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microRNA Expression Profiles in the Ventral Hippocampus during Pubertal Development and the Impact of Peri-Pubertal Binge Alcohol Exposure.

Asimes A, Kim CK, Rao YS, Bartelt K, Pak TR.

Noncoding RNA. 2019 Mar 5;5(1). pii: E21. doi: 10.3390/ncrna5010021.


Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases.

Michlmayr D, Pak TR, Rahman AH, Amir ED, Kim EY, Kim-Schulze S, Suprun M, Stewart MG, Thomas GP, Balmaseda A, Wang L, Zhu J, Suaréz-Fariñas M, Wolinsky SM, Kasarskis A, Harris E.

Mol Syst Biol. 2018 Aug 27;14(8):e7862. doi: 10.15252/msb.20177862.


Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection.

Altman DR, Sullivan MJ, Chacko KI, Balasubramanian D, Pak TR, Sause WE, Kumar K, Sebra R, Deikus G, Attie O, Rose H, Lewis M, Fulmer Y, Bashir A, Kasarskis A, Schadt EE, Richardson AR, Torres VJ, Shopsin B, van Bakel H.

Infect Immun. 2018 Sep 21;86(10). pii: e00331-18. doi: 10.1128/IAI.00331-18. Print 2018 Oct.


Binge Drinking and Intergenerational Implications: Parental Preconception Alcohol Impacts Offspring Development in Rats.

Asimes A, Kim CK, Cuarenta A, Auger AP, Pak TR.

J Endocr Soc. 2018 Jun 19;2(7):672-686. doi: 10.1210/js.2018-00051. eCollection 2018 Jul 1.


Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia.

Chacko KI, Sullivan MJ, Beckford C, Altman DR, Ciferri B, Pak TR, Sebra R, Kasarskis A, Hamula CL, van Bakel H.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02007-17. doi: 10.1128/AAC.02007-17. Print 2018 Apr.


Estimating Local Costs Associated With Clostridium difficile Infection Using Machine Learning and Electronic Medical Records.

Pak TR, Chacko KI, O'Donnell T, Huprikar SS, van Bakel H, Kasarskis A, Scott ER.

Infect Control Hosp Epidemiol. 2017 Dec;38(12):1478-1486. doi: 10.1017/ice.2017.214. Epub 2017 Nov 6.


17β-estradiol regulates the RNA-binding protein Nova1, which then regulates the alternative splicing of estrogen receptor β in the aging female rat brain.

Shults CL, Dingwall CB, Kim CK, Pinceti E, Rao YS, Pak TR.

Neurobiol Aging. 2018 Jan;61:13-22. doi: 10.1016/j.neurobiolaging.2017.09.005. Epub 2017 Sep 14.


High-dimensional CyTOF analysis of dengue virus-infected human DCs reveals distinct viral signatures.

Hamlin RE, Rahman A, Pak TR, Maringer K, Mena I, Bernal-Rubio D, Potla U, Maestre AM, Fredericks AC, Amir ED, Kasarskis A, Ramos I, Merad M, Fernandez-Sesma A.

JCI Insight. 2017 Jul 6;2(13). pii: 92424. doi: 10.1172/jci.insight.92424. eCollection 2017 Jul 6.


Structural and functional characteristics of oestrogen receptor β splice variants: Implications for the ageing brain.

Kim CK, Torcaso A, Asimes A, Chung WCJ, Pak TR.

J Neuroendocrinol. 2018 Feb;30(2). doi: 10.1111/jne.12488. Review.


Adolescent binge alcohol exposure increases risk assessment behaviors in male Wistar rats after exposure to an acute psychological stressor in adulthood.

Torcaso A, Asimes A, Meagher M, Pak TR.

Psychoneuroendocrinology. 2017 Feb;76:154-161. doi: 10.1016/j.psyneuen.2016.11.032. Epub 2016 Nov 30.


Adolescent binge-pattern alcohol exposure alters genome-wide DNA methylation patterns in the hypothalamus of alcohol-naïve male offspring.

Asimes A, Torcaso A, Pinceti E, Kim CK, Zeleznik-Le NJ, Pak TR.

Alcohol. 2017 May;60:179-189. doi: 10.1016/j.alcohol.2016.10.010. Epub 2016 Oct 24.


microRNAs and the adolescent brain: Filling the knowledge gap.

Rao YS, Pak TR.

Neurosci Biobehav Rev. 2016 Nov;70:313-322. doi: 10.1016/j.neubiorev.2016.06.008. Epub 2016 Jun 18. Review.


Differential Effects of E2 on MAPK Activity in the Brain and Heart of Aged Female Rats.

Pinceti E, Shults CL, Rao YS, Pak TR.

PLoS One. 2016 Aug 3;11(8):e0160276. doi: 10.1371/journal.pone.0160276. eCollection 2016.


Reply to Lesho.

Pak TR, Kasarskis A.

Clin Infect Dis. 2016 Apr 15;62(8):1053. doi: 10.1093/cid/ciw010. Epub 2016 Feb 6. No abstract available.


Prolonged ovarian hormone deprivation alters the effects of 17β-estradiol on microRNA expression in the aged female rat hypothalamus.

Rao YS, Shults CL, Pinceti E, Pak TR.

Oncotarget. 2015 Nov 10;6(35):36965-83. doi: 10.18632/oncotarget.5433.


Phosphorylation Alters Oestrogen Receptor β-Mediated Transcription in Neurones.

Pinceti E, Shults CL, Rao YS, Mott NN, Pak TR.

J Neuroendocrinol. 2015 Dec;27(12):861-71. doi: 10.1111/jne.12326.


Whole-genome sequencing identifies emergence of a quinolone resistance mutation in a case of Stenotrophomonas maltophilia bacteremia.

Pak TR, Altman DR, Attie O, Sebra R, Hamula CL, Lewis M, Deikus G, Newman LC, Fang G, Hand J, Patel G, Wallach F, Schadt EE, Huprikar S, van Bakel H, Kasarskis A, Bashir A.

Antimicrob Agents Chemother. 2015 Nov;59(11):7117-20. doi: 10.1128/AAC.01723-15. Epub 2015 Aug 31.


Aging and Loss of Circulating 17β-Estradiol Alters the Alternative Splicing of ERβ in the Female Rat Brain.

Shults CL, Pinceti E, Rao YS, Pak TR.

Endocrinology. 2015 Nov;156(11):4187-99. doi: 10.1210/en.2015-1514. Epub 2015 Aug 21.


How next-generation sequencing and multiscale data analysis will transform infectious disease management.

Pak TR, Kasarskis A.

Clin Infect Dis. 2015 Dec 1;61(11):1695-702. doi: 10.1093/cid/civ670. Epub 2015 Aug 6.


Parental binge alcohol abuse alters F1 generation hypothalamic gene expression in the absence of direct fetal alcohol exposure.

Przybycien-Szymanska MM, Rao YS, Prins SA, Pak TR.

PLoS One. 2014 Feb 20;9(2):e89320. doi: 10.1371/journal.pone.0089320. eCollection 2014.


Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat.

Prins SA, Przybycien-Szymanska MM, Rao YS, Pak TR.

PLoS One. 2014 Jan 8;9(1):e83166. doi: 10.1371/journal.pone.0083166. eCollection 2014.


Age-dependent Effects of 17β-estradiol on the dynamics of estrogen receptor β (ERβ) protein-protein interactions in the ventral hippocampus.

Mott NN, Pinceti E, Rao YS, Przybycien-Szymanska MM, Prins SA, Shults CL, Yang X, Glucksman MJ, Roberts JL, Pak TR.

Mol Cell Proteomics. 2014 Mar;13(3):760-79. doi: 10.1074/mcp.M113.031559. Epub 2014 Jan 5.


Estrogen signaling and the aging brain: context-dependent considerations for postmenopausal hormone therapy.

Mott NN, Pak TR.

ISRN Endocrinol. 2013 Jul 7;2013:814690. doi: 10.1155/2013/814690. Print 2013.


MicroRNAs in the aging female brain: a putative mechanism for age-specific estrogen effects.

Rao YS, Mott NN, Wang Y, Chung WC, Pak TR.

Endocrinology. 2013 Aug;154(8):2795-806. doi: 10.1210/en.2013-1230. Epub 2013 May 29.


Sex differences in health and disease: brain and heart connections--a special issue.

Wattanapermpool J, de Tombe PP, Pak TR.

Pflugers Arch. 2013 May;465(5):555-6. doi: 10.1007/s00424-013-1279-z. Epub 2013 Apr 16. No abstract available.


An emerging role for microRNAs in sexually dimorphic neurobiological systems.

Pak TR, Rao YS, Prins SA, Mott NN.

Pflugers Arch. 2013 May;465(5):655-67. doi: 10.1007/s00424-013-1227-y. Epub 2013 Feb 9. Review.


ChromoZoom: a flexible, fluid, web-based genome browser.

Pak TR, Roth FP.

Bioinformatics. 2013 Feb 1;29(3):384-6. doi: 10.1093/bioinformatics/bts695. Epub 2012 Dec 6.


Effect of repetitive daily ethanol intoxication on adult rat brain: significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate neuroinflammatory pathway activation.

Tajuddin NF, Przybycien-Szymanska MM, Pak TR, Neafsey EJ, Collins MA.

Alcohol. 2013 Feb;47(1):39-45. doi: 10.1016/j.alcohol.2012.09.003. Epub 2012 Oct 25.


Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

Rozenblatt-Rosen O, Deo RC, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares M, Pevzner SJ, Abderazzaq F, Byrdsong D, Carvunis AR, Chen AA, Cheng J, Correll M, Duarte M, Fan C, Feltkamp MC, Ficarro SB, Franchi R, Garg BK, Gulbahce N, Hao T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Pak TR, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabási AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Münger K, Marto JA, Quackenbush J, Roth FP, DeCaprio JA, Vidal M.

Nature. 2012 Jul 26;487(7408):491-5. doi: 10.1038/nature11288.


Characterisation of human oestrogen receptor beta (ERβ) splice variants in neuronal cells.

Mott NN, Pak TR.

J Neuroendocrinol. 2012 Oct;24(10):1311-21. doi: 10.1111/j.1365-2826.2012.02337.x.


17β-Estradiol is required for the sexually dimorphic effects of repeated binge-pattern alcohol exposure on the HPA axis during adolescence.

Przybycien-Szymanska MM, Gillespie RA, Pak TR.

PLoS One. 2012;7(2):e32263. doi: 10.1371/journal.pone.0032263. Epub 2012 Feb 22.


Alcohol dysregulates corticotropin-releasing-hormone (CRH) promoter activity by interfering with the negative glucocorticoid response element (nGRE).

Przybycien-Szymanska MM, Mott NN, Pak TR.

PLoS One. 2011;6(10):e26647. doi: 10.1371/journal.pone.0026647. Epub 2011 Oct 24.


Binge-pattern alcohol exposure during puberty induces long-term changes in HPA axis reactivity.

Przybycien-Szymanska MM, Mott NN, Paul CR, Gillespie RA, Pak TR.

PLoS One. 2011 Apr 13;6(4):e18350. doi: 10.1371/journal.pone.0018350.


Effects of kisspeptin on parameters of the HPA axis.

Rao YS, Mott NN, Pak TR.

Endocrine. 2011 Jun;39(3):220-8. doi: 10.1007/s12020-011-9439-4. Epub 2011 Mar 9.


Differential fibroblast growth factor 8 (FGF8)-mediated autoregulation of its cognate receptors, Fgfr1 and Fgfr3, in neuronal cell lines.

Mott NN, Chung WC, Tsai PS, Pak TR.

PLoS One. 2010 Apr 12;5(4):e10143. doi: 10.1371/journal.pone.0010143.


Binge-pattern alcohol exposure during puberty induces sexually dimorphic changes in genes regulating the HPA axis.

Przybycien-Szymanska MM, Rao YS, Pak TR.

Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E320-8. doi: 10.1152/ajpendo.00615.2009. Epub 2009 Dec 1.


Arginine vasopressin regulation in pre- and postpubertal male rats by the androgen metabolite 3beta-diol.

Pak TR, Chung WC, Hinds LR, Handa RJ.

Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1409-13. doi: 10.1152/ajpendo.00037.2009. Epub 2009 Apr 21. Erratum in: Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E270.


Detection and localization of an estrogen receptor beta splice variant protein (ERbeta2) in the adult female rat forebrain and midbrain regions.

Chung WC, Pak TR, Suzuki S, Pouliot WA, Andersen ME, Handa RJ.

J Comp Neurol. 2007 Nov 20;505(3):249-67.


Estrogen receptor-beta mediates dihydrotestosterone-induced stimulation of the arginine vasopressin promoter in neuronal cells.

Pak TR, Chung WC, Hinds LR, Handa RJ.

Endocrinology. 2007 Jul;148(7):3371-82. Epub 2007 Apr 5.


Tuning molecule-surface interactions with sub-nanometer-thick covalently bound organic monolayers.

Camillone N 3rd, Pak TR, Adib K, Osgood RM Jr.

J Phys Chem B. 2006 Jun 15;110(23):11334-43.


Progestin receptor expression in the developing rat brain depends upon activation of estrogen receptor alpha and not estrogen receptor beta.

Chung WC, Pak TR, Weiser MJ, Hinds LR, Andersen ME, Handa RJ.

Brain Res. 2006 Apr 12;1082(1):50-60. Epub 2006 Feb 28.


Ligand-independent effects of estrogen receptor beta on mouse gonadotropin-releasing hormone promoter activity.

Pak TR, Chung WC, Roberts JL, Handa RJ.

Endocrinology. 2006 Apr;147(4):1924-31. Epub 2006 Jan 26.


The androgen metabolite, 5alpha-androstane-3beta, 17beta-diol, is a potent modulator of estrogen receptor-beta1-mediated gene transcription in neuronal cells.

Pak TR, Chung WC, Lund TD, Hinds LR, Clay CM, Handa RJ.

Endocrinology. 2005 Jan;146(1):147-55. Epub 2004 Oct 7.


Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population.

Tsai PS, Moenter SM, Postigo HR, El Majdoubi M, Pak TR, Gill JC, Paruthiyil S, Werner S, Weiner RI.

Mol Endocrinol. 2005 Jan;19(1):225-36. Epub 2004 Sep 30.


Steroidal modulation of in vitro gonadotropin secretion in prepubertal and adult male Siberian hamsters.

Pak TR, Lynch GR, Tsai PS.

J Exp Zool A Comp Exp Biol. 2003 Jul 1;298(1):53-9.


Disruption of pubertal onset by exogenous testosterone and estrogen in two species of rodents.

Pak TR, Lynch GR, Ziegler DM, Lunden JB, Tsai PS.

Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E206-12. Epub 2002 Sep 11.


Estrogen accelerates gonadal recrudescence in photo-regressed male siberian hamsters.

Pak TR, Lynch GR, Tsai PS.

Endocrinology. 2002 Oct;143(10):4131-4.


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