033. Epub 2013 Jun 21.

PMID:
23849207
29.

Drosophila MOF controls Checkpoint protein2 and regulates genomic stability during early embryogenesis.

Pushpavalli SN, Sarkar A, Ramaiah MJ, Chowdhury DR, Bhadra U, Pal-Bhadra M.

BMC Mol Biol. 2013 Jan 24;14:1. doi: 10.1186/1471-2199-14-1.

30.

Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents.

Kamal A, Mallareddy A, Janaki Ramaiah M, Pushpavalli SN, Suresh P, Kishor C, Murty JN, Rao NS, Ghosh S, Addlagatta A, Pal-Bhadra M.

Eur J Med Chem. 2012 Oct;56:166-78. doi: 10.1016/j.ejmech.2012.08.021. Epub 2012 Aug 23.

PMID:
22982122
31.

Imidazo-benzothiazoles a potent microRNA modulator involved in cell proliferation.

Pushpavalli SN, Ramaiah MJ, Lavanya A, Ganesh AR, Kumbhare RM, Bhadra K, Bhadra U, Pal-Bhadra M.

Bioorg Med Chem Lett. 2012 Oct 15;22(20):6418-24. doi: 10.1016/j.bmcl.2012.08.058. Epub 2012 Aug 23.

PMID:
22981648
32.

Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2-phenyl benzothiazole as potential anticancer agents.

Kumbhare RM, Kosurkar UB, Janaki Ramaiah M, Dadmal TL, Pushpavalli SN, Pal-Bhadra M.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5424-7. doi: 10.1016/j.bmcl.2012.07.041. Epub 2012 Jul 17.

PMID:
22858144
33.

Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells.

Kamal A, Tamboli JR, Ramaiah MJ, Adil SF, Koteswara Rao G, Viswanath A, Mallareddy A, Pushpavalli SN, Pal-Bhadra M.

ChemMedChem. 2012 Aug;7(8):1453-64. doi: 10.1002/cmdc.201200205. Epub 2012 Jun 14.

PMID:
22700474
34.

Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells.

Pal-Bhadra M, Ramaiah MJ, Reddy TL, Krishnan A, Pushpavalli SN, Babu KS, Tiwari AK, Rao JM, Yadav JS, Bhadra U.

BMC Cancer. 2012 May 16;12:180. doi: 10.1186/1471-2407-12-180.

35.

Drosophila Argonaute-1 is critical for transcriptional cosuppression and heterochromatin formation.

Pushpavalli SN, Bag I, Pal-Bhadra M, Bhadra U.

Chromosome Res. 2012 Apr;20(3):333-51. doi: 10.1007/s10577-012-9279-y. Epub 2012 Apr 3.

36.

Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents.

Kamal A, Suresh P, Ramaiah MJ, Mallareddy A, Imthiajali S, Pushpavalli SN, Lavanya A, Pal-Bhadra M.

Bioorg Med Chem. 2012 Mar 15;20(6):2054-66. doi: 10.1016/j.bmc.2012.01.039. Epub 2012 Feb 9.

PMID:
22364746
37.

3-substituted 2-phenylimidazo[2,1-b]benzothiazoles: synthesis, anticancer activity, and inhibition of tubulin polymerization.

Kamal A, Sultana F, Ramaiah MJ, Srikanth YV, Viswanath A, Kishor C, Sharma P, Pushpavalli SN, Addlagatta A, Pal-Bhadra M.

ChemMedChem. 2012 Feb 6;7(2):292-300. doi: 10.1002/cmdc.201100511. Epub 2012 Jan 12.

PMID:
22241597
38.

Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.

Kamal A, Srikanth YV, Ramaiah MJ, Khan MN, Kashi Reddy M, Ashraf M, Lavanya A, Pushpavalli SN, Pal-Bhadra M.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):571-8. doi: 10.1016/j.bmcl.2011.10.080. Epub 2011 Oct 31.

PMID:
22104151
39.

Synthesis and apoptosis inducing ability of new anilino substituted pyrimidine sulfonamides as potential anticancer agents.

Kamal A, Dastagiri D, Ramaiah MJ, Reddy JS, Bharathi EV, Reddy MK, Sagar MV, Reddy TL, Pushpavalli SN, Pal-Bhadra M.

Eur J Med Chem. 2011 Dec;46(12):5817-24. doi: 10.1016/j.ejmech.2011.09.039. Epub 2011 Sep 29.

PMID:
22000207
40.

Synthesis and biological evaluation of novel Mannich bases of 2-arylimidazo[2,1-b]benzothiazoles as potential anti-cancer agents.

Kumbhare RM, Vijay Kumar K, Janaki Ramaiah M, Dadmal T, Pushpavalli SN, Mukhopadhyay D, Divya B, Anjana Devi T, Kosurkar U, Pal-Bhadra M.

Eur J Med Chem. 2011 Sep;46(9):4258-66. doi: 10.1016/j.ejmech.2011.06.031. Epub 2011 Jul 1.

PMID:
21775028
41.

Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents.

Kamal A, Suresh P, Janaki Ramaiah M, Mallareddy A, Kumar BA, Raju P, Vinay Gopal J, Pushpavalli SN, Lavanya A, Sarma P, Pal-Bhadra M.

Bioorg Med Chem. 2011 Aug 1;19(15):4589-600. doi: 10.1016/j.bmc.2011.06.017. Epub 2011 Jun 16.

PMID:
21737288
42.

Synthesis of aryl-substituted naphthalene-linked pyrrolobenzodiazepine conjugates as potential anticancer agents with apoptosis-inducing ability.

Kamal A, Reddy MK, Ramaiah MJ, Srikanth YV, Rajender, Reddy VS, Kumar GB, Pushpavalli SN, Bag I, Juvekar A, Sen S, Zingde SM, Pal-Bhadra M.

ChemMedChem. 2011 Sep 5;6(9):1665-79. doi: 10.1002/cmdc.201100207. Epub 2011 Jul 5.

PMID:
21732540
43.

Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1,2,3-triazole ring side-armed with alkane spacers.

Kamal A, Prabhakar S, Janaki Ramaiah M, Venkat Reddy P, Ratna Reddy Ch, Mallareddy A, Shankaraiah N, Lakshmi Narayan Reddy T, Pushpavalli SN, Pal-Bhadra M.

Eur J Med Chem. 2011 Sep;46(9):3820-31. doi: 10.1016/j.ejmech.2011.05.050. Epub 2011 May 30.

PMID:
21676506
44.

The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster.

Boeke J, Bag I, Ramaiah MJ, Vetter I, Kremmer E, Pal-Bhadra M, Bhadra U, Imhof A.

PLoS One. 2011;6(6):e20761. doi: 10.1371/journal.pone.0020761. Epub 2011 Jun 2.

45.

Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents.

Kamal A, Reddy MK, Ramaiah MJ, Rajender, Reddy JS, Srikanth YV, Dastagiri D, Bharathi EV, Pushpavalli SN, Sarma P, Pal-Bhadra M.

Bioorg Med Chem. 2011 Apr 15;19(8):2565-81. doi: 10.1016/j.bmc.2011.03.015. Epub 2011 Mar 12.

PMID:
21459581
46.

Synthesis of imidazothiazole-chalcone derivatives as anticancer and apoptosis inducing agents.

Kamal A, Dastagiri D, Ramaiah MJ, Reddy JS, Bharathi EV, Srinivas C, Pushpavalli SN, Pal D, Pal-Bhadra M.

ChemMedChem. 2010 Nov 8;5(11):1937-47. doi: 10.1002/cmdc.201000346.

PMID:
20836120
47.

Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole-pyrrolobenzodiazepine conjugates.

Kamal A, Dastagiri D, Ramaiah MJ, Bharathi EV, Reddy JS, Balakishan G, Sarma P, Pushpavalli SN, Pal-Bhadra M, Juvekar A, Sen S, Zingde S.

Bioorg Med Chem. 2010 Sep 15;18(18):6666-77. doi: 10.1016/j.bmc.2010.07.067. Epub 2010 Aug 1.

PMID:
20732817
48.

Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents.

Kamal A, Reddy JS, Ramaiah MJ, Bharathi EV, Dastagiri D, Reddy MK, Pushpavalli SN, Pal-Bhadra M.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5232-6. doi: 10.1016/j.bmcl.2010.06.147. Epub 2010 Jul 29.

PMID:
20673627
49.

Synthesis and anti-cancer activity of chalcone linked imidazolones.

Kamal A, Ramakrishna G, Raju P, Viswanath A, Ramaiah MJ, Balakishan G, Pal-Bhadra M.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4865-9. doi: 10.1016/j.bmcl.2010.06.097. Epub 2010 Jun 25.

PMID:
20637611
50.

Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole-pyrrolo[2,1-c][1,4]benzodiazepine conjugates.

Kamal A, Reddy KS, Khan MN, Shetti RV, Ramaiah MJ, Pushpavalli SN, Srinivas C, Pal-Bhadra M, Chourasia M, Sastry GN, Juvekar A, Zingde S, Barkume M.

Bioorg Med Chem. 2010 Jul 1;18(13):4747-61. doi: 10.1016/j.bmc.2010.05.007. Epub 2010 May 7.

PMID:
20627593

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